Tetrazepam


w62



General information:


Withdrawn ID: w62
Canonical SMILES:
Standard InChI:
Standard InChIKey:
ATC class(es): M03BX07
Molecular Formula: C16H17ClN2O
Molweight: 288.772



Withdrawal information:


Withdrawn due to drug safety reasons:Yes
First approved: 1960
First withdrawn: 2013
Last withdrawn: 2013
Reference: https://www.ncbi.nlm.nih.gov/pubmed/26012498



Side-effects:

Total reported cases (submitted by medical professionals) with Tetrazepam as primary suspect: 5


Reported final outcomes:
Congenital anomaly: 2
Disability: 1
Hospitalization (initial or prolonged): 1
Death: 1


Reported side-effects:

Side-effect Case number
Ventricular septal defect2
Transposition of the great vessels2
Hallucination, auditory2
Neutrophilia1
Product use in unapproved indication1
Presyncope1
Photophobia1
Panic attack1
Palpitations1
Pain in extremity1
Off label use1
Rash pustular1
Neurosis1
Neck pain1
Myocarditis1
Memory impairment1
Irritability1
Pulmonary congestion1
Iatrogenic injury1
Renal failure1
Respiratory distress1
Skin erosion1
Skin hyperpigmentation1
Skin hypopigmentation1
Suicidal ideation1
Supraventricular extrasystoles1
Tachycardia1
Tinnitus1
Toxicity to various agents1
Vertigo1
Xeroderma1
Dyspnoea1
Acute generalised exanthematous pustulosis1
Affect lability1
Agoraphobia1
Akinesia1
Anxiety1
Arteriosclerosis1
Asthenia1
Blister1
Cardiogenic shock1
Cell death1
Chest pain1
Cholestasis1
Completed suicide1
Disturbance in attention1
Insomnia1
Dyspnoea exertional1
Emphysema1
Encephalitis1
Erectile dysfunction1
Erythema1
Face oedema1
Haemodynamic instability1
Hallucination, visual1
Hepatocellular injury1
Hypertrophic scar1
Hypokinesia1
Hypomania1
Hypoxia1
Accommodation disorder1





Toxicity information:

Toxicity class: 4
Toxicity type: dermatological
LD50: 900 mg/kg



External links:

ChEBML: CHEMBL2105527
DrugBank: