pramipexole


EMA35



General information:


Withdrawn ID: EMA35
Canonical SMILES:
Standard InChI:
Standard InChIKey:
ATC class(es): N04BC05
Molecular Formula: C10H17N3S
Molweight: 211.327



Withdrawal information:


Withdrawn due to drug safety reasons:No



Side-effects:

Total reported cases (submitted by medical professionals) with pramipexole as primary suspect: 3222


Reported final outcomes:
Hospitalization (initial or prolonged): 873
Disability: 200
Life-Threatening condition: 141
Death: 141
Intervention required to prevent permanent impairment/damage: 42
Congenital anomaly: 5


Reported side-effects:

Side-effect Case number
IMPULSE-CONTROL DISORDER200
PATHOLOGICAL GAMBLING199
DRUG INEFFECTIVE174
CONDITION AGGRAVATED171
HALLUCINATION154
DYSKINESIA140
RESTLESS LEGS SYNDROME134
SOMNOLENCE132
HYPERSEXUALITY129
OBSESSIVE-COMPULSIVE DISORDER125
CONFUSIONAL STATE116
NAUSEA115
INSOMNIA111
DIZZINESS107
FALL102
ANXIETY99
HALLUCINATION, VISUAL95
OEDEMA PERIPHERAL94
FATIGUE87
COMPULSIVE SHOPPING86
TREMOR83
OFF LABEL USE83
DEPRESSION81
VOMITING80
GAMBLING71
ABNORMAL BEHAVIOUR71
GAIT DISTURBANCE62
AGITATION61
DYSPNOEA59
HYPONATRAEMIA58
SUICIDAL IDEATION57
DRUG INTERACTION57
HYPOTENSION55
PSYCHOTIC DISORDER53
HEADACHE53
SUICIDE ATTEMPT52
PARKINSON'S DISEASE52
Gambling disorder51
Drug withdrawal syndrome51
DEATH51
DOPAMINE DYSREGULATION SYNDROME50
DELIRIUM50
RASH45
ORTHOSTATIC HYPOTENSION44
DRUG EFFECT DECREASED44
SYNCOPE43
Stereotypy43
RESTLESSNESS43
PSYCHOMOTOR HYPERACTIVITY43
DELUSION43
ASTHENIA43
OVERDOSE42
AGGRESSION42
LOSS OF CONSCIOUSNESS41
SUDDEN ONSET OF SLEEP40
DYSTONIA39
MALAISE38
PRODUCT SUBSTITUTION ISSUE37
ON AND OFF PHENOMENON36
WEIGHT INCREASED35
PAIN35
MEDICATION ERROR34
FEELING ABNORMAL34
WITHDRAWAL SYNDROME33
PAIN IN EXTREMITY33
OEDEMA33
DRUG ABUSE33
NEUROLEPTIC MALIGNANT SYNDROME32
MANIA32
ECONOMIC PROBLEM32
ARTHRALGIA32
ROAD TRAFFIC ACCIDENT31
JEALOUS DELUSION31
DECREASED APPETITE31
GENERAL PHYSICAL HEALTH DETERIORATION30
DRUG HYPERSENSITIVITY30
MUSCLE RIGIDITY29
MEMORY IMPAIRMENT29
Unevaluable event28
PLEUROTHOTONUS28
NIGHTMARE28
LIBIDO INCREASED28
CONSTIPATION28
SLEEP DISORDER27
PALPITATIONS27
Inappropriate antidiuretic hormone secretion27
HYPERHIDROSIS27
BINGE EATING27
CARDIAC FAILURE26
WEIGHT DECREASED25
PYREXIA25
MUSCLE SPASMS25
HYPERPHAGIA25
SPEECH DISORDER24
Inappropriate schedule of drug administration24
DEPENDENCE24
COMPLETED SUICIDE24
COGNITIVE DISORDER24
VISUAL IMPAIRMENT23
TORTICOLLIS23
EATING DISORDER23
ABNORMAL DREAMS23
PNEUMONIA22
PERSONALITY CHANGE22
IMPULSIVE BEHAVIOUR22
DYSPHAGIA22
ANAEMIA22
Parkinsonism21
HYPERTENSION21
Foetal exposure during pregnancy21
DEHYDRATION21
BALANCE DISORDER21
ABDOMINAL PAIN21
Parkinsonism hyperpyrexia syndrome20
IRRITABILITY20
DEPRESSED LEVEL OF CONSCIOUSNESS20
DEMENTIA20
TOXICITY TO VARIOUS AGENTS19
TACHYCARDIA19
MUSCULAR WEAKNESS19
HYPOMANIA19
HICCUPS19
HALLUCINATION, AUDITORY19
DYSARTHRIA19
DIARRHOEA19
BRADYKINESIA19
ALTERED STATE OF CONSCIOUSNESS19
ACUTE PSYCHOSIS19
ABDOMINAL PAIN UPPER19
THERAPEUTIC RESPONSE DECREASED18
SLEEP APNOEA SYNDROME18
PRURITUS18
MYOCLONUS18
DISTURBANCE IN ATTENTION18
DEPRESSED MOOD18
CHEST PAIN18
BRADYCARDIA18
BACK PAIN18
AMNESIA18
VISION BLURRED17
VERTIGO17
URINARY TRACT INFECTION17
Surgery17
Peripheral swelling17
PARANOIA17
INCORRECT DOSE ADMINISTERED17
DRUG DEPENDENCE17
CRYING17
CHEST DISCOMFORT17
CAMPTOCORMIA17
BLOOD CREATINE PHOSPHOKINASE INCREASED17
MYALGIA16
Exposure during pregnancy16
EMOTIONAL DISTRESS16
COMPULSIONS16
BLOOD PRESSURE INCREASED16
ADVERSE DRUG REACTION16
THINKING ABNORMAL15
SLEEP ATTACKS15
HEART RATE INCREASED15
DRY MOUTH15
DRUG INTOLERANCE15
APATHY15
URINARY RETENTION14
SEDATION14
RENAL FAILURE14
POSTURE ABNORMAL14
MYOCARDIAL INFARCTION14
MUSCULOSKELETAL STIFFNESS14
FRACTURE14
DYSPEPSIA14
Dropped head syndrome14
