Nifedipine


w55



General information:


Withdrawn ID: w55
Canonical SMILES:
Standard InChI:
Standard InChIKey:
ATC class(es): C08CA05
Molecular Formula: C17H18N2O6
Molweight: 346.335



Withdrawal information:


Withdrawn due to drug safety reasons:Yes
First approved: 1981
First withdrawn: 1996
Last withdrawn: 1996
Reference: https://www.ncbi.nlm.nih.gov/pubmed/26113232



Side-effects:

Total reported cases (submitted by medical professionals) with Nifedipine as primary suspect: 2104


Reported final outcomes:
Hospitalization (initial or prolonged): 657
Death: 405
Life-Threatening condition: 139
Disability: 40
Intervention required to prevent permanent impairment/damage: 17
Congenital anomaly: 11


Reported side-effects:

Side-effect Case number
DRUG HYPERSENSITIVITY230
COMPLETED SUICIDE222
HYPOTENSION157
TOXICITY TO VARIOUS AGENTS122
Exposure during pregnancy108
DRUG INEFFECTIVE103
PREMATURE BABY93
CARDIAC ARREST91
HEADACHE87
MATERNAL EXPOSURE DURING PREGNANCY82
Foetal exposure during pregnancy80
DIZZINESS80
DRUG INTERACTION76
OEDEMA PERIPHERAL72
BRADYCARDIA71
DYSPNOEA67
HYPERTENSION65
DEATH65
Low birth weight baby64
OFF LABEL USE63
BLOOD PRESSURE INCREASED59
DRUG EXPOSURE DURING PREGNANCY53
PREMATURE DELIVERY49
PALPITATIONS49
NAUSEA48
OVERDOSE47
TACHYCARDIA46
CAESAREAN SECTION46
PULMONARY OEDEMA44
RESPIRATORY ARREST42
SHOCK41
BLOOD PRESSURE INADEQUATELY CONTROLLED38
RASH37
Acute kidney injury37
VOMITING31
MEDICATION ERROR31
BLOOD PRESSURE DECREASED31
Product use issue30
PHARMACEUTICAL PRODUCT COMPLAINT30
FATIGUE30
SYNCOPE29
MALAISE28
DRUG INTOLERANCE28
CHEST PAIN27
HYPOXIA26
ASTHENIA26
RENAL FAILURE24
LOSS OF CONSCIOUSNESS24
HEART RATE INCREASED24
Foetal growth restriction23
ACUTE PULMONARY OEDEMA23
PREMATURE LABOUR22
INTENTIONAL OVERDOSE22
ERYTHEMA22
CARDIO-RESPIRATORY ARREST22
PRE-ECLAMPSIA21
CEREBROVASCULAR ACCIDENT21
ANXIETY21
ORTHOSTATIC HYPOTENSION20
METABOLIC ACIDOSIS20
HYPERGLYCAEMIA20
DRUG TOXICITY20
CONDITION AGGRAVATED20
FLUSHING19
DYSPHAGIA19
MEDICATION RESIDUE18
CHEST DISCOMFORT18
SWELLING17
SUICIDE ATTEMPT17
RENAL FAILURE ACUTE17
PRURITUS17
GINGIVAL HYPERPLASIA17
COUGH17
BRADYCARDIA FOETAL17
BLOOD CREATININE INCREASED17
ARTHRALGIA17
Product use in unapproved indication16
OEDEMA16
FALL16
DRUG EFFECT DECREASED16
CONFUSIONAL STATE16
URTICARIA15
Suspected suicide15
SOMNOLENCE15
PRODUCT SUBSTITUTION ISSUE15
ACUTE GENERALISED EXANTHEMATOUS PUSTULOSIS15
PYREXIA14
POISONING14
PLEURAL EFFUSION14
PAIN IN EXTREMITY14
PAIN14
MUSCULAR WEAKNESS14
HYPERHIDROSIS14
FEELING ABNORMAL14
DRUG INEFFECTIVE FOR UNAPPROVED INDICATION14
CEREBRAL INFARCTION14
SINUS TACHYCARDIA13
RESPIRATORY FAILURE13
RESPIRATORY DISTRESS13
PNEUMONIA13
MYOCARDIAL INFARCTION13
LACTIC ACIDOSIS13
HYPONATRAEMIA13
HYPERTENSIVE CRISIS13
GINGIVAL HYPERTROPHY13
DEPRESSED LEVEL OF CONSCIOUSNESS13
CYANOSIS13
CIRCULATORY COLLAPSE13
BEZOAR13
SEPSIS12
INTRA-UTERINE DEATH12
HYPERKALAEMIA12
Foetal exposure timing unspecified12
FOETAL DISTRESS SYNDROME12
Foetal death12
BLOOD PRESSURE FLUCTUATION12
Accidental exposure to product by child12
PARAESTHESIA11
PALLOR11
MULTI-ORGAN FAILURE11
GENERAL PHYSICAL HEALTH DETERIORATION11
CARDIOGENIC SHOCK11
BACK PAIN11
ATRIOVENTRICULAR BLOCK11
PERIODONTITIS10
INTESTINAL OBSTRUCTION10
HYPOKALAEMIA10
GASTROINTESTINAL HAEMORRHAGE10
ANGINA UNSTABLE10
ABDOMINAL PAIN10
VISION BLURRED9
TREMOR9
TACHYPNOEA9
Seizure9
RENAL IMPAIRMENT9
PULMONARY HYPERTENSION9
PROTEINURIA9
PRODUCT QUALITY ISSUE9
Peripheral swelling9
OXYGEN SATURATION DECREASED9
MUSCLE SPASMS9
JOINT SWELLING9
HYPERSENSITIVITY9
FLUID RETENTION9
CONSTIPATION9
CEREBRAL HAEMORRHAGE9
BLOOD UREA INCREASED9
BLOOD PRESSURE SYSTOLIC INCREASED9
BLISTER9
ANGINA PECTORIS9
ABDOMINAL PAIN UPPER9
ABDOMINAL DISTENSION9
WEIGHT DECREASED8
VENTRICULAR EXTRASYSTOLES8
URINE OUTPUT DECREASED8
THROMBOCYTOPENIA8
THERAPEUTIC RESPONSE UNEXPECTED WITH DRUG SUBSTITUTION8
THERAPEUTIC RESPONSE DECREASED8
RAYNAUD'S PHENOMENON8
Product dispensing error8
PLACENTAL DISORDER8
NEONATAL RESPIRATORY DISTRESS SYNDROME8
LIVER DISORDER8
Live birth8
INTERSTITIAL LUNG DISEASE8
INSOMNIA8
HYPOAESTHESIA8
HAEMORRHAGE8
GINGIVAL SWELLING8
DRUG LEVEL INCREASED8
DIARRHOEA8
CARDIAC FAILURE CONGESTIVE8
Apgar score low8
ANAEMIA8
WEIGHT INCREASED7
VISUAL IMPAIRMENT7
URINARY TRACT INFECTION7
