Structural Bioinformatics Group

2022
Non-psychotropic cannabinoids as inhibitors of TET1 protein Antonyová V, Kejík Z, Brogyanyi T, Kaplánek R, Veselá K, Abramenko N, Ocelka T, Masařík M, Matkowski A, Gburek J, Abel R, Goede A, Preissner R, Novotný P, Jakubek M In Bioorg Chem Volume 124:105793, Apr 2022, IF: 5.275.
Real-world evidence from over one-million COVID-19 vaccinations is consistent with reactivation of the varicella-zoster virus Hertel M, Heiland M, Nahles S, von Laffert M, Mura C, Bourne PE, Preissner R, Preissner S In J Eur Acad Dermatol Venereol, Apr 2022, IF: 2.57.
Man vs. machine: comparison of pharmacogenetic expert counselling with a clinical medication support system in a study with 200 genotyped patients Preissner SH, Marchetti P, Simmaco M, Gohlke BO, Eckert A, Preissner S, Preissner R In Eur J Clin Pharmacol, Apr 2022, IF: 2.21.
Comparison of five-year survival rates among patients with oral squamous cell carcinoma with and without association with syphilis: a retrospective case-control study Hertel M, Hagedorn L, Schmidt-Westhausen AM, Dommisch H, Heiland M, Preissner R, Preissner S In BMC Cancer Volume 22, Apr 2022, IF: 4.4.
A Comparative Analysis of COVID-19 Vaccines Based on over 580,000 Cases from the Vaccination Adverse Event Reporting System Gallo K, Goede A, Mura C, Abel R, Moahamed B, Preissner S, Nahles S, Heiland M, Bourne PE, Preissner R, Mallach M In Vaccines (Basel) Volume 10(3):408, Mar 2022, IF: 4.422.
The druggability of bitter taste receptors for the treatment of neurodegenerative disorders Duarte AC, Costa AR, Gonçalves I, Quintela T, Preissner R, Santos CRA In Biochem Pharmacol Volume 197, Mar 2022, IF: 5.29.
Onset of Oral Lichenoid Lesions and Oral Lichen Planus Following COVID-19 Vaccination: A Retrospective Analysis of about 300,000 Vaccinated Patients Hertel M, Schmidt-Westhausen AM, Wendy S, Heiland M, Nahles S, Preissner R, Preissner S In Vaccines (Basel) Volume 10(3):480, Mar 2022, IF: 4.422.
Pharmacogenomics-Guided Pharmacotherapy in Patients with Major Depressive Disorder or Bipolar Disorder Affected by Treatment-Resistant Depressive Episodes: A Long-Term Follow-Up Study. Del Casale A, Pomes LM, Bonanni L, Fiaschè F, Zocchi C, Padovano A, De Luca O, Angeletti G, Brugnoli R, Girardi P, Preissner R, Borro M, Gentile G, Pompili M, Simmaco M. In Journal of Personalized Medicine Volume 12(2):316, Feb 2022, IF: 4.945.
Real-world evidence for preventive effects of statins on cancer incidence: A trans-Atlantic analysis Gohlke BO, Zincke F, Eckert A, Kobelt D, Preissner S, Liebeskind JM, Gunkel N, Putzker K, Lewis J, Preissner S, Kortüm B, Walther W, Mura C, Bourne PE, Stein U, Preissner R In Clin Transl Med Volume 12(2), Feb 2022, IF: 11.492.
2021
Translational suppression of SARS-COV-2 ORF8 protein mRNA as a Viable therapeutic target against COVID-19: Computational studies on potential roles of isolated compounds from Clerodendrum volubile leaves Erukainure OL, Atolani O, Muhammad A, Ravichandran R, Abarshi MM, Katsayal SB, Chukwuma CI, Preissner R, Banerjee P, Mesaik MA In Comput Biol Med Volume 139, Dec 2021, IF: 4.589.
SuperTCM: A biocultural database combining biological pathways and historical linguistic data of Chinese Materia Medica for drug development Chen Q, Springer L, Gohlke BO, Goede A, Dunkel M, Abel R, Gallo K, Preissner S, Eckert A, Seshadri L, Preissner R In Biomed Pharmacother Volume 144, Dec 2021, IF: 6.529.
Prediction of oral squamous cell carcinoma based on machine learning of breath samples: a prospective controlled study Mentel S, Gallo K, Wagendorf O, Preissner R, Nahles S, Heiland M, Preissner S In BMC Oral Health Volume 21(1), Oct 2021, IF: 2.74.
IL-13 is a driver of COVID-19 severity Donlan AN, Sutherland TE, Marie C, Preissner S, Bradley BT, Carpenter RM, Sturek JM, Ma JZ, Moreau GB, Donowitz JR, Buck GA, Serrano MG, Burgess SL, Abhyankar MM, Mura C, Bourne PE, Preissner R, Young MK, Lyons GR, Loomba JJ, Ratcliffe SJ, Poulter MD, Mathers AJ, Day AJ, Mann BJ, Allen JE, Petri WA Jr In JCI Insight Volume 6(15), Aug 2021, IF: 8.315.
A Birds-Eye (Re)View of Acid-Suppression Drugs, COVID-19, and the Highly Variable Literature Mura C, Preissner S, Preissner R, Bourne PE In Front Pharmacol Volume 12, Aug 2021, IF: 4.4.
Individualized Drugs' Selection by Evaluation of Drug Properties, Pharmacogenomics and Clinical Parameters: Performance of a Bioinformatic Tool Compared to a Clinically Established Counselling Process Borro M, Gentile G, Preissner SH, Pomes LM, Gohlke BO, Del Casale A, Eckert A, Marchetti P, Preissner S, Preissner R, Simmaco M In Pharmgenomics Pers Med Volume 14, Aug 2021, IF: 3.88.
