Tryptophan


w110



General information:


Withdrawn ID: w110
Canonical SMILES:
Standard InChI:
Standard InChIKey:
ATC class(es): N06AX02
Molecular Formula: C11H12N2O2
Molweight: 204.225



Withdrawal information:


Withdrawn due to drug safety reasons:Yes
First approved: 1974
First death: 1989
First withdrawn: 1989
Last withdrawn: 1989
Reference: https://www.ncbi.nlm.nih.gov/pubmed/21702023



Side-effects:

Total reported cases (submitted by medical professionals) with Tryptophan as primary suspect: 2


Reported final outcomes:
Hospitalization (initial or prolonged): 29
Death: 17
Intervention required to prevent permanent impairment/damage: 1
Life-Threatening condition: 1
Disability: 0


Reported side-effects:

Side-effect Case number
Parenteral nutrition associated liver disease50
Death18
Hyperglycaemia10
Glucose tolerance impaired10
No adverse event6
Product preparation error3
Thrombophlebitis3
DRUG DISPENSING ERROR3
Product colour issue2
Product odour abnormal2
Dyspnoea2
Drug hypersensitivity2
Pruritus2
Nausea2
Incorrect product formulation administered2
Urticaria2
Haemorrhage1
Hyperhidrosis1
HYPERSENSITIVITY1
Gastrointestinal disorder1
Hypoglycaemia1
Local swelling1
Fistula1
Hypoglycaemia neonatal1
ESCHERICHIA INFECTION1
Erythema1
Encephalopathy1
Dyspepsia1
Device occlusion1
Device connection issue1
CHILLS1
CATHETER RELATED INFECTION1
Carotid artery thrombosis1
Burning sensation1
Blood urine present1
Blood pressure decreased1
Blood glucose increased1
Alopecia1
Product quality issue1
Weight decreased1
Vomiting1
TREMOR1
Thrombosis1
Tetany1
Stoma site discharge1
Sneezing1
Skin abrasion1
Rash1
Sepsis1
PYREXIA1
Pulmonary artery occlusion1
Product supply issue1
Hypophosphataemia1
Product packaging issue1
Product dispensing error1
Product compounding quality issue1
Poor quality drug administered1
Peripheral swelling1
Pain1
Occupational exposure to product1
MEDICATION ERROR1
Wrong drug administered1
Jugular vein thrombosis1
Infection1
Incorrect dose administered1





Filtered ChEMBL targets:

Target UniProtKB ID Activity in nm Target Name Target gene
P05164 2250 Myeloperoxidase PERM_HUMAN



Toxicity information:

Toxicity class: 6
Toxicity type: hematological
LD50: 10000 mg/kg



External links:

ChEBML: CHEMBL54976
DrugBank: DB00150