SMALL INTESTINAL OBSTRUCTION7
SINUS BRADYCARDIA7
RHABDOMYOLYSIS7
RALES7
PULMONARY CONGESTION7
PLATELET COUNT DECREASED7
OLIGOHYDRAMNIOS7
NERVOUSNESS7
Medication residue present7
LETHARGY7
ISCHAEMIC STROKE7
INTENTIONAL MISUSE7
HYPOGLYCAEMIA7
GASTROINTESTINAL DISORDER7
EPISTAXIS7
ELECTROCARDIOGRAM QT PROLONGED7
ECLAMPSIA7
DYSPNOEA EXERTIONAL7
DRUG DISPENSING ERROR7
DIALYSIS7
Coma7
CARDIAC FAILURE7
BLINDNESS7
ANGIOEDEMA7
ABDOMINAL DISCOMFORT7
WRONG TECHNIQUE IN DRUG USAGE PROCESS6
URINARY INCONTINENCE6
SWELLING FACE6
SKIN ULCER6
RESPIRATORY RATE INCREASED6
RESPIRATORY DEPRESSION6
PREMATURE SEPARATION OF PLACENTA6
PERICARDIAL EFFUSION6
MATERNAL DRUGS AFFECTING FOETUS6
MALIGNANT HYPERTENSION6
LEUKOPENIA6
LEFT VENTRICULAR DYSFUNCTION6
JAUNDICE6
Intentional product misuse6
INCORRECT DOSE ADMINISTERED6
IMPAIRED WORK ABILITY6
ILEUS PARALYTIC6
HEART RATE IRREGULAR6
Gait disturbance6
FEELING HOT6
Exposure via breast milk6
ERYTHEMA MULTIFORME6
DYSGEUSIA6
Drug-induced liver injury6
DRUG ERUPTION6
DEPRESSION6
Cardiotoxicity6
BURNING SENSATION6
BUNDLE BRANCH BLOCK LEFT6
BLOOD PRESSURE ABNORMAL6
BLOOD CREATINE PHOSPHOKINASE INCREASED6
ATRIAL FIBRILLATION6
ASCITES6
ARTERIOSPASM CORONARY6
ARRHYTHMIA6
ACCIDENTAL OVERDOSE6
Accidental exposure to product6
VENTRICULAR FIBRILLATION5
Unresponsive to stimuli5
TRANSIENT ISCHAEMIC ATTACK5
TOXIC EPIDERMAL NECROLYSIS5
TOOTH LOSS5
TINNITUS5
TACHYCARDIA FOETAL5
STOMACH DISCOMFORT5
STILLBIRTH5
SPINAL CORD INFARCTION5
SKIN LESION5
SEPTIC SHOCK5
RESPIRATORY DISORDER5
RENAL FAILURE CHRONIC5
RENAL DISORDER5
RASH ERYTHEMATOUS5
PURPURA5
Product residue present5
Product prescribing error5
Posterior reversible encephalopathy syndrome5
PETECHIAE5
PANCREATITIS ACUTE5
PANCREATITIS5
NEUTROPENIA5
MYALGIA5
MULTIPLE DRUG OVERDOSE5
LUPUS-LIKE SYNDROME5
LIVER FUNCTION TEST ABNORMAL5
INTENTIONAL DRUG MISUSE5
HYPOCALCAEMIA5
HYPERKERATOSIS5
HOT FLUSH5
HEPATIC FUNCTION ABNORMAL5
GYNAECOMASTIA5
GINGIVAL DISORDER5
GINGIVAL BLEEDING5
GASTROOESOPHAGEAL REFLUX DISEASE5
Foetal heart rate deceleration abnormality5
FOETAL GROWTH RETARDATION5
FAECAL INCONTINENCE5
ELECTROCARDIOGRAM ST SEGMENT ELEVATION5
ELECTROCARDIOGRAM ST SEGMENT DEPRESSION5
DRUG LEVEL ABOVE THERAPEUTIC5
Drug effect incomplete5
Drug abuse5
DISEASE RECURRENCE5
CORONARY ARTERY DISEASE5
CONVULSION5
CARDIAC DISORDER5
C-REACTIVE PROTEIN INCREASED5
BLOOD PRESSURE SYSTOLIC DECREASED5
BLOOD POTASSIUM DECREASED5
BLOOD GLUCOSE INCREASED5
ATRIOVENTRICULAR BLOCK FIRST DEGREE5
ARTHRITIS5
APHASIA5
WRONG DRUG ADMINISTERED4
VISUAL DISTURBANCE4
VENTRICULAR TACHYCARDIA4
UNEVALUABLE EVENT4
UMBILICAL CORD VASCULAR DISORDER4
UMBILICAL CORD ABNORMALITY4
TOXIC SKIN ERUPTION4
Subacute cutaneous lupus erythematosus4
STEVENS-JOHNSON SYNDROME4
SPEECH DISORDER4
SINUSITIS4
Reversible cerebral vasoconstriction syndrome4
RESPIRATORY ALKALOSIS4
Renal ischaemia4
Product appearance confusion4
Primary hyperaldosteronism4
PRESYNCOPE4
Premature rupture of membranes4
PORPHYRIA ACUTE4
POLLAKIURIA4
PHOTOSENSITIVITY REACTION4
PERIPHERAL COLDNESS4
PERIPARTUM CARDIOMYOPATHY4
OLIGURIA4
NO THERAPEUTIC RESPONSE4
NO ADVERSE EVENT4
MYOCARDIAL ISCHAEMIA4
MENTAL STATUS CHANGES4
MELAENA4
LUNG DISORDER4
ISCHAEMIA4
INTESTINAL ISCHAEMIA4
INFECTION4
HYPOREFLEXIA4
HYPERLACTACIDAEMIA4
HEAD DISCOMFORT4
HAEMODIALYSIS4
FACE OEDEMA4
EJECTION FRACTION DECREASED4
DYSURIA4
DYSSTASIA4
DRUG RESISTANCE4
DISORIENTATION4
DELIRIUM4
DEHYDRATION4
CELLULITIS4
CARDIOMEGALY4
CARDIAC OUTPUT DECREASED4
BREECH PRESENTATION4
BRADYCARDIA NEONATAL4
BODY TEMPERATURE INCREASED4
ATRIOVENTRICULAR BLOCK COMPLETE4
ASTHMA4
APNOEA4
Amniotic fluid volume decreased4
Amniotic cavity infection4
AGITATION4
ADVERSE EVENT4
ACCIDENTAL DRUG INTAKE BY CHILD4
WHITE BLOOD CELL COUNT INCREASED3
VENTRICULAR HYPOKINESIA3
Uterine rupture3
URINARY RETENTION3
Tubulointerstitial nephritis3
TREATMENT NONCOMPLIANCE3
TREATMENT FAILURE3
SYSTEMIC LUPUS ERYTHEMATOSUS3
SUPRAVENTRICULAR EXTRASYSTOLES3
STOMATITIS3
SODIUM RETENTION3
SMALL INTESTINAL STENOSIS3
Small for dates baby3
SKIN IRRITATION3
SINUS ARRHYTHMIA3
SENSORY LOSS3
REFUSAL OF TREATMENT BY PATIENT3
REACTION TO DRUG EXCIPIENTS3
RASH GENERALISED3
PULSE ABSENT3
Product label confusion3
PRINZMETAL ANGINA3
Potentiating drug interaction3
POST PROCEDURAL COMPLICATION3
Polyhydramnios3
POISONING DELIBERATE3
PLEURISY3
PHOTOPHOBIA3
PEMPHIGOID3
PANIC ATTACK3
ORTHOPNOEA3
Neuromuscular block prolonged3
Necrotising enterocolitis neonatal3
MUSCULOSKELETAL STIFFNESS3
MUSCLE SPASTICITY3
MULTIPLE DRUG OVERDOSE INTENTIONAL3
MUCOSAL ULCERATION3
MOTOR DYSFUNCTION3
MIGRAINE3
LYMPHOCYTE STIMULATION TEST POSITIVE3
JOINT STIFFNESS3
Intestinal perforation3
INTERNATIONAL NORMALISED RATIO INCREASED3
INDUCED LABOUR3
INAPPROPRIATE ANTIDIURETIC HORMONE SECRETION3
IDIOPATHIC THROMBOCYTOPENIC PURPURA3
HYPOPERFUSION3
Hypoglycaemia neonatal3
HEPATITIS3
HEPATIC STEATOSIS3
HEPATIC CIRRHOSIS3
HEART RATE DECREASED3
HAEMORRHOIDS3
HAEMOGLOBIN DECREASED3
HAEMODYNAMIC INSTABILITY3
GINGIVITIS3
GASTRIC DISORDER3
Fracture3
FIBROSIS3
FEELING JITTERY3
FEELING COLD3
EYE PAIN3
Euglycaemic diabetic ketoacidosis3
ERUCTATION3
EOSINOPHILIC PNEUMONIA3
ENCEPHALOPATHY3
DYSPHONIA3
DYSPEPSIA3
DYSKINESIA3
DUODENITIS3
DISSEMINATED INTRAVASCULAR COAGULATION3
DISEASE PROGRESSION3
DIABETES MELLITUS INADEQUATE CONTROL3
DEAFNESS3
CYTOLYTIC HEPATITIS3
Cutaneous lupus erythematosus3
Contusion3
COLD SWEAT3
CIRCUMSTANCE OR INFORMATION CAPABLE OF LEADING TO MEDICATION ERROR3
CHEST X-RAY ABNORMAL3
Cerebellar stroke3
CARDIOVASCULAR DISORDER3
CARDIAC VALVE DISEASE3
CARDIAC FAILURE CHRONIC3
BUNDLE BRANCH BLOCK RIGHT3
BRAIN NATRIURETIC PEPTIDE INCREASED3
BLOOD PRESSURE DIASTOLIC DECREASED3
BLOOD MAGNESIUM INCREASED3
BALANCE DISORDER3
ATRIOVENTRICULAR BLOCK SECOND DEGREE3
Atrial septal defect3
ARTHROPATHY3
APLASIA PURE RED CELL3
ANTI-ERYTHROPOIETIN ANTIBODY POSITIVE3
ANION GAP INCREASED3
ANGIONEUROTIC OEDEMA3
ANAPHYLACTIC REACTION3
ALTERED STATE OF CONSCIOUSNESS3
ALANINE AMINOTRANSFERASE INCREASED3
AGRANULOCYTOSIS3
ACUTE RESPIRATORY DISTRESS SYNDROME3
ACUTE MYOCARDIAL INFARCTION3
ACIDOSIS3
Wrong technique in product usage process2
WITHDRAWAL HYPERTENSION2
WHITE BLOOD CELL COUNT DECREASED2
WEIGHT FLUCTUATION2
VISUAL FIELD DEFECT2
VISUAL ACUITY REDUCED2
Ventricular septal defect2
VENTRICULAR DYSFUNCTION2
VASOSPASM2
Vasodilatation2
VASCULAR RESISTANCE SYSTEMIC INCREASED2
VASCULAR RESISTANCE SYSTEMIC DECREASED2
VARICES OESOPHAGEAL2
Vaginal haemorrhage2
UTERINE LEIOMYOMA2
Twin pregnancy2
TROPONIN INCREASED2
Trigeminal neuralgia2
Transcription medication error2
TOOTH HYPOPLASIA2
TOOTH DISORDER2
TONGUE OEDEMA2
Thyroid function test abnormal2
Thrombotic thrombocytopenic purpura2
THROMBOCYTOPENIA NEONATAL2
THERAPY NON-RESPONDER2
TETANY2
SURGERY2
SUPRAVENTRICULAR TACHYCARDIA2
Subdural haematoma2
Stress2
STOOL ANALYSIS ABNORMAL2
Speech disorder developmental2
Sopor2
Skin reaction2
SKIN DISCOLOURATION2
SJOGREN'S SYNDROME2
SENSATION OF HEAVINESS2
RETAINED PLACENTA OR MEMBRANES2
RESPIRATORY DISORDER NEONATAL2
Renin decreased2
Renal tubular necrosis2
RENAL TRANSPLANT2
Renal artery stenosis2
Rebound effect2
RASH PRURITIC2
RASH MACULAR2
QUADRIPLEGIA2
Pulseless electrical activity2
PULMONARY EMBOLISM2
PSYCHOTIC DISORDER2
PSORIASIS2
Pseudolymphoma2
PROTEIN URINE PRESENT2
PRODUCTIVE COUGH2
PRODUCT TASTE ABNORMAL2
Product size issue2
Product physical issue2
Product name confusion2
Product colour issue2
Prescribed overdose2
PREGNANCY2
POST PROCEDURAL HAEMATOMA2
POOR SUCKING REFLEX2
POLYURIA2
POLYDACTYLY2
Pneumonia aspiration2
Pneumatosis2
Placental insufficiency2
PITTING OEDEMA2
PHARYNGEAL OEDEMA2
PHAEOCHROMOCYTOMA2
PERIPHERAL MOTOR NEUROPATHY2
Peripheral ischaemia2
Patent ductus arteriosus2
PARKINSONISM2
PARALYSIS FLACCID2
OSTEOARTHRITIS2
ORGANISING PNEUMONIA2
OPISTHOTONUS2
OESOPHAGEAL ULCER2
Oesophageal obstruction2
OESOPHAGEAL DISORDER2
OCULOGYRIC CRISIS2
OCULAR HYPERAEMIA2
NO ADVERSE EFFECT2
NO ADVERSE DRUG EFFECT2
NEPHROTIC SYNDROME2
NEONATAL DISORDER2
Necrotising colitis2
NASOPHARYNGITIS2
MYOCLONUS2
MUSCULOSKELETAL PAIN2
MUSCLE DISORDER2
MOVEMENT DISORDER2
Mouth haemorrhage2
MOBILITY DECREASED2
MITRAL VALVE INCOMPETENCE2
Mental disorder2
Memory impairment2
MATERNAL CONDITION AFFECTING FOETUS2
Macroglossia2
LUNG CONSOLIDATION2
Lower gastrointestinal haemorrhage2
LIP OEDEMA2
LEUKOPENIA NEONATAL2
LEUKOCYTOSIS2
LARYNGEAL OEDEMA2
LARGE INTESTINE PERFORATION2
Joint contracture2
JAUNDICE NEONATAL2
INTESTINAL STENOSIS2
Intercepted product selection error2
Intentional product use issue2
INFLAMMATION2
INFARCTION2
IMMOBILE2
Illness2
Ill-defined disorder2
Hypoxic-ischaemic encephalopathy2
Hypovolaemic shock2
HYPOVOLAEMIA2
Hypotonic-hyporesponsive episode2
HYPOTHYROIDISM2
HYPOPROTEINAEMIA2
Hypoplastic right heart syndrome2
HYPOPHAGIA2
HYPOKINESIA2
HYPERCALCAEMIA2
Hydronephrosis2
HISTONE ANTIBODY POSITIVE2
HIATUS HERNIA2
Hepatotoxicity2
HEPATOMEGALY2
HEPATOCELLULAR DAMAGE2
HEPATIC NECROSIS2
Hepatic failure2
Hepatic cytolysis2
Hemiparesis2
HEART RATE ABNORMAL2
Heart disease congenital2
Head injury2
HALLUCINATION, VISUAL2
Haemoptysis2
HAEMOLYSIS2
HAEMATURIA2
HAEMATOCHEZIA2
HAEMATEMESIS2
GLYCOSYLATED HAEMOGLOBIN INCREASED2
GENERALISED OEDEMA2
GENERALISED ERYTHEMA2
GASTROINTESTINAL SOUNDS ABNORMAL2
GASTROINTESTINAL HYPOMOTILITY2
GASTRITIS2
GASTRIC ULCER2
Gastric haemorrhage2
GAMMA-GLUTAMYLTRANSFERASE INCREASED2
FOREIGN BODY TRAUMA2
FOETAL MOVEMENTS DECREASED2
FOETAL HEART RATE DECREASED2
FOETAL DISORDER2
FLOPPY INFANT2
Femur fracture2
EXTRASYSTOLES2
Exposure via ingestion2
ERYTHROMELALGIA2
EOSINOPHILIA2
EOSINOPHIL COUNT INCREASED2
Endometritis2
ENDOMETRIAL CANCER2
EMOTIONAL DISTRESS2
ELECTROLYTE IMBALANCE2
ELECTROCARDIOGRAM T WAVE INVERSION2
ELECTROCARDIOGRAM QRS COMPLEX SHORTENED2
Ectopic pregnancy2
DYSTONIA2
DUODENAL ULCER2
Ductus arteriosus premature closure2
DRY MOUTH2
DRUG WITHDRAWAL SYNDROME2
DRUG PRESCRIBING ERROR2
DRUG EXPOSURE VIA BREAST MILK2
Drug delivery system issue2
Diverticulum intestinal haemorrhagic2
DISTURBANCE IN ATTENTION2
Diabetic ketoacidosis2
DIABETES MELLITUS NON-INSULIN-DEPENDENT2
DERMATITIS BULLOUS2
DEPRESSED MOOD2
DELUSION2
DEAFNESS TRANSITORY2
CREPITATIONS2
CREATININE RENAL CLEARANCE DECREASED2
COORDINATION ABNORMAL2
Contraindicated product administered2
Coma scale abnormal2
Colonic pseudo-obstruction2
CHROMATURIA2
Cholestasis2
CHOLELITHIASIS2
CHOKING2
CHILLS2
CHEST EXPANSION DECREASED2
Cerebral venous sinus thrombosis2
CEREBRAL PALSY2
Cerebellar ischaemia2
CENTRAL VENOUS PRESSURE INCREASED2
CD30 expression2
Cataract2
CARDIAC FIBRILLATION2
CACHEXIA2
BREATH SOUNDS ABNORMAL2
BRAIN OEDEMA2
BRADYARRHYTHMIA2
BONE MARROW FAILURE2
BLOOD SODIUM DECREASED2
BLOOD GLUCOSE DECREASED2
BLOOD CREATINE INCREASED2
BLOOD CALCIUM INCREASED2
BLOOD ALKALINE PHOSPHATASE INCREASED2
Blood aldosterone increased2
BLINDNESS TRANSIENT2
BLADDER CANCER2
BASAL CELL CARCINOMA2
Autonomic dysreflexia2
Atelectasis2
ATAXIA2
ASPARTATE AMINOTRANSFERASE INCREASED2
AREFLEXIA2
Anuria2
Anaphylactoid reaction2
ANAPHYLACTIC SHOCK2
AMYOTROPHIC LATERAL SCLEROSIS2
ALOPECIA2
AKINESIA2
ADVERSE REACTION2
ADHESION2
Acute respiratory failure2
Acute lung injury2
ACTIVITIES OF DAILY LIVING IMPAIRED2
Activated partial thromboplastin time prolonged2
Accidental poisoning2
ACCIDENTAL EXPOSURE2
ACANTHOLYSIS2
ABORTION INDUCED2
ABNORMAL BEHAVIOUR2
ABASIA2
Wrong product stored1
Wound infection1
WOUND HAEMORRHAGE1
WOUND COMPLICATION1
WEIGHT BEARING DIFFICULTY1
WALKING AID USER1
VITREOUS FLOATERS1
VIRAL INFECTION1
VIITH NERVE PARALYSIS1
VERTIGO1
VERTEBROBASILAR INSUFFICIENCY1
VENTRICULAR HYPERTROPHY1
VENTRICULAR DYSKINESIA1
VENTRICULAR ARRHYTHMIA1
VENOUS PRESSURE JUGULAR INCREASED1
Vein disorder1
Vascular rupture1
Vaginal disorder1
VACUUM EXTRACTOR DELIVERY1
Uterine infection1
Uterine contractions during pregnancy1
USE OF ACCESSORY RESPIRATORY MUSCLES1
URINE OUTPUT INCREASED1
URINE KETONE BODY PRESENT1
URINE FLOW DECREASED1
URINE COLOUR ABNORMAL1
Urinary tract disorder1
URINARY HESITATION1
Umbilical cord haemorrhage1
Trisomy 211
TRACHEITIS1
TORSADE DE POINTES1
TOOTH EXTRACTION1
TONGUE BITING1
TOCOLYSIS1
THYROID DISORDER1
THYROID CANCER1
Thrombotic microangiopathy1
Thoracic outlet syndrome1
THIRST1
THINKING ABNORMAL1
Therapeutic response unexpected1
THERAPEUTIC PRODUCT INEFFECTIVE1
Therapeutic product effect incomplete1
THERAPEUTIC AGENT TOXICITY1
Tension headache1
TENDERNESS1
Temperature intolerance1
Telangiectasia1
Tachyarrhythmia1
SYSTOLIC HYPERTENSION1
Symptom masked1
Suprapubic pain1
SUNCT syndrome1
Suicidal ideation1
SUFFOCATION FEELING1
Sudden infant death syndrome1
Subdural haemorrhage1
STROKE VOLUME DECREASED1
Stress cardiomyopathy1
STARING1
SQUAMOUS CELL CARCINOMA OF SKIN1
Spine malformation1
Spinal pain1
SMALL INTESTINE GANGRENE1
Sleep disorder1
SKIN WARM1
SKIN LACERATION1
SKIN INJURY1
SKIN EXFOLIATION1
SKIN EROSION1
Skin disorder1
Skin burning sensation1
Sinus node dysfunction1
Sinus disorder1
SINUS CONGESTION1
SIMILAR REACTION ON PREVIOUS EXPOSURE TO DRUG1
SICK SINUS SYNDROME1
Shortened cervix1
Serotonin syndrome1
Sepsis neonatal1
SENSORY INTEGRATIVE DYSFUNCTION1
Sensory disturbance1
SENSITIVITY OF TEETH1
SEASONAL ALLERGY1
SCOTOMA1
SCLERODERMA1
SCIATICA1
SCHIZOPHRENIA1
Scar1
SCAN BONE MARROW ABNORMAL1
Scab1
ROAD TRAFFIC ACCIDENT1
RHYTHM IDIOVENTRICULAR1
RHINORRHOEA1
RHEUMATOID ARTHRITIS1
Retinopathy of prematurity1
RETINAL HAEMORRHAGE1
Retinal detachment1
RETICULOCYTE COUNT INCREASED1
RESTLESSNESS1
RESPIRATORY TRACT INFECTION1
Respiratory tract congestion1
RESPIRATORY RATE DECREASED1
Respiratory acidosis1
Respiration abnormal1
RENAL INJURY1
Renal hypoplasia1
RENAL FUNCTION TEST ABNORMAL1
RENAL FAILURE NEONATAL1
Renal cyst1
Renal cancer1
Renal atrophy1
REFLUX OESOPHAGITIS1
Red ear syndrome1
RED BLOOD CELLS URINE POSITIVE1
RED BLOOD CELL COUNT DECREASED1
RECTAL HAEMORRHAGE1
RASH PUSTULAR1
Rash papular1
Rash morbilliform1
RASH MACULO-PAPULAR1
Pyelocaliectasis1
Pulmonary hypoplasia1
PULMONARY HAEMORRHAGE1
PULMONARY ARTERIAL PRESSURE INCREASED1
PROSTATE EXAMINATION ABNORMAL1
Prostate cancer1
Product use complaint1
Product substitution error1
Product solubility abnormal1
Product selection error1
PRODUCT ODOUR ABNORMAL1
Product identification number issue1
Product difficult to swallow1
Product communication issue1
Product administered to patient of inappropriate age1
PROCTALGIA1
Procedural hypotension1
Procedural haemorrhage1
PROCEDURAL COMPLICATION1
Postural tremor1
POST PROCEDURAL PAIN1
POST PROCEDURAL HAEMORRHAGE1
POOR QUALITY SLEEP1
Poor quality drug administered1
POOR PERIPHERAL CIRCULATION1
POLYCYTHAEMIA1
PNEUMOTHORAX1
PNEUMONITIS1
PNEUMONIA CYTOMEGALOVIRAL1
Pneumonia bacterial1
PNEUMOCYSTIS JIROVECI INFECTION1
Pneumatosis intestinalis1
PLEURITIC PAIN1
Placental necrosis1
Placenta praevia haemorrhage1
Placenta accreta1
PIGMENTATION DISORDER1
PHARYNGOLARYNGEAL PAIN1
PHARYNGEAL OPERATION1
pH body fluid normal1
PEYRONIE'S DISEASE1
PERSONALITY DISORDER OF CHILDHOOD1
Peritonitis1
PERIPHERAL VASCULAR DISORDER1
PERICARDITIS1
PERICARDIAL RUB1
Parkinson's disease1
Paraproteinaemia1
PARANOIA1
Paraesthesia oral1
PAPULOERYTHRODERMA OF OFUJI1
PAPILLOMA VIRAL INFECTION1
PANCREATIC CARCINOMA1
PALMAR-PLANTAR ERYTHRODYSAESTHESIA SYNDROME1
PAIN IN JAW1
OTITIS MEDIA1
Osteopenia1
OSTEONECROSIS1
ORTHOSTATIC INTOLERANCE1
OROPHARYNGEAL SWELLING1
Oropharyngeal pain1
OROPHARYNGEAL DISCOMFORT1
ORAL SOFT TISSUE DISORDER1
Oral pustule1
ORAL LICHEN PLANUS1
ORAL FIBROMA1
Oral disorder1
ORAL CANDIDIASIS1
OPTIC ISCHAEMIC NEUROPATHY1
OESTRADIOL DECREASED1
OESOPHAGITIS1
Oesophageal stenosis1
Oesophageal irritation1
Oesophageal haemorrhage1
OESOPHAGEAL FISTULA1
Oesophageal carcinoma1
Oesophageal candidiasis1
Ocular icterus1
Obstructive uropathy1
OBSTRUCTION1
OBSTETRIC PROCEDURE COMPLICATION1
NUCLEAR MAGNETIC RESONANCE IMAGING ABNORMAL1
Normal newborn1
Nonreassuring foetal heart rate pattern1
NODAL ARRHYTHMIA1
NIGHTMARE1
Night sweats1
NEUTROPHILIA1
Neurotoxicity1
Neuromuscular blockade1
NEUROLOGICAL SYMPTOM1
NEUROLOGICAL DECOMPENSATION1
Neurogenic bladder1
Neurodevelopmental disorder1
Neuralgia1
NERVE INJURY1
Nephropathy toxic1
NEPHROLITHIASIS1
Nephrocalcinosis1
NEPHRITIS1
Nephrectomy1
Neoplasm malignant1
Neonatal tachycardia1
Neonatal respiratory distress1
NEONATAL RESPIRATORY DEPRESSION1
NEONATAL HYPOXIA1
Neonatal hypotension1
Neonatal asphyxia1
Necrosis1
Neck pain1
Neck injury1
NASAL DRYNESS1
NASAL CONGESTION1
MYOSITIS1
MYOPATHY1
MYOCARDITIS1
Myocardial depression1
Myasthenia gravis crisis1
Myasthenia gravis1
Musculoskeletal disorder1
Muscle tightness1
Muscle strain1
Muscle rigidity1
MUSCLE NECROSIS1
MUSCLE FATIGUE1
Muscle contracture1
MUSCLE ATROPHY1
Multiple organ dysfunction syndrome1
MULTIPLE DRUG OVERDOSE ACCIDENTAL1
MULTI-ORGAN DISORDER1
MUCOSAL EROSION1
MUCOSAL DISCOLOURATION1
MOOD SWINGS1
MONOCYTE COUNT INCREASED1
Mirror syndrome1
MINERAL METABOLISM DISORDER1
MINERAL DEFICIENCY1
MICTURITION URGENCY1
Microcytic anaemia1
METABOLIC ALKALOSIS1
Mental impairment1
MENISCUS LESION1
MENIERE'S DISEASE1
Mediastinal haematoma1
Meconium abnormal1
MECHANICAL ILEUS1
MEAN CELL VOLUME INCREASED1
MEAN CELL HAEMOGLOBIN INCREASED1
MASTICATION DISORDER1
MANTLE CELL LYMPHOMA1
MALLORY-WEISS SYNDROME1
Malignant neoplasm progression1
MALIGNANT MELANOMA OF SITES OTHER THAN SKIN1
MALIGNANT MELANOMA1
MALARIA1
MACULOPATHY1
Macrosomia1
Macrocephaly1
Macroamylasaemia1
Lymphoproliferative disorder1
LYMPHOPENIA1
LUNG NEOPLASM1
LUNG INFILTRATION1
LUNG CREPITATION1
Loss of personal independence in daily activities1
LIVER TRANSPLANT1
Livedo reticularis1
Liquid product physical issue1
LIP EROSION1
LIP AND/OR ORAL CAVITY CANCER1
LIMB DISCOMFORT1
Ligament sprain1
LICHENOID KERATOSIS1
LEUKOENCEPHALOMYELITIS1
LEUKOCYTOCLASTIC VASCULITIS1
LEGIONELLA SEROLOGY POSITIVE1
LEFT VENTRICULAR HYPERTROPHY1
LEFT VENTRICULAR FAILURE1
LEFT VENTRICULAR END-DIASTOLIC PRESSURE INCREASED1
LARYNGEAL OPERATION1
Laryngeal discomfort1
Large intestinal obstruction1
LACUNAR INFARCTION1
LABOUR INDUCTION1
LABORATORY TEST ABNORMAL1
Labelled drug-drug interaction medication error1
KIDNEY TRANSPLANT REJECTION1
JUVENILE ARTHRITIS1
JOINT LOCK1
Joint injury1
Jaw disorder1
Ischaemic cerebral infarction1
IRRITABILITY1
Iron deficiency anaemia1
Investigation1
Intraventricular haemorrhage neonatal1
Intraocular pressure increased1
Intracranial venous sinus thrombosis1
INTRA-ABDOMINAL HAEMORRHAGE1
Intra-abdominal haematoma1
INTESTINAL ULCER1
INTESTINAL POLYP1
Intestinal angioedema1
INTERVERTEBRAL DISC SPACE NARROWING1
INTERVERTEBRAL DISC PROTRUSION1
INTERVERTEBRAL DISC DISORDER1
International normalised ratio decreased1
Intercepted medication error1
Intentional self-injury1
Intensive care1
Influenza like illness1
Infantile apnoeic attack1
INCREASED UPPER AIRWAY SECRETION1
Inappropriate schedule of product administration1
Inappropriate schedule of drug administration1
IMPAIRED GASTRIC EMPTYING1
IMPAIRED DRIVING ABILITY1
Immunoglobulin G4 related sclerosing disease1
Ileus1
HYSTERECTOMY1
HYPOTHERMIA NEONATAL1
HYPOTHERMIA1
Hypomagnesaemia1
Hypochromic anaemia1
HYPOCAPNIA1
Hypoacusis1
Hyperuricaemia1
HYPERTROPHY OF TONGUE PAPILLAE1
HYPERTROPHY1
HYPERTROPHIC CARDIOMYOPATHY1
Hyperthyroidism1
HYPERTHERMIA1
Hypertensive nephropathy1
HYPERREFLEXIA1
Hyperbilirubinaemia1
Hyperamylasaemia1
HYPERAESTHESIA1
HYPERAEMIA1
HYPERACUSIS1
Hydrothorax1
Hydrocephalus1
HOSPITALISATION1
HODGKIN'S DISEASE1
Histiocytic necrotising lymphadenitis1
Herpes zoster1
HERPES VIRUS INFECTION1
Herbal interaction1
HEPATITIS B VIRUS1
HEPATITIS ACUTE1
Hepatic rupture1
Hepatic haematoma1
HELLP syndrome1
HAPTOGLOBIN DECREASED1
HALLUCINATIONS, MIXED1
HALLUCINATION, AUDITORY1
HALLUCINATION1
Haemorrhoidal haemorrhage1
HAEMORRHAGIC DISORDER1
Haemorrhage in pregnancy1
Haemorrhage foetal1
HAEMOGLOBIN INCREASED1
Haemodialysis complication1
HAEMATOMA1
HAEMATOCRIT DECREASED1
GROWTH RETARDATION1
Grip strength decreased1
GRAVITATIONAL OEDEMA1
GRAND MAL CONVULSION1
Gout1
GLUCOSE TOLERANCE IMPAIRED1
GLOSSOPTOSIS1
Glossitis1
GLOMERULONEPHRITIS MEMBRANOPROLIFERATIVE1
Glomerular filtration rate decreased1
GINGIVAL RECESSION1
GINGIVAL PAIN1
GINGIVAL OEDEMA1
GINGIVAL HYPOPLASIA1
Genital burning sensation1
Generalised tonic-clonic seizure1
Gene mutation1
GASTROINTESTINAL ULCER1
Gastrointestinal perforation1
GASTROINTESTINAL MUCOSAL DISORDER1
GASTROINTESTINAL MOTILITY DISORDER1
GASTROENTERITIS1
GASTRITIS HAEMORRHAGIC1
GASTRIC LAVAGE1
Gastric cancer1
GASTRIC BYPASS1
Gangrene1
Fungal sepsis1
Frustration tolerance decreased1
Foreign body1
FORCEPS DELIVERY1
FOOD INTERACTION1
Foetal monitoring abnormal1
Foetal malpresentation1
Foetal hypokinesia1
FOETAL HEART RATE DECELERATION1
Foetal exposure during delivery1
FOETAL CARDIAC DISORDER1
Foetal arrhythmia1
Foetal acidosis1
Fluid overload1
FLATULENCE1
FIBROMYALGIA1
FIBROCYSTIC BREAST DISEASE1
FIBROADENOMA OF BREAST1
FIBRIN D DIMER INCREASED1
FEMORAL NECK FRACTURE1
FEELING OF BODY TEMPERATURE CHANGE1
FEELING GUILTY1
Feeding disorder1
FEAR1
FAECES DISCOLOURED1
FAECAL VOMITING1
Facial paresis1
FACIAL PAIN1
Eyelid oedema1
Eye swelling1
Eye pruritus1
Eye haemorrhage1
EYE DISORDER1
Exposure via inhalation1
Exposure during breast feeding1
Expired product administered1
EXOSTOSIS1
EXERCISE TOLERANCE DECREASED1
EXCORIATION1
EXCESSIVE GRANULATION TISSUE1
EUPHORIC MOOD1
Eschar1
ERECTILE DYSFUNCTION1
EPILEPSY1
ENTEROCOLITIS HAEMORRHAGIC1
ENDOTRACHEAL INTUBATION COMPLICATION1
ENDOTRACHEAL INTUBATION1
ENDODONTIC PROCEDURE1
ELECTROCARDIOGRAM T WAVE ABNORMAL1
ELECTROCARDIOGRAM ST-T SEGMENT ABNORMAL1