DISORIENTATION14
Parkinsonian gait13
PARAPHILIA13
LETHARGY13
DISEASE PROGRESSION13
CHILLS13
Therapeutic response shortened12
RHABDOMYOLYSIS12
RENAL FAILURE ACUTE12
PARAESTHESIA12
MOTOR DYSFUNCTION12
MENTAL DISORDER12
JOINT SWELLING12
INJURY12
HYPERSOMNIA12
FLUID RETENTION12
COMPULSIVE SEXUAL BEHAVIOUR12
COMA12
CARDIAC DISORDER12
ATRIAL FIBRILLATION12
ALOPECIA12
THROMBOCYTOPENIA11
Therapeutic response unexpected11
SOPOR11
RESPIRATORY FAILURE11
Product use in unapproved indication11
MOVEMENT DISORDER11
MENTAL STATUS CHANGES11
Intentional product misuse11
HEAD INJURY11
DISINHIBITION11
Depressive symptom11
Compulsive hoarding11
CIRCULATORY COLLAPSE11
BLOOD PRESSURE SYSTOLIC INCREASED11
APHASIA11
ANGINA PECTORIS11
Wound10
SOMNAMBULISM10
Seizure10
PRESYNCOPE10
PANIC ATTACK10
NERVOUSNESS10
MOOD ALTERED10
INTESTINAL OBSTRUCTION10
INTENTIONAL SELF-INJURY10
HYPERTHERMIA10
HYPERSENSITIVITY10
EMOTIONAL DISORDER10
DRUG DISPENSING ERROR10
Anhedonia10
ABDOMINAL DISCOMFORT10
Wrong technique in product usage process9
Sexually inappropriate behaviour9
Product use issue9
Poor quality sleep9
PNEUMONIA ASPIRATION9
LOGORRHOEA9
JAUNDICE9
INTERSTITIAL LUNG DISEASE9
INITIAL INSOMNIA9
FEELING JITTERY9
ERECTILE DYSFUNCTION9
DYSSTASIA9
Drug-induced liver injury9
DRUG PRESCRIBING ERROR9
Chorea9
CEREBROVASCULAR ACCIDENT9
ATAXIA9
ACCIDENTAL OVERDOSE9
ABORTION SPONTANEOUS9
VOYEURISM8
SPONTANEOUS PENILE ERECTION8
SEPSIS8
RESPIRATORY DISTRESS8
PULMONARY EMBOLISM8
Orthostatic intolerance8
OBSESSIVE THOUGHTS8
MUSCULOSKELETAL PAIN8
MUSCLE TWITCHING8
MOOD SWINGS8
MARITAL PROBLEM8
LIBIDO DECREASED8
Intentional overdose8
HYPOAESTHESIA8
HALLUCINATIONS, MIXED8
Haematoma8
EOSINOPHILIA8
Drug ineffective for unapproved indication8
COORDINATION ABNORMAL8
CONVULSION8
BLOOD PRESSURE DECREASED8
Acute kidney injury8
VISUAL ACUITY REDUCED7
TRANSIENT ISCHAEMIC ATTACK7
Therapeutic product effect incomplete7
Therapeutic product effect decreased7
SUSPICIOUSNESS7
SEXUAL DYSFUNCTION7
RENAL IMPAIRMENT7
PULMONARY FIBROSIS7
Product residue present7
PERSECUTORY DELUSION7
OBSESSIVE-COMPULSIVE PERSONALITY DISORDER7
NARCOLEPSY7
MUSCLE ATROPHY7
Multiple organ dysfunction syndrome7
MIDDLE INSOMNIA7
MAJOR DEPRESSION7
HYPOGLYCAEMIA7
Hyperventilation7
HYPERKINESIA7
HOSPITALISATION7
HEPATIC ENZYME INCREASED7
Haemoglobin decreased7
GRIP STRENGTH DECREASED7
GASTROOESOPHAGEAL REFLUX DISEASE7
GASTROINTESTINAL HAEMORRHAGE7
EXTRASYSTOLES7
EXTRAPYRAMIDAL DISORDER7
EUPHORIC MOOD7
ENCEPHALOPATHY7
ELECTROCARDIOGRAM QT PROLONGED7
Dysphoria7
DYSGRAPHIA7
CONTUSION7
CHRONIC OBSTRUCTIVE PULMONARY DISEASE7
CEREBRAL INFARCTION7
BLOOD CREATININE INCREASED7
BLINDNESS TRANSIENT7
Anticoagulation drug level above therapeutic7
ACTIVITIES OF DAILY LIVING IMPAIRED7
ABASIA7
WRIST FRACTURE6
VISUAL DISTURBANCE6
URINARY INCONTINENCE6
UNRESPONSIVE TO STIMULI6
TREATMENT NONCOMPLIANCE6
STRESS6
SKIN LACERATION6
SEROTONIN SYNDROME6
RENAL APLASIA6
PULMONARY OEDEMA6
Product prescribing error6
Product administration error6
PRESCRIBED OVERDOSE6
POLLAKIURIA6
Pituitary haemorrhage6
NASAL CONGESTION6
LIVER DISORDER6
Listless6
Labelled drug-drug interaction medication error6
JOINT INJURY6
HEPATIC FAILURE6
HEART RATE DECREASED6
GASTROINTESTINAL DISORDER6
DYSURIA6
DYSPNOEA EXERTIONAL6
DRUG ADMINISTRATION ERROR6
DIPLOPIA6
Delusional disorder, jealous type6
COUGH6
Chronic hepatitis6
Cholelithiasis6
BULIMIA NERVOSA6
Bipolar I disorder6
ALCOHOLISM6
AKINESIA6
Abnormal loss of weight6
Abdominal pain lower6
ABDOMINAL DISTENSION6
VISUAL FIELD DEFECT5
VACTERL syndrome5
URTICARIA5
Toxic skin eruption5
THEFT5
SWELLING FACE5
SWELLING5
SUPRAVENTRICULAR TACHYCARDIA5
Social avoidant behaviour5
Sleep paralysis5
Sinus node dysfunction5
Sinoatrial block5
Respiratory rate decreased5
RASH GENERALISED5
QUALITY OF LIFE DECREASED5
PRURITUS GENERALISED5
POLYNEUROPATHY5
Nocturia5
NIGHT SWEATS5
Myopathy5
Muscle contracture5
Mouth swelling5
MIGRAINE5
MACULAR DEGENERATION5
LIMB DISCOMFORT5
LEFT VENTRICULAR DYSFUNCTION5
Intentional product use issue5
INTENTIONAL DRUG MISUSE5
Incorrect route of drug administration5
Ileus5
HYPOTHERMIA5
HYPOPHAGIA5
Hypokalaemia5
HOT FLUSH5
Hemivertebra5
Heart disease congenital5
FOOD CRAVING5
FEAR5
Faecaloma5
ERECTION INCREASED5
DYSPHONIA5
DYSGEUSIA5
DRUG ABUSER5
DISTURBANCE IN SEXUAL AROUSAL5
DEPRESSION SUICIDAL5
Crime5
Congenital musculoskeletal disorder of limbs5
CHROMATURIA5
CATATONIA5
CARDIAC ARREST5
BLOOD GLUCOSE INCREASED5
BLEPHAROSPASM5
Behaviour disorder5
ARRHYTHMIA5
Acute pulmonary oedema5
THIRST4
Therapy cessation4
SUBDURAL HAEMATOMA4
Stoma site erythema4
Social problem4
Skin necrosis4
Sinus tachycardia4
Resting tremor4
Renal disorder4
Regurgitation4
Reduced facial expression4
RECTAL HAEMORRHAGE4
Psychomotor skills impaired4
PSYCHIATRIC SYMPTOM4
Product quality issue4
Product dispensing error4
Premature baby4
PANCREATITIS ACUTE4
PALLOR4
OSTEOARTHRITIS4
Myocarditis4
Mydriasis4
Multiple sclerosis4
MORBID THOUGHTS4
MOBILITY DECREASED4
Micturition urgency4
MENTAL IMPAIRMENT4
Lower respiratory tract infection4
Loss of personal independence in daily activities4
LIVER FUNCTION TEST ABNORMAL4
Left ventricular failure4
JOINT STIFFNESS4
IVTH NERVE PARESIS4
INCREASED APPETITE4
Inappropriate schedule of product administration4
Hypervigilance4
HYPERTENSIVE CRISIS4
HERPES ZOSTER4
HEPATITIS4
Hand deformity4
Haemorrhage intracranial4
HAEMATEMESIS4
GLAUCOMA4
Generalised tonic-clonic seizure4
Frustration tolerance decreased4
FLUSHING4
Fibroma4
Feeling of despair4
FEELING HOT4
FEELING GUILTY4
FAMILY STRESS4
EYELID OEDEMA4
EYE SWELLING4
EXCESSIVE MASTURBATION4
ERYTHEMA4
EJECTION FRACTION DECREASED4
Dysaesthesia4
Drug level decreased4
Drug effect incomplete4
DIZZINESS POSTURAL4
DISEASE RECURRENCE4
DISCOMFORT4
DISABILITY4
DERMATITIS ALLERGIC4
Decreased interest4
Coronavirus infection4
CORONARY ARTERY OCCLUSION4
Concomitant disease aggravated4
COMPRESSION FRACTURE4
Complex regional pain syndrome4
Cholecystitis4
CARDIOVASCULAR DISORDER4
CARDIAC FAILURE CONGESTIVE4
BURNING SENSATION4
BRONCHITIS4
Blood lactic acid increased4
ANAPHYLACTIC REACTION4
ALCOHOL USE4
ADVERSE REACTION4
Acute respiratory failure4
WHITE BLOOD CELL COUNT DECREASED3
Volvulus3
Vaccination site pruritus3
Vaccination site pain3
Vaccination site oedema3
Vaccination site erythema3
Vaccination site bruising3
URINE OUTPUT DECREASED3
Treatment failure3
THROAT IRRITATION3
TENDON RUPTURE3
TARDIVE DYSKINESIA3
SWOLLEN TONGUE3
Substance-induced psychotic disorder3
Subileus3
Stoma site pain3
Stoma site infection3
Stoma site discharge3
STAPHYLOCOCCAL INFECTION3
SOMATIC HALLUCINATION3
Somatic delusion3
SLEEP-RELATED EATING DISORDER3
SLEEP TERROR3
Skull fracture3
SKIN DISORDER3
SHOPLIFTING3
SHOCK3
SEXUAL ABUSE3
SENSORY DISTURBANCE3
SENSATION OF HEAVINESS3
SEGMENTED HYALINISING VASCULITIS3
SALIVARY HYPERSECRETION3
RIB FRACTURE3
Rheumatoid arthritis3
RETINAL TEAR3
RETCHING3
Repetitive speech3
RASH PRURITIC3
PULMONARY HYPERTENSION3
PSYCHOSEXUAL DISORDER3
Product formulation issue3
POTENTIATING DRUG INTERACTION3
Postural tremor3
Poor quality product administered3
POLYDIPSIA3
Poisoning deliberate3
Pleural effusion3
PLATELET COUNT DECREASED3
PHYSICAL ASSAULT3
PHARMACEUTICAL PRODUCT COMPLAINT3
Phaeochromocytoma3
PETIT MAL EPILEPSY3
PERSONALITY DISORDER3
PERIODIC LIMB MOVEMENT DISORDER3
Patient elopement3
PARALYSIS3
PAEDOPHILIA3
Oropharyngeal pain3
Oesophageal obstruction3
Obesity3
NEUTROPENIA3
NEOPLASM MALIGNANT3
NECK PAIN3
Nasopharyngitis3
MULTIPLE FRACTURES3
MULTI-ORGAN FAILURE3
MICTURITION DISORDER3
Medication residue present3
Maternal exposure during pregnancy3
MALIGNANT MELANOMA3
LYMPHOMA3
Lung disorder3
JUDGEMENT IMPAIRED3
JOB DISSATISFACTION3
