nateglinide


EMA28



General information:


Withdrawn ID: EMA28
Canonical SMILES:
Standard InChI:
Standard InChIKey:
ATC class(es): A10BX03
Molecular Formula: C19H27NO3
Molweight: 317.429



Withdrawal information:


Withdrawn due to drug safety reasons:No



Side-effects:

Total reported cases (submitted by medical professionals) with nateglinide as primary suspect: 199


Reported final outcomes:
Hospitalization (initial or prolonged): 106
Death: 34
Life-Threatening condition: 14
Disability: 5
Intervention required to prevent permanent impairment/damage: 2


Reported side-effects:

Side-effect Case number
HYPOGLYCAEMIA21
ASPARTATE AMINOTRANSFERASE INCREASED21
ALANINE AMINOTRANSFERASE INCREASED21
GAMMA-GLUTAMYLTRANSFERASE INCREASED17
BLOOD ALKALINE PHOSPHATASE INCREASED14
VOMITING13
DEATH12
LIVER DISORDER11
DYSPNOEA11
DISEASE PROGRESSION11
BLOOD GLUCOSE INCREASED10
HEPATIC FUNCTION ABNORMAL9
DRUG INEFFECTIVE9
DIZZINESS9
DIARRHOEA9
ABDOMINAL PAIN UPPER9
RASH8
NAUSEA8
CHEST PAIN8
BLOOD UREA INCREASED8
BLOOD LACTATE DEHYDROGENASE INCREASED8
BLOOD CREATININE INCREASED8
SEPSIS7
PNEUMONIA7
MALAISE7
HYPERSENSITIVITY7
DIABETES MELLITUS INADEQUATE CONTROL7
BLOOD BILIRUBIN INCREASED7
ABDOMINAL PAIN7
PYREXIA6
JAUNDICE6
DEPRESSED LEVEL OF CONSCIOUSNESS6
DECREASED APPETITE6
CONVULSION6
CARDIAC FAILURE CONGESTIVE6
C-REACTIVE PROTEIN INCREASED6
WHITE BLOOD CELL COUNT INCREASED5
RENAL FAILURE5
PANCREATITIS5
MYOCARDIAL ISCHAEMIA5
MYOCARDIAL INFARCTION5
HYPOTENSION5
HYPOGLYCAEMIC COMA5
HYPERTENSION5
HYPERGLYCAEMIA5
HAEMOGLOBIN DECREASED5
GLYCOSYLATED HAEMOGLOBIN INCREASED5
ANGINA PECTORIS5
WHITE BLOOD CELL COUNT DECREASED4
WEIGHT DECREASED4
URTICARIA4
PRURITUS4
PLATELET COUNT DECREASED4
OEDEMA PERIPHERAL4
MENTAL STATUS CHANGES4
HEPATIC STEATOSIS4
DRUG HYPERSENSITIVITY4
CORONARY ARTERY DISEASE4
CARDIAC FAILURE4
CARDIAC ARREST4
BLOOD GLUCOSE FLUCTUATION4
BLOOD GLUCOSE DECREASED4
ASTHENIA4
ABDOMINAL DISCOMFORT4
URINARY TRACT INFECTION3
THROMBOCYTOPENIA3
SYNCOPE3
SURGERY3
RESPIRATORY ARREST3
RENAL IMPAIRMENT3
RENAL DISORDER3
RED BLOOD CELL COUNT DECREASED3
PANCREATITIS ACUTE3
NEOPLASM MALIGNANT3
MULTI-ORGAN FAILURE3
HEPATITIS3
HEPATIC ENZYME INCREASED3
HEADACHE3
GASTRITIS3
FEELING ABNORMAL3
FATIGUE3
FALL3
ERYTHEMA3
EPILEPSY3
EOSINOPHILIA3
DYSARTHRIA3
DIVERTICULUM INTESTINAL3
DEHYDRATION3
COUGH3
CONDITION AGGRAVATED3
COLONIC POLYP3
CHEST DISCOMFORT3
BLOOD SODIUM DECREASED3
BLOOD PRESSURE INCREASED3
BLOOD POTASSIUM INCREASED3
ASCITES3
ANAEMIA3
ABDOMINAL DISTENSION3
VIIth nerve paralysis2
VERTIGO2
VENTRICULAR FIBRILLATION2
URINARY RETENTION2
Toxicity to various agents2
TACHYCARDIA2
SMALL INTESTINAL HAEMORRHAGE2