Real-world evidence for improved outcomes with histamine antagonists and aspirin in 22,560 COVID-19 patients Mura C, Preissner S, Nahles S, Heiland M, Bourne PE, Preissner R In Signal Transduct Target Ther Volume 6(1), Jul 2021, IF: 18.187.
VirtualTaste: a web server for the prediction of organoleptic properties of chemical compounds Fritz F, Preissner R, Banerjee P In Nucleic Acids Res Volume 49(W1), Jul 2021, IF: 16.971.
Reynoutria Rhizomes as a Natural Source of SARS-CoV-2 Mpro Inhibitors-Molecular Docking and In Vitro Study Nawrot-Hadzik I, Zmudzinski M, Matkowski A, Preissner R, Kęsik-Brodacka M, Hadzik J, Drag M, Abel R In Pharmaceuticals (Basel) Volume 14(8), Jul 2021, IF: 5.68.
L-leucine stimulation of glucose uptake and utilization involves modulation of glucose - lipid metabolic switch and improved bioenergetic homeostasis in isolated rat psoas muscle ex vivo Erukainure OL, Salau VF, Atolani O, Ravichandran R, Banerjee P, Preissner R, Koorbanally NA, Islam MS In Amino Acids Volume 53(7), Jul 2021, IF: 3.23.
Evaluation of Drug-Drug Interactions in EGFR-Mutated Non-Small-Cell Lung Cancer Patients during Treatment with Tyrosine-Kinase Inhibitors Occhipinti M, Brambilla M, Galli G, Manglaviti S, Giammaruco M, Prelaj A, Ferrara R, De Toma A, Proto C, Beninato T, Zattarin E, Lo Russo G, Gelibter AJ, Simmaco M, Preissner R, Garassino MC, De Braud F, Marchetti P In J Pers Med Volume 11(5), May 2021, IF: 4.45.
Voronoia 4-ever Staritzbichler R, Ristic N, Goede A, Preissner R, Hildebrand PW In Nucleic Acids Res Volume 49(W1), May 2021, IF: 16.971.
Sensitive to Infection but Strong in Defense-Female Sex and the Power of Oestradiol in the COVID-19 Pandemic Newson L, Manyonda I, Lewis R, Preissner R, Preissner S, Seeland U In Front Glob Womens Health Volume 11;2, May 2021, IF: .
Allosteric Modulation of the CB1 Cannabinoid Receptor by Cannabidiol-A Molecular Modeling Study of the N-Terminal Domain and the Allosteric-Orthosteric Coupling Jakowiecki J, Abel R, Orzeł U, Pasznik P, Preissner R, Filipek S In Molecules Volume 26(9), Apr 2021, IF: 4.411.
IL-13 is a driver of COVID-19 severity Donlan AN, Sutherland TE, Marie C, Preissner S, Bradley BT, Carpenter RM, Sturek JM, Ma JZ, Moreau GB, Donowitz JR, Buck GA, Serrano MG, Burgess SL, Abhyankar MM, Mura C, Bourne PE, Preissner R, Young MK, Lyons GR, Loomba JJ, Ratcliffe SJ, Poulter MD, Mathers AJ, Day A, Mann BJ, Allen JE, Petri WA Jr In medRxiv, Mar 2021, IF: .
Oxidative testicular injury: effect of L-leucine on redox, cholinergic and purinergic dysfunctions, and dysregulated metabolic pathways Erukainure OL, Atolani O, Banerjee P, Abel R, Pooe OJ, Adeyemi OS, Preissner R, Chukwuma CI, Koorbanally NA, Islam MS In Amino Acids Volume 53(3), Mar 2021, IF: 3.23.
PROMISCUOUS 2.0: a resource for drug-repositioning Gallo K, Goede A, Eckert A, Moahamed B, Preissner R, Gohlke BO In Nucleic Acids Res Volume 49(D1), Jan 2021, IF: 16.971.
Oestrogen-mediated upregulation of the Mas receptor contributes to sex differences in acute lung injury and lung vascular barrier regulation Erfinanda L, Ravindran K, Kohse F, Gallo K, Preissner R, Walther T, Kuebler WM In Eur Respir J Volume 57(1), Jan 2021, IF: 16.67.
A minigene DNA vaccine encoding peptide epitopes derived from Galectin-1 has protective antitumoral effects in a model of neuroblastoma Liebscher L, Weißenborn C, Langwisch S, Gohlke BO, Preissner R, Rabinovich GA, Christiansen N, Christiansen H, Zenclussen AC, Fest S In Cancer Lett Volume 509, 2021, IF: 8.679.
Comparison of Computerized Prescription Support Systems in COVID-19 Patients: INTERCheck and Drug-PIN Martocchia A, Bruscia C, Conforti G, Falangone F, Marini V, Pennica A, Pezzuto A, March MR, Sentimentale A, Spuntarelli V, Tafaro L, Ricci A, Simmaco M, Sesti G, Preissner R, Martelletti P In SN Compr Clin Med Volume 4(1), 2021, IF: .
2020
Computational prediction of potential inhibitors of the main protease of SARS-CoV-2 Abel.R, Paredes Ramos. M, Chen.Q, Pérez Sánchez. H, Coluzzi. F, Rocco. M, Mura. C, Simmaco. M, Bourne .P, Preissner. R and Banerjee. P In Molecular Studies of COVID-19 studies, Dec 2020, IF: 3.994.
Norditerpenoids with Selective Anti-Cholinesterase Activity from the Roots of Perovskia atriplicifolia Benth Slusarczyk,S.,Sezer Senol Deniz,F.,Abel,R.,Pecio,L.,Perez-Sanchez,H.,Ceron-Carrasco,J.,den-Haan,H.,Banerjee,P., Preissner,R.,Krzyzak,E.,Oleszek,W.,Orhan,IE.,Matkowski,A. In International Journal of Molecular Sciences Volume 21, Jun 2020, IF: 5.542.
SuperCYPsPred- A Web Server for the Prediction of Cytochrome Activity Banerjee P, Dunkel M, Kemmler E and Preissner R In Nucleic Acids Research Volume NAR-web-server issue 2020, Mar 2020, IF: 16.971.
Isolation, Characterisation and In Silico Toxicity Evaluations of Thiocarbamates, Isothiocyanates, Nitrile, Glucosinolate and Lipids from Moringa oleifera Lam. Seed Atolani O, Olorundare OE, Banerjee P, Osin OA, Preissner R, Njan AA In Journal of the Turkish Chemical Society Section A: Chemistry Volume 7, Jan 2020, IF: 0.83.
2018
SuperDRUG2: a one stop resource for approved/marketed drugs Siramshetty, V. B., Eckert, O. A., Gohlke, B. O., Goede, A., Chen, Q., Devarakonda, P., Preissner, S. and Preissner, R. In Nucleic Acids Res. Volume 46, D1137-D1143, Jan 2018, IF: 10.162.
mVOC 2.0: a database of microbial volatiles Lemfack, M. C., Gohlke, B. O., Toguem, S. M. T., Preissner, S., Piechulla, B. and Preissner, R. In Nucleic Acids Res. Volume 46, D1261-D1265, Jan 2018, IF: 10.162.
2017
The target landscape of clinical kinase drugs Klaeger, S., Heinzlmeir, S., Wilhelm, M., Polzer, H., Vick, B., Koenig, P. A., Reinecke, M., Ruprecht, B., Petzoldt, S., Meng, C., Zecha, J., Reiter, K., Qiao, H., Helm, D., Koch, H., Schoof, M., Canevari, G., Casale, E., Depaolini, S. R., Feuchtinger, A., Wu, Z., Schmidt, T., Rueckert, L., Becker, W., Huenges, J., Garz, A. K., Gohlke, B. O., Zolg, D. P., Kayser, G., Vooder, T., Preissner, R., Hahne, H., Tonisson, N., Kramer, K., Gotze, K., Bassermann, F., Schlegl, J., Ehrlich, H. C., Aiche, S., Walch, A., Greif, P. A., Schneider, S., Felder, E. R., Ruland, J., Medard, G., Jeremias, I., Spiekermann, K. and Kuster, B. In Science Volume 358, Dec 2017, IF: 37.205.
Volatile Organic Compounds in the Breath of Oral Squamous Cell Carcinoma Patients: A Pilot Study Hartwig, S., Raguse, J. D., Pfitzner, D., Preissner, R., Paris, S. and Preissner, S. In Otolaryngol Head Neck Surg Volume 157, 981–987, Dec 2017, IF: 2.021.
Computational prediction of immune cell cytotoxicity Schrey, A. K., Nickel-Seeber, J., Drwal, M. N., Zwicker, P., Schultze, N., Haertel, B. and Preissner, R. In Food Chem. Toxicol. Volume 107, 150–166, Sep 2017, IF: 3.584.
Drugs as habitable planets in the space of dark chemical matter Siramshetty, V. B. and Preissner, R. In Drug Discov. Today, Jul 2017, IF: 6.369.
Volatile organic compounds in the breath of oral candidiasis patients: a pilot study Hertel, M., Schuette, E., Kastner, I., Hartwig, S., Schmidt-Westhausen, A. M., Preissner, R., Paris, S. and Preissner, S. In Clin Oral Investig, Jun 2017, IF: 2.207.
Statin and rottlerin small-molecule inhibitors restrict colon cancer progression and metastasis via MACC1 Juneja, M., Kobelt, D., Walther, W., Voss, C., Smith, J., Specker, E., Neuenschwander, M., Gohlke, B. O., Dahlmann, M., Radetzki, S., Preissner, R., von Kries, J. P., Schlag, P. M. and Stein, U. In PLoS Biol. Volume 15, e2000784, Jun 2017, IF: 8.668.
Bax/Bak-independent mitochondrial depolarization and reactive oxygen species induction by sorafenib overcome resistance to apoptosis in renal cell carcinoma Gillissen, B., Richter, A., Richter, A., Preissner, R., Schulze-Osthoff, K., Essmann, F. and Daniel, P. T. In J. Biol. Chem. Volume 292, 6478–6492, April 2017, IF: 4.573.
CardioScape mapping the cardiovascular funding landscape in Europe Pries, A. R., Naoum, A., Habazettl, H., Dunkel, M., Preissner, R., Coats, C. J., Tornada, A., Orso, F., Van de Werf, F. and Wood, D. A. In Eur. Heart J., Apr 2017, IF: 20.212.
Anti-diabetic effect of the ethyl acetate fraction of Clerodendrum volubile: protocatechuic acid suppresses phagocytic oxidative burst and modulates inflammatory cytokines Erukainure, O. L., Hafizur, R. M., Choudhary, M. I., Adhikari, A., Mesaik, A. M., Atolani, O., Banerjee, P., Preissner, R., Muhammad, A. and Islam, M. S. In Biomed. Pharmacother. Volume 86, 307–315, Feb 2017, IF: 2.326.
2016
TRPC6 G757D Loss-of-Function Mutation Associates with FSGS Riehle, M., Buscher, A. K., Gohlke, B. O., Kassmann, M., Kolatsi-Joannou, M., Brasen, J. H., Nagel, M., Becker, J. U., Winyard, P., Hoyer, P. F., Preissner, R., Krautwurst, D., Gollasch, M., Weber, S. and Harteneck, C. In J. Am. Soc. Nephrol. Volume 27, 2771–2783, Sep 2016, IF: 9.343.
SL2: an interactive webtool for modeling of missing segments in proteins Ismer, J., Rose, A. S., Tiemann, J. K., Goede, A., Preissner, R. and Hildebrand, P. W. In Nucleic Acids Res. Volume 44, W390–394, Jul 2016, IF: 9.202.