IRRITABLE BOWEL SYNDROME3
Internal haemorrhage3
Inhibitory drug interaction3
INFLAMMATION3
INFECTION3
IMPAIRED DRIVING ABILITY3
HYPOTONIA3
Hypomagnesaemia3
HYPOKINESIA3
HYPOACUSIS3
Hypertonic bladder3
Hypertonia3
Hyperkalaemia3
Homicidal ideation3
Hepatic steatosis3
Head discomfort3
HALLUCINATION, TACTILE3
Haemorrhage3
GENERALISED OEDEMA3
GASTRITIS3
Freezing phenomenon3
FOOD INTERACTION3
Foetal growth restriction3
FLIGHT OF IDEAS3
FIBROMYALGIA3
Femur fracture3
Femoral neck fracture3
EXCESSIVE SEXUAL FANTASIES3
EXCESSIVE EXERCISE3
EPISTAXIS3
EPILEPSY3
Dysphemia3
DRY EYE3
Drug level increased3
Drug dispensed to wrong patient3
DISTURBANCE IN SOCIAL BEHAVIOUR3
DIABETES MELLITUS3
Dermatitis exfoliative generalised3
Dermatitis bullous3
DEMENTIA WITH LEWY BODIES3
DEMENTIA ALZHEIMER'S TYPE3
Delusion of replacement3
Delusion of parasitosis3
Defaecation disorder3
DEEP BRAIN STIMULATION3
Contraindicated product prescribed3
Contraindicated product administered3
Contraindicated drug prescribed3
COLD SWEAT3
CEREBRAL HAEMORRHAGE3
CELLULITIS3
CARDIO-RESPIRATORY ARREST3
Caesarean section3
BUNDLE BRANCH BLOCK LEFT3
BONE PAIN3
BLOOD PRESSURE FLUCTUATION3
BLOOD CHOLESTEROL INCREASED3
BLISTER3
BIPOLAR DISORDER3
BENIGN PROSTATIC HYPERPLASIA3
AUTONOMIC NERVOUS SYSTEM IMBALANCE3
ASPHYXIA3
AORTIC VALVE INCOMPETENCE3
AORTIC VALVE DISEASE3
Alcohol interaction3
ALCOHOL ABUSE3
AGEUSIA3
AFFECT LABILITY3
ACUTE MYOCARDIAL INFARCTION3
Accommodation disorder3
WRONG DRUG ADMINISTERED2
White blood cell count increased2
VITREOUS DETACHMENT2
Ventricular septal defect2
VENTRICULAR EXTRASYSTOLES2
VEIN DISORDER2
VASCULITIC RASH2
UNDERDOSE2
Umbilical hernia2
Type 2 diabetes mellitus2
Troponin increased2
Trisomy 212
TRISMUS2
TOOTH LOSS2
TINNITUS2
Thrombosis2
Thrombophlebitis2
Therapeutic product effect variable2
TENSION2
TACHYPNOEA2
SYSTEMIC LUPUS ERYTHEMATOSUS2
SUICIDAL BEHAVIOUR2
Substance dependence2
STUPOR2
Sputum discoloured2
Social phobia2
Sleep disorder due to a general medical condition2
SKIN LESION2
SKIN DISCOLOURATION2
SEXUAL ACTIVITY INCREASED2
Serum serotonin increased2
Serum ferritin decreased2
SENSORY LOSS2
Self-medication2
SELF-INJURIOUS IDEATION2
SCROTAL OEDEMA2
SCHIZOPHRENIA2
SCAR2
SALIVA ALTERED2
Sadism2
Rotator cuff syndrome2
Right ventricular failure2
RETROPERITONEAL FIBROSIS2
Retinal detachment2
RESPIRATORY ARREST2
RENAL TUBULAR DISORDER2
Renal cyst2
Relapsing-remitting multiple sclerosis2
Rehabilitation therapy2
REFUSAL OF TREATMENT BY PATIENT2
RAYNAUD'S PHENOMENON2
RASH PAPULAR2
RASH MACULAR2
RASH ERYTHEMATOUS2
RAPID EYE MOVEMENTS SLEEP ABNORMAL2
PROTEINURIA2
Product dose omission2
Pressure of speech2
Premature delivery2
Pneumonia pneumococcal2
Pneumonia influenzal2
Plantar fasciitis2
Physical disability2
Pharyngitis2
PERITONEAL FIBROSIS2
PERIPHERAL COLDNESS2
Peripheral arterial occlusive disease2
PERIORBITAL OEDEMA2
Periarthritis2
PEPTIC ULCER2
PENIS INJURY2
PENIS DISORDER2
PEMPHIGOID2
PARTNER STRESS2
Parkinson's disease psychosis2
PARAESTHESIA ORAL2
PANIC REACTION2
Panic disorder2
PANCYTOPENIA2
OXYGEN SATURATION DECREASED2
Oliguria2
OCULAR HYPERAEMIA2
NO THERAPEUTIC RESPONSE2
Neuropathy peripheral2
NEUROMUSCULAR BLOCKADE2
NERVOUS SYSTEM DISORDER2
NERVE INJURY2
NEPHROTIC SYNDROME2
Needle fatigue2
Nasal discharge discolouration2
Myositis2
Mutism2
MUSCULOSKELETAL DISCOMFORT2
Muscle spasticity2
MUSCLE FATIGUE2
Multiple sclerosis relapse2
Monoparesis2
MIOSIS2
MIGRAINE WITH AURA2
Microcephaly2
METASTASES TO LIVER2
METABOLIC ENCEPHALOPATHY2
Metabolic acidosis2
MELANOCYTIC NAEVUS2
Mediastinitis2
MALABSORPTION2
LYMPHADENOPATHY2
Lumbar vertebral fracture2
Loss of employment2
Localised infection2
Ligament sprain2
Leukocytosis2
LEGAL PROBLEM2
Left ventricular hypertrophy2
LACRIMATION INCREASED2
Kyphosis2
Joint range of motion decreased2
Joint lock2
Joint contracture2
