2,4,6-Trimethylpyridine

108-75-8

2,4,6-COLLIDINE

s-Collidine

gamma-Collidine

Pyridine, 2,4,6-trimethyl-

COLLIDINE

sym-Collidine

2,4,6-Kollidin

.gamma.-Collidine

2,4,6-trimethyl-pyridine

NSC 460

MFCD00006338

.alpha.,.gamma.,.alpha.'-Collidine

2,4,6-trimethyl pyridine

7IE4BK5J5V

CHEMBL1209580

NSC-460

2,4,6-Collidine (2,4,6-Trimethylpyridine)

2,4,6-Kollidin [Czech]

alpha,gamma,alpha'-Collidine

HSDB 57

EINECS 203-613-3

2,4,6 Trimethylpyridine

UNII-7IE4BK5J5V

BRN 0107283

collidin

2,4,6 COLLIDINE

AI3-10050

2,4,6-collidin

2,4,6-Collinine

2,4,6- collidine

2,4,6-trimethypyridine

Pyridine,4,6-trimethyl-

2,4,6-tri-methylpyridine

2,4,6-Trimethylpyridinium

SCHEMBL7489

NCIOpen2_009389

.alpha.,.alpha.'-Collidine

5-20-06-00093 (Beilstein Handbook Reference)

2-HYDROXYDODECANOICACID

2,4,6-Collidine;s-Collidine

NSC460

DTXSID1051561

CHEBI:189131

2,4,6-COLLIDINE [HSDB]

AMY23190

STR03652

BDBM50416505

STL146741

AKOS000119121

CS-W018506

MCULE-3564511532

PS-5252

SB52289

2,4,6-TRIMETHYLPYRIDINE [MI]

BP-30156

DB-015912

NS00014381

T0716

2,4,6-Trimethylpyridine, >=98.0% (GC)

EN300-19114

D77846

2,4,6-Trimethylpyridine, ReagentPlus(R), 99%

Q409155

Q-200178

2,4,6-Trimethylpyridine, Vetec(TM) reagent grade, 98%

F0001-0178

Z104472822

2,4,6-Trimethylpyridine, puriss. p.a., >=99.0% (GC)

InChI=1/C8H11N/c1-6-4-7(2)9-8(3)5-6/h4-5H,1-3H

The Henry's Law constant for 2,4,6-trimethylpyridine is estimated as 8.8X10-6 atm-cu m/mole(SRC) derived from its vapor pressure, 2 mm Hg(1), and water solubility, 3.5X10+4 mg/l(2). This Henry's Law constant indicates that 2,4,6-trimethylpyridine is expected to volatilize from water surfaces(3). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(3) is estimated as 3.1 days(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(3) is estimated as 38 days(SRC). 2,4,6-Trimethylpyridine's estimated Henry's Law constant indicates that volatilization from moist soil surfaces may occur(SRC). However, the pKa of 2,4,6-trimethylpyridine is 7.4(4) which suggests that volatilization from water surfaces is expected to be attenuated slightly since ions are not expected to volatilize(SRC). 2,4,6-Trimethylpyridine is expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(1).
Literature: (1) Chao J et al; J Phys Chem Ref Data 12: 1033-63 (1983) (2) Budavari S, ed; The Merck Index. Whitehouse Station, NJ: Merck and Co Inc, p. 1656 (1996) (3) Lyman WJ et al; Handbook of Chemical Property Estimation Methods. Washington, DC: Amer Chem Soc pp. 15-1 to 15-29 (1990) (4) Perrin DD; Dissociation Constants of Organic Bases in Aqueous Solution. IUPAC Chem Data Ser, Buttersworth, London (1965)

Sol in methanol, ethanol, chloroform, benzene, toluene, and dil acids; miscible with ether
Literature: Budavari, S. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Whitehouse Station, NJ: Merck and Co., Inc., 1996., p. 1656
Literature: #Sol in acetone
Literature: Lide, DR (ed.). CRC Handbook of Chemistry and Physics. 81st Edition. CRC Press LLC, Boca Raton: FL 2000, p. 3-301
Literature: #Sol in water (in g/100 ml water): 20.8 g @ 6 deg C, 3.5 g @ 20 deg C, 1.8 g @ 100 deg C
Literature: Budavari, S. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Whitehouse Station, NJ: Merck and Co., Inc., 1996., p. 1656

The Koc of 2,4,6-trimethylpyridine is estimated as 250(SRC), using a log Kow of 1.9(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that 2,4,6-collidine is expected to have moderate mobility in soil(SRC). The pKa of 2,4,6-trimethylpyridine is 7.4(4), indicating that this compound will partially exist in the protonated form in the environment and cations generally adsorb to organic carbon and clay more strongly than their neutral counterparts(5).
Literature: (1) Hansch C et al; Exploring QSAR. Hydrophobic, Electronic, and Steric Constants. ACS Prof Ref Book. Heller SR, consult. ed., Washington, DC: Amer Chem Soc p. 45 (1995) (2) Lyman WJ et al; Handbook of Chemical Property Estimation Methods. Washington, DC: Amer Chem Soc pp. 4-9 (1990) (3) Swann RL et al; Res Rev 85: 17-28 (1983) (4) Perrin DD; Dissociation Constants of Organic Bases in Aqueous Solution. IUPAC Chem Data Ser, Buttersworth, London (1965) (5) Doucette WJ; pp. 141-188 in Handbook of Property Estimation Methods for Chemicals. Boethling RS, Mackay D, eds, Baca Raton, FL: Lewis Publ (2000)