Adjuvant antifungal therapy using tissue tolerable plasma on oral mucosa and removable dentures in oral candidiasis patients: a randomised double-blinded split-mouth pilot study Preissner, S., Kastner, I., Schutte, E., Hartwig, S., Schmidt-Westhausen, A. M., Paris, S., Preissner, R. and Hertel, M. In Mycoses Volume 59, 467–475, Jul 2016, IF: 2.239.
Chemical Proteomics Reveals Ferrochelatase as a Common Off-target of Kinase Inhibitors Klaeger, S., Gohlke, B., Perrin, J., Gupta, V., Heinzlmeir, S., Helm, D., Qiao, H., Bergamini, G., Handa, H., Savitski, M. M., Bantscheff, M., Medard, G., Preissner, R. and Kuster, B. In ACS Chem. Biol. Volume 11, 1245–1254, May 2016, IF: 5.331.
Inhibition of DNA-Topoisomerase I by Acylated Triterpene Saponins from Pittosporum angustifolium Lodd Backer, C., Drwal, M. N., Preissner, R. and Lindequist, U. In Nat Prod Bioprospect Volume 6, 141–147, Apr 2016.
Identification of signature volatiles to discriminate Candida albicans, glabrata, krusei and tropicalis using gas chromatography and mass spectrometry Hertel, M., Hartwig, S., Schutte, E., Gillissen, B., Preissner, R., Schmidt-Westhausen, A. M., Paris, S., Kastner, I. and Preissner, S. In Mycoses Volume 59, 117–126, Feb 2016, IF: 2.24.
Detection of signature volatiles for cariogenic microorganisms Hertel, M., Preissner, R., Gillissen, B., Schmidt-Westhausen, A. M., Paris, S. and Preissner, S. In Eur. J. Clin. Microbiol. Infect. Dis. Volume 35, 235–244, Feb 2016, IF: 2.67.
CancerResource–updated database of cancer-relevant proteins, mutations and interacting drugs Gohlke, B. O., Nickel, J., Otto, R., Dunkel, M. and Preissner, R. In Nucleic Acids Res. Volume 44, D932–937, Jan 2016, IF: 9.11.
WITHDRAWN–a resource for withdrawn and discontinued drugs Siramshetty, V. B., Nickel, J., Omieczynski, C., Gohlke, B. O., Drwal, M. N. and Preissner, R. In Nucleic Acids Res. Volume 44, D1080–1086, Jan 2016, IF: 9.11.
Computational methods for prediction of in vitro effects of new chemical structures Banerjee, P., Siramshetty, V. B., Drwal, M. N. and Preissner, R. In J Cheminform Volume 8, 51, 2016, IF: 3.949.
2015
DBEndo: a web-based endodontic case management tool Preissner, S., Kostka, E., Mokross, M., Kersten, N. V., Blunck, U. and Preissner, R. In BMC Res Notes Volume 8, 685, Nov 2015.
2D and 3D similarity landscape analysis identifies PARP as a novel off-target for the drug Vatalanib Gohlke, B. O., Overkamp, T., Richter, A., Richter, A., Daniel, P. T., Gillissen, B. and Preissner, R. In BMC Bioinformatics Volume 16, 308, Sep 2015, IF: 2.58.
Super Natural II–a database of natural products Banerjee, P., Erehman, J., Gohlke, B. O., Wilhelm, T., Preissner, R. and Dunkel, M. In Nucleic Acids Res. Volume 43, D935–939, Jan 2015, IF: 8.81.
Personalized Cancer Therapy Considering Cytochrome P450 Variability Preissner, S., Simmaco, M., Gentile, G. and Preissner, R. In Adv. Pharmacol. Volume 74, 113–130, 2015.
*Acyclovir Has Low but Detectable Influence on HLA-B57:01 Specificity without Inducing Hypersensitivity** Metushi, I. G., Wriston, A., Banerjee, P., Gohlke, B. O., English, A. M., Lucas, A., Moore, C., Sidney, J., Buus, S., Ostrov, D. A., Mallal, S., Phillips, E., Shabanowitz, J., Hunt, D. F., Preissner, R. and Peters, B. In PLoS ONE Volume 10, e0124878, 2015.
2014
SuperPred: update on drug classification and target prediction Nickel, J., Gohlke, B. O., Erehman, J., Banerjee, P., Rong, W. W., Goede, A., Dunkel, M. and Preissner, R. In Nucleic Acids Res. Volume 42, 26–31, Jul 2014, IF: 8.026.
ProTox: a web server for the in silico prediction of rodent oral toxicity Drwal, M. N., Banerjee, P., Dunkel, M., Wettig, M. R. and Preissner, R. In Nucleic Acids Res. Volume 42, W53–58, Jul 2014, IF: 8.026.
The Transformer database: biotransformation of xenobiotics Hoffmann, M. F., Preissner, S. C., Nickel, J., Dunkel, M., Preissner, R. and Preissner, S. In Nucleic Acids Res. Volume 42, D1113–1117, Jan 2014, IF: 8.026.
mVOC: a database of microbial volatiles Lemfack, M. C., Nickel, J., Dunkel, M., Preissner, R. and Piechulla, B. In Nucleic Acids Res. Volume 42, D744–748, Jan 2014, IF: 8.026.
SuperPain–a resource on pain-relieving compounds targeting ion channels Gohlke, B. O., Preissner, R. and Preissner, S. In Nucleic Acids Res. Volume 42, D1107–1112, Jan 2014, IF: 8.026.
GenderMedDB: an interactive database of sex and gender-specific medical literature Oertelt-Prigione, S., Gohlke, B. O., Dunkel, M., Preissner, R. and Regitz-Zagrosek, V. In Biol Sex Differ Volume 5, 7, 2014, IF: 3.237.
