Suprofen


w88



General information:


Withdrawn ID: w88
Canonical SMILES:
Standard InChI:
Standard InChIKey:
ATC class(es): M01AE07
Molecular Formula: C14H12O3S
Molweight: 260.308



Withdrawal information:


Withdrawn due to drug safety reasons:Yes
First approved: 1985
First withdrawn: 1986
Last withdrawn: 1986
Reference: https://www.ncbi.nlm.nih.gov/pubmed/3142236



Side-effects:

Total reported cases (submitted by medical professionals) with Suprofen as primary suspect: 278


Reported final outcomes:
Hospitalization (initial or prolonged): 217
Death: 34
Life-Threatening condition: 14
Disability: 6
Congenital anomaly: 2


Reported side-effects:

Side-effect Case number
DRUG INTERACTION41
CONFUSIONAL STATE36
VOMITING18
SOMNOLENCE16
Fall16
MALAISE13
INTERNATIONAL NORMALISED RATIO INCREASED12
RENAL FAILURE ACUTE11
HYPONATRAEMIA11
DISORIENTATION11
OVERDOSE10
AGITATION10
HALLUCINATION, VISUAL9
DYSPNOEA9
COMA9
THROMBOCYTOPENIA8
RENAL FAILURE8
NEUTROPENIA8
NAUSEA8
MIOSIS8
CHOLESTASIS8
URINARY RETENTION7
LOSS OF CONSCIOUSNESS7
WITHDRAWAL SYNDROME6
PYREXIA6
HYPOTENSION6
HYPOGLYCAEMIA6
Hepatocellular injury6
HALLUCINATION6
ASTHENIA6
ASPARTATE AMINOTRANSFERASE INCREASED6
ABDOMINAL PAIN6
VERTIGO5
TRANSAMINASES INCREASED5
TACHYCARDIA5
RESPIRATORY DISTRESS5
RASH MACULO-PAPULAR5
LEUKOPENIA5
FACE OEDEMA5
DRUG DEPENDENCE5
DISTURBANCE IN ATTENTION5
CYTOLYTIC HEPATITIS5
CONSTIPATION5
BRADYPNOEA5
ANAEMIA5
ALANINE AMINOTRANSFERASE INCREASED5
AGRANULOCYTOSIS5
WEIGHT DECREASED4
TREMOR4
PRURITUS4
PANCREATITIS ACUTE4
PAIN4
MYOCLONUS4
MULTIPLE DRUG OVERDOSE INTENTIONAL4
INTENTIONAL OVERDOSE4
INSOMNIA4
HYPERTENSION4
HYPERHIDROSIS4
HAEMATOMA4
GAMMA-GLUTAMYLTRANSFERASE INCREASED4
EOSINOPHILIA4
DEHYDRATION4
DEATH4
CARDIO-RESPIRATORY ARREST4
BLOOD ALKALINE PHOSPHATASE INCREASED4
ALTERED STATE OF CONSCIOUSNESS4
ACUTE GENERALISED EXANTHEMATOUS PUSTULOSIS4
STATUS EPILEPTICUS3
SINUS BRADYCARDIA3
SEROTONIN SYNDROME3
SEPTIC SHOCK3
RESPIRATORY FAILURE3
RESPIRATORY DEPRESSION3
RASH3
OEDEMA PERIPHERAL3
MELAENA3
LUNG DISORDER3
INTESTINAL OBSTRUCTION3
HYPOKALAEMIA3
HYPERTHERMIA3
HUMERUS FRACTURE3
HEPATOCELLULAR DAMAGE3
HEPATITIS FULMINANT3
HEPATITIS3
HEPATIC ENZYME INCREASED3
HEADACHE3
HAEMATEMESIS3
GENERAL PHYSICAL HEALTH DETERIORATION3
FATIGUE3
ERYTHEMA3
DRUG EXPOSURE DURING PREGNANCY3
DIZZINESS3
DIARRHOEA3
DERMATITIS EXFOLIATIVE3
DERMATITIS BULLOUS3
DEPRESSED LEVEL OF CONSCIOUSNESS3
CONVULSION3
CHOLESTATIC LIVER INJURY3
CEREBROVASCULAR ACCIDENT3
BRADYCARDIA3
ATRIAL FIBRILLATION3
ASPHYXIA3
AGGRESSION3
ACCIDENTAL OVERDOSE3
TOOTH FRACTURE2
THROMBOCYTOPENIC PURPURA2
SUICIDE ATTEMPT2
SUBDURAL HAEMATOMA2
SEPSIS2
Rhabdomyolysis2
RESPIRATORY DISORDER2
RESPIRATORY ACIDOSIS2
RASH MACULAR2
RALES2
PURPURA2
PULMONARY OEDEMA2
PULMONARY EMBOLISM2
PROTHROMBIN TIME PROLONGED2
PLEURAL EFFUSION2
PHOTOPSIA2
MYOCARDIAL INFARCTION2
Muscle haemorrhage2
MULTI-ORGAN FAILURE2
LOCKED-IN SYNDROME2
LARYNGEAL OEDEMA2
INFLAMMATION2
INAPPROPRIATE ANTIDIURETIC HORMONE SECRETION2
HYPERSENSITIVITY2
HYPERKALAEMIA2
HOT FLUSH2
HEPATIC FAILURE2
GINGIVAL BLEEDING2
Femoral neck fracture2
Faecaloma2
EPISTAXIS2
EPILEPSY2
DRUG TOXICITY2
DRUG RASH WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS2
DRUG INEFFECTIVE2
DRUG DISPENSING ERROR2
DELIRIUM2
DEEP VEIN THROMBOSIS2
CIRCULATORY COLLAPSE2
CHOLECYSTITIS2
CEREBRAL ATROPHY2
CARDIAC FAILURE2
BLOOD POTASSIUM DECREASED2
BALANCE DISORDER2
APHASIA2
ACUTE PULMONARY OEDEMA2
Acute kidney injury2
ABORTION INDUCED2
ABNORMAL BEHAVIOUR2
Abdominal pain upper2
WHEEZING1
WEIGHT INCREASED1
VITREOUS FLOATERS1
Visual impairment1
VISUAL FIELD DEFECT1
VISUAL DISTURBANCE1
VISCERAL CONGESTION1
Ventricular extrasystoles1
VENTRICULAR DYSFUNCTION1
Venous thrombosis limb1
VENOUS PRESSURE JUGULAR INCREASED1
VATER SYNDROME1
VASCULAR PURPURA1
VASCULAR ANOMALY1
URINARY TRACT INFECTION1
URINARY INCONTINENCE1
UPPER GASTROINTESTINAL HAEMORRHAGE1
TUBERCULOSIS1
Transcription medication error1
Toxic skin eruption1
TOXIC EPIDERMAL NECROLYSIS1
TORSADE DE POINTES1
TIC1
Thrombophlebitis superficial1
Therapy cessation1
THERAPEUTIC RESPONSE UNEXPECTED1
SYSTEMIC LUPUS ERYTHEMATOSUS1
SYNCOPE VASOVAGAL1
SUPERINFECTION1
SUBARACHNOID HAEMORRHAGE1
STRESS1
Strabismus1
STAPHYLOCOCCAL INFECTION1
SPINAL FRACTURE1
SPEECH DISORDER1
SOMNAMBULISM1
SMALL INTESTINAL OBSTRUCTION1
SLEEP APNOEA SYNDROME1
SKIN ULCER1
SKIN NECROSIS1
SKIN INFECTION1
Skin exfoliation1
SINGLE UMBILICAL ARTERY1
SHOCK HAEMORRHAGIC1
SHOCK1
Sensorimotor disorder1
SEDATION1
SCOTOMA1
SCIATICA1
ROAD TRAFFIC ACCIDENT1
RIB FRACTURE1
RHINORRHOEA1
Restless legs syndrome1
RESPIRATORY TRACT INFECTION1
RESPIRATORY ARREST1
RENAL FAILURE CHRONIC1
RENAL CANCER1
Red blood cell count decreased1
Red blood cell count abnormal1
RECTOSIGMOID CANCER1
Rectal haemorrhage1
RASH PUSTULAR1
RASH PRURITIC1
RASH PAPULAR1
Rash erythematous1
PULMONARY HAEMORRHAGE1
PULMONARY ARTERY STENOSIS CONGENITAL1
Prothrombin level decreased1
PROTEINURIA1
PROSTATITIS1
PRESCRIPTION FORM TAMPERING1
Potentiating drug interaction1
POST PROCEDURAL COMPLICATION1
POISONING DELIBERATE1
PNEUMONIA MYCOPLASMAL1
PNEUMONIA KLEBSIELLA1
Pneumonia aspiration1
PLATELET COUNT DECREASED1
PHALANGEAL AGENESIS1
Peritonitis1
PERITONEAL HAEMORRHAGE1
PERIORBITAL HAEMATOMA1
PAPILLOEDEMA1
Pancytopenia1
PANCREATIC NECROSIS1
OXYGEN SATURATION DECREASED1
OSTEITIS1
ORTHOSTATIC HYPOTENSION1
OPIATES POSITIVE1
OPEN WOUND1
OESOPHAGEAL ATRESIA1
OBSTRUCTIVE AIRWAYS DISORDER1
NOSOCOMIAL INFECTION1
NEUTROPHIL PERCENTAGE INCREASED1
NERVOUS SYSTEM DISORDER1
Nerve compression1
NEPHROTIC SYNDROME1
NECK PAIN1
NASOPHARYNGITIS1
MYOCARDITIS1
MYDRIASIS1
MYALGIA1
MUSCULAR WEAKNESS1
MUSCLE SPASMS1
MOVEMENT DISORDER1
MORBID THOUGHTS1
MIGRAINE1
METABOLIC ENCEPHALOPATHY1
METABOLIC DISORDER1
MENTAL STATUS CHANGES1
MENTAL IMPAIRMENT1
MENINGITIS1
MENINGEAL DISORDER1
Medication error1
Maternal exposure during pregnancy1
Mania1
LYMPHOPENIA1
LYMPHOMA1
Lung infection1
LOCALISED OEDEMA1
LOCALISED INFECTION1
LIVER DISORDER1
LEUKOENCEPHALOPATHY1
LEUKOCYTURIA1
LEUKOCYTOCLASTIC VASCULITIS1
LETHARGY1
LEFT VENTRICULAR FAILURE1
LABORATORY TEST ABNORMAL1
JOINT SPRAIN1
Joint dislocation1
JAUNDICE1
Ischaemic stroke1
Intestinal anastomosis complication1
Intentional product use issue1
INJECTION SITE HAEMORRHAGE1
Infusion site warmth1
Infusion site reaction1
Infusion site pain1
Infusion site oedema1
Infusion site erythema1
INFERTILITY MALE1
INCORRECT DOSE ADMINISTERED1
ILEUS PARALYTIC1
HYPOVOLAEMIA1
HYPOVENTILATION1
Hypoprothrombinaemia1
HYPOPROTEINAEMIA1
Hypoglycaemic coma1
HYPERTELORISM OF ORBIT1
Hypercapnic coma1
Hyperaesthesia1
HOARSENESS1
Hepatitis cholestatic1
HEPATIC STEATOSIS1
HEPATIC PAIN1
HEPATIC CIRRHOSIS1
HEMIPARESIS1
HEART SOUNDS ABNORMAL1
Heart rate increased1
HEART RATE DECREASED1
HALLUCINATIONS, MIXED1
Hallucination, auditory1
Haemorrhagic anaemia1
HAEMORRHAGE1
HAEMOLYTIC ANAEMIA1
HAEMOGLOBIN DECREASED1
HAEMATURIA1
Haemarthrosis1
GRAND MAL CONVULSION1
Generalised tonic-clonic seizure1
GENERALISED OEDEMA1
GENERALISED ERYTHEMA1
GENERAL PHYSICAL CONDITION1
GASTROINTESTINAL NECROSIS1
GASTROINTESTINAL HAEMORRHAGE1
Fracture1
FOREIGN BODY ASPIRATION1
FOETAL CYSTIC HYGROMA1
FEMUR FRACTURE1
Feeling abnormal1
Eyelid oedema1
EYE DISORDER1
EXTRAPYRAMIDAL DISORDER1
Erythema multiforme1
ERYSIPELAS1
EPSTEIN-BARR VIRUS ANTIBODY POSITIVE1
ENCEPHALOPATHY1
ELECTROENCEPHALOGRAM ABNORMAL1
ELECTROCARDIOGRAM REPOLARISATION ABNORMALITY1
ELECTROCARDIOGRAM QT PROLONGED1
ELECTROCARDIOGRAM PR PROLONGATION1
EJECTION FRACTION DECREASED1
ECZEMA1
ECCHYMOSIS1
DYSPNOEA EXERTIONAL1
DYSPHAGIA1
DYSKINESIA1
DRY MOUTH1
Drug-induced liver injury1
DRUG RESISTANCE1
Drug intolerance1
DRUG ABUSE1
DIVERTICULAR PERFORATION1
DISEASE RECURRENCE1
Diplopia1
DIFFUSE LARGE B-CELL LYMPHOMA1
DEVICE RELATED INFECTION1
DERMATOMYOSITIS1
DEPRESSION1
DECREASED APPETITE1
CYANOSIS1
CRANIAL NEUROPATHY1
CONGESTIVE CARDIOMYOPATHY1
CONGENITAL THYMUS ABSENCE1
CONGENITAL CENTRAL NERVOUS SYSTEM ANOMALY1
CONDITION AGGRAVATED1
COMPLETED SUICIDE1
Colonic abscess1
COLITIS1
Cold sweat1
COAGULOPATHY1
Clonus1
CLONIC CONVULSION1
CHILLS1
CHEST PAIN1
CHEST DISCOMFORT1
CEREBROVASCULAR INSUFFICIENCY1
CEREBRAL VENTRICLE DILATATION1
CEREBRAL HAEMORRHAGE1
CARDIOACTIVE DRUG LEVEL ABOVE THERAPEUTIC1
CAESAREAN SECTION1
BRONCHOSPASM1
BRONCHITIS BACTERIAL1
BRAIN SCAN ABNORMAL1
BODY TEMPERATURE DECREASED1
BLOOD PRESSURE SYSTOLIC INCREASED1
Blood pressure increased1
BLOOD LACTIC ACID INCREASED1
BLOOD GLUCOSE DECREASED1
BLOOD CREATINE PHOSPHOKINASE INCREASED1
BLOOD CALCIUM DECREASED1
AZOOSPERMIA1
ATRIOVENTRICULAR BLOCK FIRST DEGREE1
ATRIOVENTRICULAR BLOCK1
ATRIAL SEPTAL DEFECT1
ATELECTASIS1
ASPIRATION1
ARTHRITIS BACTERIAL1
ARTHRALGIA1
ARRHYTHMIA1
APRAXIA1
APNOEA1
Antibiotic level above therapeutic1
Anorexia nervosa1
ANOREXIA1
Anaphylactic shock1
AMNESIA1
ALOPECIA1
ABORTION SPONTANEOUS1
ABORTION1





Filtered ChEMBL targets:

Target UniProtKB ID Activity in nm Target Name Target gene
P23219 560 Prostaglandin G/H synthase 1 PGH1_HUMAN
P35354 2750 Prostaglandin G/H synthase 2 PGH2_HUMAN



Toxicity information:

Toxicity class: 3
Toxicity type: renal
LD50: 70.6 mg/kg



External links:

ChEBML: CHEMBL956
DrugBank: DB00870