SHOCK2
RASH GENERALISED2
PYELONEPHRITIS2
PULMONARY CONGESTION2
PROTHROMBIN TIME PROLONGED2
PRODUCT SUBSTITUTION ISSUE2
POLYURIA2
PLEURISY2
PLEURAL EFFUSION2
PANCYTOPENIA2
PAIN2
OSTEOMYELITIS2
OSTEOARTHRITIS2
OEDEMA2
MYELODYSPLASTIC SYNDROME2
MYALGIA2
MUSCLE TWITCHING2
LYMPHADENOPATHY2
LOWER RESPIRATORY TRACT INFECTION2
LEUKOPENIA2
LETHARGY2
INTERSTITIAL LUNG DISEASE2
INFLAMMATION2
INFECTION2
INFARCTION2
IMPAIRED INSULIN SECRETION2
ILEUS2
HYPOTHYROIDISM2
HYPONATRAEMIA2
HYPOAESTHESIA2
HYPERKALAEMIA2
HYPERHIDROSIS2
HEMIPARESIS2
HEART RATE INCREASED2
HAEMATOCRIT DECREASED2
GASTROOESOPHAGEAL REFLUX DISEASE2
GASTROINTESTINAL DISORDER2
GASTRITIS EROSIVE2
FAECES DISCOLOURED2
EYE HAEMORRHAGE2
DYSPEPSIA2
DIABETIC NEUROPATHY2
DIABETIC NEPHROPATHY2
DIABETES MELLITUS2
CORONARY ARTERY STENOSIS2
CONCOMITANT DISEASE PROGRESSION2
COLECTOMY2
CHOLELITHIASIS2
CHOLANGITIS2
CEREBROVASCULAR ACCIDENT2
CARDIO-RESPIRATORY ARREST2
CARDIAC DISORDER2
BRADYCARDIA2
BLOOD LACTIC ACID INCREASED2
BLOOD CHOLESTEROL INCREASED2
BLADDER CATHETERISATION2
BILIRUBIN CONJUGATED INCREASED2
BILE DUCT STONE2
ATRIOVENTRICULAR BLOCK FIRST DEGREE2
ATRIAL FLUTTER2
ARRHYTHMIA2
ANOREXIA2
ALTERED STATE OF CONSCIOUSNESS2
ACUTE MYOCARDIAL INFARCTION2
Acute kidney injury2
Wrong technique in product usage process1
WOUND DEHISCENCE1
WOUND ABSCESS1
White matter lesion1
WEIGHT INCREASED1
Vitamin D decreased1
VENTRICULAR TACHYCARDIA1
VENTRICULAR EXTRASYSTOLES1
Vasodilatation1
VASCULITIS1
VASCULAR BYPASS GRAFT1
UVEITIS1
URINE OUTPUT DECREASED1
URINE OSMOLARITY INCREASED1
URETERIC FISTULA1
URETERAL STENT INSERTION1
UNRESPONSIVE TO STIMULI1
UNEVALUABLE EVENT1
UMBILICAL HERNIA1
TYPE 1 DIABETES MELLITUS1
TREMOR1
TRANSPLANT REJECTION1
TRANSAMINASES INCREASED1
TRACHEAL DEVIATION1
TOXIC EPIDERMAL NECROLYSIS1
TONGUE DRY1
TINNITUS1
THYROID CANCER1
THROMBOPHLEBITIS1
THIRST1
THERMAL BURN1
Swelling1
SUICIDE ATTEMPT1
SUDDEN DEATH1
STEVENS-JOHNSON SYNDROME1
SPLENECTOMY1
SKIN NEOPLASM EXCISION1
SKIN IRRITATION1
SKIN HAEMORRHAGE1
SKIN EXFOLIATION1
SKIN DISCOLOURATION1
Sinusitis1
Sinus bradycardia1
SIMPLE PARTIAL SEIZURES1
SENSORY DISTURBANCE1
SECRETION DISCHARGE1
RHABDOMYOLYSIS1
Restlessness1
RESPIRATORY RATE DECREASED1
RESPIRATORY FAILURE1
RESPIRATORY DISTRESS1
RENAL PAIN1
RENAL INJURY1
RENAL FAILURE ACUTE1
RENAL COLIC1
RENAL ARTERY STENOSIS1
REFLUX OESOPHAGITIS1
RECTAL HAEMORRHAGE1
RASH PRURITIC1
QRS AXIS ABNORMAL1
PYELONEPHRITIS CHRONIC1
PSORIASIS1
PROTEIN URINE PRESENT1
PRODUCTIVE COUGH1
PRODUCT TASTE ABNORMAL1
PRODUCT QUALITY ISSUE1
POSTURE ABNORMAL1
POST PROCEDURAL HAEMATOMA1
POLLAKIURIA1
PNEUMONIA ASPIRATION1
PLATELET COUNT INCREASED1
