Sibutramine


w139



General information:


Withdrawn ID: w139
Canonical SMILES:
Standard InChI:
Standard InChIKey:
ATC class(es): A08AA10
Molecular Formula: C17H26ClN
Molweight: 279.848



Withdrawal information:


Withdrawn due to drug safety reasons:Yes
First approved: 1997
First death: 2002
First withdrawn: 2010
Last withdrawn: 2010
Reference: https://www.ncbi.nlm.nih.gov/pubmed/5050908



Side-effects:

Total reported cases (submitted by medical professionals) with Sibutramine as primary suspect: 434


Reported final outcomes:
Hospitalization (initial or prolonged): 136
Intervention required to prevent permanent impairment/damage: 72
Disability: 33
Death: 30
Life-Threatening condition: 25
Congenital anomaly: 12


Reported side-effects:

Side-effect Case number
HEADACHE23
BLOOD PRESSURE INCREASED23
DYSPNOEA22
PALPITATIONS21
DRUG EXPOSURE DURING PREGNANCY19
INSOMNIA18
DIZZINESS18
DEPRESSION18
NAUSEA16
ANXIETY15
PSYCHOTIC DISORDER14
MALAISE14
HYPERTENSION13
DRUG INTERACTION13
DRUG INEFFECTIVE13
MYOCARDIAL INFARCTION12
VOMITING11
HEART RATE INCREASED11
CHEST PAIN11
CEREBROVASCULAR ACCIDENT10
ASTHENIA10
ARRHYTHMIA10
ABORTION SPONTANEOUS10
ABORTION INDUCED10
PULMONARY EMBOLISM9
AGITATION9
ABDOMINAL PAIN9
TACHYCARDIA8
LOSS OF CONSCIOUSNESS8
FATIGUE8
CONFUSIONAL STATE8
WEIGHT INCREASED7
SYNCOPE7
SUICIDE ATTEMPT7
PARAESTHESIA7
PAIN IN EXTREMITY7
HYPOTENSION7
ABNORMAL BEHAVIOUR7
OVERDOSE6
NERVOUSNESS6
HYPOAESTHESIA6
HAEMORRHAGE6
CHEST DISCOMFORT6
CARDIAC ARREST6
VISION BLURRED5
URINARY RETENTION5
RENAL FAILURE5
PRURITUS5
MATERNAL DRUGS AFFECTING FOETUS5
IRRITABILITY5
HYPERHIDROSIS5
HALLUCINATION5
DYSGEUSIA5
DISORIENTATION5
DEPRESSED MOOD5
CONVULSION5
CONSTIPATION5
ABDOMINAL PAIN UPPER5
URTICARIA4
UNEVALUABLE EVENT4
TREMOR4
TRANSIENT ISCHAEMIC ATTACK4
THROMBOSIS4
SUICIDAL IDEATION4
RENAL FAILURE ACUTE4
RASH4
PYREXIA4
PARALYSIS4
OEDEMA PERIPHERAL4
HOT FLUSH4
HALLUCINATION, AUDITORY4
FEELING ABNORMAL4
DRY MOUTH4
DISTURBANCE IN ATTENTION4
DEHYDRATION4
COUGH4
ATRIAL FIBRILLATION4
ANOREXIA4
AMNESIA4
ABDOMINAL DISTENSION4
WEIGHT LOSS POOR3
VENTRICULAR FIBRILLATION3
URINARY TRACT INFECTION3
UNINTENDED PREGNANCY3
THIRST3
SPEECH DISORDER3
SINUS TACHYCARDIA3
ROAD TRAFFIC ACCIDENT3
RENAL FAILURE CHRONIC3
PREMATURE BABY3
PREGNANCY3
POST PROCEDURAL COMPLICATION3
PNEUMONIA3
NEUROPATHY PERIPHERAL3
NEPHRITIS INTERSTITIAL3
MIGRAINE3
INCREASED APPETITE3
HYPERSENSITIVITY3
HUNGER3
HEMIPARESIS3
HAEMATEMESIS3
FLUSHING3
ERECTILE DYSFUNCTION3
EPILEPSY3
DRUG SCREEN POSITIVE3
DIPLOPIA3
DELUSION3
CONTUSION3
CONGENITAL ANOMALY3
CHOLELITHIASIS3
CEREBRAL ISCHAEMIA3
BLOOD PRESSURE FLUCTUATION3
BLOOD GLUCOSE INCREASED3
BENIGN PROSTATIC HYPERPLASIA3
BACK PAIN3
APHASIA3
AMENORRHOEA3
VISUAL IMPAIRMENT2
VISUAL FIELD DEFECT2
VISUAL DISTURBANCE2
VASOSPASM2
VASCULITIS2
VAGINAL HAEMORRHAGE2
UNRESPONSIVE TO STIMULI2
TINNITUS2
THROMBOCYTOPENIA2
SUDDEN DEATH2
SUBARACHNOID HAEMORRHAGE2
STRESS SYMPTOMS2
SOMNOLENCE2
SMALL INTESTINAL PERFORATION2
SMALL FOR DATES BABY2
SEPSIS2
SELF-MEDICATION2
RETINAL VEIN OCCLUSION2
RETINAL DETACHMENT2
RECTAL HAEMORRHAGE2
PULMONARY HYPERTENSION2
PSYCHOMOTOR HYPERACTIVITY2
PROSTATITIS2
PRODUCT QUALITY ISSUE2
PLATELET COUNT DECREASED2
PHLEBITIS2
Persecutory delusion2
PAROSMIA2
PARANOIA2
PANNICULITIS2
PANIC DISORDER2
PANIC ATTACK2
PANCREATITIS ACUTE2
PAIN2
NEPHROTIC SYNDROME2
MYALGIA2
MUSCULAR WEAKNESS2
MUSCLE SPASMS2
MULTIPLE CONGENITAL ABNORMALITIES2
MONOPLEGIA2
MENTAL STATUS CHANGES2
MENORRHAGIA2
MANIA2
LOWER RESPIRATORY TRACT INFECTION2
LOW DENSITY LIPOPROTEIN INCREASED2
LEUKOPENIA2
LARYNGEAL OEDEMA2
JOINT SWELLING2
INTESTINAL OBSTRUCTION2
INTENTIONAL OVERDOSE2
HYPOAESTHESIA FACIAL2
HYPERTHYROIDISM2
HYPERTENSIVE CRISIS2
HEPATITIS2
HEPATIC ENZYME INCREASED2
HEART RATE IRREGULAR2
GLOMERULONEPHRITIS2
GINGIVAL BLEEDING2
GASTROENTERITIS2
GAIT DISTURBANCE2
FOETAL GROWTH RETARDATION2
FLANK PAIN2
FEELING JITTERY2
EYE PAIN2
EUPHORIC MOOD2
EMOTIONAL DISTRESS2
ELEVATED MOOD2
ELECTROMECHANICAL DISSOCIATION2
ELECTROCARDIOGRAM QT PROLONGED2
DYSPHASIA2
DYSPHAGIA2
DYSARTHRIA2
DRUG WITHDRAWAL SYNDROME2
DRUG TOXICITY2
DEMYELINATION2
DEEP VEIN THROMBOSIS2
DEATH2
CORONARY ARTERY DISEASE2
CONDITION AGGRAVATED2
COMPLICATIONS OF MATERNAL EXPOSURE TO THERAPEUTIC DRUGS2
COMA2
COGNITIVE DISORDER2
CEREBRAL INFARCTION2
CEREBRAL HAEMORRHAGE2
CATARACT2
CARDIOMYOPATHY2
CARDIOMEGALY2
CARDIO-RESPIRATORY ARREST2
CARDIAC VALVE DISEASE2
CARDIAC FAILURE CONGESTIVE2
CARDIAC DISORDER2
BREAST CANCER2
BRADYCARDIA2
BALANCE DISORDER2
ASTHMA2
ASPARTATE AMINOTRANSFERASE INCREASED2
ARTHRALGIA2
ANGIOEDEMA2
ALANINE AMINOTRANSFERASE INCREASED2
ADVERSE DRUG REACTION2
ACUTE LYMPHOCYTIC LEUKAEMIA2
WEIGHT FLUCTUATION1
WEIGHT DECREASED1
WALKING DISABILITY1
VULVOVAGINAL MYCOTIC INFECTION1
VITH NERVE PARALYSIS1
VISUAL ACUITY REDUCED1
VIRAL UPPER RESPIRATORY TRACT INFECTION1
VERTIGO1
VENTRICULAR TACHYCARDIA1
VENTRICULAR SEPTAL DEFECT1
VENTRICULAR HYPOKINESIA1
VENTRICULAR HYPERTROPHY1
VASCULITIS NECROTISING1
VASCULITIS GASTROINTESTINAL1
VASCULITIC RASH1
UTEROVAGINAL PROLAPSE1
UROGENITAL DISORDER1
URINE OUTPUT DECREASED1
URINE ODOUR ABNORMAL1
URINARY TRACT DISORDER1
URINARY INCONTINENCE1
URETHRAL STRICTURE1
UPPER RESPIRATORY TRACT INFECTION1
UPPER LIMB FRACTURE1
UNWANTED PREGNANCY1
ULCER1
TRISOMY 181
TRISMUS1
TOXIC INDUCED ENCEPHALOPATHY1
TONGUE BITING1
THYROID ADENOMA1
THROMBOEMBOLIC STROKE1
THROMBOCYTOPENIC PURPURA1
THROAT TIGHTNESS1
TENDON INJURY1
SYNOVIAL CYST1
SYNCOPE VASOVAGAL1
SWOLLEN TONGUE1
SWELLING FACE1
SUPRAVENTRICULAR TACHYCARDIA1
SUICIDAL BEHAVIOUR1
STUPOR1
STRESS URINARY INCONTINENCE1
STREPTOCOCCAL INFECTION1
STEVENS-JOHNSON SYNDROME1
STEM CELL TRANSPLANT1
STARING1
STAPHYLOCOCCAL SEPSIS1
SPUTUM DISCOLOURED1
SPINAL SHOCK1
SPINAL CORD INFARCTION1
SPINA BIFIDA1
SOPOR1
Sleep disorder1
SLEEP APNOEA SYNDROME1
SKIN ULCER1
SKIN MALFORMATION1
SKIN LESION1
SKIN BURNING SENSATION1
SINUSITIS1
SINUS BRADYCARDIA1
SINUS ARRHYTHMIA1
SEROTONIN SYNDROME1
SEPTIC SHOCK1
SENSORY LOSS1
SENSE OF OPPRESSION1
SENSATION OF PRESSURE1
SENSATION OF FOREIGN BODY1
SENSATION OF BLOCK IN EAR1
SELF ESTEEM INFLATED1
SELF ESTEEM DECREASED1
SEDATION1
SCHIZOPHRENIA1
RUPTURED CEREBRAL ANEURYSM1
RIB FRACTURE1
RHEUMATOID VASCULITIS1
RHABDOMYOLYSIS1
RETINAL VASCULAR OCCLUSION1
RETINAL ARTERY OCCLUSION1
RETCHING1
RESPIRATORY ARREST1
RENAL INFARCT1
RENAL IMPAIRMENT1
RENAL DISORDER1
RENAL COLIC1
RENAL CELL CARCINOMA STAGE UNSPECIFIED1
RENAL ARTERY STENOSIS1
REFUSAL OF TREATMENT BY PATIENT1
REFLUX OESOPHAGITIS1
RECTAL CANCER1
REBOUND HYPERTENSION1
RASH MACULAR1
RASH GENERALISED1
QUADRIPLEGIA1
PYELONEPHRITIS1
PURPURA1
PULMONARY OEDEMA1
PULMONARY INFARCTION1
PSYCHOMOTOR AGITATION1
PSYCHIATRIC EVALUATION1
PROTEINURIA1
PROTEIN TOTAL DECREASED1
PRODUCTIVE COUGH1
PROCTITIS1
PROCTALGIA1
PREGNANCY ON ORAL CONTRACEPTIVE1
PRECANCEROUS SKIN LESION1
POST PROCEDURAL HAEMATOMA1
POLYSEROSITIS1
POLYCYTHAEMIA1
POLYCHONDRITIS1
PLEURITIC PAIN1
PLEURISY1
PLEURAL EFFUSION1
PLATELET COUNT INCREASED1
PHYSICAL DISABILITY1
PHAEOCHROMOCYTOMA1
PETIT MAL EPILEPSY1
PETECHIAE1
PERSONALITY DISORDER1
PERSONALITY CHANGE1
PERIPHERAL EMBOLISM1
PERIDIVERTICULAR ABSCESS1
PERICARDIAL HAEMORRHAGE1
PERICARDIAL EFFUSION1
PATENT DUCTUS ARTERIOSUS1
PARASITIC GASTROENTERITIS1
PANCREATITIS1
PANCREATIC DISORDER1
PANCREATIC CARCINOMA1
OVARIAN CANCER1
OSTEONECROSIS1
OSTEOARTHRITIS1
OROPHARYNGEAL DISCOMFORT1
ORAL DISCOMFORT1
OOPHORECTOMY1
OESOPHAGEAL SPASM1
OEDEMATOUS PANCREATITIS1
OBSESSIVE-COMPULSIVE DISORDER1
OBSESSIVE THOUGHTS1
NYSTAGMUS1
NUCLEAR MAGNETIC RESONANCE IMAGING BRAIN ABNORMAL1
NO THERAPEUTIC RESPONSE1
NO ADVERSE EFFECT1
NIGHTMARE1
NIGHT SWEATS1
NEUROLOGICAL SYMPTOM1
NEUROGENIC BLADDER1
NERVOUS SYSTEM DISORDER1
NERVE COMPRESSION1
NEPHROPATHY TOXIC1
NEPHROLITHIASIS1
NEONATAL RESPIRATORY DISTRESS SYNDROME1
NEONATAL ASPIRATION1
NECROTISING GRANULOMATOUS LYMPHADENITIS1
NECROSIS1
NASOPHARYNGITIS1
NASOPHARYNGEAL DISORDER1
NASAL INFLAMMATION1
NAIL DISCOLOURATION1
MYOSITIS1
MYOCARDIAL ISCHAEMIA1
MYDRIASIS1
MUSCULOSKELETAL STIFFNESS1
MUSCULOSKELETAL DISCOMFORT1
MUSCLE TWITCHING1
MUSCLE CONTRACTURE1
MOUNTAIN SICKNESS ACUTE1
Motor dysfunction1
MORBID THOUGHTS1
MOOD SWINGS1
MONOPARESIS1
MONONEUROPATHY1
MIDDLE INSOMNIA1
MICROPHTHALMOS1
MICROANGIOPATHY1
METABOLIC ACIDOSIS1
MENTAL DISORDER1
MENISCUS LESION1
MENINGOCOCCAL SEPSIS1
MENIERE'S DISEASE1
MEDICATION ERROR1
MEDICAL DEVICE IMPLANTATION1
MASTICATION DISORDER1
MALIGNANT MELANOMA1
MALIGNANT HYPERTENSION1
LUNG INFECTION1
LIPIDS INCREASED1
LIP AND/OR ORAL CAVITY CANCER1
LIBIDO DECREASED1
LETHARGY1
LEIOMYOMA1
LACRIMATION INCREASED1
LABYRINTHITIS1
LABORATORY TEST ABNORMAL1
JUDGEMENT IMPAIRED1
JOINT WARMTH1
JAUNDICE1
ISCHAEMIC STROKE1
INTRAOCULAR PRESSURE INCREASED1
INTRACRANIAL PRESSURE INCREASED1
INTESTINAL ISCHAEMIA1
INTERSTITIAL LUNG DISEASE1
INTERNATIONAL NORMALISED RATIO INCREASED1
INGUINAL HERNIA1
INFLUENZA1
INFERTILITY1
INFECTION1
IMPAIRED WORK ABILITY1
IDIOPATHIC THROMBOCYTOPENIC PURPURA1
HYPOXIC ENCEPHALOPATHY1
HYPOTHYROIDISM1
HYPOTHERMIA1
HYPOSPADIAS1
HYPONATRAEMIA1
HYPOKALAEMIA1
HYPOGLYCAEMIA1
HYPOALBUMINAEMIA1
HYPOAESTHESIA ORAL1
HYPNAGOGIC HALLUCINATION1
HYPERTHERMIA1
HYPERLIPIDAEMIA1
HYPERKALAEMIA1
HYDROTHORAX1
HYDRONEPHROSIS1
HOMICIDAL IDEATION1
HIP SURGERY1
HERPES SIMPLEX1
HERNIA1
HEREDITARY ANGIOEDEMA1
HEPATITIS TOXIC1
HEPATITIS FULMINANT1
HEPATITIS ACUTE1
HEPATIC PAIN1
HEPATIC FAILURE1
HENOCH-SCHONLEIN PURPURA1
HEMIPLEGIA1
HEART VALVE INCOMPETENCE1
HEART RATE DECREASED1
HEART INJURY1
HEAD INJURY1
HEAD DISCOMFORT1
HAIRY CELL LEUKAEMIA1
HAEMORRHOIDS1
HAEMOLYTIC ANAEMIA1
HAEMOGLOBIN DECREASED1
HAEMODIALYSIS1
HAEMATURIA1
GUILLAIN-BARRE SYNDROME1
GLOMERULOSCLEROSIS1
GLOMERULONEPHRITIS MEMBRANOPROLIFERATIVE1
GLOBULINS INCREASED1
GLAUCOMA1
GENERAL PHYSICAL HEALTH DETERIORATION1
GASTROOESOPHAGEAL REFLUX DISEASE1
GASTROINTESTINAL OEDEMA1
GASTROINTESTINAL HAEMORRHAGE1
GASTRITIS1
GASTRIC ULCER1
GASTRIC HAEMORRHAGE1
GAMMA-GLUTAMYLTRANSFERASE INCREASED1
FUNISITIS1
FOOT FRACTURE1
FOETAL HEART RATE ABNORMAL1
FOETAL GROWTH RESTRICTION1
FLUID RETENTION1
FIBRIN D DIMER INCREASED1
FEELING OF DESPAIR1
FEELING HOT1
FEELING DRUNK1
FEAR1
FALL1
FAECALOMA1
FACIAL PARESIS1
EYELID OEDEMA1
EYE ROLLING1
EYE DISORDER1
EXTRASYSTOLES1
EXOPHTHALMOS1
EXCITABILITY1
ESCHERICHIA URINARY TRACT INFECTION1
ESCHERICHIA INFECTION1
ERYTHEMA1
EMOTIONAL DISORDER1
EMBOLISM1
EMBOLIC STROKE1
ELECTROLYTE IMBALANCE1
ELECTROCUTION1
ELECTROCARDIOGRAM ST-T CHANGE1
ELECTROCARDIOGRAM ABNORMAL1
EJECTION FRACTION DECREASED1
EJECTION FRACTION ABNORMAL1
ECTOPIC PREGNANCY1
ECHOCARDIOGRAM ABNORMAL1
EAR PAIN1
EAR MALFORMATION1
DYSURIA1
DYSTONIA1
DYSTHYMIC DISORDER1
DYSSTASIA1
DYSPHORIA1
DYSPHONIA1
DYSKINESIA1
DRUG EFFECT DECREASED1
DRUG DOSE OMISSION1
DIVERTICULITIS1
DISTRACTIBILITY1
DISSEMINATED INTRAVASCULAR COAGULATION1
DISEASE RECURRENCE1
DISCOMFORT1
DISABILITY1
DILATATION VENTRICULAR1
DIFFUSE VASCULITIS1
DIFFICULTY IN WALKING1
DIABETES MELLITUS1
DIABETES INSIPIDUS1
DEVICE DISLOCATION1
DERMATILLOMANIA1
DEPRESSED LEVEL OF CONSCIOUSNESS1
DECREASED APPETITE1
DECREASED ACTIVITY1
CYSTITIS INTERSTITIAL1
CYSTITIS1
CYANOSIS1
CRYING1
CRUSH SYNDROME1
CROHN'S DISEASE1
CONNECTIVE TISSUE DISORDER1
CONJUNCTIVAL HAEMORRHAGE1
CONGESTIVE CARDIOMYOPATHY1
CONGENITAL VENTRICULAR SEPTAL DEFECT1
CONGENITAL JAW MALFORMATION1
CONGENITAL ATRIAL SEPTAL DEFECT1
CONDUCTION DISORDER1
COLON CANCER1
COLITIS ISCHAEMIC1
COLITIS1
COLD SWEAT1
CLUMSINESS1
CLEFT PALATE1
CLEFT LIP AND PALATE1
CIRCULATORY COLLAPSE1
CHORIORETINITIS1
CHORIOAMNIONITIS1
CHONDROPATHY1
CHOLECYSTITIS ACUTE1
CHOLECYSTITIS1
CHOKING1
CEREBRAL ARTERY EMBOLISM1
CELLULITIS1
CAROTID ARTERY STENOSIS1
CARDIOGENIC SHOCK1
CARDIAC TAMPONADE1
CARDIAC MURMUR1
CARDIAC FAILURE1
CALCULUS BLADDER1
BURNING SENSATION1
BUNDLE BRANCH BLOCK RIGHT1
BUNDLE BRANCH BLOCK LEFT1
BREATH ODOUR1
BREAST RECONSTRUCTION1
BREAST MICROCALCIFICATION1
BREAST MASS1
BRAIN OEDEMA1
BRAIN HYPOXIA1
BRAIN DEATH1
BODY MASS INDEX INCREASED1
BLOOD TRIGLYCERIDES INCREASED1
BLOOD PROLACTIN INCREASED1
BLOOD PRESSURE DECREASED1
BLOOD PRESSURE ABNORMAL1
BLOOD POTASSIUM ABNORMAL1
BLOOD IRON DECREASED1
BLOOD FOLLICLE STIMULATING HORMONE INCREASED1
BLOOD DISORDER1
BLOOD CREATININE INCREASED1
BLOOD CREATINE PHOSPHOKINASE INCREASED1
BLOOD CHOLESTEROL INCREASED1
BLOOD CALCIUM ABNORMAL1
BLOOD BLISTER1
BLOOD BILIRUBIN INCREASED1
BLOOD ALKALINE PHOSPHATASE INCREASED1
BLADDER PROLAPSE1
BASAL CELL CARCINOMA1
ATRIOVENTRICULAR BLOCK COMPLETE1
ATRIAL FLUTTER1
ARTHROPATHY1
ARTERIOSCLEROSIS CORONARY ARTERY1
ARTERIAL THROMBOSIS1
ARTERIAL DISORDER1
ARRESTED LABOUR1
ARNOLD-CHIARI MALFORMATION1
APPENDICITIS1
APHONIA1
APALLIC SYNDROME1
AORTIC RUPTURE1
AORTIC DILATATION1
ANGINA UNSTABLE1
ANGER1
ANEURYSM1
ANAPHYLACTOID REACTION1
ANAL HAEMORRHAGE1
ANAEMIA OF PREGNANCY1
ANAEMIA1
AMPHETAMINES POSITIVE1
AMNIOTIC FLUID VOLUME DECREASED1
ALOPECIA1
ALCOHOLISM1
ALCOHOL INTOLERANCE1
ALBUMINURIA1
AGGRESSION1
AGEUSIA1
AFFECTIVE DISORDER1
ACUTE PULMONARY OEDEMA1
ACUTE PSYCHOSIS1
ACUTE MYELOID LEUKAEMIA1
ACIDOSIS1
ABORTION MISSED1
ABDOMINAL PAIN LOWER1
ABDOMINAL MASS1





Toxicity information:

Toxicity class: 3
Toxicity type: cardiovascular
LD50: 200 mg/kg



External links:

ChEBML: CHEMBL1419
DrugBank: DB01105