Nalmefene


1415



General information:


Withdrawn ID: 1415
Canonical SMILES:
Standard InChI:
Standard InChIKey:
ATC class(es): N07BB05
Molecular Formula: C21H25NO3
Molweight: 339.428



Withdrawal information:


Withdrawn due to drug safety reasons:No
First approved: 1995



Side-effects:

Total reported cases (submitted by medical professionals) with Nalmefene as primary suspect: 2


Reported final outcomes:


Reported side-effects:
Side-effect Case number
Intentional overdose2
Agitation1
ASTHENIA1
DIARRHOEA1
EPIGASTRIC DISCOMFORT1
FATIGUE1
LOOSE STOOLS1
NAUSEA1
Suicide attempt1
VOMITING1





Filtered ChEMBL targets:

Target UniProtKB ID Activity in nm Target Name Target gene
P35372 0.24 Mu-type opioid receptor OPRM_HUMAN
P41143 0.912 Delta-type opioid receptor OPRD_HUMAN
P41145 0.083 Kappa-type opioid receptor OPRK_HUMAN



Toxicity information:

Toxicity class: 4
Toxicity type: N/A
LD50: 402 mg/kg



External links:

ChEBML: CHEMBL982
DrugBank: