Nalidixic acid
General information:
| Withdrawn ID: | 339 |
|---|---|
| Canonical SMILES: | |
| Standard InChI: | |
| Standard InChIKey: | |
| ATC class(es): | J01MB02 |
| Molecular Formula: | C12H12N2O3 |
| Molweight: | 232.235 |
Withdrawal information:
| Withdrawn due to drug safety reasons: | No |
|---|---|
| First approved: | 1964 |
| First withdrawn: | 1992 |
| Last withdrawn: | 1992 |
Side-effects:
| Total reported cases (submitted by medical professionals) with Nalidixic acid as primary suspect: | 11 |
|---|
Reported final outcomes:
| Hospitalization (initial or prolonged): | 8 |
|---|---|
| Death: | 2 |
| Life-Threatening condition: | 1 |
Reported side-effects:
| Side-effect | Case number |
|---|---|
| SOMNOLENCE | 2 |
| AGITATION | 2 |
| Benign intracranial hypertension | 2 |
| DEPENDENCE | 2 |
| LOSS OF CONSCIOUSNESS | 2 |
| IRRITABILITY | 2 |
| Condition aggravated | 2 |
| DRUG ERUPTION | 1 |
| FALL | 1 |
| DIZZINESS | 1 |
| Diarrhoea haemorrhagic | 1 |
| Depressed level of consciousness | 1 |
| DEATH | 1 |
| CRYING | 1 |
| Coma | 1 |
| CHILLS | 1 |
| Cardiac arrest | 1 |
| Bradycardia | 1 |
| AGGRESSION | 1 |
| ACCIDENTAL OVERDOSE | 1 |
| INSOMNIA | 1 |
| Staring | 1 |
| Shigella infection | 1 |
| Sepsis | 1 |
| POSTURE ABNORMAL | 1 |
| Pathogen resistance | 1 |
| NEPHRITIS INTERSTITIAL | 1 |
| MYDRIASIS | 1 |
| MELAENA | 1 |
| Drug ineffective | 1 |
| Hypertension | 1 |
| GASTROINTESTINAL HAEMORRHAGE | 1 |
| Fontanelle bulging | 1 |
| FOAMING AT MOUTH | 1 |
| FATIGUE | 1 |
| Treatment failure | 1 |
| DRUG INTERACTION | 1 |
Filtered ChEMBL targets:
| Target UniProtKB ID | Activity in nm | Target Name | Target gene |
|---|---|---|---|
| P02545 | 125.9 | Prelamin-A/C | LMNA_HUMAN |
Toxicity information:
| Toxicity class: | 4 |
|---|---|
| Toxicity type: | N/A |
| LD50: | 1286 mg/kg |
External links:
| ChEBML: | CHEMBL5 |
|---|---|
| DrugBank: | DB00779 |