Meprobamate


DB00371



General information:


Withdrawn ID: DB00371
Canonical SMILES:
Standard InChI:
Standard InChIKey:
ATC class(es): N05BC51
N05CX01
N05BC01
Molecular Formula: C9H18N2O4
Molweight: 218.25



Withdrawal information:


Withdrawn due to drug safety reasons:Yes
First withdrawn: 2012
Reference: https://www.ema.europa.eu/en/medicines/human/referrals/meprobamate



Side-effects:

Total reported cases (submitted by medical professionals) with Meprobamate as primary suspect: 52


Reported final outcomes:
Death: 21
Hospitalization (initial or prolonged): 15
Congenital anomaly: 5
Intervention required to prevent permanent impairment/damage: 2
Life-Threatening condition: 1


Reported side-effects:

Side-effect Case number
TOXICITY TO VARIOUS AGENTS12
SUICIDE ATTEMPT9
DRUG EXPOSURE DURING PREGNANCY7
LOSS OF CONSCIOUSNESS6
POISONING DELIBERATE5
MATERNAL DRUGS AFFECTING FOETUS5
Drug abuse5
CARDIAC ARREST5
UNRESPONSIVE TO STIMULI4
SOMNOLENCE4
RESPIRATORY ARREST4
Drug ineffective4
DEATH4
COMPLETED SUICIDE4
Seizure3
RESPIRATORY DEPRESSION3
PANCREATITIS ACUTE3
OVERDOSE3
Lethargy3
INCORRECT DOSE ADMINISTERED3
HYPOTENSION3
EXTRAPYRAMIDAL DISORDER3
CONVULSION3
CONGENITAL NOSE MALFORMATION3
CARDIOVASCULAR INSUFFICIENCY3
Wrong technique in product usage process2
WRONG TECHNIQUE IN DRUG USAGE PROCESS2
TACHYCARDIA2
SINUS TACHYCARDIA2
Product substitution issue2
PERIPHERAL ISCHAEMIA2
PAIN IN EXTREMITY2
Off label use2
Nausea2
MUSCLE SPASMS2
METABOLIC ACIDOSIS2
MATERNAL ALCOHOL USE2
LEUKOCYTOSIS2
INTENTIONAL OVERDOSE2
INTELLIGENCE TEST ABNORMAL2
INJURY2
Hypertension2
GANGRENE2
Fine motor skill dysfunction2
FALL2
DRUG WITHDRAWAL SYNDROME2
DEPRESSED LEVEL OF CONSCIOUSNESS2
CYANOSIS2
CRYPTORCHISM2
CONGENITAL ANOMALY2
Confusional state2
CIRCULATORY COLLAPSE2
Balance disorder2
ABORTION SPONTANEOUS2
VICTIM OF CRIME1
VENTRICULAR FIBRILLATION1
VENTRICULAR EXTRASYSTOLES1
URINARY TRACT INFECTION1
Tremor1
Tenderness1
STRABISMUS1
SKIN GRAFT1
Serotonin syndrome1
Self-medication1
SALIVARY HYPERSECRETION1
Road traffic accident1
RHONCHI1
Resuscitation1
Respiratory failure1
RESPIRATORY DISORDER1
Respiratory acidosis1
Pulse pressure decreased1
Pulmonary oedema1
Pulmonary congestion1
PSEUDOMONAL SEPSIS1
PROTEIN URINE PRESENT1
Product use in unapproved indication1
Product taste abnormal1
Product odour abnormal1
POVERTY OF SPEECH1
POISONING1
Pneumonia1
PHLEBITIS1
Paraesthesia1
Palpitations1
Pallor1
OSTEOARTHRITIS1
OROPHARYNGEAL PAIN1
Oedema peripheral1
Nystagmus1
Nervous system disorder1
Necrosis1
MYDRIASIS1
MULTIPLE DRUG OVERDOSE1
Mucosal ulceration1
MICROCEPHALY1
Mental status changes1
MENTAL IMPAIRMENT1
Memory impairment1
Medication error1
Malaise1
MACROCEPHALY1
LIP DISORDER1
Legal problem1
Left ventricular hypertrophy1
Intentional underdose1
INTENTIONAL SELF-INJURY1
Insomnia1
INCORRECT ROUTE OF DRUG ADMINISTRATION1
Impaired driving ability1
HYPOTHERMIA1
HYPOSPADIAS1
Hyporeflexia1
Hypokinesia1
HYPERTONIA1
Hypertensive cardiomyopathy1
Hypersensitivity1
HYPERLACTACIDAEMIA1
HYPEREXPLEXIA1
HIP DYSPLASIA1
HIGH ARCHED PALATE1
HAEMATOMA1
HAEMANGIOMA OF LIVER1
GENERAL PHYSICAL HEALTH DETERIORATION1
FOETAL ALCOHOL SYNDROME1
Feeling hot1
Feeling cold1
Fatigue1
EXTREMITY NECROSIS1
Excoriation1
DYSPNOEA1
DYSMORPHISM1
Dyskinesia1
Dysarthria1
Drug use disorder1
DRUG TOXICITY1
DRUG LEVEL DECREASED1
Drug interaction1
DROWNING1
Dizziness1
Disinhibition1
Diarrhoea1
COUGH1
Coordination abnormal1
Contusion1
Constipation1
Condition aggravated1
COMA1
CHOLESTASIS1
CHOLELITHIASIS1
CEREBRAL ATROPHY1
Cardiomegaly1
CARDIOGENIC SHOCK1
CARDIO-RESPIRATORY ARREST1
BRONCHITIS1
BLOOD URINE PRESENT1
BLOOD PRESSURE DIASTOLIC DECREASED1
BLOOD PRESSURE DECREASED1
Blood iron decreased1
BLOOD GLUCOSE INCREASED1
BLOOD ALCOHOL INCREASED1
Bladder disorder1
BEZOAR1
Anxiety1
ANOMALY OF EXTERNAL EAR CONGENITAL1
ANKYLOGLOSSIA CONGENITAL1
AGITATION1
AMPUTATION1
ACCIDENTAL EXPOSURE1
ACCIDENTAL DEATH1
ABNORMAL PALMAR/PLANTAR CREASES1
Abdominal pain upper1
Abdominal pain lower1
Abdominal pain1





Filtered ChEMBL targets:

Target UniProtKB ID Activity in nm Target Name Target gene
P02545 446.7 Prelamin-A/C LMNA_HUMAN



Toxicity information:



External links:

ChEBML: CHEMBL979