Pemoline
General information:
| Withdrawn ID: | w95 |
|---|---|
| Canonical SMILES: | |
| Standard InChI: | |
| Standard InChIKey: | |
| ATC class(es): | N06BA05 |
| Molecular Formula: | C9H8N2O2 |
| Molweight: | 176.172 |
Withdrawal information:
| Withdrawn due to drug safety reasons: | Yes |
|---|---|
| First approved: | 1975 |
| First death: | 1989 |
| First withdrawn: | 1997 |
| Last withdrawn: | 1997 |
| Reference: | https://www.ncbi.nlm.nih.gov/pubmed/21574210 |
Side-effects:
| Total reported cases (submitted by medical professionals) with Pemoline as primary suspect: | 13 |
|---|
Reported final outcomes:
| Hospitalization (initial or prolonged): | 3 |
|---|---|
| Intervention required to prevent permanent impairment/damage: | 2 |
| Death: | 2 |
| Disability: | 1 |
| Life-Threatening condition: | 1 |
Reported side-effects:
| Side-effect | Case number |
|---|---|
| AGITATION | 2 |
| ASCITES | 2 |
| PHARMACEUTICAL PRODUCT COMPLAINT | 2 |
| FEELING JITTERY | 2 |
| DRUG INEFFECTIVE | 2 |
| CEREBROVASCULAR ACCIDENT | 1 |
| HEPATITIS TOXIC | 1 |
| HEPATIC NECROSIS | 1 |
| HEPATIC FIBROSIS | 1 |
| HEPATIC FAILURE | 1 |
| HEPATIC ENCEPHALOPATHY | 1 |
| GRANDIOSITY | 1 |
| FEELING OF DESPAIR | 1 |
| FEELING ABNORMAL | 1 |
| FATIGUE | 1 |
| DISTURBANCE IN SOCIAL BEHAVIOUR | 1 |
| DISTURBANCE IN ATTENTION | 1 |
| INFLAMMATION | 1 |
| CARBON MONOXIDE POISONING | 1 |
| BEREAVEMENT REACTION | 1 |
| APHAGIA | 1 |
| APATHY | 1 |
| ANXIETY | 1 |
| ALCOHOL USE | 1 |
| AGGRESSION | 1 |
| ABNORMAL BEHAVIOUR | 1 |
| ABDOMINAL DISTENSION | 1 |
| MYOCARDIAL INFARCTION | 1 |
| THERAPEUTIC RESPONSE UNEXPECTED WITH DRUG SUBSTITUTION | 1 |
| SUICIDAL IDEATION | 1 |
| SUDDEN CARDIAC DEATH | 1 |
| STRESS SYMPTOMS | 1 |
| SPLENOMEGALY | 1 |
| RELATIONSHIP BREAKDOWN | 1 |
| REBOUND EFFECT | 1 |
| PSYCHOMOTOR HYPERACTIVITY | 1 |
| PORTAL HYPERTENSION | 1 |
| PAIN | 1 |
| OVERDOSE | 1 |
| OEDEMA PERIPHERAL | 1 |
| HEPATOMEGALY | 1 |
| MOOD ALTERED | 1 |
| MENTAL DISORDER | 1 |
| MANIA | 1 |
| LOSS OF EMPLOYMENT | 1 |
| LIVER TRANSPLANT | 1 |
| LIVER INJURY | 1 |
| LIVER FUNCTION TEST ABNORMAL | 1 |
| LISTLESS | 1 |
| JAUNDICE | 1 |
| IRRITABILITY | 1 |
| INSOMNIA | 1 |
| WITHDRAWAL SYNDROME | 1 |
Filtered ChEMBL targets:
| Target UniProtKB ID | Activity in nm | Target Name | Target gene |
|---|---|---|---|
| P51151 | 1258.9 | Ras-related protein Rab-9A | RAB9A_HUMAN |
Toxicity information:
| Toxicity class: | 4 |
|---|---|
| Toxicity type: | hepatic |
| LD50: | 485 mg/kg |
External links:
| ChEBML: | CHEMBL1177 |
|---|---|
| DrugBank: | DB01230 |