PITYRIASIS ROSEA1
PHOTOSENSITIVITY REACTION1
PHARMACEUTICAL PRODUCT COMPLAINT1
Peripheral arterial occlusive disease1
PERICARDIAL HAEMORRHAGE1
PERICARDIAL EFFUSION1
PARKINSON'S DISEASE1
Paralysis1
PANCREATIC CARCINOMA1
PANCREATIC ATROPHY1
PALPITATIONS1
PALMAR ERYTHEMA1
Pain in extremity1
OXYGEN SATURATION DECREASED1
Osteoporosis1
OBSTRUCTION1
NON-SMALL CELL LUNG CANCER1
NON-HODGKIN'S LYMPHOMA STAGE IV1
NODULE1
NOCTURIA1
NO THERAPEUTIC RESPONSE1
NIGHT SWEATS1
NEUTROPHIL PERCENTAGE INCREASED1
Neutrophil count decreased1
NEPHROLITHIASIS1
NEOPLASM PROGRESSION1
MYOSITIS1
MUSCULOSKELETAL STIFFNESS1
MUSCLE SPASTICITY1
MUCOSAL ULCERATION1
MOUTH ULCERATION1
Mouth swelling1
MOUTH BREATHING1
MOTOR DYSFUNCTION1
MICROALBUMINURIA1
METASTASES TO LYMPH NODES1
METASTASES TO LIVER1
METABOLIC ACIDOSIS1
Mental disorder1
Memory impairment1
MELAENA1
MEAN CELL VOLUME INCREASED1
MASS EXCISION1
LYMPHOMA1
LYMPHOCYTE STIMULATION TEST POSITIVE1
LYMPHOCYTE STIMULATION TEST1
LYMPHOCYTE PERCENTAGE INCREASED1
LYMPHOCYTE PERCENTAGE DECREASED1
LYMPHOCYTE COUNT INCREASED1
LUPUS-LIKE SYNDROME1
LUNG NEOPLASM MALIGNANT1
LUNG INFECTION1
LUNG CONSOLIDATION1
LOW DENSITY LIPOPROTEIN INCREASED1
LOBAR PNEUMONIA1
LEUCINE AMINOPEPTIDASE INCREASED1
LEFT VENTRICULAR FAILURE1
LDL/HDL RATIO INCREASED1
LAPAROTOMY1
Lacunar infarction1
LABORATORY TEST INTERFERENCE1
LABORATORY TEST ABNORMAL1
KNEE ARTHROPLASTY1
KIDNEY INFECTION1
JAUNDICE CHOLESTATIC1
INTESTINAL RESECTION1
INTESTINAL OPERATION1
INTESTINAL HAEMORRHAGE1
INTESTINAL FISTULA1
INTERNATIONAL NORMALISED RATIO INCREASED1
INTENTIONAL OVERDOSE1
INSULIN C-PEPTIDE DECREASED1
Insomnia1
INJECTION SITE OEDEMA1
INJECTION SITE ERYTHEMA1
INCREASED BRONCHIAL SECRETION1
INCOHERENT1
INAPPROPRIATE ANTIDIURETIC HORMONE SECRETION1
HYPOXIA1
HYPOTHERMIA1
HYPOREFLEXIA1
HYPOPHAGIA1
HYPOALBUMINAEMIA1
HYPERTENSIVE CRISIS1
Hip fracture1
HIGH DENSITY LIPOPROTEIN DECREASED1
HICCUPS1
HIATUS HERNIA1
HERPES ZOSTER1
HEPATOCELLULAR DAMAGE1
HEPATITIS B ANTIBODY POSITIVE1
HEPATITIS ACUTE1
HEMIPLEGIA1
HELICOBACTER INFECTION1
HELICOBACTER GASTRITIS1
HEART RATE DECREASED1
HAND FRACTURE1
HALLUCINATION1
HAEMOSTASIS1
HAEMOPTYSIS1
HAEMOLYTIC ANAEMIA1
HAEMOGLOBIN E PRESENT1
HAEMODIALYSIS1
HAEMATOMA INFECTION1
HAEMATOMA EVACUATION1
GOUTY ARTHRITIS1
GOITRE1
GLUCOSE TOLERANCE IMPAIRED1
GLOMERULAR FILTRATION RATE DECREASED1
GIARDIASIS1
GASTROINTESTINAL TUBE INSERTION1
GASTROINTESTINAL HAEMORRHAGE1
GASTROENTERITIS1
GASTRODUODENITIS1
GASTRIC ULCER1
GASTRIC PH DECREASED1
GASTRIC OPERATION1
GASTRIC LAVAGE1
GASTRIC DISORDER1
GASTRIC CANCER1
GASTRIC BYPASS1
Gangrene1
FOLLICLE CENTRE LYMPHOMA, FOLLICULAR GRADE I, II, III STAGE IV1
