Sertindole
General information:
| Withdrawn ID: | w48 |
|---|---|
| Canonical SMILES: | |
| Standard InChI: | |
| Standard InChIKey: | |
| ATC class(es): | N05AE03 |
| Molecular Formula: | C24H26ClFN4O |
| Molweight: | 440.941 |
Withdrawal information:
| Withdrawn due to drug safety reasons: | Yes |
|---|---|
| First approved: | 1996 |
| First death: | 1996 |
| First withdrawn: | 1998 |
| Last withdrawn: | 1998 |
| Reference: | https://www.ncbi.nlm.nih.gov/pubmed/25583364 |
Filtered ChEMBL targets:
| Target UniProtKB ID | Activity in nm | Target Name | Target gene |
|---|---|---|---|
| P08183 | 6500 | ATP-dependent translocase ABCB1 | MDR1_HUMAN |
| P14416 | 0.45 | D(2) dopamine receptor | DRD2_HUMAN |
| P28335 | 0.2 | 5-hydroxytryptamine receptor 2C | 5HT2C_HUMAN |
| P35367 | 0.51 | Histamine H1 receptor | HRH1_HUMAN |
| P50406 | 5 | 5-hydroxytryptamine receptor 6 | 5HT6R_HUMAN |
| Q12809 | 2.7 | Potassium voltage-gated channel subfamily H member 2 | KCNH2_HUMAN |
Toxicity information:
| Toxicity type: | cardiovascular |
|---|
External links:
| ChEBML: | CHEMBL12713 |
|---|---|
| DrugBank: | DB06144 |