Troglitazone
General information:
| Withdrawn ID: | w47 |
|---|---|
| Canonical SMILES: | |
| Standard InChI: | |
| Standard InChIKey: | |
| ATC class(es): | A10BG01 |
| Molecular Formula: | C24H27NO5S |
| Molweight: | 441.54 |
Withdrawal information:
| Withdrawn due to drug safety reasons: | Yes |
|---|---|
| First approved: | 1997 |
| First death: | 1997 |
| First withdrawn: | 2000 |
| Last withdrawn: | 2000 |
| Reference: | https://www.ncbi.nlm.nih.gov/pubmed/16096514 |
Side-effects:
| Total reported cases (submitted by medical professionals) with Troglitazone as primary suspect: | 4 |
|---|
Reported final outcomes:
| Hospitalization (initial or prolonged): | 3 |
|---|---|
| Death: | 2 |
| Life-Threatening condition: | 1 |
Reported side-effects:
| Side-effect | Case number |
|---|---|
| MALAISE | 3 |
| JAUNDICE | 3 |
| COAGULOPATHY | 3 |
| NAUSEA | 2 |
| LIVER TRANSPLANT | 2 |
| ENCEPHALOPATHY | 2 |
| NO THERAPEUTIC RESPONSE | 1 |
| MULTI-ORGAN FAILURE | 1 |
| MENTAL STATUS CHANGES | 1 |
| Drug intolerance | 1 |
| ARTHRALGIA | 1 |
| ABDOMINAL PAIN | 1 |
Filtered ChEMBL targets:
| Target UniProtKB ID | Activity in nm | Target Name | Target gene |
|---|---|---|---|
| O95342 | 2700 | Bile salt export pump | ABCBB_HUMAN |
| P00918 | 970 | Carbonic anhydrase 2 | CAH2_HUMAN |
| P24557 | 2966 | Thromboxane-A synthase | THAS_HUMAN |
| P27338 | 2070 | Amine oxidase [flavin-containing] B | AOFB_HUMAN |
| P37231 | 215 | Peroxisome proliferator-activated receptor gamma | PPARG_HUMAN |
| Q08050 | 51.97 | Forkhead box protein M1 | FOXM1_HUMAN |
Toxicity information:
| Toxicity type: | hepatic |
|---|
External links:
| ChEBML: | CHEMBL408 |
|---|---|
| DrugBank: | DB00197 |