Thioridazine


w78



General information:


Withdrawn ID: w78
Canonical SMILES:
Standard InChI:
Standard InChIKey:
ATC class(es): N05AC02
Molecular Formula: C21H26N2S2
Molweight: 370.575



Withdrawal information:


Withdrawn due to drug safety reasons:Yes
First approved: 1962
First withdrawn: 2005
Last withdrawn: 2005
Reference: https://www.ncbi.nlm.nih.gov/pubmed/22941581



Side-effects:

Total reported cases (submitted by medical professionals) with Thioridazine as primary suspect: 84


Reported final outcomes:
Hospitalization (initial or prolonged): 24
Death: 22
Life-Threatening condition: 6
Disability: 4


Reported side-effects:

Side-effect Case number
OVERDOSE6
SUICIDE ATTEMPT5
PYREXIA5
ELECTROCARDIOGRAM QT PROLONGED5
ARRHYTHMIA4
NEUROLEPTIC MALIGNANT SYNDROME3
HYPOTHERMIA3
Hepatitis3
DRUG WITHDRAWAL SYNDROME3
DRUG LEVEL INCREASED3
DEPRESSION3
DEPRESSED LEVEL OF CONSCIOUSNESS3
CARDIO-RESPIRATORY ARREST3
CARDIAC ARREST3
BLINDNESS3
ANAEMIA3
WEIGHT DECREASED2
UNRESPONSIVE TO STIMULI2
TREMOR2
TARDIVE DYSKINESIA2
SUDDEN DEATH2
Pulmonary embolism2
PSYCHOTIC DISORDER2
PARKINSONISM2
OPTIC NEURITIS2
NOCTURIA2
NAUSEA2
MULTIPLE DRUG OVERDOSE2
MIOSIS2
INTENTIONAL OVERDOSE2
Hyperprolactinaemia2
EPILEPSY2
EATING DISORDER2
DYSPNOEA2
DRUG INTERACTION2
DIABETES MELLITUS2
DELIRIUM2
DECREASED ACTIVITY2
CONVULSION2
COMA2
BLOOD PRESSURE SYSTOLIC DECREASED2
ASPIRATION2
AGITATION2
ABNORMAL BEHAVIOUR2
WRIST FRACTURE1
WHITE BLOOD CELL COUNT DECREASED1
VISION BLURRED1
Ventricular tachycardia1
VASOCONSTRICTION1
VANISHING BILE DUCT SYNDROME1
URINARY TRACT INFECTION1
URINARY INCONTINENCE1
UPPER AIRWAY OBSTRUCTION1
UNEVALUABLE EVENT1
TREATMENT NONCOMPLIANCE1
TRANSAMINASES INCREASED1
Torsade de pointes1
THROMBOPHLEBITIS1
THROMBOCYTOPENIA1
Therapy non-responder1
TACHYCARDIA1
Systemic inflammatory response syndrome1
SYNCOPE1
SUICIDAL IDEATION1
SUDDEN CARDIAC DEATH1
STAPHYLOCOCCAL INFECTION1
SOMNOLENCE1
SINUSITIS1
Sinus tachycardia1
SEPSIS1
SELF-INJURIOUS IDEATION1
SEDATION1
SCHIZOPHRENIA1
SALIVARY HYPERSECRETION1
RIB FRACTURE1
RETINOPATHY1
RESPIRATORY RATE INCREASED1
RESPIRATORY PARALYSIS1
RESPIRATORY DISORDER1
PUPILLARY REFLEX IMPAIRED1
Pulseless electrical activity1
PSYCHIATRIC SYMPTOM1
Product prescribing error1
Priapism1
POLYNEUROPATHY1
POISONING1
PNEUMONIA STAPHYLOCOCCAL1
PNEUMONIA PNEUMOCOCCAL1
PCO2 DECREASED1
PARTNER STRESS1
PARKINSON'S DISEASE1
PARAESTHESIA1
PANIC ATTACK1
PANCYTOPENIA1
PANCREATITIS ACUTE1
PANCREATIC PSEUDOCYST1
OXYGEN SATURATION DECREASED1
Orthopnoea1
OESOPHAGITIS1
OESOPHAGEAL OBSTRUCTION1
Oedema peripheral1
OEDEMA1
OBSTRUCTIVE AIRWAYS DISORDER1
NIGHT BLINDNESS1
NEUTROPHIL COUNT DECREASED1
NEUROMYOPATHY1
MYOCARDIAL INFARCTION1
MYDRIASIS1
MUSCLE DISORDER1
Movement disorder1
MOOD ALTERED1
MENTAL RETARDATION1
MEIGE'S SYNDROME1
Medulloblastoma1
MEDICATION ERROR1
MANIA1
Maculopathy1
LOSS OF CONSCIOUSNESS1
KNEE OPERATION1
ISCHAEMIC STROKE1
ISCHAEMIA1
INTRACRANIAL VENOUS SINUS THROMBOSIS1
Intercepted product dispensing error1
Influenza1
INCONTINENCE1
HYPOTHERMIA NEONATAL1
HYPERGLYCAEMIA1
HEPATOSPLENOMEGALY1
HEPATIC FIBROSIS1
HEPATIC ENZYME INCREASED1
HEART RATE INCREASED1
HEART RATE DECREASED1
HEADACHE1
HALLUCINATIONS, MIXED1
HAEMATOSPERMIA1
GRANULOCYTOPENIA1
GENERALISED ANXIETY DISORDER1
Gaze palsy1
Gait disturbance1
FUNGAL INFECTION1
FLUSHING1
FEELING ABNORMAL1
FEEDING PROBLEM IN NEWBORN1
FEBRILE BONE MARROW APLASIA1
FEAR1
FALL1
FAECAL INCONTINENCE1
FACE INJURY1
EYELID FUNCTION DISORDER1
EXTRAPYRAMIDAL DISORDER1
Exercise tolerance decreased1
ERYTHEMA1
Erectile dysfunction1
ELECTROCARDIOGRAM ABNORMAL1
DYSSTASIA1
DYSPHAGIA1
DYSKINESIA1
DYSARTHRIA1
DRUG TOXICITY1
Drug intolerance1
Drug ineffective1
DRUG HYPERSENSITIVITY1
DRUG EXPOSURE DURING PREGNANCY1
DRUG EFFECT DECREASED1
Dizziness1
DISORIENTATION1
Disease progression1
DIET REFUSAL1
DIARRHOEA1
DETACHMENT OF RETINAL PIGMENT EPITHELIUM1
DEPRESSED MOOD1
DELUSION1
DECREASED APPETITE1
DEATH1
CRYING1
CORONARY ARTERY DISEASE1
CONTUSION1
CONDITION AGGRAVATED1
COLOUR BLINDNESS1
Chromaturia1
CHOLESTASIS1
CHOKING1
CEREBROVASCULAR ACCIDENT1
Cerebral artery embolism1
CATATONIA1
CARDIAC FIBRILLATION1
CARDIAC FAILURE ACUTE1
Cardiac failure1
CARDIAC DISORDER1
BRUGADA SYNDROME1
BRONCHOPNEUMONIA1
BLOOD PRESSURE INCREASED1
Blood pressure diastolic decreased1
BLOOD CREATINE PHOSPHOKINASE MB INCREASED1
BIPOLAR DISORDER1
BALINT'S SYNDROME1
BACK PAIN1
ATRIOVENTRICULAR BLOCK SECOND DEGREE1
ASTHENIA1
ASPHYXIA1
ARTHRALGIA1
ARTERIOSCLEROSIS1
APRAXIA1
ANEURYSM1
ANAPHYLACTIC REACTION1
ALCOHOLISM1
ALCOHOL USE1
AGRANULOCYTOSIS1
AGGRESSION1
Affect lability1
ACCIDENTAL DEATH1





Filtered ChEMBL targets:

Target UniProtKB ID Activity in nm Target Name Target gene
P11309 6890 Serine/threonine-protein kinase pim-1 PIM1_HUMAN
P34969 70 5-hydroxytryptamine receptor 7 5HT7R_HUMAN
Q12809 33.2 Potassium voltage-gated channel subfamily H member 2 KCNH2_HUMAN
Q13936 1320 Voltage-dependent L-type calcium channel subunit alpha-1C CAC1C_HUMAN
Q14524 1830 Sodium channel protein type 5 subunit alpha SCN5A_HUMAN
Q9UDY8 3430 Mucosa-associated lymphoid tissue lymphoma translocation protein 1 MALT1_HUMAN



Toxicity information:

Toxicity class: 4
Toxicity type: cardiovascular
LD50: 520 mg/kg



External links:

ChEBML: CHEMBL479
DrugBank: DB00679