Phenprocoumon


228



General information:


Withdrawn ID: 228
Canonical SMILES:
Standard InChI:
Standard InChIKey:
ATC class(es): B01AA04
Molecular Formula: C18H16O3
Molweight: 280.318



Withdrawal information:


Withdrawn due to drug safety reasons:No
First approved: 1957



Side-effects:

Total reported cases (submitted by medical professionals) with Phenprocoumon as primary suspect: 47


Reported final outcomes:
Hospitalization (initial or prolonged): 34
Life-Threatening condition: 12
Death: 5
Congenital anomaly: 1


Reported side-effects:

Side-effect Case number
DRUG INTERACTION16
GASTROINTESTINAL HAEMORRHAGE10
International normalised ratio increased8
MELAENA5
Haematochezia4
FALL4
Anaemia4
Vomiting3
SUBDURAL HAEMATOMA3
PROTHROMBIN TIME PROLONGED3
Overdose3
NAUSEA3
GENERAL PHYSICAL HEALTH DETERIORATION3
Cerebral haemorrhage3
ASTHENIA3
UPPER GASTROINTESTINAL HAEMORRHAGE2
Renal failure2
PROTHROMBIN TIME SHORTENED2
MUSCLE HAEMORRHAGE2
HYPONATRAEMIA2
HYPOKALAEMIA2
HAEMORRHAGIC ANAEMIA2
HAEMATEMESIS2
ELECTROLYTE IMBALANCE2
DIZZINESS2
Decreased appetite2
Coagulation time prolonged2
Coagulation test abnormal2
Cerebral ischaemia2
Vitamin K deficiency1
TRANSAMINASES INCREASED1
Toxicity to various agents1
Thrombocytopenia1
SUBDURAL HAEMORRHAGE1
SKIN DISORDER1
Sinus tachycardia1
RHABDOMYOLYSIS1
Retinal haemorrhage1
RESPIRATORY ALKALOSIS1
Renal failure chronic1
Rectal haemorrhage1
Prothrombin level decreased1
Peripheral swelling1
PERIPHERAL NERVE INJURY1
Performance status decreased1
PEPTIC ULCER HAEMORRHAGE1
Pain in extremity1
OESOPHAGITIS HAEMORRHAGIC1
OEDEMA PERIPHERAL1
OEDEMA1
Muscular weakness1
METABOLIC ALKALOSIS1
Lower gastrointestinal haemorrhage1
LOSS OF CONSCIOUSNESS1
LIVER INJURY1
Leukopenia1
LABELLED DRUG-DRUG INTERACTION MEDICATION ERROR1
Jaundice1
International normalised ratio decreased1
HYPOTENSION1
HYPOPHOSPHATAEMIA1
HYPOCHLORAEMIA1
HYPOCALCAEMIA1
HYPERVENTILATION1
Hyperkalaemia1
HIATUS HERNIA1
HEPATOMEGALY1
HEPATIC STEATOSIS1
HEPATIC NECROSIS1
HEPATIC FIBROSIS1
Hepatic failure1
Heart rate increased1
Haemorrhagic diathesis1
Haemoglobin decreased1
HAEMATOMA1
GINGIVAL BLEEDING1
General physical condition abnormal1
GASTROENTERITIS VIRAL1
GASTRITIS EROSIVE1
Foetal exposure during pregnancy1
Feeling hot1
Fatigue1
Faeces pale1
EPISTAXIS1
Dyspepsia1
Dysmorphism1
DUODENITIS HAEMORRHAGIC1
DUODENAL ULCER HAEMORRHAGE1
Drug-induced liver injury1
Drug ineffective1
Dandy-Walker syndrome1
Cyst1
CONTUSION1
Contraindicated product administered1
Congenital central nervous system anomaly1
COAGULOPATHY1
CHOLELITHIASIS1
CHOLECYSTITIS1
Chest discomfort1
Cardiac tamponade1
BRAIN STEM HAEMORRHAGE1
Blood pressure decreased1
BLOOD OSMOLARITY DECREASED1
BLEEDING TIME PROLONGED1
Balance disorder1
Atrial fibrillation1
Ataxia1
Aspiration1
Aphagia1
ANURIA1
Acute myocardial infarction1
Acute hepatic failure1
Abdominal pain upper1
Abdominal distension1





Toxicity information:

Toxicity class: 3
Toxicity type: N/A
LD50: 190 mg/kg



External links:

ChEBML: CHEMBL1465
DrugBank: DB00946