Propoxyphene


w160



General information:


Withdrawn ID: w160
Canonical SMILES:
Standard InChI:
Standard InChIKey:
ATC class(es): N02AC04
Molecular Formula: C22H29NO2
Molweight: 339.471



Withdrawal information:


Withdrawn due to drug safety reasons:Yes
First approved: 1957
First withdrawn: 2010
Last withdrawn: 2010
Reference: https://www.ncbi.nlm.nih.gov/pubmed/19258204



Side-effects:

Total reported cases (submitted by medical professionals) with Propoxyphene as primary suspect: 1790


Reported final outcomes:
Disability: 1558
Death: 263
Hospitalization (initial or prolonged): 167
Life-Threatening condition: 11
Intervention required to prevent permanent impairment/damage: 6


Reported side-effects:

Side-effect Case number
CARDIOVASCULAR DISORDER1443
Nervous system disorder1234
Movement disorder1234
CARDIAC DISORDER230
DEATH147
ARRHYTHMIA66
CARDIAC ARREST54
RESPIRATORY ARREST44
COMPLETED SUICIDE42
MYOCARDIAL INFARCTION39
DRUG INEFFECTIVE37
TACHYCARDIA29
BRADYCARDIA25
ATRIAL FIBRILLATION20
HEART RATE IRREGULAR18
PALPITATIONS17
CARDIO-RESPIRATORY ARREST16
SUPRAVENTRICULAR TACHYCARDIA13
POISONING13
ELECTROCARDIOGRAM QT PROLONGED12
VENTRICULAR TACHYCARDIA10
SYNCOPE10
NAUSEA10
OVERDOSE9
VENTRICULAR FIBRILLATION8
VENTRICULAR EXTRASYSTOLES8
TOXICITY TO VARIOUS AGENTS8
PHARMACEUTICAL PRODUCT COMPLAINT8
DIZZINESS8
MULTIPLE DRUG OVERDOSE7
CONFUSIONAL STATE7
CHEST PAIN7
VOMITING6
INTENTIONAL DRUG MISUSE6
PSYCHOTIC DISORDER5
MULTIPLE DRUG OVERDOSE INTENTIONAL5
FALL5
DYSPNOEA5
DRUG TOXICITY5
DRUG INTERACTION5
CARDIAC FAILURE CONGESTIVE5
BUNDLE BRANCH BLOCK RIGHT5
ATRIAL FLUTTER5
URTICARIA4
Sinus tachycardia4
RASH4
POISONING DELIBERATE4
MEDICATION ERROR4
HYPOTENSION4
HYPERTENSION4
HYPERHIDROSIS4
HEART RATE INCREASED4
HALLUCINATION4
DEPRESSION4
CHILLS4
CEREBROVASCULAR ACCIDENT4
ASTHENIA4
ANXIETY4
THERAPEUTIC RESPONSE UNEXPECTED WITH DRUG SUBSTITUTION3
SUPRAVENTRICULAR EXTRASYSTOLES3
SUICIDAL IDEATION3
SUDDEN DEATH3
SOMNOLENCE3
MENTAL STATUS CHANGES3
LOSS OF CONSCIOUSNESS3
LETHARGY3
DRUG ABUSE3
DISORIENTATION3
CONVULSION3
Cardiac valve disease3
BLOOD PRESSURE INCREASED3
Atrial tachycardia3
Ventricular arrhythmia2
URINARY TRACT INFECTION2
TREMOR2
STOMACH DISCOMFORT2
SEDATION2
ROAD TRAFFIC ACCIDENT2
PYREXIA2
PULMONARY OEDEMA2
PRURITUS2
PRODUCT QUALITY ISSUE2
PAIN IN EXTREMITY2
PAIN2
NIGHTMARE2
MULTIPLE INJURIES2
INFLUENZA LIKE ILLNESS2
INCORRECT DOSE ADMINISTERED2
HEART RATE ABNORMAL2
Heart injury2
HEADACHE2
HALLUCINATION, VISUAL2
HALLUCINATION, OLFACTORY2
GALLBLADDER DISORDER2
FATIGUE2
Extrasystoles2
DRUG WITHDRAWAL SYNDROME2
DRUG EFFECT DECREASED2
DELUSION2
DEHYDRATION2
CONTUSION2
CONSTIPATION2
CHEST DISCOMFORT2
Cardiomyopathy2
CARDIOMEGALY2
CARDIAC MURMUR2
Cardiac failure2
Bundle branch block left2
Bundle branch block2
BIPOLAR DISORDER2
ASPARTATE AMINOTRANSFERASE INCREASED2
Arrhythmia supraventricular2
AORTIC ANEURYSM2
ALANINE AMINOTRANSFERASE INCREASED2
AGITATION2
AGGRESSION2
ABDOMINAL PAIN UPPER2
ABDOMINAL PAIN2
ABDOMINAL DISCOMFORT2
WOUND INFECTION STAPHYLOCOCCAL1
WHEEZING1
WEIGHT DECREASED1
VITAL FUNCTIONS ABNORMAL1
VISION BLURRED1
VERTIGO1
VARICOSE VEIN1
UTERINE POLYP1
UTERINE HAEMORRHAGE1
UROGENITAL FISTULA1
URINARY RETENTION1
UNRESPONSIVE TO STIMULI1
UNEVALUABLE EVENT1
TRICUSPID VALVE INCOMPETENCE1
TOXICOLOGIC TEST ABNORMAL1
THROMBOSIS1
THROAT TIGHTNESS1
THROAT IRRITATION1