ELECTROCARDIOGRAM QRS COMPLEX PROLONGED1
ELECTROCARDIOGRAM QRS COMPLEX ABNORMAL1
ELECTROCARDIOGRAM Q WAVE ABNORMAL1
ELECTROCARDIOGRAM POOR R-WAVE PROGRESSION1
ELECTROCARDIOGRAM P WAVE ABNORMAL1
ELECTROCARDIOGRAM1
ECZEMA1
ECONOMIC PROBLEM1
Early repolarisation syndrome1
Ear pain1
Ear discomfort1
DYSPNOEA EXACERBATED1
DYSARTHRIA1
Duodenal atresia1
DRUG TOLERANCE DECREASED1
DRUG TOLERANCE1
Drug titration error1
DRUG RASH WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS1
DRUG NAME CONFUSION1
DRUG LEVEL BELOW THERAPEUTIC1
DRUG INTERACTION POTENTIATION1
Drug administered to patient of inappropriate age1
DRUG ABUSER1
Diverticulum intestinal1
DIVERTICULUM1
Disturbance of thermoregulation of newborn1
DISSOCIATION1
Discomfort1
Diplopia1
DIPLEGIA1
DILATATION VENTRICULAR1
DIGITAL ULCER1
DIFFICULTY IN WALKING1
DIASTOLIC DYSFUNCTION1
DIABETIC RETINOPATHY1
Diabetic foot1
DEVELOPMENTAL DELAY1
Dermo-hypodermitis1
Dermatitis exfoliative1
Dermatitis1
DENTAL PLAQUE1
Dementia1
DELUSION OF REFERENCE1
DEEP VEIN THROMBOSIS1
DECUBITUS ULCER1
Decreased appetite1
DEATH OF SPOUSE1
DEATH OF CHILD1
Dandy-Walker syndrome1
CYTOMEGALOVIRUS INFECTION1
Cytokine release syndrome1
Cyanosis neonatal1
CUTANEOUS VASCULITIS1
CORONARY ARTERY STENOSIS1
Coronary artery occlusion1
CORONARY ARTERY ATHEROSCLEROSIS1
Corneal opacity1
CONTRAINDICATION TO MEDICAL TREATMENT1
CONTINUOUS HAEMODIAFILTRATION1
CONNECTIVE TISSUE DISORDER1
Congenital spinal cord anomaly1
Congenital pyelocaliectasis1
CONGENITAL HYPOTHYROIDISM1
Congenital central nervous system anomaly1
CONDUCTION DISORDER1
COMPUTERISED TOMOGRAM ABNORMAL1
COMPLICATIONS OF MATERNAL EXPOSURE TO THERAPEUTIC DRUGS1
COMPLICATION OF PREGNANCY1
Complex regional pain syndrome1
COLON OPERATION1
COLON GANGRENE1
COGNITIVE DISORDER1
Coarctation of the aorta1
Coagulopathy1
Cluster headache1
CLONUS1
CHRONIC OBSTRUCTIVE PULMONARY DISEASE1
CHRONIC MYELOID LEUKAEMIA1
Chronic kidney disease1
CHROMOSOME ANALYSIS ABNORMAL1
CHORIOAMNIONITIS1
Cholinergic syndrome1
CHOLECYSTECTOMY1
CEREBROVASCULAR DISORDER1
Cerebral vasoconstriction1
CEREBRAL ISCHAEMIA1
Cerebral hypoperfusion1
CEREBRAL ATROPHY1
CENTRAL NERVOUS SYSTEM LESION1
Carotid bruit1
Carotid artery occlusion1
CARDIOMYOPATHY1
CARDIOACTIVE DRUG LEVEL ABOVE THERAPEUTIC1
CARDIAC OPERATION1
Cardiac murmur1
Cardiac index decreased1
CARDIAC ENZYMES INCREASED1
Cardiac discomfort1
Cardiac death1
Calcium ionised decreased1
Burns third degree1
Burns second degree1
BRUXISM1
Bronchopulmonary dysplasia1
BRONCHITIS1
Breech delivery1
BREATH SOUNDS DECREASED1
BREAST NECROSIS1
Breast engorgement1
BREAST DISCOMFORT1
BREAST ADENOMA1
BRASH syndrome1
Brain compression1
Bowel movement irregularity1
BONE PAIN1
Bone marrow oedema1
Bone disorder1
BODY TEMPERATURE DECREASED1
Body modification1
BLOOD UREA DECREASED1
BLOOD TRIGLYCERIDES INCREASED1
BLOOD TEST ABNORMAL1
BLOOD PRESSURE SYSTOLIC ABNORMAL1
Blood pressure systolic1
BLOOD PRESSURE MANAGEMENT1
Blood pressure immeasurable1
Blood magnesium decreased1
BLOOD LUTEINISING HORMONE DECREASED1
BLOOD LACTIC ACID INCREASED1
BLOOD FOLLICLE STIMULATING HORMONE DECREASED1
Blood ethanol increased1
BLOOD CREATINE PHOSPHOKINASE MB INCREASED1
BLOOD COUNT ABNORMAL1
BLOOD CHOLESTEROL INCREASED1
BLOOD CHLORIDE INCREASED1
BLADDER CATHETERISATION1
BIPOLAR DISORDER1
BEDRIDDEN1
Baseline foetal heart rate variability disorder1
Bartter's syndrome1
BARRETT'S OESOPHAGUS1
BAND NEUTROPHIL COUNT INCREASED1
Back disorder1
AXONAL NEUROPATHY1
Autoimmune disorder1
Attention deficit hyperactivity disorder1
Atrioventricular septal defect1
ATRIOVENTRICULAR DISSOCIATION1
Atrial flutter1
Atrial enlargement1
ASTERIXIS1
Aspiration1
Arthropod bite1
ARTERIOSCLEROSIS OBLITERANS1
ARTERIAL STENOSIS1
APRAXIA1
APLASTIC ANAEMIA1
Aplasia cutis congenita1
Aortic aneurysm1
Antiphospholipid syndrome1
Anger1
Aneurysm1
ANASTOMOTIC STENOSIS1
Anaphylactoid syndrome of pregnancy1
Anaesthetic complication1
Anaemia neonatal1
AMYOTROPHY1
AMNESIA1
ALLERGY TO ARTHROPOD STING1
Allergic oedema1
ALEXIA1
ALDOLASE INCREASED1
ALCOHOL USE1
AIRWAY BURNS1
AGGRESSION1
AGE INDETERMINATE MYOCARDIAL INFARCTION1
AFFECT LABILITY1
Adenocarcinoma of colon1
ACANTHOSIS1
Abortion spontaneous1
Abortion induced complicated1
ABNORMAL SENSATION IN EYE1
Abnormal faeces1
ABDOMINAL HERNIA1
ABDOMINAL ADHESIONS1