Ischaemic stroke2
INTESTINAL PERFORATION2
INTERVERTEBRAL DISC PROTRUSION2
International normalised ratio decreased2
Inguinal hernia2
Infusion site urticaria2
Influenza2
Increased upper airway secretion2
Incorrect route of product administration2
INAPPROPRIATE AFFECT2
IMPRISONMENT2
Immune thrombocytopenic purpura2
Immune thrombocytopenia2
Illusion2
ILL-DEFINED DISORDER2
HYPOXIA2
Hypoglycaemia neonatal2
Hyperpyrexia2
Hypernatraemia2
HYPERLIPIDAEMIA2
Hyperhomocysteinaemia2
Hypercapnia2
HYPERACUSIS2
Homicide2
HIP SURGERY2
HIATUS HERNIA2
Hepatosplenomegaly2
HEPATIC ENCEPHALOPATHY2
Hepatic cirrhosis2
HANGOVER2
Gynaecomastia2
Grandiosity2
GRAND MAL CONVULSION2
Gout2
Gingival pain2
Gestational diabetes2
GENERAL SYMPTOM2
Gastrostomy2
GASTRIC ULCER2
GASTRIC HAEMORRHAGE2
Gastric fistula2
Gastric disorder2
GASTRIC CANCER2
GALLBLADDER OPERATION2
Gait spastic2
FEMALE ORGASMIC DISORDER2
FEEDING DISORDER2
FEAR OF DEATH2
Faecal incontinence2
FACIAL BONES FRACTURE2
Extra dose administered2
EXHIBITIONISM2
Erysipelas2
EROSIVE OESOPHAGITIS2
ELECTROCARDIOGRAM ST SEGMENT DEPRESSION2
ECZEMA2
ECCHYMOSIS2
Eating disorder symptom2
DRY SKIN2
DRUG TOXICITY2
Drug tolerance decreased2
DRUG SCREEN POSITIVE2
Drug resistance2
DROP ATTACKS2
DIABETES MELLITUS INADEQUATE CONTROL2
DENTAL CARIES2
DELUSIONAL DISORDER, UNSPECIFIED TYPE2
DELUSIONAL DISORDER, PERSECUTORY TYPE2
DELINQUENCY2
DEAFNESS2
Crystal urine2
Cotard's syndrome2
Costochondritis2
CONVERSION DISORDER2
Compulsive handwashing2
Communication disorder2
COLON CANCER2
Colitis microscopic2
Colitis ischaemic2
Clostridium difficile infection2
CHOLESTASIS2
CHOLANGITIS2
Choking2
Cerebral salt-wasting syndrome2
CEREBRAL ATROPHY2
Central nervous system lesion2
Catecholamines urine increased2
CATARACT2
Cardiomegaly2
Burn oral cavity2
Bruxism2
Bone disorder2
BLINDNESS2
Bilirubinuria2
Bacterial infection2
Atrioventricular block complete2
Atrioventricular block2
ASTHMA2
ASTHENOPIA2
ASPARTATE AMINOTRANSFERASE INCREASED2
Arthropathy2
Arthritis2
ARTERIOSPASM CORONARY2
ARTERIOSCLEROSIS2
Apraxia2
APNOEA2
Anticholinergic syndrome2
ANOREXIA2
ANGIOEDEMA2
ANGER2
ALANINE AMINOTRANSFERASE INCREASED2
Affective disorder2
ADVERSE EVENT2
Adjustment disorder2
ACUTE MYELOID LEUKAEMIA2
Acute hepatic failure2
Accidental exposure to product2
ACCIDENTAL DRUG INTAKE BY CHILD2
ABNORMAL SLEEP-RELATED EVENT2
Yellow skin1
Wrong product administered1
Wrong patient received medication1
Wound infection1
Wound decomposition1
WHEEZING1
Wheelchair user1
Weight loss poor1
Weight fluctuation1
WALKING DISABILITY1
WALKING AID USER1
Vitreous floaters1
VITREOUS DEGENERATION1
VIBRATORY SENSE INCREASED1
Vestibular disorder1
Verbigeration1
Verbal abuse1
Ventricular tachycardia1
Venous thrombosis1
VASCULITIS1
VASCULAR OPERATION1
Vascular graft1
VASCULAR ENCEPHALOPATHY1
VASCULAR ANOMALY1
Varicose vein1
UTERINE PROLAPSE1
UTERINE CANCER1
URINARY TRACT DISORDER1
Urinary hesitation1
UPPER RESPIRATORY TRACT INFECTION1
UPPER GASTROINTESTINAL HAEMORRHAGE1
Upper airway resistance syndrome1
UNRESPONSIVE TO VERBAL STIMULI1
UNINTENDED PREGNANCY1
Ultrasound uterus abnormal1
Ulnar nerve injury1
TUBULOINTERSTITIAL NEPHRITIS1
TROPONIN T INCREASED1
Trigeminal neuralgia1
Tricuspid valve incompetence1
TRANSVESTISM1
TRANSAMINASES INCREASED1
Tracheostomy1
TRACHEITIS1
Toxic epidermal necrolysis1
Tooth injury1
Tinea pedis1
TIC1
THROMBOCYTOSIS1
Throat tightness1
Thought blocking1
THORACIC OUTLET SYNDROME1
THERMAL BURN1
Therapy responder1
Therapy partial responder1
Therapy change1
THERAPEUTIC PRODUCT INEFFECTIVE1
TERMINAL STATE1
Testicular necrosis1
Tenosynovitis1
TENDONITIS1
TEMPORAL ARTERITIS1
Talipes1
TACHYPHYLAXIS1
Tachyphrenia1
TACHYARRHYTHMIA1
Swelling of eyelid1
SUDDEN DEATH1
Substance-induced mood disorder1
SUBSTANCE ABUSE1
Subretinal fluid1
SUBARACHNOID HAEMORRHAGE1
Stridor1