THINKING ABNORMAL1
THERAPEUTIC AGENT TOXICITY1
SWOLLEN TONGUE1
SURGERY1
Suicide attempt1
SUDDEN CARDIAC DEATH1
SPLEEN CONGESTION1
SPINAL OSTEOARTHRITIS1
SPINAL DISORDER1
SPEECH DISORDER1
SKIN STRIAE1
SKELETAL INJURY1
Sinus rhythm1
Sinus bradycardia1
SICK SINUS SYNDROME1
RHONCHI1
RHINORRHOEA1
RESPIRATORY RATE DECREASED1
RECTAL HAEMORRHAGE1
PULMONARY EMBOLISM1
PULMONARY CONGESTION1
PRURITUS GENERALISED1
PRODUCTIVE COUGH1
PRODUCT SUBSTITUTION ISSUE1
POSTURAL ORTHOSTATIC TACHYCARDIA SYNDROME1
POST PROCEDURAL HAEMATOMA1
POST PROCEDURAL COMPLICATION1
POLYTRAUMATISM1
POLYSUBSTANCE DEPENDENCE1
PNEUMONIA1
PLEURISY1
PLATELET COUNT DECREASED1
PILOERECTION1
PHOBIA1
PERFORATED ULCER1
PARANOIA1
PANCREATITIS1
PANCREATIC NEOPLASM1
PAIN EXACERBATED1
OVERGROWTH BACTERIAL1
OFF LABEL USE1
ODYNOPHAGIA1
OBESITY1
NO THERAPEUTIC RESPONSE1
NO ADVERSE EVENT1
MYALGIA1
MOOD SWINGS1
MICROANGIOPATHY1
METASTATIC NEOPLASM1
METABOLIC ACIDOSIS1
MALIGNANT HYPERTENSION1
MALAISE1
LIVER FUNCTION TEST ABNORMAL1
LISTLESS1
Left ventricular dysfunction1
LARGE INTESTINAL ULCER HAEMORRHAGE1
LARGE INTESTINAL ULCER1
LABILE HYPERTENSION1
JOINT DISLOCATION1
IRRITABLE BOWEL SYNDROME1
INTERVERTEBRAL DISC COMPRESSION1
INTERNATIONAL NORMALISED RATIO INCREASED1
INTENTIONAL MISUSE1
INSOMNIA1
Incoherent1
INADEQUATE ANALGESIA1
ILEUS1
HYPOPNOEA1
HYPOPHAGIA1
HYPERTENSIVE HEART DISEASE1
HYPERSENSITIVITY1
HOMICIDAL IDEATION1
HIP FRACTURE1
HEPATOMEGALY1
HEPATIC TRAUMA1
HEPATIC STEATOSIS1
Heart rate decreased1
HEART RATE1
HEAD INJURY1
HALLUCINATIONS, MIXED1
HALLUCINATION, AUDITORY1
HAEMORRHOIDS1
HAEMORRHAGE INTRACRANIAL1
HAEMATURIA1
GRAND MAL CONVULSION1
GASTROINTESTINAL INJURY1
GASTRIC INFECTION1
GAMMA-GLUTAMYLTRANSFERASE INCREASED1
GALLBLADDER OEDEMA1
GAIT DISTURBANCE1
FEELING ABNORMAL1
ENCEPHALOPATHY1
Electrocardiogram T wave peaked1
Electrocardiogram T wave inversion1
Electrocardiogram T wave abnormal1
ELECTROCARDIOGRAM QRS COMPLEX PROLONGED1
Electrocardiogram PR prolongation1
DYSPHASIA1
DYSPEPSIA1
DYSKINESIA1
DUODENITIS1
DRUG SCREEN POSITIVE1
DRUG LEVEL INCREASED1
DRUG INEFFECTIVE FOR UNAPPROVED INDICATION1
DRUG HYPERSENSITIVITY1
DRUG DISPENSING ERROR1
DRUG ABUSER1
Disability1
DELIRIUM1
DECREASED APPETITE1
DAYDREAMING1
COUGH1
CONDITION AGGRAVATED1
COMPUTERISED TOMOGRAM ABNORMAL1
CIRCULATORY COLLAPSE1
CHRONIC OBSTRUCTIVE PULMONARY DISEASE1
CEREBRAL ISCHAEMIA1
CEREBRAL INFARCTION1
Cardiac ventricular disorder1
CARDIAC FLUTTER1
CARBON DIOXIDE INCREASED1
BRONCHITIS1
BRAIN OEDEMA1
BONE DISORDER1
BLOOD UREA INCREASED1
BLOOD PRESSURE SYSTOLIC INCREASED1
BLOOD PRESSURE DIASTOLIC INCREASED1
Blood pressure decreased1
BLOOD GLUCOSE INCREASED1
BLOOD ETHANOL INCREASED1
BLOOD CREATINE INCREASED1
BLOOD CHOLESTEROL INCREASED1
BLOOD ALKALINE PHOSPHATASE INCREASED1
BILIARY DILATATION1
BILE DUCT STONE1
BALANCE DISORDER1
BACTERIAL INFECTION1
ASPIRATION1
ARTHRALGIA1
AREFLEXIA1
APHASIA1
AORTIC VALVE STENOSIS1
Aortic valve disease1
AORTIC VALVE CALCIFICATION1
ANTICONVULSANT DRUG LEVEL INCREASED1
ANTHRAX1
ANOREXIA1
ANGINA PECTORIS1
AMNESTIC DISORDER1
AMNESIA1
ALCOHOL USE1
ADVERSE REACTION1
ADVERSE DRUG REACTION1
ADRENAL INSUFFICIENCY1
ADRENAL DISORDER1
ACTIVITIES OF DAILY LIVING IMPAIRED1
ABASIA1





Toxicity information:

Toxicity class: 3
Toxicity type: cardiovascular
LD50: 182 mg/kg



External links:

ChEBML: CHEMBL1213351
DrugBank: DB00647