FLATULENCE1
FIBRIN D DIMER INCREASED1
FEMORAL NECK FRACTURE1
FEMORAL ARTERY OCCLUSION1
FEELING HOT1
FEBRILE NEUTROPENIA1
Face oedema1
Eyelid oedema1
EYE MOVEMENT DISORDER1
ESCHERICHIA INFECTION1
ERYTHEMA MULTIFORME1
EROSIVE OESOPHAGITIS1
EPISTAXIS1
EOSINOPHILIC MYOCARDITIS1
ENTERAL NUTRITION1
EMOTIONAL DISTRESS1
ELECTROCARDIOGRAM ST SEGMENT DEPRESSION1
ELECTROCARDIOGRAM ABNORMAL1
ECZEMA1
DYSURIA1
DYSPNOEA EXERTIONAL1
Dysphagia1
DUODENITIS1
Duodenal ulcer haemorrhage1
Dry skin1
DRUG TOXICITY1
DRUG ERUPTION1
DIVERTICULITIS1
DISEASE RECURRENCE1
DIPLOPIA1
DIARRHOEA HAEMORRHAGIC1
DERMATITIS1
DEPRESSION1
CYANOSIS1
CREPITATIONS1
CORONARY ARTERY THROMBOSIS1
COORDINATION ABNORMAL1
COMPUTERISED TOMOGRAM ABNORMAL1
COMPLETED SUICIDE1
COMA1
COLON CANCER STAGE II1
COLECTOMY TOTAL1
CIRCULATORY COLLAPSE1
CHRONIC HEPATITIS1
CHOLESTASIS1
CHOLECYSTITIS CHRONIC1
CHOLECYSTECTOMY1
CHILLS1
CHEST X-RAY ABNORMAL1
CHEST WALL MASS1
Cheilitis1
Cervicobrachial syndrome1
Cerebral atrophy1
CATHETERISATION CARDIAC1
CARDIOVASCULAR DISORDER1
CARDIOMYOPATHY1
CARDIOMEGALY1
CARDIAC PACEMAKER INSERTION1
CARDIAC MURMUR1
CARDIAC ENZYMES INCREASED1
CARDIAC ABLATION1
CARCINOEMBRYONIC ANTIGEN INCREASED1
CARBOHYDRATE ANTIGEN 19-9 INCREASED1
BRONCHITIS CHRONIC1
Bronchitis1
BREATH SOUNDS ABNORMAL1
BRAIN NATRIURETIC PEPTIDE INCREASED1
BONE MARROW FAILURE1
BONE MARROW DISORDER1
BODY MASS INDEX DECREASED1
BLOOD TRIGLYCERIDES INCREASED1
BLOOD PRESSURE SYSTOLIC INCREASED1
Blood pressure decreased1
BLOOD PRESSURE ABNORMAL1
BLOOD POTASSIUM DECREASED1
BLOOD OSMOLARITY DECREASED1
BLOOD GLUCOSE ABNORMAL1
BLOOD CREATININE DECREASED1
BLOOD CHOLINESTERASE INCREASED1
Blood cholesterol decreased1
BLOOD CHLORIDE DECREASED1
BLOOD ANTIDIURETIC HORMONE INCREASED1
BLOOD AMYLASE INCREASED1
BLOOD ALBUMIN DECREASED1
BLISTER1
BLINDNESS TRANSIENT1
BLADDER IRRIGATION1
BIOPSY HEART ABNORMAL1
BILIARY TRACT INFECTION1
BILIARY DILATATION1
BILE DUCT T-TUBE INSERTION1
BILE DUCT STENT INSERTION1
BENIGN COLONIC NEOPLASM1
BASAL CELL CARCINOMA1
BACTERIA URINE1
AUTOIMMUNE THYROIDITIS1
Atrial fibrillation1
ATELECTASIS1
ARTHRALGIA1
ARTERIOVENOUS MALFORMATION1
ARTERIOSCLEROSIS1
ARTERIAL OCCLUSIVE DISEASE1
ARTERIAL INJURY1
ARTERIAL DISORDER1
APHASIA1
APALLIC SYNDROME1
AORTIC CALCIFICATION1
ANTINUCLEAR ANTIBODY POSITIVE1
ANGIOPLASTY1
ANGIODYSPLASIA1
ANGINA UNSTABLE1
ANASTOMOTIC LEAK1
AMNESIA1
ACUTE RESPIRATORY DISTRESS SYNDROME1
ACUTE MYELOID LEUKAEMIA1
ACIDOSIS1
ACCIDENTAL EXPOSURE1
Accident1
ABSCESS DRAINAGE1
ABDOMINAL TENDERNESS1





Toxicity information:

Toxicity class: 4
Toxicity type: N/A
LD50: 800 mg/kg



External links:

ChEBML: CHEMBL783
DrugBank: DB00731