STRESS SYMPTOMS1
Stress cardiomyopathy1
STREPTOCOCCAL INFECTION1
STOMACH DISCOMFORT1
Stillbirth1
Sticky skin1
STEVENS-JOHNSON SYNDROME1
Sternal fracture1
STATUS EPILEPTICUS1
Staphylococcal bacteraemia1
SQUAMOUS CELL CARCINOMA1
Spinal stenosis1
Spinal osteoarthritis1
Spinal operation1
Spinal instability1
SPINAL DISORDER1
Spinal deformity1
Spinal compression fracture1
Soft tissue injury1
Snoring1
Small intestinal perforation1
Small cell lung cancer1
SLUGGISHNESS1
SKULL MALFORMATION1
Skin wrinkling1
SKIN ULCER1
Skin reaction1
Skin mass1
SKIN HAEMORRHAGE1
SKIN FIBROSIS1
SKIN EXFOLIATION1
Skin cancer1
Skin atrophy1
SINUSITIS1
Shock haemorrhagic1
SEPTIC SHOCK1
SENSORIMOTOR DISORDER1
Sensation of foreign body1
Self injurious behaviour1
SCREAMING1
Scoliosis1
Schizoaffective disorder1
RHINORRHOEA1
RETINOPATHY1
Retinal oedema1
Retinal haemorrhage1
RETINAL DISORDER1
RETINAL DEGENERATION1
Respiratory tract infection viral1
Respiratory muscle weakness1
Respiratory fatigue1
RESPIRATORY DYSKINESIA1
RESPIRATORY DEPRESSION1
RESPIRATORY ALKALOSIS1
Renal transplant1
RENAL FAILURE CHRONIC1
RENAL CELL CARCINOMA STAGE UNSPECIFIED1
REGRESSIVE BEHAVIOUR1
RECTAL PROLAPSE1
Recall phenomenon1
REBOUND EFFECT1
REACTION TO PRESERVATIVES1
RASH PUSTULAR1
Radius fracture1
Radiculitis brachial1
PUNCTURE SITE HAEMORRHAGE1
PULMONARY HYPOPLASIA1
Psychotic symptom1
Psychiatric decompensation1
Psoriatic arthropathy1
PSEUDOMONAS INFECTION1
Protrusion tongue1
PROTEIN URINE1
PROSTATE CANCER1
Progressive muscular atrophy1
Product substitution error1
Product preparation error1
PRODUCT MEASURED POTENCY ISSUE1
PRODUCT LABEL ISSUE1
Product counterfeit1
PROCTITIS1
Procrastination1
Procalcitonin increased1
Prescribed underdose1
Premature labour1
Postoperative delirium1
Posterior reversible encephalopathy syndrome1
Post procedural haemorrhage1
Poor personal hygiene1
POOR PERIPHERAL CIRCULATION1
POLYURIA1
PO2 decreased1
Pneumothorax1
PNEUMONIA STAPHYLOCOCCAL1
PNEUMONIA PRIMARY ATYPICAL1
Pneumonia mycoplasmal1
Pneumoconiosis1
Plasma cell myeloma1
Placental insufficiency1
Pituitary-dependent Cushing's syndrome1
Pickwickian syndrome1
PICA1
PHOTOPSIA1
PHOTOPHOBIA1
PHARYNGEAL OEDEMA1
PEYRONIE'S DISEASE1
Personal relationship issue1
PERIPHERAL VASCULAR DISORDER1
PERIORBITAL HAEMATOMA1
PERICARDITIS CONSTRICTIVE1
Pericardial operation1
Pericardial effusion1
PENILE SWELLING1
PELVIC FLOOR MUSCLE WEAKNESS1
PAROSMIA1
PARADOXICAL DRUG REACTION1
Panic disorder with agoraphobia1
Overweight1
Overlap syndrome1
OSTEOPOROTIC FRACTURE1
OSTEONECROSIS1
Osteomyelitis1
ORTHOSTATIC HYPERTENSION1
Orthopaedic procedure1
Oromandibular dystonia1
ORGASM ABNORMAL1
Organising pneumonia1
ORAL MUCOSAL BLISTERING1
ORAL INTAKE REDUCED1
Optic nerve injury1
OPTIC DISC DISORDER1
Opisthotonus1
Onychomalacia1
Oncologic complication1
Oligohydramnios1
OESOPHAGITIS1
OESOPHAGEAL ULCER1
Oesophageal disorder1
OESOPHAGEAL CARCINOMA1
OESOPHAGEAL ACHALASIA1
Ocular discomfort1
Occult blood1
Obstruction1
Nutritional condition abnormal1
NORMAL TENSION GLAUCOMA1
NON-SMALL CELL LUNG CANCER1
NODULE1
Nocturnal dyspnoea1
No reaction on previous exposure to drug1
No adverse event1
NEUROPSYCHOLOGICAL TEST ABNORMAL1
NEUROPATHY1
Neurological symptom1
Neuroendocrine carcinoma of the skin1
Neuroendocrine carcinoma1
NEPHROPATHY1
NEPHRITIS1
Neonatal tachypnoea1
NEONATAL RESPIRATORY DISTRESS SYNDROME1
NEGLECT OF PERSONAL APPEARANCE1
NEGATIVE THOUGHTS1
Necrotising myositis1
Neck injury1
Nasal septum deviation1
MYOPIA1
Myelodysplastic syndrome1
Myasthenia gravis1
Musculoskeletal disorder1
MUSCLE TIGHTNESS1
Muscle strain1
Muscle necrosis1
Muscle injury1
Mucosal dryness1
MOTION SICKNESS1
Mixed liver injury1
MITRAL VALVE PROLAPSE1
METASTASES TO SPINE1
METASTASES TO CENTRAL NERVOUS SYSTEM1
Mental fatigue1
Mental disability1
MENINGITIS1
Meningioma1
Melaena1
MEDICATION RESIDUE1
MEDIASTINUM NEOPLASM1
Maternal drugs affecting foetus1
MASTITIS1
MASTICATION DISORDER1
Masked facies1
MARASMUS1
MALIGNANT MELANOMA STAGE II1
MALIGNANT MELANOMA IN SITU1
MALE SEXUAL DYSFUNCTION1
Malabsorption from administration site1
Madarosis1
Lymphoedema1
LYMPHADENITIS1
LYMPH NODE PAIN1
Lung cyst1
Lumbar spinal stenosis1
Lower gastrointestinal perforation1
Lower gastrointestinal haemorrhage1
LOW DENSITY LIPOPROTEIN INCREASED1
LOSS OF CONTROL OF LEGS1
Local swelling1
LIVIDITY1
Liver injury1
Livedo reticularis1
LIPOMA1
LIPIDS ABNORMAL1
LIP SWELLING1
LIP INJURY1
Lip haemorrhage1
LIMB INJURY1
Limb deformity1
LIGHT CHAIN DISEASE1
Ligament disorder1
Large intestine polyp1
Large for dates baby1
Lacrimation decreased1
Laboratory test interference1
Labelled drug-drug interaction issue1
Knee operation1
Kleptomania1
JOINT DISLOCATION1
Jaw fracture1
Jaw disorder1
Iron deficiency anaemia1
Intestinal resection1
INTESTINAL HAEMORRHAGE1
INTERVERTEBRAL DISC DISORDER1
INTERVERTEBRAL DISC DEGENERATION1
INTERNATIONAL NORMALISED RATIO INCREASED1
INTERCOSTAL NEURALGIA1
Intercepted product administration error1
Intention tremor1
INFLUENZA LIKE ILLNESS1
INFLAMMATORY CARCINOMA OF THE BREAST1
Infection susceptibility increased1
Indifference1
INCREASED TENDENCY TO BRUISE1
Incorrect storage of drug1
Incorrect drug dosage form administered1
Incorrect dosage administered1
Incontinence1
IMPAIRED SELF-CARE1
IMMOBILE1
Ilium fracture1
Hysterectomy1
HYPOVENTILATION1
HYPOTRICHOSIS1
Hypotony of eye1
HYPOTHYROIDISM1
Hypothermia neonatal1
Hypospadias1
Hypoproteinaemia1
Hyponatraemic syndrome1
Hypochromic anaemia1
HYPOALBUMINAEMIA1
Hypoaesthesia oral1
Hyperthyroidism1
Hyperthermia malignant1
Hyperreflexia1
Hyperprolactinaemia1
Hypermobility syndrome1
Hypercreatinaemia1
HYPERAESTHESIA1
HUNGER1
HOSTILITY1
HOFFMANN'S SIGN1
HIP FRACTURE1
Hip arthroplasty1
Hernia1
Hereditary disorder1
HEREDITARY ANGIOEDEMA1
HEPATOTOXICITY1
Hepatitis E virus test positive1
Hepatitis E1
Hepatitis chronic active1
Hepatitis B1
HEPATITIS ACUTE1
HEPATIC NEOPLASM MALIGNANT1
HEPATIC LESION1
Hepatic haemorrhage1
Hepatic cancer1
HEMIPLEGIA1
HEMIPARESIS1
Helplessness1
Heat stroke1
Heat illness1
HEART VALVE REPLACEMENT1
Heart valve incompetence1
HEART RATE IRREGULAR1
HEARING IMPAIRED1
Hallucination, olfactory1
Haemorrhagic stroke1
Haematuria1
Haematoma muscle1
Haematochezia1
GROIN PAIN1
GRAVITATIONAL OEDEMA1
Granulomatosis with polyangiitis1
GLUCAGONOMA1
Glomerular filtration rate decreased1
GLOBAL AMNESIA1
Genitourinary operation1
GASTROSTOMY TUBE INSERTION1
Gastrointestinal tube insertion1
Gastrointestinal perforation1
Gastrointestinal obstruction1
Gastrointestinal carcinoma1
GASTRIC BYPASS1
Gastrectomy1
Gamma-glutamyltransferase increased1
Gait inability1
Fungal infection1
Fractured sacrum1
Formication1
FOREIGN BODY TRAUMA1
Foreign body in throat1
Foot operation1
Foot deformity1
FOOD HOARDING1
Foetal death1
Fluid overload1
FLUID INTAKE REDUCED1
FLATULENCE1
FLAT AFFECT1
Fine motor skill dysfunction1
FEELINGS OF WORTHLESSNESS1
FEELING DRUNK1
Facial paresis1
FACE OEDEMA1
Eyelid ptosis1
EYE PRURITUS1
Eye oedema1
Eye disorder1
EYE ABSCESS1
Exposure via ingestion1
EXERCISE TOLERANCE DECREASED1
Executive dysfunction1
EXCORIATION1
Erythema multiforme1
Ergot poisoning1
EOSINOPHILIC PNEUMONIA1
Enterostomy1
ENERGY INCREASED1
Endotracheal intubation1
Elevated mood1
Electrocardiogram abnormal1
Effusion1
Eastern Cooperative Oncology Group performance status worsened1
Early retirement1
EAR PAIN1
EAR INFECTION1
Dyslexia1
Dyslalia1
Drug use disorder1
DRUG TOLERANCE1
Drug therapy1
DRUG SCREEN FALSE POSITIVE1
Drug level below therapeutic1
DRUG EFFECT DELAYED1
DRUG DOSE OMISSION1
Drug administered to patient of inappropriate age1
Diverticulum1
DISTRACTIBILITY1
Dissociation1
Disseminated intravascular coagulation1
Diffuse large B-cell lymphoma1
DIFFICULTY IN WALKING1
Diaphragmatic spasm1
Diaphragmatic paralysis1
Diaphragmatic disorder1
Diabetic neuropathy1
Diabetic ketoacidosis1
Diabetic gangrene1
DERMATITIS EXFOLIATIVE1
Dermatitis1
DERMAL CYST1
DEPENDENT RUBOR1
Dental leakage1
Delusional disorder, somatic type1
Delusion of grandeur1
Deja vu1
Deep vein thrombosis1
Decubitus ulcer1
Decreased activity1
Decerebrate posture1
DEATH OF SPOUSE1
DEATH OF RELATIVE1
Deafness bilateral1
DAYDREAMING1
CYTOLYTIC HEPATITIS1
Cystitis noninfective1
Cystitis1
CREATININE RENAL CLEARANCE1
COVID-19 pneumonia1
CORONARY ARTERY DISSECTION1
Coronary artery disease1
Conjunctival hyperaemia1
Congestive cardiomyopathy1
Congenital hypothyroidism1
Colitis ulcerative1
Cogwheel rigidity1
Coarctation of the aorta1
Clostridium difficile colitis1
CLONUS1
Clavicle fracture1
CIRCUMSTANCE OR INFORMATION CAPABLE OF LEADING TO MEDICATION ERROR1
CIRCADIAN RHYTHM SLEEP DISORDER1
CHRONIC RESPIRATORY FAILURE1
Chronic kidney disease1
CHONDROCALCINOSIS PYROPHOSPHATE1
Cholestatic liver injury1
Cholecystitis chronic1
CHANGE OF BOWEL HABIT1
CERVICAL SPINAL STENOSIS1
Cerebral palsy1
CEREBRAL ISCHAEMIA1
Cerebral disorder1
Cerebellar infarction1
Catecholamines urine1
CATAPLEXY1
Carpal tunnel syndrome1
CARDIOVASCULAR INSUFFICIENCY1
Cardiotoxicity1
CARDIOMYOPATHY1
Cardiogenic shock1
Cardiac murmur1
Cardiac hypertrophy1
CARDIAC FLUTTER1
CARDIAC FAILURE HIGH OUTPUT1
Cardiac failure chronic1
CARDIAC DEATH1
Cardiac amyloidosis1
Carbohydrate antigen 19-9 increased1
CAECITIS1
C-reactive protein increased1
BRONCHOSPASM1
BRONCHITIS ACUTE1
Breast cyst1
BREAST CANCER METASTATIC1
BREAST CANCER1
BREAKTHROUGH PAIN1
BRAIN SCAN ABNORMAL1
BRAIN DAMAGE1
BRADYPHRENIA1
BRADYARRHYTHMIA1
BONE MARROW FAILURE1
Body temperature decreased1
BLOOD URINE PRESENT1
BLOOD UREA INCREASED1
BLOOD TESTOSTERONE DECREASED1
BLOOD TEST ABNORMAL1
BLOOD PROLACTIN INCREASED1
BLOOD PROLACTIN DECREASED1
BLOOD POTASSIUM DECREASED1
BLOOD LACTATE DEHYDROGENASE INCREASED1
BLOOD GLUCOSE FLUCTUATION1
BLOOD GLUCOSE DECREASED1
BLOOD FOLLICLE STIMULATING HORMONE DECREASED1
BLOOD CREATINE INCREASED1
Blood chromogranin A increased1
BLOOD CHLORIDE DECREASED1
BLOOD BILIRUBIN INCREASED1
BLOOD ALCOHOL INCREASED1
Blighted ovum1
BLADDER PERFORATION1
Bladder operation1
Bile duct stone1
Bile duct cancer1
Basal ganglion degeneration1
Basal cell carcinoma1
BARRETT'S OESOPHAGUS1
BARBITURATES POSITIVE1
BANKRUPTCY1
Ballismus1
Back disorder1
Automatism1
ATTENTION DEFICIT/HYPERACTIVITY DISORDER1
Atrioventricular block first degree1
Atrial septal defect1
ATRIAL FLUTTER1
Aspiration bronchial1
ASPIRATION1
Ascites1
ARTICULAR CALCIFICATION1
ARTERIOVENOUS MALFORMATION1
ARRHYTHMIA SUPRAVENTRICULAR1
Appendicitis1
Appendicectomy1
Aplastic anaemia1
APHTHOUS STOMATITIS1
Aphonia1
Aortic valve stenosis1
AORTIC STENOSIS1
Anxiety disorder1
Anuria1
ANTIDIURETIC HORMONE ABNORMALITY1
Ankle fracture1
Angle closure glaucoma1
Angiopathy1
ANEURYSM1
ANASTOMOTIC STENOSIS1
ALVEOLITIS FIBROSING1
Akathisia1
Agoraphobia1
Agitated depression1
ADENOCARCINOMA1
Acute respiratory distress syndrome1
Acute hepatitis B1
Acute generalised exanthematous pustulosis1
ACUTE CORONARY SYNDROME1
Acquired gene mutation1
ACCIDENTAL POISONING1
Accidental exposure to product by child1
ACCIDENTAL EXPOSURE1
ACCIDENT1
Abulia1
ABORTION INDUCED1
Abnormal weight gain1
Abnormal faeces1
ABDOMINAL WALL MASS1





Filtered ChEMBL targets:

Target UniProtKB ID Activity in nm Target Name Target gene
P14416 5 D(2) dopamine receptor DRD2_HUMAN
P21917 8.1 D(4) dopamine receptor DRD4_HUMAN
P28223 1174.9 5-hydroxytryptamine receptor 2A 5HT2A_HUMAN
P35462 0.7244 D(3) dopamine receptor DRD3_HUMAN



Toxicity information:

Toxicity class: 4
Toxicity type: N/A
LD50: 800 mg/kg



External links:

ChEBML: CHEMBL301265
DrugBank: DB00413