2013
Residues of a proposed gate region in type I ATP-binding cassette import systems are crucial for function as revealed by mutational analysis Weidlich, D., Wiesemann, N., Heuveling, J., Wardelmann, K., Landmesser, H., Sani, K. B., Worth, C. L., Preissner, R. and Schneider, E. In Biochim. Biophys. Acta Volume 1828, 2164–2172, Sep 2013, IF: 3.99.
Targeted therapy of the XIAP/proteasome pathway overcomes TRAIL-resistance in carcinoma by switching apoptosis signaling to a Bax/Bak-independent 'type I' mode Gillissen, B., Richter, A., Richter, A., Overkamp, T., Essmann, F., Hemmati, P. G., Preissner, R., Belka, C. and Daniel, P. T. In Cell Death Dis Volume 4, e643, May 2013, IF: 5.333.
VaccImm: simulating peptide vaccination in cancer therapy von Eichborn, J., Woelke, A. L., Castiglione, F. and Preissner, R. In BMC Bioinformatics Volume 14, 127, Apr 2013, IF: 3.02.
SynSysNet: integration of experimental data on synaptic protein-protein interactions with drug-target relations von Eichborn, J., Dunkel, M., Gohlke, B. O., Preissner, S. C., Hoffmann, M. F., Bauer, J. M., Armstrong, J. D., Schaefer, M. H., Andrade-Navarro, M. A., Le Novere, N., Croning, M. D., Grant, S. G., van Nierop, P., Smit, A. B. and Preissner, R. In Nucleic Acids Res. Volume 41, D834–840, Jan 2013, IF: 8.026.
Mapping discontinuous protein-binding sites via structure-based peptide libraries: combining in silico and in vitro approaches Jaeger, I. S., Kretzschmar, I., Korner, J., Weiser, A. A., Mahrenholz, C. C., Potty, A., Kourentzi, K., Willson, R. C., Volkmer, R. and Preissner, R. In J. Mol. Recognit. Volume 26, 23–31, Jan 2013, IF: 3.31.
Polymorphic cytochrome P450 enzymes (CYPs) and their role in personalized therapy Preissner, S. C., Hoffmann, M. F., Preissner, R., Dunkel, M., Gewiess, A. and Preissner, S. In PLoS ONE Volume 8, e82562, 2013, IF: 4.411.
A new algorithm for integrated analysis of miRNA-mRNA interactions based on individual classification reveals insights into bladder cancer Hecker, N., Stephan, C., Mollenkopf, H. J., Jung, K., Preissner, R. and Meyer, H. A. In PLoS ONE Volume 8, e64543, 2013, IF: 4.411.
2012
Binding sites in membrane proteins–diversity, druggability and prospects Adams, R., Worth, C. L., Guenther, S., Dunkel, M., Lehmann, R. and Preissner, R. In Eur. J. Cell Biol. Volume 91, 326–339, Apr 2012, IF: 3.63.
SuperTarget goes quantitative: update on drug-target interactions Hecker, N., Ahmed, J., von Eichborn, J., Dunkel, M., Macha, K., Eckert, A., Gilson, M. K., Bourne, P. E. and Preissner, R. In Nucleic Acids Res. Volume 40, D1113–1117, Jan 2012, IF: 7.836.
Drug cocktail optimization in chemotherapy of cancer Preissner, S., Dunkel, M., Hoffmann, M. F., Preissner, S. C., Genov, N., Rong, W. W., Preissner, R. and Seeger, K. In PLoS ONE Volume 7, e51020, 2012, IF: 4.411.
2011
SDM–a server for predicting effects of mutations on protein stability and malfunction Worth, C. L., Preissner, R. and Blundell, T. L. In Nucleic Acids Res. Volume 39, W215–222, Jul 2011, IF: 7.836.
Cobweb: a Java applet for network exploration and visualisation von Eichborn, J., Bourne, P. E. and Preissner, R. In Bioinformatics Volume 27, 1725–1726, Jun 2011, IF: 4.926.
PROMISCUOUS: a database for network-based drug-repositioning von Eichborn, J., Murgueitio, M. S., Dunkel, M., Koerner, S., Bourne, P. E. and Preissner, R. In Nucleic Acids Res. Volume 39, D1060–1066, Jan 2011, IF: 7.836.
FragmentStore–a comprehensive database of fragments linking metabolites, toxic molecules and drugs Ahmed, J., Worth, C. L., Thaben, P., Matzig, C., Blasse, C., Dunkel, M. and Preissner, R. In Nucleic Acids Res. Volume 39, D1049–1054, Jan 2011.
SuperSweet–a resource on natural and artificial sweetening agents Ahmed, J., Preissner, S., Dunkel, M., Worth, C. L., Eckert, A. and Preissner, R. In Nucleic Acids Res. Volume 39, D377–382, Jan 2011.
CancerResource: a comprehensive database of cancer-relevant proteins and compound interactions supported by experimental knowledge Ahmed, J., Meinel, T., Dunkel, M., Murgueitio, M. S., Adams, R., Blasse, C., Eckert, A., Preissner, S. and Preissner, R. In Nucleic Acids Res. Volume 39, D960–967, Jan 2011.
Development of immune-specific interaction potentials and their application in the multi-agent-system VaccImm Woelke, A. L., von Eichborn, J., Murgueitio, M. S., Worth, C. L., Castiglione, F. and Preissner, R. In PLoS ONE Volume 6, e23257, 2011.
2010
Analysis of sex and gender-specific research reveals a common increase in publications and marked differences between disciplines Oertelt-Prigione, S., Parol, R., Krohn, S., Preissner, R. and Regitz-Zagrosek, V. In BMC Med Volume 8, 70, Nov 2010, IF: 3.99.
Novel compounds with antiangiogenic and antiproliferative potency for growth control of testicular germ cell tumours Nitzsche, B., Gloesenkamp, C., Schrader, M., Ocker, M., Preissner, R., Lein, M., Zakrzewicz, A., Hoffmann, B. and Hopfner, M. In Br. J. Cancer Volume 103, 18–28, Jun 2010, IF: 4.346.
