Niclosamide


532



General information:


Withdrawn ID: 532
Canonical SMILES:
Standard InChI:
Standard InChIKey:
ATC class(es): P02DA01
Molecular Formula: C13H8Cl2N2O4
Molweight: 327.12



Withdrawal information:


Withdrawn due to drug safety reasons:No
First approved: 1982



Filtered ChEMBL targets:

Target UniProtKB ID Activity in nm Target Name Target gene
O15118 39.8 NPC intracellular cholesterol transporter 1 NPC1_HUMAN
O75496 316.2 Geminin GEMI_HUMAN
P00352 3548.1 Retinal dehydrogenase 1 AL1A1_HUMAN
P02545 25.1 Prelamin-A/C LMNA_HUMAN
P04637 501.2 Cellular tumor antigen p53 P53_HUMAN
P10636 3162.3 Microtubule-associated protein tau TAU_HUMAN
P14618 3162.3 Pyruvate kinase PKM KPYM_HUMAN
P16473 501.2 Thyrotropin receptor TSHR_HUMAN
P28482 501.2 Mitogen-activated protein kinase 1 MK01_HUMAN
P40225 100 Thrombopoietin TPO_HUMAN
P40763 210 Signal transducer and activator of transcription 3 STAT3_HUMAN
P42345 1166.8 Serine/threonine-protein kinase mTOR MTOR_HUMAN
P42858 794.3 Huntingtin HD_HUMAN
P51151 79.4 Ras-related protein Rab-9A RAB9A_HUMAN
Q01453 379.3 Peripheral myelin protein 22 PMP22_HUMAN
Q16637 125.9 Survival motor neuron protein SMN_HUMAN
Q16665 1995.3 Hypoxia-inducible factor 1-alpha HIF1A_HUMAN
Q9NUW8 39.8 Tyrosyl-DNA phosphodiesterase 1 TYDP1_HUMAN



Toxicity information:

Toxicity class: 4
Toxicity type: N/A
LD50: 725 mg/kg



External links:

ChEBML: CHEMBL1448
DrugBank: DB06803