Mianserin
General information:
| Withdrawn ID: | w235 |
|---|---|
| Canonical SMILES: | |
| Standard InChI: | |
| Standard InChIKey: | |
| ATC class(es): | N06AX03 |
| Molecular Formula: | C18H20N2 |
| Molweight: | 264.365 |
Withdrawal information:
| Withdrawn due to drug safety reasons: | Yes |
|---|---|
| First approved: | 1976 |
| First withdrawn: | 1988 |
| Last withdrawn: | 1988 |
| Reference: | https://www.ncbi.nlm.nih.gov/pubmed/10942986 |
Side-effects:
| Total reported cases (submitted by medical professionals) with Mianserin as primary suspect: | 6 |
|---|
Reported final outcomes:
| Hospitalization (initial or prolonged): | 4 |
|---|---|
| Death: | 1 |
Reported side-effects:
| Side-effect | Case number |
|---|---|
| Somnolence | 2 |
| DRUG INTERACTION | 2 |
| Hepatocellular injury | 1 |
| ACUTE RESPIRATORY FAILURE | 1 |
| Cholestasis | 1 |
| Cognitive disorder | 1 |
| CONDITION AGGRAVATED | 1 |
| Drug abuse | 1 |
| Drug reaction with eosinophilia and systemic symptoms | 1 |
| Eosinophilia | 1 |
| Face oedema | 1 |
| General physical health deterioration | 1 |
| Hepatitis | 1 |
| TOXICITY TO VARIOUS AGENTS | 1 |
| Hyperthermia | 1 |
| HYPOTHYROIDISM | 1 |
| Lymphocytosis | 1 |
| Prescription form tampering | 1 |
| Rash morbilliform | 1 |
| SEROTONIN SYNDROME | 1 |
| Subdural haematoma | 1 |
| SUICIDE ATTEMPT | 1 |
| THERAPEUTIC RESPONSE UNEXPECTED | 1 |
Filtered ChEMBL targets:
| Target UniProtKB ID | Activity in nm | Target Name | Target gene |
|---|---|---|---|
| P02545 | 158.5 | Prelamin-A/C | LMNA_HUMAN |
| P08913 | 4.8 | Alpha-2A adrenergic receptor | ADA2A_HUMAN |
| P14416 | 2197 | D(2) dopamine receptor | DRD2_HUMAN |
| P18825 | 3.8 | Alpha-2C adrenergic receptor | ADA2C_HUMAN |
| P28223 | 1.2 | 5-hydroxytryptamine receptor 2A | 5HT2A_HUMAN |
| P28335 | 1.7 | 5-hydroxytryptamine receptor 2C | 5HT2C_HUMAN |
| P34969 | 56 | 5-hydroxytryptamine receptor 7 | 5HT7R_HUMAN |
| P35367 | 1.7 | Histamine H1 receptor | HRH1_HUMAN |
| P35462 | 2841 | D(3) dopamine receptor | DRD3_HUMAN |
| P50406 | 55 | 5-hydroxytryptamine receptor 6 | 5HT6R_HUMAN |
Toxicity information:
| Toxicity class: | 4 |
|---|---|
| Toxicity type: | hematological |
| LD50: | 370 mg/kg |
External links:
| ChEBML: | CHEMBL6437 |
|---|---|
| DrugBank: | DB06148 |