Endogenous Bak inhibitors Mcl-1 and Bcl-xL: differential impact on TRAIL resistance in Bax-deficient carcinoma Gillissen, B., Wendt, J., Richter, A., Richter, A., Muer, A., Overkamp, T., Gebhardt, N., Preissner, R., Belka, C., Dorken, B. and Daniel, P. T. In J. Cell Biol. Volume 188, 851–862, Mar 2010, IF: 9.12.
Enzymatic, expression and structural divergences among carboxyl O-methyltransferases after gene duplication and speciation in Nicotiana Hippauf, F., Michalsky, E., Huang, R., Preissner, R., Barkman, T. J. and Piechulla, B. In Plant Mol. Biol. Volume 72, 311–330, Feb 2010, IF: 3.541.
Structural features and evolution of protein-protein interactions Von Eichborn, J., Gunther, S. and Preissner, R. In Genome Inform Volume 22, 1–10, Jan 2010, IF: 3.609.
SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions Preissner, S., Kroll, K., Dunkel, M., Senger, C., Goldsobel, G., Kuzman, D., Guenther, S., Winnenburg, R., Schroeder, M. and Preissner, R. In Nucleic Acids Res. Volume 38, D237–243, Jan 2010, IF: 6.954.
DNA vaccination: using the patient's immune system to overcome cancer Eschenburg, G., Stermann, A., Preissner, R., Meyer, H. A. and Lode, H. N. In Clin. Dev. Immunol. Volume 2010, 169484, 2010, IF: 3.0.
Theoretical modeling techniques and their impact on tumor immunology Woelke, A. L., Murgueitio, M. S. and Preissner, R. In Clin. Dev. Immunol. Volume 2010, 271794, 2010, IF: 3.0.
2009
Computer-assisted identification of small-molecule Bcl-2 modulators Fullbeck, M., Gebhardt, N., Hossbach, J., Daniel, P. T. and Preissner, R. In Comput Biol Chem Volume 33, 451–456, Dec 2009, IF: 1.837.
Inhibiting the inhibitors: retro-inverso Smac peptides Hossbach, J., Michalsky, E., Henklein, P., Jaeger, M., Daniel, P. T. and Preissner, R. In Peptides Volume 30, 2374–2379, Dec 2009, IF: 2.565.
Cellular fingerprints: a novel approach using large-scale cancer cell line data for the identification of potential anticancer agents Fullbeck, M., Dunkel, M., Hossbach, J., Daniel, P. T. and Preissner, R. In Chem Biol Drug Des Volume 74, 439–448, Nov 2009.
SuperLooper–a prediction server for the modeling of loops in globular and membrane proteins Hildebrand, P. W., Goede, A., Bauer, R. A., Gruening, B., Ismer, J., Michalsky, E. and Preissner, R. In Nucleic Acids Res. Volume 37, W571–574, Jul 2009, IF: 6.954.
Survivin minigene DNA vaccination is effective against neuroblastoma Fest, S., Huebener, N., Bleeke, M., Durmus, T., Stermann, A., Woehler, A., Baykan, B., Zenclussen, A. C., Michalsky, E., Jaeger, I. S., Preissner, R., Hohn, O., Weixler, S., Gaedicke, G. and Lode, H. N. In Int. J. Cancer Volume 125, 104–114, Jul 2009, IF: 4.555.
SuperToxic: a comprehensive database of toxic compounds Schmidt, U., Struck, S., Gruening, B., Hossbach, J., Jaeger, I. S., Parol, R., Lindequist, U., Teuscher, E. and Preissner, R. In Nucleic Acids Res. Volume 37, D295–299, Jan 2009, IF: 6.954.
Voronoia: analyzing packing in protein structures Rother, K., Hildebrand, P. W., Goede, A., Gruening, B. and Preissner, R. In Nucleic Acids Res. Volume 37, D393–395, Jan 2009, IF: 6.954.
SuperScent–a database of flavors and scents Dunkel, M., Schmidt, U., Struck, S., Berger, L., Gruening, B., Hossbach, J., Jaeger, I. S., Effmert, U., Piechulla, B., Eriksson, R., Knudsen, J. and Preissner, R. In Nucleic Acids Res. Volume 37, D291–294, Jan 2009, IF: 6.954.
SuperSite: dictionary of metabolite and drug binding sites in proteins Bauer, R. A., Gunther, S., Jansen, D., Heeger, C., Thaben, P. F. and Preissner, R. In Nucleic Acids Res. Volume 37, 195–200, Jan 2009, IF: 6.954.
JAIL: a structure-based interface library for macromolecules Gunther, S., von Eichborn, J., May, P. and Preissner, R. In Nucleic Acids Res. Volume 37, D338–341, Jan 2009, IF: 6.954.
2008
Notch inhibition blocks multiple myeloma cell-induced osteoclast activation Schwarzer, R., Kaiser, M., Acikgoez, O., Heider, U., Mathas, S., Preissner, R., Sezer, O., Doerken, B. and Jundt, F. In Leukemia Volume 22, 2273–2277, Dec 2008, IF: 6.924.
Superimpose: a 3D structural superposition server Bauer, R. A., Bourne, P. E., Formella, A., Frommel, C., Gille, C., Goede, A., Guerler, A., Hoppe, A., Knapp, E. W., Poschel, T., Wittig, B., Ziegler, V. and Preissner, R. In Nucleic Acids Res. Volume 36, 47–54, Jul 2008, IF: 6.954.
SuperPred: drug classification and target prediction Dunkel, M., Gunther, S., Ahmed, J., Wittig, B. and Preissner, R. In Nucleic Acids Res. Volume 36, W55–59, Jul 2008, IF: 6.954.