Filtered ChEMBL targets:

Target UniProtKB ID Activity in nm Target Name Target gene
P00352 7943.3 Retinal dehydrogenase 1 AL1A1_HUMAN
P02545 1122 Prelamin-A/C LMNA_HUMAN
P0DMS8 8290 Adenosine receptor A3 AA3R_HUMAN
P10636 3548.1 Microtubule-associated protein tau TAU_HUMAN
P16473 158.5 Thyrotropin receptor TSHR_HUMAN
P22460 6100 Potassium voltage-gated channel subfamily A member 5 KCNA5_HUMAN
P40225 1584.9 Thrombopoietin TPO_HUMAN
P54132 3981.1 Bloom syndrome protein BLM_HUMAN
Q01668 1350 Voltage-dependent L-type calcium channel subunit alpha-1D CAC1D_HUMAN
Q13936 22 Voltage-dependent L-type calcium channel subunit alpha-1C CAC1C_HUMAN
Q15746 2020 Myosin light chain kinase, smooth muscle MYLK_HUMAN
Q16637 5623.4 Survival motor neuron protein SMN_HUMAN
Q16665 501.2 Hypoxia-inducible factor 1-alpha HIF1A_HUMAN
Q99714 7943.3 3-hydroxyacyl-CoA dehydrogenase type-2 HCD2_HUMAN



Toxicity information:

Toxicity class: 3
Toxicity type: cardiovascular
LD50: 202 mg/kg



External links:

ChEBML: CHEMBL193
DrugBank: DB01115