Vasopressin


454



General information:


Withdrawn ID: 454
Canonical SMILES:
Standard InChI:
Standard InChIKey:
ATC class(es): H01BA01
Molecular Formula: C46H65N15O12S2
Molweight: 1084.25



Withdrawal information:


Withdrawn due to drug safety reasons:No
First approved: 1982



Side-effects:

Total reported cases (submitted by medical professionals) with Vasopressin as primary suspect: 76


Reported final outcomes:
Hospitalization (initial or prolonged): 23
Death: 11
Life-Threatening condition: 6
Disability: 3


Reported side-effects:

Side-effect Case number
DIABETES INSIPIDUS14
DRUG INEFFECTIVE11
OFF LABEL USE10
Product use issue9
Platelet count decreased9
Blood urea increased9
Blood lactic acid increased9
Hyponatraemia7
HYPOTENSION6
CARDIAC ARREST6
Blood creatinine increased6
Shock5
Product label confusion5
PULSE ABSENT4
Product use in unapproved indication4
Product packaging confusion4
INTESTINAL ISCHAEMIA4
HEART RATE DECREASED4
DEATH4
UNRESPONSIVE TO STIMULI3
SEPTIC SHOCK3
Product quality issue3
Peripheral ischaemia3
OXYGEN SATURATION DECREASED3
HYPERTENSION3
HYPERNATRAEMIA3
BRADYCARDIA3
Wrong product stored2
Vomiting2
VENTRICULAR EXTRASYSTOLES2
VENTRICULAR ARRHYTHMIA2
VASOCONSTRICTION2
TACHYCARDIA2
Tachyarrhythmia2
SINUS BRADYCARDIA2
RESPIRATORY FAILURE2
Respiratory disorder2
RENAL FAILURE ACUTE2
PULMONARY OEDEMA2
Product dispensing error2
Product appearance confusion2
POST PROCEDURAL HAEMORRHAGE2
PNEUMONIA2
PALLOR2
OXYGEN SATURATION IMMEASURABLE2
Overdose2
Nausea2
Myocardial ischaemia2
MEDICATION ERROR2
Intercepted product dispensing error2
HYPERKALAEMIA2
GRAND MAL CONVULSION2
ELECTROCARDIOGRAM ST SEGMENT DEPRESSION2
Condition aggravated2
Cerebrovascular accident2
Catheter site extravasation2
CARDIOGENIC SHOCK2
Cardiac failure2
Bradyarrhythmia2
BLOOD PRESSURE INCREASED2
BLOOD PRESSURE DECREASED2
Acute kidney injury2
Wrong product administered1
WITHDRAWAL SYNDROME1
Vocal cord paralysis1
Vasospasm1
Vasoplegia syndrome1
Urine output decreased1
TRISMUS1
TREATMENT FAILURE1
Transcription medication error1
Toxicity to various agents1
Tongue discolouration1
Thoracic haemorrhage1
Supraventricular tachycardia1
Suicide attempt1
Somnolence1
Skin laceration1
SKIN DISCOLOURATION1
Sinus tachycardia1
Sepsis1
Salivary hypersecretion1
Rhabdomyolysis1
RENAL IMPAIRMENT1
RADIAL PULSE ABNORMAL1
Pulmonary thrombosis1
Pulmonary embolism1
Product use complaint1
Product size issue1
Product selection error1
Product prescribing error1
Product label issue1
Product distribution issue1
Product design confusion1
Pneumomediastinum1
Paraesthesia1
OLIGURIA1
NO THERAPEUTIC RESPONSE1
Nephrogenic diabetes insipidus1
Necrotising colitis1
Mydriasis1
MUSCLE RIGIDITY1
Multi-organ failure1
Mitral valve incompetence1
METABOLIC ACIDOSIS1
Mental status changes postoperative1
Mechanical ventilation1
MEAN ARTERIAL PRESSURE DECREASED1
Malaise1
Lung infiltration1
LOW CARDIAC OUTPUT SYNDROME1
LOSS OF CONSCIOUSNESS1
Left ventricle outflow tract obstruction1
Ischaemic cerebral infarction1
INTRA-ABDOMINAL HAEMATOMA1
Intercepted product administration error1
INFECTION1
INCORRECT ROUTE OF DRUG ADMINISTRATION1
Hyponatraemic seizure1
Hypoaesthesia1
Hypervolaemia1
Hyperhidrosis1
Hepatitis acute1
Hepatic enzyme increased1
HEART RATE INCREASED1
HAEMORRHAGE1
Haemodynamic instability1
GENERAL PHYSICAL HEALTH DETERIORATION1
Gastrointestinal perforation1
Gastrointestinal haemorrhage1
Fluid retention1
FLUID OVERLOAD1
EXTRASYSTOLES1
Emphysema1
Electrocardiogram QT prolonged1
Dyspnoea1
Dysphagia1
Dry gangrene1
DRUG WITHDRAWAL SYNDROME1
Drug therapy1
Drug ineffective for unapproved indication1
DRUG DISPENSING ERROR1
Disturbance in attention1
Device dispensing error1
Device computer issue1
Delirium1
Cyanosis1
Crush syndrome1
Convulsion1
CONTINUOUS HAEMODIAFILTRATION1
Communication disorder1
Clostridium difficile infection1
Circumstance or information capable of leading to medication error1
Circulatory collapse1
Chest wall necrosis1
Cerebral vasoconstriction1
Cardiac output decreased1
Breast necrosis1
BLOOD SODIUM DECREASED1
BLOOD PRESSURE IMMEASURABLE1
ATRIOVENTRICULAR BLOCK1
Atrial fibrillation1
ATRIAL BIGEMINY1
Atelectasis1
Aptyalism1
ANURIA1
Anticholinergic syndrome1
Anaphylactic reaction1
AIRWAY PEAK PRESSURE INCREASED1
Agranulocytosis1
ACIDOSIS1
Abnormal behaviour1





Filtered ChEMBL targets:

Target UniProtKB ID Activity in nm Target Name Target gene
P30518 0.05 Vasopressin V2 receptor V2R_HUMAN
P30559 0.1 Oxytocin receptor OXYR_HUMAN
P37288 0.2344 Vasopressin V1a receptor V1AR_HUMAN
P47901 0.49 Vasopressin V1b receptor V1BR_HUMAN



Toxicity information:

Toxicity class: 4
Toxicity type: N/A
LD50: 510.26 mg/kg



External links:

ChEBML: CHEMBL373742
DrugBank: DB00067