Pergolide


w169



General information:


Withdrawn ID: w169
Canonical SMILES:
Standard InChI:
Standard InChIKey:
ATC class(es): N04BC02
Molecular Formula: C19H26N2S
Molweight: 314.488



Withdrawal information:


Withdrawn due to drug safety reasons:Yes
First approved: 1988
First withdrawn: 2007
Last withdrawn: 2007
Reference: https://www.ncbi.nlm.nih.gov/pubmed/25804611



Side-effects:

Total reported cases (submitted by medical professionals) with Pergolide as primary suspect: 220


Reported final outcomes:
Hospitalization (initial or prolonged): 121
Death: 25
Life-Threatening condition: 19
Disability: 13
Intervention required to prevent permanent impairment/damage: 4
Congenital anomaly: 1


Reported side-effects:

Side-effect Case number
MITRAL VALVE INCOMPETENCE62
AORTIC VALVE INCOMPETENCE50
TRICUSPID VALVE INCOMPETENCE46
CARDIAC VALVE DISEASE46
PLEURAL EFFUSION31
DYSPNOEA31
CARDIAC FAILURE28
OEDEMA PERIPHERAL26
MITRAL VALVE DISEASE21
PULMONARY HYPERTENSION20
CONDITION AGGRAVATED16
CHEST PAIN16
FATIGUE15
CARDIAC MURMUR15
ATRIAL FIBRILLATION15
WEIGHT INCREASED14
RETROPERITONEAL FIBROSIS14
CARDIOMEGALY14
HEART VALVE INSUFFICIENCY13
PARKINSON'S DISEASE12
PULMONARY OEDEMA11
PERICARDIAL EFFUSION11
HALLUCINATION11
DRUG INEFFECTIVE11
CARDIAC FAILURE CONGESTIVE11
PNEUMONIA10
PLEURAL FIBROSIS10
DILATATION ATRIAL10
ANXIETY10
PULMONARY VALVE INCOMPETENCE9
HYDRONEPHROSIS9
AORTIC VALVE SCLEROSIS9
PYREXIA8
EJECTION FRACTION DECREASED8
DYSKINESIA8
CORONARY ARTERY DISEASE8
AORTIC VALVE STENOSIS8
AORTIC VALVE DISEASE8
POST PROCEDURAL COMPLICATION7
PALPITATIONS7
NAUSEA7
LOSS OF CONSCIOUSNESS7
HYPERTENSION7
FALL7
DYSPNOEA EXERTIONAL7
DIZZINESS7
DEPRESSION7
ASTHENIA7
SOMNOLENCE6
RIGHT VENTRICULAR FAILURE6
RENAL FAILURE6
PULMONARY FIBROSIS6
PNEUMONIA ASPIRATION6
PATHOLOGICAL GAMBLING6
PAIN IN EXTREMITY6
OEDEMA6
LYMPHADENOPATHY6
INSOMNIA6
HYPERLIPIDAEMIA6
DILATATION VENTRICULAR6
DEPRESSED LEVEL OF CONSCIOUSNESS6
COUGH6
BLOOD CREATINE PHOSPHOKINASE INCREASED6
TRICUSPID VALVE DISEASE5
TACHYCARDIA5
SLEEP APNOEA SYNDROME5
PLEURISY5
GENERAL PHYSICAL HEALTH DETERIORATION5
CARDIOMYOPATHY5
BLOOD LACTATE DEHYDROGENASE INCREASED5
ARRHYTHMIA5
ABDOMINAL DISTENSION5
WEIGHT DECREASED4
VOMITING4
VENTRICULAR HYPERTROPHY4
STRESS4
SPEECH DISORDER4
PULMONARY ARTERIAL PRESSURE INCREASED4
PRESCRIBED OVERDOSE4
PNEUMONITIS4
PERICARDITIS4
NEUROLEPTIC MALIGNANT SYNDROME4
MUSCLE RIGIDITY4
MITRAL VALVE SCLEROSIS4
MITRAL VALVE PROLAPSE4
MALAISE4
LYMPHOEDEMA4
INTERSTITIAL LUNG DISEASE4
HYPOTENSION4
HEPATIC FUNCTION ABNORMAL4
DISSEMINATED INTRAVASCULAR COAGULATION4
DELIRIUM4
DECREASED APPETITE4
CARDIOVASCULAR DISORDER4
CARDIAC FAILURE ACUTE4
BACK PAIN4
ASPARTATE AMINOTRANSFERASE INCREASED4
AORTIC DILATATION4
ANOREXIA4
ANAEMIA4
ALANINE AMINOTRANSFERASE INCREASED4
ACUTE PULMONARY OEDEMA4
ACTIVITIES OF DAILY LIVING IMPAIRED4
TORTICOLLIS3
SYNCOPE3
SPINAL OSTEOARTHRITIS3
SLEEP DISORDER3
ROAD TRAFFIC ACCIDENT3
RHEUMATIC HEART DISEASE3
RESTRICTIVE PULMONARY DISEASE3
PSYCHOTIC DISORDER3
PERICARDITIS CONSTRICTIVE3
OSTEOPOROSIS3
ORTHOSTATIC HYPOTENSION3
ORTHOPNOEA3
ORAL INTAKE REDUCED3
MULTI-ORGAN FAILURE3
MITRAL VALVE CALCIFICATION3
MASKED FACIES3
LIVER DISORDER3
INTESTINAL OBSTRUCTION3
HYPOKINESIA3
HYPERSEXUALITY3
HYPERCAPNIA3
HEART VALVE INCOMPETENCE3
HALLUCINATION, VISUAL3
GAMBLING3
GAIT DISTURBANCE3
FEELING ABNORMAL3
DYSTONIA3
DYSPHAGIA3
DRUG EFFECT DECREASED3
DIFFICULTY IN WALKING3
DEMENTIA3
DEHYDRATION3
DEEP VEIN THROMBOSIS3
CONSTIPATION3
CONGESTIVE CARDIOMYOPATHY3
CHORDAE TENDINAE RUPTURE3
CELLULITIS3
CARDIAC ARREST3
BLOOD ALKALINE PHOSPHATASE INCREASED3
ATRIOVENTRICULAR BLOCK COMPLETE3
ARTHRALGIA3
AORTIC ATHEROSCLEROSIS3
ANGINA PECTORIS3
ABNORMAL BEHAVIOUR3
WHITE BLOOD CELL COUNT INCREASED2
VENTRICULAR EXTRASYSTOLES2
VENTRICULAR DYSFUNCTION2
VENOUS STASIS2
URINARY TRACT INFECTION2
UMBILICAL HERNIA2
TREMOR2
TOTAL LUNG CAPACITY DECREASED2
THROMBOCYTOPENIA2
THERAPY NON-RESPONDER2
THERAPEUTIC PRODUCT INEFFECTIVE2
SUPRAVENTRICULAR EXTRASYSTOLES2
SUICIDE ATTEMPT2
SUICIDAL IDEATION2
SPINAL FRACTURE2
SICK SINUS SYNDROME2
ROTATOR CUFF SYNDROME2
ROSAI-DORFMAN SYNDROME2
RESTLESSNESS2
RENAL IMPAIRMENT2
RED BLOOD CELL SEDIMENTATION RATE INCREASED2
PRODUCTIVE COUGH2
PLATELET COUNT DECREASED2
PHARMACEUTICAL PRODUCT COMPLAINT2
PERICARDIAL FIBROSIS2
PELVIC PAIN2
PARKINSONISM2
PARAPHILIA2
PARANOIA2
PANIC REACTION2
PANIC DISORDER2
OVERWEIGHT2
OVERDOSE2
OSTEITIS DEFORMANS2
OESOPHAGEAL ULCER2
OBESITY2
NIGHTMARE2
NEUTROPHIL PERCENTAGE DECREASED2
NEUROMA2
MUSCULAR WEAKNESS2
MUSCLE SPASMS2
MOTOR DYSFUNCTION2
MOOD DISORDER DUE TO A GENERAL MEDICAL CONDITION2
MONOCYTOSIS2
MONOCYTE PERCENTAGE DECREASED2
MOBILITY DECREASED2
MITRAL VALVE STENOSIS2
MENTAL IMPAIRMENT2
MASS2
LYMPHADENOPATHY MEDIASTINAL2
LUNG DISORDER2
LOCALISED OEDEMA2
LEFT VENTRICULAR HYPERTROPHY2
LACERATION2
LABORATORY TEST ABNORMAL2
JOINT SPRAIN2
INTERVERTEBRAL DISC PROTRUSION2
INFLAMMATION2
IMPULSE-CONTROL DISORDER2
HYPOXIA2
Hypotony of eye2
HYPOKALAEMIA2
HYPERHIDROSIS2
HAEMODIALYSIS2
GASTROINTESTINAL DISORDER2
GAMMA-GLUTAMYLTRANSFERASE INCREASED2
FIBROSIS2
FIBROMYALGIA2
FACE INJURY2
ENDOCARDIAL FIBROSIS2
EMOTIONAL DISTRESS2
DYSURIA2
DYSSTASIA2
DYSPNOEA PAROXYSMAL NOCTURNAL2
DYSPHONIA2
DRUG TOXICITY2
DIVERTICULUM2
DISEASE RECURRENCE2
DEREALISATION2
DENTAL TREATMENT2
DELUSION2
CORONARY ARTERY STENOSIS2
COR PULMONALE CHRONIC2
CONTUSION2
CONFUSIONAL STATE2
COLONIC POLYP2
CIRCULATORY COLLAPSE2
Choroidal effusion2
CHOLELITHIASIS2
CHOLECYSTECTOMY2
CHEST X-RAY ABNORMAL2
CARDIAC VALVE SCLEROSIS2
BUNDLE BRANCH BLOCK RIGHT2
BRADYKINESIA2
BONE DENSITY DECREASED2
BLOOD SODIUM DECREASED2
BLOOD PRESSURE DECREASED2
BLOOD CHOLESTEROL INCREASED2
ASPIRATION2
ARRHYTHMIA SUPRAVENTRICULAR2
AORTIC VALVE DISEASE MIXED2
AORTIC VALVE CALCIFICATION2
AORTIC DISORDER2
ANTINUCLEAR ANTIBODY POSITIVE2
ALOPECIA2
AKINESIA2
ABASIA2
VOCAL CORD PARALYSIS1
VITAMIN B12 DEFICIENCY1
VITAMIN B12 DECREASED1
VISUAL ACUITY REDUCED1
VENTRICULAR INTERNAL DIAMETER ABNORMAL1
VENTRICULAR HYPOKINESIA1
VENTRICULAR FIBRILLATION1
VENOUS INSUFFICIENCY1
VEIN DISORDER1
VASCULAR OPERATION1
VASCULAR BYPASS GRAFT1
URINARY RETENTION1
URINARY INCONTINENCE1
URETERIC OBSTRUCTION1
URETERIC DILATATION1
URETERAL DISORDER1
ULNA FRACTURE1
TUBERCULOSIS1
TROPONIN T INCREASED1
TRIGEMINAL NEURALGIA1
TRICUSPID VALVE STENOSIS1
TRI-IODOTHYRONINE INCREASED1
TREATMENT NONCOMPLIANCE1
TONGUE DRY1
THROMBOSIS1
THINKING ABNORMAL1
THERMAL BURN1
THERAPEUTIC RESPONSE DECREASED1
TELANGIECTASIA1
TACHYPNOEA1
TACHYARRHYTHMIA1
SUDDEN DEATH1
SUBILEUS1
SUBCLAVIAN ARTERY STENOSIS1
STREPTOCOCCAL INFECTION1
STATUS EPILEPTICUS1
STASIS DERMATITIS1
STARING1
SPUTUM RETENTION1
SOMATOFORM DISORDER1
SOFT TISSUE DISORDER1
SLEEP ATTACKS1
SKIN DISCOLOURATION1
SKELETAL INJURY1
SINUSITIS1
SINUS ARRHYTHMIA1
SHOCK1
SERUM FERRITIN INCREASED1
SENSATION OF HEAVINESS1
SELF-MEDICATION1
SCLERODERMA1
SCIATICA1
SCAN ABNORMAL1
SALIVARY HYPERSECRETION1
RIGHT VENTRICULAR SYSTOLIC PRESSURE INCREASED1
RIGHT VENTRICULAR SYSTOLIC PRESSURE DECREASED1
RESTRICTIVE CARDIOMYOPATHY1
RESTLESS LEGS SYNDROME1
RESPIRATORY FAILURE1
RESPIRATORY DISTRESS1
Respiratory disorder1
RESPIRATORY ARREST1
RENAL PAIN1
RENAL FAILURE ACUTE1
REFLEXES ABNORMAL1
RED BLOOD CELL COUNT DECREASED1
RADIUS FRACTURE1
PYELONEPHRITIS1
PURPURA1
PULMONARY VALVE STENOSIS1
PULMONARY VALVE DISEASE1
PULMONARY EMBOLISM1
PULMONARY ARTERIAL PRESSURE DECREASED1
PULMONARY ALVEOLAR HAEMORRHAGE1
PSYCHOTIC DISORDER DUE TO A GENERAL MEDICAL CONDITION1
PSYCHOMOTOR HYPERACTIVITY1
PROGRESSIVE SUPRANUCLEAR PALSY1
PROCEDURAL COMPLICATION1
POVERTY OF SPEECH1
POSTRENAL FAILURE1
PORIOMANIA1
POLLAKIURIA1
PO2 DECREASED1
PNEUMONIA PRIMARY ATYPICAL1
PNEUMONIA CYTOMEGALOVIRAL1
PNEUMOCYSTIS JIROVECI PNEUMONIA1
PLEUROTHOTONUS1
PLEURITIC PAIN1
PLEURAL DISORDER1
PLEURAL CALCIFICATION1
PHIMOSIS1
PERSONALITY CHANGE1
PERSECUTORY DELUSION1
PERIPHERAL ISCHAEMIA1
PERIPHERAL COLDNESS1
PERIODIC LIMB MOVEMENT DISORDER1
PERICARDITIS MALIGNANT1
PERICARDIAL HAEMORRHAGE1
PCO2 INCREASED1
PARESIS1
PANIC ATTACK1
PALLOR1
PAIN1
PAEDOPHILIA1
OXYGEN SATURATION DECREASED1
OSTEONECROSIS1
OSTEOARTHRITIS1
OLIGURIA1
OEDEMA GENITAL1
OBSESSIVE-COMPULSIVE DISORDER1
NUCLEAR MAGNETIC RESONANCE IMAGING BRAIN ABNORMAL1
NUCHAL RIGIDITY1
NOCTURNAL DYSPNOEA1
NOCTURIA1
NO THERAPEUTIC RESPONSE1
NEUTROPHIL COUNT INCREASED1
NEUROGENIC BOWEL1
NERVOUSNESS1
NERVOUS SYSTEM DISORDER1
NEPHRITIS INTERSTITIAL1
NECK PAIN1
NASAL DISCOMFORT1
NARCOLEPSY1
NAIL TINEA1
MYOTONIA1
MYOCARDIAL ISCHAEMIA1
MYOCARDIAL INFARCTION1
MYALGIA1
MUSCLE CRAMP1
MUSCLE ATROPHY1
MOVEMENT DISORDER1
MOOD SWINGS1
MITRAL VALVE REPLACEMENT1
MITRAL VALVE DISEASE MIXED1
MICTURITION URGENCY1
MESOTHELIOMA1
MEMORY IMPAIRMENT1
MEDICATION ERROR1
MECHANICAL COMPLICATION OF IMPLANT1
MALNUTRITION1
LYMPHOPENIA1
LYMPHOCYTE STIMULATION TEST POSITIVE1
LYMPHOCYTE PERCENTAGE INCREASED1
LYMPHOCYTE PERCENTAGE DECREASED1
LYMPHATIC DISORDER1
LUPUS-LIKE SYNDROME1
LUNG NEOPLASM MALIGNANT1
LUNG INFILTRATION1
LUNG CONSOLIDATION1
LUMBAR VERTEBRA INJURY1
LOW DENSITY LIPOPROTEIN INCREASED1
LOBAR PNEUMONIA1
LISTLESS1
LETHARGY1
LEG AMPUTATION1
LEFT VENTRICULAR FAILURE1
LEFT VENTRICULAR DYSFUNCTION1
LARYNGEAL DYSPNOEA1
LACUNAR INFARCTION1
KIDNEY ENLARGEMENT1
JUDGEMENT IMPAIRED1
JEALOUS DELUSION1
IVTH NERVE PARESIS1
INTERVERTEBRAL DISC DISORDER1
INTERVERTEBRAL DISC DEGENERATION1
INTERMITTENT CLAUDICATION1
INCORRECT DOSE ADMINISTERED1
INAPPROPRIATE ANTIDIURETIC HORMONE SECRETION1
IMPAIRED SELF-CARE1
ILEUS1
HYPOTONIA1
HYPONATRAEMIA1
HYPOAESTHESIA1
HYPERTHERMIA1
HYPERKINESIA1
HYPERKERATOSIS1
HYPERCHOLESTEROLAEMIA1
HYDROTHORAX1
HYDROCELE1
HOARSENESS1
HIP SWELLING1
HIP FRACTURE1
HEPATIC CONGESTION1
HEART RATE IRREGULAR1
HEART RATE DECREASED1
HEART RATE ABNORMAL1
HEADACHE1
HEAD INJURY1
HALLUCINATION, AUDITORY1
HAEMOTHORAX1
HAEMORRHOIDS1
HAEMOGLOBIN DECREASED1
HAEMODYNAMIC INSTABILITY1
HAEMATOCRIT DECREASED1
GENERALISED OEDEMA1
GASTROINTESTINAL HAEMORRHAGE1
GASTRITIS1
GASTRIC ULCER HAEMORRHAGE1
GASTRIC NEOPLASM1
GASTRIC CANCER1
FRACTURE1
FOREIGN BODY TRAUMA1
FLAT AFFECT1
FIBROMUSCULAR DYSPLASIA1
Fetishism1
FEMORAL NECK FRACTURE1
FEMORAL ARTERY OCCLUSION1
FEELING OF DESPAIR1
FAMILY STRESS1
FACIAL DYSMORPHISM1
FACET JOINT SYNDROME1
EYE PAIN1
EYE MOVEMENT DISORDER1
EYE DISORDER1
EXHIBITIONISM1
EXCITABILITY1
ERYTHROMELALGIA1
ERYTHEMA1
ERYSIPELAS1
EPISTAXIS1
EPICONDYLITIS1
EOSINOPHILIC PNEUMONIA ACUTE1
EOSINOPHIL PERCENTAGE INCREASED1
ENDOCARDITIS1
EMBOLIC CEREBRAL INFARCTION1
ELECTROCARDIOGRAM ABNORMAL1
ECONOMIC PROBLEM1
ECHOCARDIOGRAM ABNORMAL1
ECCHYMOSIS1
EATING DISORDER1
Dysphoria1
DYSLALIA1
DRUG TOLERANCE DECREASED1
DRUG INTOLERANCE1
DRUG HYPERSENSITIVITY1
DRUG EXPOSURE DURING PREGNANCY1
DRESSLER'S SYNDROME1
Dopamine dysregulation syndrome1
DISORIENTATION1
DISEASE PROGRESSION1
DIPLOPIA1
DIARRHOEA1
DIABETES MELLITUS1
DERMOID CYST1
DEPRESSED MOOD1
DECREASED ACTIVITY1
DEATH1
DEAFNESS UNILATERAL1
DEAFNESS1
CYCLOTHYMIC DISORDER1
CYANOSIS1
CORONARY ARTERY OCCLUSION1
COORDINATION ABNORMAL1
CONJUNCTIVAL HAEMORRHAGE1
COMPULSIVE SHOPPING1
COMA1
COLONIC HAEMORRHAGE1
COLON OPERATION1
COLON CANCER1
COLITIS1
COGWHEEL RIGIDITY1
COGNITIVE DISORDER1
CHRONIC OBSTRUCTIVE PULMONARY DISEASE1
CHOLESTASIS1
CHOLECYSTITIS1
CHOLANGITIS1
CHOKING1
CHEST WALL MASS1
CHEST DISCOMFORT1
CERVICAL CYST1
CEREBROVASCULAR ACCIDENT1
CEREBRAL INFARCTION1
CEREBELLAR INFARCTION1
CEREBELLAR ATROPHY1
CELLS IN URINE1
CATHETERISATION CARDIAC1
CARPAL TUNNEL DECOMPRESSION1
CAROTID BRUIT1
CAROTID ARTERY DISSECTION1
CAROTID ARTERY DISEASE1
CAROTID ARTERY ATHEROMA1
CARDIO-RESPIRATORY ARREST1
CARDIAC VALVE REPLACEMENT COMPLICATION1
CARDIAC STRESS TEST ABNORMAL1
CARDIAC NEOPLASM UNSPECIFIED1
CARDIAC FAILURE CHRONIC1
CARDIAC DISORDER1
CARDIAC ANEURYSM1
CARCINOID SYNDROME1
BUNDLE BRANCH BLOCK LEFT1
BULIMIA NERVOSA1
BRONCHITIS CHRONIC1
BRONCHIAL OBSTRUCTION1
BREATH SOUNDS DECREASED1
BREAST HYPERPLASIA1
BRADYCARDIA1
BODY TEMPERATURE INCREASED1
BLOOD PRESSURE SYSTOLIC DECREASED1
BLOOD PRESSURE DIASTOLIC INCREASED1
BLOOD PRESSURE ABNORMAL1
BLOOD PH INCREASED1
BLOOD PH DECREASED1
BLOOD OSMOLARITY DECREASED1
BLOOD IRON INCREASED1
BLOOD IMMUNOGLOBULIN M INCREASED1
BLOOD IMMUNOGLOBULIN G INCREASED1
BLOOD HOMOCYSTEINE INCREASED1
BLOOD ELECTROLYTES ABNORMAL1
BLOOD CULTURE POSITIVE1
BLOOD CREATINE PHOSPHOKINASE MB INCREASED1
BLOOD CHOLESTEROL DECREASED1
BLOOD CHLORIDE DECREASED1
BLOOD BILIRUBIN INCREASED1
BLOOD ALBUMIN INCREASED1
BLOOD ALBUMIN DECREASED1
BLINDNESS UNILATERAL1
BLEPHAROSPASM1
BILIARY TRACT INFECTION1
BENIGN PROSTATIC HYPERPLASIA1
BEDRIDDEN1
BASOPHIL PERCENTAGE DECREASED1
BASEDOW'S DISEASE1
BALANCE DISORDER1
AUTONOMIC NERVOUS SYSTEM IMBALANCE1
AUTONOMIC FAILURE SYNDROME1
ATRIOVENTRICULAR BLOCK FIRST DEGREE1
ATRIOVENTRICULAR BLOCK1
ATELECTASIS1
ATAXIA1
ASTHMA1
ASCITES1
ARTERIOGRAM ABNORMAL1
APNOEA1
APHAGIA1
APATHY1
AORTIC STENOSIS1
AORTIC CALCIFICATION1
AORTIC ARTERIOSCLEROSIS1
AORTIC ANEURYSM1
ANXIETY DISORDER1
ANTIPHOSPHOLIPID ANTIBODIES POSITIVE1
ANGIOPATHY1
ANGINA UNSTABLE1
AMYLOIDOSIS1
AMNESIA1
ALVEOLITIS ALLERGIC1
ALVEOLITIS1
ALTERED STATE OF CONSCIOUSNESS1
AGITATION1
AGGRESSION1
AFFECTIVE DISORDER1
ACCIDENTAL EXPOSURE1
ACCIDENTAL DRUG INTAKE BY CHILD1
ACCIDENTAL DEATH1
ACANTHOMA1
ABDOMINAL PAIN1
Abdominal adhesions1





Filtered ChEMBL targets:

Target UniProtKB ID Activity in nm Target Name Target gene
P08908 4 5-hydroxytryptamine receptor 1A 5HT1A_HUMAN
P14416 0.3548 D(2) dopamine receptor DRD2_HUMAN
P28223 8.913 5-hydroxytryptamine receptor 2A 5HT2A_HUMAN
P28335 218.78 5-hydroxytryptamine receptor 2C 5HT2C_HUMAN
P35462 0.8511 D(3) dopamine receptor DRD3_HUMAN
P37840 7900 Alpha-synuclein SYUA_HUMAN
Q12809 120.23 Potassium voltage-gated channel subfamily H member 2 KCNH2_HUMAN



Toxicity information:

Toxicity class: 3
Toxicity type: cardiovascular
LD50: 100 mg/kg



External links:

ChEBML: CHEMBL531
DrugBank: DB01186