A rationally designed tyrosine hydroxylase DNA vaccine induces specific antineuroblastoma immunity Huebener, N., Fest, S., Strandsby, A., Michalsky, E., Preissner, R., Zeng, Y., Gaedicke, G. and Lode, H. N. In Mol. Cancer Ther. Volume 7, 2241–2251, Jul 2008, IF: 5.137.
Hydrogen-bonding and packing features of membrane proteins: functional implications Hildebrand, P. W., Gunther, S., Goede, A., Forrest, L., Frommel, C. and Preissner, R. In Biophys. J. Volume 94, 1945–1953, Mar 2008, IF: 4.757.
SuperTarget and Matador: resources for exploring drug-target relationships Gunther, S., Kuhn, M., Dunkel, M., Campillos, M., Senger, C., Petsalaki, E., Ahmed, J., Urdiales, E. G., Gewiess, A., Jensen, L. J., Schneider, R., Skoblo, R., Russell, R. B., Bourne, P. E., Bork, P. and Preissner, R. In Nucleic Acids Res. Volume 36, D919–922, Jan 2008, IF: 6.954.
Suffix techniques as a rapid method for RNA substructure search Bauer, R. A., Rother, K., Bujnicki, J. M. and Preissner, R. In Genome Inform Volume 20, 183–198, 2008.
Comparative VEGF receptor tyrosine kinase modeling for the development of highly specific inhibitors of tumor angiogenesis Schmidt, U., Ahmed, J., Michalsky, E., Hoepfner, M. and Preissner, R. In Genome Inform Volume 20, 243–251, 2008.
Toxicity versus potency: elucidation of toxicity properties discriminating between toxins, drugs, and natural compounds Struck, S., Schmidt, U., Gruening, B., Jaeger, I. S., Hossbach, J. and Preissner, R. In Genome Inform Volume 20, 231–242, 2008.
2007
Docking without docking: ISEARCH–prediction of interactions using known interfaces Gunther, S., May, P., Hoppe, A., Frommel, C. and Preissner, R. In Proteins Volume 69, 839–844, Dec 2007, IF: 3.73.
SuperHapten: a comprehensive database for small immunogenic compounds Gunther, S., Hempel, D., Dunkel, M., Rother, K. and Preissner, R. In Nucleic Acids Res. Volume 35, D906–910, Jan 2007.
A structural genomics approach to the regulation of apoptosis: chimp vs. human Ahmed, J., Gunther, S., Moller, F. and Preissner, R. In Genome Inform Volume 18, 22–34, 2007.
2006
Characterization of GD2 peptide mimotope DNA vaccines effective against spontaneous neuroblastoma metastases Fest, S., Huebener, N., Weixler, S., Bleeke, M., Zeng, Y., Strandsby, A., Volkmer-Engert, R., Landgraf, C., Gaedicke, G., Riemer, A. B., Michalsky, E., Jaeger, I. S., Preissner, R., Forster-Wald, E., Jensen-Jarolim, E. and Lode, H. N. In Cancer Res. Volume 66, 10567–10575, Nov 2006, IF: 7.616.
Legionella pneumophila induces IFNbeta in lung epithelial cells via IPS-1 and IRF3, which also control bacterial replication Opitz, B., Vinzing, M., van Laak, V., Schmeck, B., Heine, G., Gunther, S., Preissner, R., Slevogt, H., N'Guessan, P. D., Eitel, J., Goldmann, T., Flieger, A., Suttorp, N. and Hippenstiel, S. In J. Biol. Chem. Volume 281, 36173–36179, Nov 2006.
Photoactivation of an inhibitor of the 12/15-lipoxygenase pathway Herre, S., Schadendorf, T., Ivanov, I., Herrberger, C., Steinle, W., Ruck-Braun, K., Preissner, R. and Kuhn, H. In Chembiochem Volume 7, 1089–1095, Jul 2006, IF: 3.94.
Analysis and prediction of helix-helix interactions in membrane channels and transporters Hildebrand, P. W., Lorenzen, S., Goede, A. and Preissner, R. In Proteins Volume 64, 253–262, Jul 2006, IF: 4.684.
Natural products: sources and databases Fullbeck, M., Michalsky, E., Dunkel, M. and Preissner, R. In Nat Prod Rep Volume 23, 347–356, Jun 2006, IF: 7.89.
Representation of target-bound drugs by computed conformers: implications for conformational libraries Gunther, S., Senger, C., Michalsky, E., Goede, A. and Preissner, R. In BMC Bioinformatics Volume 7, 293, Jun 2006, IF: 5.423.
SuperMimic–fitting peptide mimetics into protein structures Goede, A., Michalsky, E., Schmidt, U. and Preissner, R. In BMC Bioinformatics Volume 7, 11, Jan 2006, IF: 5.423.
SuperNatural: a searchable database of available natural compounds Dunkel, M., Fullbeck, M., Neumann, S. and Preissner, R. In Nucleic Acids Res. Volume 34, D678–683, Jan 2006, IF: 7.552.
Design and biological evaluation of photo-switchable inhibitors Fullbeck, M., Michalsky, E., Jaeger, I. S., Henklein, P., Kuhn, H., Ruck-Braun, K. and Preissner, R. In Genome Inform Volume 17, 141–151, 2006.
2005
SUPERFICIAL–surface mapping of proteins via structure-based peptide library design Goede, A., Jaeger, I. S. and Preissner, R. In BMC Bioinformatics Volume 6, 223, Sep 2005, IF: 5.423.
Novel curcumin- and emodin-related compounds identified by in silico 2D/3D conformer screening induce apoptosis in tumor cells Fullbeck, M., Huang, X., Dumdey, R., Frommel, C., Dubiel, W. and Preissner, R. In BMC Cancer Volume 5, 97, Aug 2005, IF: 2.293.
SuperLigands - a database of ligand structures derived from the Protein Data Bank Michalsky, E., Dunkel, M., Goede, A. and Preissner, R. In BMC Bioinformatics Volume 6, 122, May 2005, IF: 5.423.
In silico screening of drug databases for TSE inhibitors Lorenzen, S., Dunkel, M. and Preissner, R. In BioSystems Volume 80, 117–122, May 2005, IF: 1.144.
SuperDrug: a conformational drug database Goede, A., Dunkel, M., Mester, N., Frommel, C. and Preissner, R. In Bioinformatics Volume 21, 1751–1753, May 2005, IF: 6.701.
Molecular packing and packing defects in helical membrane proteins Hildebrand, P. W., Rother, K., Goede, A., Preissner, R. and Frommel, C. In Biophys. J. Volume 88, 1970–1977, Mar 2005, IF: 4.463.
Columba: an integrated database of proteins, structures, and annotations Trissl, S., Rother, K., Muller, H., Steinke, T., Koch, I., Preissner, R., Frommel, C. and Leser, U. In BMC Bioinformatics Volume 6, 81, Mar 2005, IF: 5.423.
Conservation of cis prolyl bonds in proteins during evolution Lorenzen, S., Peters, B., Goede, A., Preissner, R. and Frommel, C. In Proteins Volume 58, 589–595, Feb 2005, IF: 5.239.
2004
Structural features of transmembrane helices Hildebrand, P. W., Preissner, R. and Frommel, C. In FEBS Lett. Volume 559, 145–151, Feb 2004.
Comparison of 2D similarity and 3D superposition. Application to searching a conformational drug database Thimm, M., Goede, A., Hougardy, S. and Preissner, R. In J Chem Inf Comput Sci Volume 44, 1816–1822, 2004.
2003
Loops In Proteins (LIP)–a comprehensive loop database for homology modelling Michalsky, E., Goede, A. and Preissner, R. In Protein Eng. Volume 16, 979–985, Dec 2003, IF: 2.065.
Accelerating screening of 3D protein data with a graph theoretical approach Frommel, C., Gille, C., Goede, A., Gropl, C., Hougardy, S., Nierhoff, T., Preissner, R. and Thimm, M. In Bioinformatics Volume 19, 2442–2447, Dec 2003, IF: 6.701.
Inhomogeneous molecular density: reference packing densities and distribution of cavities within proteins Rother, K., Preissner, R., Goede, A. and Frommel, C. In Bioinformatics Volume 19, 2112–2121, Nov 2003.
Inverse sequence similarity of proteins does not imply structural similarity Lorenzen, S., Gille, C., Preissner, R. and Frommel, C. In FEBS Lett. Volume 545, 105–109, Jun 2003, IF: 3.609.
A comprehensive view on proteasomal sequences: implications for the evolution of the proteasome Gille, C., Goede, A., Schloetelburg, C., Preissner, R., Kloetzel, P. M., Gobel, U. B. and Frommel, C. In J. Mol. Biol. Volume 326, 1437–1448, Mar 2003, IF: 5.239.
2002
The RTP site shared by the HIV-1 Tat protein and the 11S regulator subunit alpha is crucial for their effects on proteasome function including antigen processing Huang, X., Seifert, U., Salzmann, U., Henklein, P., Preissner, R., Henke, W., Sijts, A. J., Kloetzel, P. M. and Dubiel, W. In J. Mol. Biol. Volume 323, 771–782, Nov 2002.
2001
Matching organic libraries with protein-substructures Preissner, R., Goede, A., Rother, K., Osterkamp, F., Koert, U. and Froemmel, C. In J. Comput. Aided Mol. Des. Volume 15, 811–817, Sep 2001, IF: 3.194.
2000
Conservation of substructures in proteins: interfaces of secondary structural elements in proteasomal subunits Gille, C., Goede, A., Preissner, R., Rother, K. and Frommel, C. In J. Mol. Biol. Volume 299, 1147–1154, Jun 2000.
1999
Spare parts for helix-helix interaction Preissner, R., Goede, A. and Frommel, C. In Protein Eng. Volume 12, 825–832, Oct 1999, IF: 3.209.
Homonyms and synonyms in the Dictionary of Interfaces in Proteins (DIP) Preissner, R., Goede, A. and Frommel, C. In Bioinformatics Volume 15, 832–836, Oct 1999, IF: 6.701.
Sequence information within proteasomal prosequences mediates efficient integration of beta-subunits into the 20 S proteasome complex Schmidt, M., Zantopf, D., Kraft, R., Kostka, S., Preissner, R. and Kloetzel, P. M. In J. Mol. Biol. Volume 288, 117–128, Apr 1999, IF: 5.239.
1998
Dictionary of interfaces in proteins (DIP). Data bank of complementary molecular surface patches Preissner, R., Goede, A. and Frommel, C. In J. Mol. Biol. Volume 280, 535–550, Jul 1998, IF: 6.701.
1997
Inverse sequence similarity in proteins and its relation to the three-dimensional fold Preissner, R., Goede, A., Michalski, E. and Frommel, C. In FEBS Lett. Volume 414, 425–429, Sep 1997.
1991
On alpha-helices terminated by glycine. 1. Identification of common structural features Preissner, R. and Bork, P. In Biochem. Biophys. Res. Commun. Volume 180, 660–665, Oct 1991.
On alpha-helices terminated by glycine. 2. Recognition by sequence patterns Bork, P. and Preissner, R. In Biochem. Biophys. Res. Commun. Volume 180, 666–672, Oct 1991, IF: 2.836.
Occurrence of bifurcated three-center hydrogen bonds in proteins Preissner, R., Egner, U. and Saenger, W. In FEBS Lett. Volume 288, 192–196, Aug 1991, IF: 3.609.
1990
Prediction of prolyl residues in cis-conformation in protein structures on the basis of the amino acid sequence Frommel, C. and Preissner, R. In FEBS Lett. Volume 277, 159–163, Dec 1990, IF: 3.609.

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