Pipobroman


367



General information:


Withdrawn ID: 367
Canonical SMILES:
Standard InChI:
Standard InChIKey:
ATC class(es): L01AX02
Molecular Formula: C10H16Br2N2O2
Molweight: 356.054



Withdrawal information:


Withdrawn due to drug safety reasons:No
First approved: 1966
First withdrawn: 2015
Last withdrawn: 2015



Side-effects:

Total reported cases (submitted by medical professionals) with Pipobroman as primary suspect: 49


Reported final outcomes:
Hospitalization (initial or prolonged): 32
Life-Threatening condition: 9
Death: 8
Disability: 2
Intervention required to prevent permanent impairment/damage: 1


Reported side-effects:

Side-effect Case number
ANAEMIA8
PANCYTOPENIA7
THROMBOCYTOPENIA6
ASTHENIA4
SEPTIC SHOCK3
PAIN IN EXTREMITY3
GENERAL PHYSICAL HEALTH DETERIORATION3
DYSPNOEA3
CYTOLYTIC HEPATITIS3
ACUTE MYELOID LEUKAEMIA3
SOMNOLENCE2
SKIN DISCOLOURATION2
SEPSIS2
RENAL FAILURE ACUTE2
RASH MACULO-PAPULAR2
PORTAL HYPERTENSION2
PNEUMOCOCCAL INFECTION2
NEUROPATHY PERIPHERAL2
LUNG DISORDER2
LEUKOPENIA2
HYPERTHERMIA2
HEPATIC FUNCTION ABNORMAL2
HEPATIC ENCEPHALOPATHY2
HEADACHE2
GAIT DISTURBANCE2
ESCHERICHIA INFECTION2
DECREASED APPETITE2
CONDITION AGGRAVATED2
CARDIAC FAILURE2
BREAST CANCER2
BONE MARROW FAILURE2
BONE MARROW DEPRESSION2
APLASIA2
AGRANULOCYTOSIS2
ACUTE LEUKAEMIA2
ABDOMINAL PAIN2
Vomiting1
VARICOSE ULCERATION1
URTICARIA1
URINARY TRACT INFECTION1
Unevaluable event1
ULCERATIVE KERATITIS1
TOXICITY TO VARIOUS AGENTS1
THROMBOSIS1
TACHYPNOEA1
SYSTEMIC INFLAMMATORY RESPONSE SYNDROME1
STAPHYLOCOCCAL BACTERAEMIA1
SKIN ULCER1
SKIN PLAQUE1
SENSATION OF HEAVINESS1
SCHIZOPHRENIA1
SCAR1
RENAL FAILURE1
REFRACTORY ANAEMIA WITH AN EXCESS OF BLASTS1
RASH ERYTHEMATOUS1
RALES1
PYREXIA1
PYRAMIDAL TRACT SYNDROME1
PURPURA1
PULMONARY FIBROSIS1
PULMONARY EMBOLISM1
PSYCHOTIC DISORDER1
PSEUDOMONAL BACTERAEMIA1
PRURITUS1
PRURIGO1
PREPYLORIC STENOSIS1
POLYCYTHAEMIA VERA1
PLEURAL EFFUSION1
PLATELET COUNT DECREASED1
PHLEBITIS SUPERFICIAL1
PALLOR1
PAINFUL RESPIRATION1
OXYGEN SATURATION DECREASED1
Overdose1
OLIGURIA1
OEDEMA PERIPHERAL1
NEUTROPENIA1
Nausea1
MYELOPROLIFERATIVE DISORDER1
Myelofibrosis1
MYELODYSPLASTIC SYNDROME1
MOTOR DYSFUNCTION1
MOBILITY DECREASED1
MEIBOMIANITIS1
Medication error1
MALAISE1
LYMPHOPENIA1
LYMPHOCYTE MORPHOLOGY ABNORMAL1
LUNG INFILTRATION1
LUNG INFECTION1
LIVER DISORDER1
Laboratory test abnormal1
JAUNDICE1
INTERSTITIAL LUNG DISEASE1
INFLAMMATION1
INFECTION1
HYPOXIA1
HYPOTENSION1
HYPERSOMNIA1
HYPERKERATOSIS1
HEPATITIS ACUTE1
HEPATIC NECROSIS1
HEPATIC LESION1
HEPATIC FAILURE1
HAEMOGLOBIN DECREASED1
GENERALISED ERYTHEMA1
GENERAL PHYSICAL CONDITION ABNORMAL1
GASTRIC ULCER1
FINGERPRINT LOSS1
FEELING ABNORMAL1
FATIGUE1
ERYTHROPENIA1
ERYTHEMA1
DYSPEPSIA1
DRUG TOXICITY1
DRUG ERUPTION1
DISTURBANCE IN ATTENTION1
DIPLEGIA1
Diarrhoea1
DERMATITIS CONTACT1
DERMATITIS BULLOUS1
DEREALISATION1
DELIRIUM1
DEEP VEIN THROMBOSIS1
CONVULSION1
COGNITIVE DISORDER1
COAGULATION FACTOR DECREASED1
CHROMATURIA1
CHILLS1
CHEST X-RAY ABNORMAL1
CHEST PAIN1
CHALAZION1
CEREBROVASCULAR ACCIDENT1
CD4 LYMPHOCYTES INCREASED1
BRAIN NATRIURETIC PEPTIDE INCREASED1
BONE MARROW NECROSIS1
BICYTOPENIA1
BACK PAIN1
ASCITES1
AMYOTROPHIC LATERAL SCLEROSIS1
AMNESTIC DISORDER1
ACUTE MEGAKARYOCYTIC LEUKAEMIA1
ACUTE CORONARY SYNDROME1
ACTIVITIES OF DAILY LIVING IMPAIRED1
ABDOMINAL STRANGULATED HERNIA1





Filtered ChEMBL targets:

Target UniProtKB ID Activity in nm Target Name Target gene
O75604 10000 Ubiquitin carboxyl-terminal hydrolase 2 UBP2_HUMAN
P00352 891.3 Retinal dehydrogenase 1 AL1A1_HUMAN
P02545 501.2 Prelamin-A/C LMNA_HUMAN
Q9NUW8 7943.3 Tyrosyl-DNA phosphodiesterase 1 TYDP1_HUMAN



Toxicity information:

Toxicity class: 4
Toxicity type: N/A
LD50: 1750 mg/kg



External links:

ChEBML: CHEMBL1585
DrugBank: DB00236