Sulfamethizole
General information:
| Withdrawn ID: | w142 |
|---|---|
| Canonical SMILES: | |
| Standard InChI: | |
| Standard InChIKey: | |
| ATC class(es): | B05CA04 |
| D06BA04 | |
| J01EB02 | |
| S01AB01 | |
| Molecular Formula: | C9H10N4O2S2 |
| Molweight: | 270.331 |
Withdrawal information:
| Withdrawn due to drug safety reasons: | Yes |
|---|---|
| First approved: | 1953 |
| First withdrawn: | 1984 |
| Last withdrawn: | 1984 |
| Reference: | https://static-content.springer.com/esm/art%3A10.1186%2Fs12916-016-0553-2/MediaObjects/12916_2016_553_MOESM3_ESM.pdf |
Side-effects:
| Total reported cases (submitted by medical professionals) with Sulfamethizole as primary suspect: | 2 |
|---|
Reported final outcomes:
| Intervention required to prevent permanent impairment/damage: | 1 |
|---|---|
| Hospitalization (initial or prolonged): | 1 |
Reported side-effects:
| Side-effect | Case number |
|---|---|
| FATIGUE | 1 |
| ABDOMINAL TENDERNESS | 1 |
| ANAEMIA | 1 |
| ANISOCYTOSIS | 1 |
| BLOOD ALBUMIN INCREASED | 1 |
| BLOOD METHAEMOGLOBIN PRESENT | 1 |
| CONSTIPATION | 1 |
| CYANOSIS | 1 |
| DIZZINESS | 1 |
| DYSPNOEA EXERTIONAL | 1 |
| EOSINOPHILIA | 1 |
| EPIGASTRIC DISCOMFORT | 1 |
| UROBILIN URINE PRESENT | 1 |
| HAEMOLYSIS | 1 |
| HAPTOGLOBIN DECREASED | 1 |
| HEART RATE INCREASED | 1 |
| NEPHROLITHIASIS | 1 |
| OXYGEN SATURATION DECREASED | 1 |
| PO2 DECREASED | 1 |
| POLYCHROMASIA | 1 |
| PROTEIN TOTAL INCREASED | 1 |
| SOMNOLENCE | 1 |
| SULPHAEMOGLOBINAEMIA | 1 |
Filtered ChEMBL targets:
| Target UniProtKB ID | Activity in nm | Target Name | Target gene |
|---|---|---|---|
| P02545 | 4466.8 | Prelamin-A/C | LMNA_HUMAN |
Toxicity information:
| Toxicity class: | 5 |
|---|---|
| Toxicity type: | unknown |
| LD50: | 3500 mg/kg |
External links:
| ChEBML: | CHEMBL1191 |
|---|---|
| DrugBank: | DB00576 |