leflunomide

General information:

Withdrawn ID:	EMA25
Canonical SMILES:
Standard InChI:
Standard InChIKey:
ATC class(es):	L04AA13
Molecular Formula:	C12H9F3N2O2
Molweight:	270.207

Withdrawal information:

Withdrawn due to drug safety reasons:	No

Side-effects:

Total reported cases (submitted by medical professionals) with leflunomide as primary suspect:	6044

Reported final outcomes:

Hospitalization (initial or prolonged):	1721
Death:	359
Life-Threatening condition:	331
Disability:	230
Congenital anomaly:	109
Intervention required to prevent permanent impairment/damage:	15

Reported side-effects:

Side-effect	Case number
DRUG INEFFECTIVE	2008
RHEUMATOID ARTHRITIS	925
DRUG INTOLERANCE	671
DIARRHOEA	542
ARTHRALGIA	535
JOINT SWELLING	522
NAUSEA	514
RASH	486
PAIN	466
FATIGUE	428
ALANINE AMINOTRANSFERASE INCREASED	370
Contraindicated product administered	352
DRUG HYPERSENSITIVITY	328
Treatment failure	325
PYREXIA	320
DYSPNOEA	319
ASPARTATE AMINOTRANSFERASE INCREASED	319
ALOPECIA	304
CONDITION AGGRAVATED	296
SYNOVITIS	277
DRUG EXPOSURE DURING PREGNANCY	276
Exposure during pregnancy	275
HEPATIC ENZYME INCREASED	268
HEADACHE	267
ABDOMINAL DISCOMFORT	265
HYPERSENSITIVITY	250
VOMITING	247
OFF LABEL USE	247
INFECTION	238
MALAISE	236
PNEUMONIA	226
Therapeutic product effect decreased	225
Peripheral swelling	219
MUSCULOSKELETAL STIFFNESS	210
PRURITUS	205
GASTROINTESTINAL DISORDER	197
BLOOD ALKALINE PHOSPHATASE INCREASED	193
Arthropathy	191
SWELLING	190
PAIN IN EXTREMITY	185
HYPERTENSION	175
GAMMA-GLUTAMYLTRANSFERASE INCREASED	173
C-REACTIVE PROTEIN INCREASED	170
LEUKOPENIA	167
MATERNAL EXPOSURE DURING PREGNANCY	150
LIVER FUNCTION TEST ABNORMAL	148
WEIGHT DECREASED	146
ASTHENIA	146
STOMATITIS	144
ABDOMINAL PAIN	141
Therapeutic product effect incomplete	140
COUGH	140
NASOPHARYNGITIS	139
INTERSTITIAL LUNG DISEASE	138
DIZZINESS	138
BLOOD LACTATE DEHYDROGENASE INCREASED	135
THERAPEUTIC RESPONSE DECREASED	130
HEPATOTOXICITY	127
ANAEMIA	122
ARTHRITIS	121
Loss of personal independence in daily activities	120
SINUSITIS	117
WHITE BLOOD CELL COUNT DECREASED	116
GAIT DISTURBANCE	114
BACK PAIN	113
Hand deformity	112
OSTEOARTHRITIS	110
GENERAL PHYSICAL HEALTH DETERIORATION	109
WEIGHT INCREASED	108
MOBILITY DECREASED	107
IMPAIRED HEALING	107
PANCYTOPENIA	106
LOWER RESPIRATORY TRACT INFECTION	105
CONFUSIONAL STATE	105
INSOMNIA	104
SYSTEMIC LUPUS ERYTHEMATOSUS	102
LIVER DISORDER	102
FOETAL EXPOSURE DURING PREGNANCY	101
BLISTER	99
NEUTROPENIA	98
TRANSAMINASES INCREASED	96
HEPATITIS	94
JAUNDICE	93
SEPSIS	91
Infusion related reaction	90
INFLAMMATION	90
DRUG-INDUCED LIVER INJURY	90
HAEMOGLOBIN DECREASED	86
THROMBOCYTOPENIA	85
RENAL FAILURE	85
C-reactive protein abnormal	85
ABORTION SPONTANEOUS	85
Irritable bowel syndrome	84
HEPATIC FUNCTION ABNORMAL	84
HYPOAESTHESIA	83
Anti-cyclic citrullinated peptide antibody positive	83
ILL-DEFINED DISORDER	81
BLOOD BILIRUBIN INCREASED	81
ABDOMINAL PAIN UPPER	81
Liver function test increased	80
RED BLOOD CELL SEDIMENTATION RATE INCREASED	79
PARAESTHESIA	78
Product use issue	77
DECREASED APPETITE	77
PEMPHIGUS	76
CHEST PAIN	76
ADVERSE DRUG REACTION	76
RESPIRATORY FAILURE	75
FALL	75
Psoriatic arthropathy	74
PLATELET COUNT DECREASED	74
GLOSSODYNIA	74
Folliculitis	74
ERYTHEMA	74
DYSPEPSIA	74
DEPRESSION	74
URTICARIA	72
Rheumatoid factor positive	72
MUSCLE INJURY	70
PULMONARY FIBROSIS	69
PERICARDITIS	69
MOUTH ULCERATION	69
CONTUSION	69
DRUG INTERACTION	67
PNEUMONITIS	66
Discomfort	66
ADVERSE EVENT	66
Sleep disorder due to general medical condition, insomnia type	65
MYALGIA	65
HEPATIC FAILURE	65
DRUG EFFECT DECREASED	65
BLOOD PRESSURE INCREASED	65
NEUROPATHY PERIPHERAL	64
Drug effect incomplete	64
TOXICITY TO VARIOUS AGENTS	63
SLEEP DISORDER	63
PSORIASIS	63
CARDIAC FAILURE	63
Unevaluable event	62
MUSCULOSKELETAL PAIN	62
ABORTION INDUCED	62
WOUND	60
VISUAL IMPAIRMENT	60
CONGENITAL ANOMALY	60
BLOOD CREATININE INCREASED	60
WHITE BLOOD CELL COUNT INCREASED	59
URINARY TRACT INFECTION	57
PLEURAL EFFUSION	57
RASH PRURITIC	56
HELICOBACTER INFECTION	56
NODULE	55
LUNG DISORDER	55
PALPITATIONS	54
FEELING ABNORMAL	54
PULMONARY EMBOLISM	53
RHEUMATOID NODULE	52
Duodenal ulcer perforation	52
MYOCARDIAL INFARCTION	51
SKIN ULCER	50
JOINT STIFFNESS	50
FIBROMYALGIA	50
OSTEOPOROSIS	49
NECK PAIN	49
MUSCULAR WEAKNESS	48
LIVER INJURY	48
COLITIS	48
BLOOD CHOLESTEROL INCREASED	48
SEPTIC SHOCK	47
PREGNANCY	47
Bone erosion	47
OEDEMA PERIPHERAL	46
JOINT RANGE OF MOTION DECREASED	46
BRONCHITIS	46
HEPATIC STEATOSIS	45
DEATH	45
ANXIETY	45
ANOREXIA	45
RENAL IMPAIRMENT	44
Red blood cell sedimentation rate abnormal	44
SYNCOPE	43
RENAL FAILURE ACUTE	43
LOSS OF CONSCIOUSNESS	43
HYPOTENSION	43
DIVERTICULITIS	43
CELLULITIS	43
TACHYCARDIA	42
Knee arthroplasty	42
HYPERHIDROSIS	42
DRUG ERUPTION	42
DEHYDRATION	42
ABDOMINAL DISTENSION	42
RHEUMATOID LUNG	41
STRESS	40
HERPES ZOSTER	40
CEREBROVASCULAR ACCIDENT	40
PULMONARY MASS	39
LOCALISED INFECTION	39
HEPATIC CIRRHOSIS	38
GASTROINTESTINAL HAEMORRHAGE	38
SKIN LESION	37
FOOT DEFORMITY	37
DIABETES MELLITUS	37
CHILLS	37
BLOOD UREA INCREASED	37
VASCULITIS	36
THERAPY NON-RESPONDER	36
Tenosynovitis	36
RED BLOOD CELL COUNT DECREASED	36
Gastric disorder	36
Gait inability	36
DYSPHAGIA	36
BREAST CANCER	36
ATRIAL FIBRILLATION	36
UPPER RESPIRATORY TRACT INFECTION	35
POLYNEUROPATHY	35
MULTI-ORGAN FAILURE	35
DEEP VEIN THROMBOSIS	35
BONE MARROW FAILURE	35
ASCITES	35
STEVENS-JOHNSON SYNDROME	34
STAPHYLOCOCCAL INFECTION	33
RASH MACULO-PAPULAR	33
PULMONARY TOXICITY	33
EOSINOPHILIA	33
Acute kidney injury	33
LYMPHADENOPATHY	32
DYSPNOEA EXERTIONAL	32
DRY MOUTH	32
Impaired work ability	31
HYPERTENSIVE CRISIS	31
OROPHARYNGEAL PAIN	30
OEDEMA	30
INFLUENZA LIKE ILLNESS	30
Deformity	30
CONSTIPATION	30
PULMONARY HYPERTENSION	29
MUSCLE SPASMS	29
Joint effusion	29
Hip arthroplasty	29
BLOOD ALBUMIN DECREASED	29
ASTHMA	29
ANAPHYLACTIC REACTION	29
ULCER	28
RESPIRATORY DISORDER	28
PULMONARY ARTERIAL HYPERTENSION	28
PANCREATITIS	28
OSTEOMYELITIS	28
Disability	28
CROHN'S DISEASE	28
TUBERCULOSIS	27
TREMOR	27
SKIN EXFOLIATION	27
Musculoskeletal disorder	27
LUNG INFILTRATION	27
Limb discomfort	27
GASTROOESOPHAGEAL REFLUX DISEASE	27
DRY EYE	27
CHOLESTASIS	27
ACUTE RESPIRATORY DISTRESS SYNDROME	27
TOXIC EPIDERMAL NECROLYSIS	26
Product use in unapproved indication	26
ORAL PAIN	26
MEDICATION ERROR	26
LYMPHOMA	26
HYPOXIA	26
BLOOD GLUCOSE INCREASED	26
NO ADVERSE EVENT	25
HEPATIC FIBROSIS	25
CHRONIC OBSTRUCTIVE PULMONARY DISEASE	25
SURGERY	24
RASH ERYTHEMATOUS	24
PNEUMOTHORAX	24
Intentional product use issue	24
Injection site reaction	24
HYPOTHYROIDISM	24
HEPATOCELLULAR INJURY	24
HAEMATOCRIT DECREASED	24
Drug reaction with eosinophilia and systemic symptoms	24
DISEASE PROGRESSION	24
CATARACT	24
BURNING SENSATION	24
AMNESIA	24
AGRANULOCYTOSIS	24
SHOCK	23
RECTAL HAEMORRHAGE	23
Polyarthritis	23
PLATELET COUNT INCREASED	23
DRUG TOLERANCE DECREASED	23
VISION BLURRED	22
TENDERNESS	22
PERICARDIAL EFFUSION	22
MIGRAINE	22
LUNG INFECTION	22
HYPOKALAEMIA	22
HEART RATE INCREASED	22
GASTRIC ULCER	22
EPISTAXIS	22
CHROMATURIA	22
BASAL CELL CARCINOMA	22
SYNOVIAL CYST	21
SOMNOLENCE	21
PULMONARY OEDEMA	21
PANNICULITIS	21
NIGHT SWEATS	21
Injection site pain	21
INFLUENZA	21
Inflammatory marker increased	21
GASTROENTERITIS	21
DERMATITIS ALLERGIC	21
ARTHRITIS BACTERIAL	21
VASCULITIC RASH	20
SWELLING FACE	20
Retinal toxicity	20
PRODUCTIVE COUGH	20
POSTERIOR REVERSIBLE ENCEPHALOPATHY SYNDROME	20
LUNG NEOPLASM	20
LABORATORY TEST ABNORMAL	20
CHOLELITHIASIS	20
ACUTE HEPATIC FAILURE	20
VERTIGO	19
TRANSIENT ISCHAEMIC ATTACK	19
TACHYPNOEA	19
SKIN NECROSIS	19
SKIN DISORDER	19
RHINORRHOEA	19
NEOPLASM MALIGNANT	19
MUCOSAL INFLAMMATION	19
LEUKOCYTOSIS	19
HOT FLUSH	19
HEPATIC ENZYME ABNORMAL	19
Eye disorder	19
DYSGEUSIA	19
CYSTITIS	19
CONVULSION	19
COLITIS MICROSCOPIC	19
COAGULOPATHY	19
Adverse reaction	19
VIRAL INFECTION	18
Type 2 diabetes mellitus	18
TREATMENT NONCOMPLIANCE	18
TRANSMISSION OF DRUG VIA SEMEN	18
SCIATICA	18
OSTEOPENIA	18
MYELODYSPLASTIC SYNDROME	18
LUPUS-LIKE SYNDROME	18
HYPERCALCAEMIA	18
HAEMORRHAGE	18
HAEMOPTYSIS	18
FINGER DEFORMITY	18
FEMUR FRACTURE	18
DYSSTASIA	18
COLITIS ULCERATIVE	18
CHEST DISCOMFORT	18
ARRHYTHMIA	18
X-ray abnormal	17
UROSEPSIS	17
Seizure	17
SCAR	17
PUSTULAR PSORIASIS	17
PREMATURE BABY	17
PHARYNGEAL OEDEMA	17
PALLOR	17
OSTEONECROSIS OF JAW	17
NON-HODGKIN'S LYMPHOMA	17
MEMORY IMPAIRMENT	17
LETHARGY	17
DERMATITIS	17
COVID-19	17
CARDIOMYOPATHY	17
CARDIAC ARREST	17
BURSITIS	17
BLOOD CREATINE PHOSPHOKINASE INCREASED	17
ANGIOEDEMA	17
ACUTE MYOCARDIAL INFARCTION	17
SWOLLEN TONGUE	16
SQUAMOUS CELL CARCINOMA	16
SKIN REACTION	16
RENAL DISORDER	16
PULMONARY CAVITATION	16
Pneumocystis jirovecii pneumonia	16
PHOTOSENSITIVITY REACTION	16
OXYGEN SATURATION DECREASED	16
NASAL CONGESTION	16
MELAENA	16
LYMPHOCYTE PERCENTAGE DECREASED	16
HISTIOCYTOSIS HAEMATOPHAGIC	16
HEPATOMEGALY	16
HAEMATURIA	16
GASTRITIS	16
DRUG EXPOSURE BEFORE PREGNANCY	16
Bone density decreased	16
TENDONITIS	15
RHABDOMYOLYSIS	15
RESPIRATORY TRACT INFECTION	15
PROTEIN TOTAL DECREASED	15
ORAL CANDIDIASIS	15
NEUTROPHIL PERCENTAGE INCREASED	15
NEPHROLITHIASIS	15
Musculoskeletal discomfort	15
MATERNAL EXPOSURE BEFORE PREGNANCY	15
Joint injury	15
Joint arthroplasty	15
ISCHAEMIC STROKE	15
INCORRECT DOSE ADMINISTERED	15
FEELING HOT	15
Encephalitis	15
CARDIO-RESPIRATORY ARREST	15
CARDIAC FAILURE CONGESTIVE	15
Suicidal ideation	14
SPEECH DISORDER	14
Secretion discharge	14
PROTEINURIA	14
PROTEIN URINE PRESENT	14
PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY	14
OVARIAN CANCER	14
OSTEONECROSIS	14
LUNG NEOPLASM MALIGNANT	14
INTERNATIONAL NORMALISED RATIO INCREASED	14
Inappropriate schedule of product administration	14
HYPOGLYCAEMIA	14
HEPATOCELLULAR DAMAGE	14
HEPATITIS TOXIC	14
HAEMATOCHEZIA	14
Granuloma skin	14
GRANULOMA	14
Foot fracture	14
FOOD INTOLERANCE	14
Exposure via father	14
ENCEPHALOPATHY	14
EMPHYSEMA	14
Drug dependence	14
CYTOMEGALOVIRUS INFECTION	14
CARPAL TUNNEL SYNDROME	14
CAESAREAN SECTION	14
Back disorder	14
AUTOIMMUNE HEPATITIS	14
ANTINUCLEAR ANTIBODY POSITIVE	14
ANGINA PECTORIS	14
ACUTE RESPIRATORY FAILURE	14
Tuberculin test positive	13
SPLENOMEGALY	13
SJOGREN'S SYNDROME	13
Retinopathy	13
RASH GENERALISED	13
ORAL HERPES	13
Joint dislocation	13
IRON DEFICIENCY ANAEMIA	13
INTESTINAL PERFORATION	13
INTERVERTEBRAL DISC PROTRUSION	13
Illness	13
HYPERTHYROIDISM	13
HYPERCHOLESTEROLAEMIA	13
HOSPITALISATION	13
HALLUCINATION	13
Fracture delayed union	13
EATING DISORDER	13
DERMATITIS BULLOUS	13
Dactylitis	13
CARDIAC DISORDER	13
Blood parathyroid hormone decreased	13
ATELECTASIS	13
APHASIA	13
Viral upper respiratory tract infection	12
SUBARACHNOID HAEMORRHAGE	12
SPINAL OSTEOARTHRITIS	12
RESPIRATORY DISTRESS	12
RASH MACULAR	12
PURPURA	12
PROTHROMBIN TIME PROLONGED	12
PLEURISY	12
OVERDOSE	12
NEUTROPHIL COUNT DECREASED	12
NECROSIS	12
NAIL DISORDER	12
MENINGITIS	12
MALIGNANT MELANOMA	12
HIATUS HERNIA	12
HEPATITIS ACUTE	12
HAEMOLYTIC ANAEMIA	12
ERYTHEMA MULTIFORME	12
DRY SKIN	12
Drug resistance	12
DISEASE RECURRENCE	12
DEPRESSED LEVEL OF CONSCIOUSNESS	12
DELIRIUM	12
DEAFNESS	12
CYST	12
CUTANEOUS LUPUS ERYTHEMATOSUS	12
CHOLECYSTITIS	12
BRONCHIECTASIS	12
BLOOD SODIUM DECREASED	12
BLOOD PRESSURE FLUCTUATION	12
BLOOD PRESSURE DECREASED	12
Ankylosing spondylitis	12
Alanine aminotransferase abnormal	12
VAGINAL HAEMORRHAGE	11
Uveitis	11
TUBULOINTERSTITIAL NEPHRITIS	11
TOOTHACHE	11
THYROID DISORDER	11
SKIN DISCOLOURATION	11
SINUS TACHYCARDIA	11
PYODERMA GANGRENOSUM	11
PULMONARY TUBERCULOSIS	11
Physical disability	11
Oral discomfort	11
NEUTROPHIL COUNT INCREASED	11
NERVOUS SYSTEM DISORDER	11
MYOSITIS	11
METABOLIC ACIDOSIS	11
LYMPHOCYTE COUNT DECREASED	11
KERATOACANTHOMA	11
INJURY	11
IMMUNOSUPPRESSION	11
HYPOALBUMINAEMIA	11
HEPATIC NECROSIS	11
HAEMATEMESIS	11
GLAUCOMA	11
FLATULENCE	11
Fear of injection	11
EYE PRURITUS	11
Enthesopathy	11
ECZEMA	11
DISSEMINATED INTRAVASCULAR COAGULATION	11
DISORIENTATION	11
Cytopenia	11
CUTANEOUS VASCULITIS	11
CARDIOMEGALY	11
Candida infection	11
ANAPHYLACTIC SHOCK	11
AGEUSIA	11
SKIN MASS	10
SARCOIDOSIS	10
Rotator cuff syndrome	10
RASH PAPULAR	10
PYELONEPHRITIS	10
PROSTATE CANCER	10
PERITONITIS	10
PATERNAL DRUGS AFFECTING FOETUS	10
PANCREATITIS ACUTE	10
Neuralgia	10
Musculoskeletal deformity	10
Multiple organ dysfunction syndrome	10
MEAN CELL VOLUME DECREASED	10
LUNG ABSCESS	10
Intentional product misuse	10
Injection site erythema	10
HYPONATRAEMIA	10
HISTOPLASMOSIS	10
HEPATOSPLENOMEGALY	10
GENERALISED OEDEMA	10
Gastrointestinal toxicity	10
FUNGAL INFECTION	10
FEBRILE NEUTROPENIA	10
ESCHERICHIA URINARY TRACT INFECTION	10
ERYSIPELAS	10
ELECTROLYTE IMBALANCE	10
Ear infection	10
DYSURIA	10
DYSARTHRIA	10
DUODENAL ULCER	10
DRUG TOXICITY	10
Dislocation of vertebra	10
DIPLOPIA	10
DEMYELINATION	10
COMA	10
Cognitive disorder	10
BONE PAIN	10
BONE MARROW TOXICITY	10
BLOOD POTASSIUM INCREASED	10
BALANCE DISORDER	10
Back injury	10
APHTHOUS STOMATITIS	10
ACUTE MYELOID LEUKAEMIA	10
TINNITUS	9
THROMBOSIS	9
Spinal stenosis	9
Skin fissures	9
Seronegative arthritis	9
RADICULOPATHY	9
Pseudarthrosis	9
POLLAKIURIA	9
PNEUMONIA BACTERIAL	9
PNEUMOCYSTIS JIROVECI PNEUMONIA	9
PEPTIC ULCER	9
Oral mucosal exfoliation	9
NORMOCHROMIC NORMOCYTIC ANAEMIA	9
MYOCARDITIS	9
MYCOBACTERIAL INFECTION	9
LYMPHOPENIA	9
LOWER LIMB FRACTURE	9
Intervertebral disc degeneration	9
INJECTION SITE RASH	9
HYPOKINESIA	9
HYPERTRANSAMINASAEMIA	9
HYPERKERATOSIS	9
HEPATITIS B	9
HEMIPARESIS	9
GRIP STRENGTH DECREASED	9
GALLBLADDER DISORDER	9
FLUSHING	9
FAECES DISCOLOURED	9
FACE OEDEMA	9
ESCHERICHIA INFECTION	9
CYTOLYTIC HEPATITIS	9
CREPITATIONS	9
CORONARY ARTERY DISEASE	9
COLON CANCER	9
Chronic kidney disease	9
CHEST X-RAY ABNORMAL	9
CARDIAC MURMUR	9
BRONCHOPULMONARY ASPERGILLOSIS	9
BRONCHOPNEUMONIA	9
BREATH SOUNDS ABNORMAL	9
BLOOD URINE PRESENT	9
BLOOD PRESSURE SYSTOLIC INCREASED	9
BLOOD POTASSIUM DECREASED	9
BACTERIAL INFECTION	9
AGITATION	9
Wound infection	8
VISUAL ACUITY REDUCED	8
Tooth disorder	8
Steatohepatitis	8
STAPHYLOCOCCAL SEPSIS	8
Spinal column stenosis	8
SMALL INTESTINAL OBSTRUCTION	8
Sensitivity to weather change	8
RED CELL DISTRIBUTION WIDTH INCREASED	8
Red blood cell sedimentation rate	8
RALES	8
PSEUDOMONAS INFECTION	8
PRURITUS GENERALISED	8
PRODUCT SUBSTITUTION ISSUE	8
PHARYNGOLARYNGEAL PAIN	8
PHARYNGITIS	8
PETECHIAE	8
PERONEAL NERVE PALSY	8
Papule	8
ORGANISING PNEUMONIA	8
MITRAL VALVE INCOMPETENCE	8
METASTASES TO LYMPH NODES	8
MENTAL STATUS CHANGES	8
MEAN CELL HAEMOGLOBIN DECREASED	8
Local swelling	8
Intervertebral disc space narrowing	8
Injection site swelling	8
Injection site inflammation	8
Infusion site reaction	8
IMPAIRED GASTRIC EMPTYING	8
IMMUNODEFICIENCY	8
IMMUNE SYSTEM DISORDER	8
Hysterectomy	8
HYPOACUSIS	8
Hypersensitivity vasculitis	8
HYPERKALAEMIA	8
HEPATIC LESION	8
HEPATIC ENCEPHALOPATHY	8
HEART RATE DECREASED	8
GUILLAIN-BARRE SYNDROME	8
Feeding disorder	8
Extremity contracture	8
ENDOCARDITIS	8
Drug ineffective for unapproved indication	8
DEAFNESS NEUROSENSORY	8
CONJUNCTIVITIS	8
CONGESTIVE CARDIOMYOPATHY	8
Clostridium difficile infection	8
CEREBRAL HAEMORRHAGE	8
CARDIOGENIC SHOCK	8
CACHEXIA	8
BRONCHITIS CHRONIC	8
BRAIN OEDEMA	8
BONE DISORDER	8
BODY TEMPERATURE INCREASED	8
BLOOD TEST ABNORMAL	8
BLINDNESS	8
BACTERAEMIA	8
ARTHRITIS INFECTIVE	8
Aphthous ulcer	8
ABORTION	8
VERTIGO POSITIONAL	7
UPPER GASTROINTESTINAL HAEMORRHAGE	7
TRICUSPID VALVE INCOMPETENCE	7
Tongue disorder	7
TENDON DISORDER	7
SKIN INFECTION	7
Skin cancer	7
Scoliosis	7
Retinitis	7
PREGNANCY OF PARTNER	7
Postoperative wound infection	7
POLYOMAVIRUS-ASSOCIATED NEPHROPATHY	7
POLYMYOSITIS	7
PERIPHERAL SENSORY NEUROPATHY	7
OVARIAN NEOPLASM	7
ORTHOSTATIC HYPOTENSION	7
OLIGURIA	7
Ocular toxicity	7
OCULAR HYPERAEMIA	7
NEPHROTIC SYNDROME	7
MONOCYTE COUNT INCREASED	7
MIXED LIVER INJURY	7
MALIGNANT HYPERTENSION	7
LIVER TRANSPLANT	7
LICHEN PLANUS	7
LARYNGITIS	7
Joint destruction	7
JAUNDICE CHOLESTATIC	7
Injection site pruritus	7
HYPERTRIGLYCERIDAEMIA	7
HYPERBILIRUBINAEMIA	7
HYDRONEPHROSIS	7
HERPES VIRUS INFECTION	7
HEPATITIS CHOLESTATIC	7
Groin pain	7
GLYCOSYLATED HAEMOGLOBIN INCREASED	7
GLUCOSE URINE PRESENT	7
FIBROSIS	7
Eye infection	7
Exostosis	7
EOSINOPHILIC PNEUMONIA	7
EMPYEMA	7
ECCHYMOSIS	7
Dyslipidaemia	7
Drug tolerance	7
DIALYSIS	7
Crying	7
CARBOHYDRATE ANTIGEN 125 INCREASED	7
CANDIDIASIS	7
BRONCHOSPASM	7
BREAST CANCER FEMALE	7
BRADYCARDIA	7
Blood disorder	7
BEDRIDDEN	7
Arthrodesis	7
APPARENT DEATH	7
Anti-cyclic citrullinated peptide antibody	7
WHEEZING	6
UTERINE CANCER	6
Urine odour abnormal	6
TOOTH INFECTION	6
Tooth abscess	6
THYROID NEOPLASM	6
THROMBOTIC MICROANGIOPATHY	6
THIRST	6
TENDON RUPTURE	6
STREPTOCOCCAL INFECTION	6
SPUTUM DISCOLOURED	6
Spinal fusion surgery	6
Spinal disorder	6
SPINAL COMPRESSION FRACTURE	6
Sleep disorder due to a general medical condition	6
SKIN PLAQUE	6
Shoulder arthroplasty	6
SERUM FERRITIN INCREASED	6
Sensory disturbance	6
RETINAL DETACHMENT	6
RENAL FAILURE CHRONIC	6
Red cell distribution width decreased	6
RASH VESICULAR	6
PULMONARY GRANULOMA	6
Prescribed overdose	6
POST PROCEDURAL COMPLICATION	6
PORPHYRIA ACUTE	6
PNEUMONIA STAPHYLOCOCCAL	6
PLEURAL FIBROSIS	6
PHARYNGEAL ULCERATION	6
PATENT DUCTUS ARTERIOSUS	6
PAROTITIS	6
PAPILLOEDEMA	6
PAIN IN JAW	6
Osteosclerosis	6
OSTEITIS	6
ORTHOPNOEA	6
Obesity	6
Neck deformity	6
Myelosuppression	6
Mycobacterium tuberculosis complex test positive	6
MUCOSAL ULCERATION	6
MOVEMENT DISORDER	6
MENTAL DISORDER	6
MEAN PLATELET VOLUME DECREASED	6
MARKEDLY REDUCED DIETARY INTAKE	6
MACULAR DEGENERATION	6
LYMPHOCYTOSIS	6
LIPASE INCREASED	6
Lip swelling	6
Limb deformity	6
LARGE INTESTINE PERFORATION	6
IRRITABILITY	6
INTERVERTEBRAL DISCITIS	6
Injection site bruising	6
INFLAMMATORY BOWEL DISEASE	6
Immobile	6
HYPOPROTEINAEMIA	6
HYPOGAMMAGLOBULINAEMIA	6
HYPOCALCAEMIA	6
HYPERLIPIDAEMIA	6
HERPES SIMPLEX	6
HEPATORENAL SYNDROME	6
HEPATIC TRAUMA	6
Heart rate irregular	6
Gout	6
GINGIVAL BLEEDING	6
GENERALISED ERYTHEMA	6
GASTRIC HAEMORRHAGE	6
FRACTURE	6
FOETAL DISTRESS SYNDROME	6
FLUID RETENTION	6
EYE PAIN	6
EYE INFLAMMATION	6
Extradural abscess	6
Essential hypertension	6
EOSINOPHIL COUNT INCREASED	6
ENCEPHALITIS VIRAL	6
Elbow deformity	6
EAR PAIN	6
DYSPNOEA AT REST	6
DYSPHONIA	6
DRUG RASH WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS	6
Disturbance in attention	6
DERMATITIS EXFOLIATIVE	6
CYTOMEGALOVIRUS VIRAEMIA	6
CIRCULATORY COLLAPSE	6
CHRONIC LYMPHOCYTIC LEUKAEMIA	6
CHOLECYSTECTOMY	6
CHOLANGITIS	6
CHOKING	6
CEREBRAL INFARCTION	6
BONE MARROW DEPRESSION	6
Bone density abnormal	6
BLOOD URIC ACID INCREASED	6
BLOOD IRON DECREASED	6
BLOOD CREATININE DECREASED	6
BLOOD CREATINE INCREASED	6
B-CELL LYMPHOMA	6
ARTERIOSCLEROSIS	6
APLASTIC ANAEMIA	6
Anaemia macrocytic	6
ACTIVATED PARTIAL THROMBOPLASTIN TIME PROLONGED	6
ACNE	6
ABSCESS LIMB	6
ABSCESS	6
Abnormal loss of weight	6
ABDOMINAL TENDERNESS	6
Vitreous floaters	5
Vascular access complication	5
TOOTH FRACTURE	5
TONSILLITIS	5
THYROIDITIS	5
THROAT TIGHTNESS	5
TACHYARRHYTHMIA	5
Spinal column injury	5
SLEEP APNOEA SYNDROME	5
SKIN PAPILLOMA	5
SKIN HYPERPIGMENTATION	5
SKIN BURNING SENSATION	5
Shoulder operation	5
SHOCK HAEMORRHAGIC	5
Seasonal allergy	5
SCAB	5
Sacroiliitis	5
Road traffic accident	5
RHEUMATOID FACTOR INCREASED	5
Rheumatic fever	5
RESTLESS LEGS SYNDROME	5
RENAL CYST	5
RENAL CELL CARCINOMA	5
RASH PUSTULAR	5
PULMONARY SARCOIDOSIS	5
PREMATURE RUPTURE OF MEMBRANES	5
PREMATURE LABOUR	5
POST PROCEDURAL INFECTION	5
Poor quality sleep	5
PO2 DECREASED	5
PLANTAR FASCIITIS	5
PHOTOPHOBIA	5
PERIPHERAL COLDNESS	5
Pathogen resistance	5
PANCREATIC CARCINOMA	5
Otitis media	5
Onychoclasis	5
OESOPHAGEAL CANDIDIASIS	5
ODYNOPHAGIA	5
OCCULT BLOOD POSITIVE	5
OBSTRUCTIVE AIRWAYS DISORDER	5
NECROTISING FASCIITIS	5
NECK MASS	5
MYOPATHY	5
MYASTHENIA GRAVIS	5
Multiple fractures	5
METRORRHAGIA	5
Metastases to meninges	5
Metabolic surgery	5
MENORRHAGIA	5
MENINGITIS ASEPTIC	5
Maternal exposure timing unspecified	5
MATERNAL DRUGS AFFECTING FOETUS	5
MALNUTRITION	5
MACULOPATHY	5
LUNG ADENOCARCINOMA	5
Low density lipoprotein increased	5
LIVEDO RETICULARIS	5
Limb operation	5
Lepromatous leprosy	5
Latent tuberculosis	5
LARGE INTESTINAL ULCER	5
Kidney infection	5
Joint noise	5
Infectious pleural effusion	5
Incorrect route of product administration	5
Immune reconstitution inflammatory syndrome	5
HYPOVOLAEMIC SHOCK	5
HYPERPLASIA	5
HYPERGLYCAEMIA	5
HYPERAESTHESIA	5
HEPATITIS FULMINANT	5
Hepatitis E	5
HEPATIC NEOPLASM	5
HEAD INJURY	5
HAEMORRHOIDS	5
GLOMERULAR FILTRATION RATE DECREASED	5
GINGIVITIS	5
GASTRIC CANCER	5
Frequent bowel movements	5
Foot operation	5
Fine motor skill dysfunction	5
FEELING COLD	5
FAECES PALE	5
ERECTILE DYSFUNCTION	5
EPILEPSY	5
Enterocutaneous fistula	5
ENTEROCOLITIS	5
ENTEROCOCCAL INFECTION	5
Endodontic procedure	5
EMOTIONAL DISTRESS	5
DRUG LEVEL INCREASED	5
DIARRHOEA HAEMORRHAGIC	5
Diabetic ketoacidosis	5
DERMATOSIS	5
DENTAL CARIES	5
DEFAECATION URGENCY	5
CYANOSIS	5
COVID-19 pneumonia	5
Contraindication to medical treatment	5
COMPUTERISED TOMOGRAM ABNORMAL	5
COLITIS COLLAGENOUS	5
Chronic gastritis	5
Caudal regression syndrome	5
CARDIOVASCULAR DISORDER	5
CARDIAC FAILURE CHRONIC	5
C-REACTIVE PROTEIN DECREASED	5
C-reactive protein	5
BLOOD TRIGLYCERIDES INCREASED	5
BLOOD PRESSURE ABNORMAL	5
BLOOD GLUCOSE FLUCTUATION	5
BLOOD AMYLASE INCREASED	5
Axonal neuropathy	5
ATAXIA	5
ASPERGILLOSIS	5
AREFLEXIA	5
Antibody test positive	5
ANOSMIA	5
ANAEMIA MEGALOBLASTIC	5
Amyotrophic lateral sclerosis	5
AMMONIA INCREASED	5
ALVEOLITIS	5
Allergy to chemicals	5
Activities of daily living impaired	5
ACTINIC KERATOSIS	5
Accident	5
ABORTION MISSED	5
ABASIA	5
Wrong technique in product usage process	4
WRIST SURGERY	4
Wheelchair user	4
WALKING DISABILITY	4
Vitamin D deficiency	4
VITAMIN B12 DEFICIENCY	4
VIITH NERVE PARALYSIS	4
VENTRICULAR TACHYCARDIA	4
Ventricular septal defect	4
VENTRICULAR HYPOKINESIA	4
VENTRICULAR HYPERTROPHY	4
URINE ABNORMALITY	4
Urinary retention	4
URINARY INCONTINENCE	4
Ulcerative keratitis	4
TROPONIN INCREASED	4
TOXIC SKIN ERUPTION	4
Tooth extraction	4
THERAPEUTIC RESPONSE UNEXPECTED WITH DRUG SUBSTITUTION	4
THERAPEUTIC RESPONSE UNEXPECTED	4
Temperature intolerance	4
T-CELL LYMPHOMA	4
SYSTEMIC INFLAMMATORY RESPONSE SYNDROME	4
Swollen joint count increased	4
Surgical failure	4
SUICIDE ATTEMPT	4
SUBCUTANEOUS ABSCESS	4
Stoma site ulcer	4
SPONDYLITIS	4
Spinal operation	4
Spinal instability	4
Spinal fracture	4
Spinal cord infection	4
Spina bifida occulta	4
Smear cervix abnormal	4
SLUGGISHNESS	4
Skin hypopigmentation	4
Skin abrasion	4
Sinusitis bacterial	4
SINUS DISORDER	4
RIB FRACTURE	4
RHONCHI	4
RHINITIS ALLERGIC	4
RHINITIS	4
RHEUMATOID VASCULITIS	4
Rheumatoid factor negative	4
RETINAL HAEMORRHAGE	4
RESPIRATORY RATE INCREASED	4
Renal cancer	4
REFLUX OESOPHAGITIS	4
PURULENT DISCHARGE	4
Pulmonary artery thrombosis	4
PSYCHIATRIC SYMPTOM	4
Product dose omission issue	4
Prescribed underdose	4
Prerenal failure	4
Premature delivery	4
Postpartum haemorrhage	4
PORTAL HYPERTENSION	4
Poor venous access	4
POLYURIA	4
PNEUMONIA CYTOMEGALOVIRAL	4
PNEUMOMEDIASTINUM	4
Pierre Robin syndrome	4
Pharyngitis streptococcal	4
PERIPHERAL VASCULAR DISORDER	4
PERIODONTAL DISEASE	4
PELVIC PAIN	4
PARAPARESIS	4
Osteoporotic fracture	4
OESOPHAGITIS	4
OCULAR ICTERUS	4
Nonalcoholic fatty liver disease	4
Nightmare	4
NEUTROPHILIA	4
NEUTROPENIC SEPSIS	4
NERVOUSNESS	4
NERVE COMPRESSION	4
NEPHRITIS INTERSTITIAL	4
Neovascularisation	4
NAIL PSORIASIS	4
Muscle twitching	4
MUSCLE STRAIN	4
Multiple allergies	4
MUCOUS MEMBRANE DISORDER	4
Mucosal dryness	4
Motor dysfunction	4
Mood swings	4
Mineral metabolism disorder	4
Middle insomnia	4
MICROCYTIC ANAEMIA	4
METASTASES TO LIVER	4
MEAN CELL HAEMOGLOBIN CONCENTRATION DECREASED	4
MASS	4
Malabsorption	4
LYMPHOPROLIFERATIVE DISORDER	4
LYMPHADENOPATHY MEDIASTINAL	4
LUNG CONSOLIDATION	4
LUNG CANCER METASTATIC	4
LEUKOENCEPHALOPATHY	4
LEFT VENTRICULAR FAILURE	4
LACTIC ACIDOSIS	4
KERATITIS	4
KAPOSI'S SARCOMA	4
Juvenile idiopathic arthritis	4
Joint space narrowing	4
Joint lock	4
Joint contracture	4
Joint ankylosis	4
Investigation abnormal	4
Intraocular pressure increased	4
INTESTINAL OBSTRUCTION	4
INTESTINAL ISCHAEMIA	4
Injection site induration	4
Infrequent bowel movements	4
Infection susceptibility increased	4
INFARCTION	4
HYPOVOLAEMIA	4
Hyporeflexia	4
Hypogeusia	4
HYPERTHERMIA	4
Hyperpyrexia	4
HYPERAMMONAEMIA	4
HLA-B*27 positive	4
HIP FRACTURE	4
HEPATITIS VIRAL	4
HEPATITIS C	4
HEPATIC CONGESTION	4
HEMIPLEGIA	4
Heart block congenital	4
Hand fracture	4
HAEMOTHORAX	4
Haemophagocytic lymphohistiocytosis	4
HAEMOLYTIC URAEMIC SYNDROME	4
HAEMOGLOBIN INCREASED	4
HAEMODYNAMIC INSTABILITY	4
HAEMATOMA	4
Granulomatous dermatitis	4
GRAND MAL CONVULSION	4
Gastric polyps	4
Gastric bypass	4
Furuncle	4
FOETAL DEATH	4
Fibula fracture	4
Facial paralysis	4
Eye haemorrhage	4
ESCHERICHIA BACTERAEMIA	4
ERYTHEMA NODOSUM	4
Erythema elevatum diutinum	4
EOSINOPHIL PERCENTAGE INCREASED	4
DYSPNOEA EXACERBATED	4
DYSKINESIA	4
DYSAESTHESIA	4
DIVERTICULUM INTESTINAL	4
DIVERTICULAR PERFORATION	4
DILATATION VENTRICULAR	4
DIFFUSE LARGE B-CELL LYMPHOMA	4
DIABETES MELLITUS INADEQUATE CONTROL	4
Depressed mood	4
DEMENTIA	4
DECREASED IMMUNE RESPONSIVENESS	4
DECREASED ACTIVITY	4
Cytomegalovirus infection reactivation	4
Cytology abnormal	4
Contraindicated product prescribed	4
CONGENITAL NOSE MALFORMATION	4
Computerised tomogram thorax abnormal	4
COLLAPSE OF LUNG	4
Chondropathy	4
CHOLURIA	4
Cholecystitis acute	4
Cerebral disorder	4
Cerebellar ataxia	4
BREECH PRESENTATION	4
Bone swelling	4
Bone cyst	4
BLOOD URIC ACID DECREASED	4
BLOOD UREA DECREASED	4
BLOOD PRESSURE DIASTOLIC DECREASED	4
BLOOD FIBRINOGEN INCREASED	4
BLOOD CALCIUM DECREASED	4
BLOOD ALKALINE PHOSPHATASE ABNORMAL	4
BLADDER CANCER	4
BIOPSY LIVER ABNORMAL	4
BILIRUBIN CONJUGATED INCREASED	4
BILE DUCT STONE	4
Bicytopenia	4
BENIGN PROSTATIC HYPERPLASIA	4
AUTOIMMUNE DISORDER	4
ATRIAL FLUTTER	4
Atlantoaxial instability	4
APPENDICITIS PERFORATED	4
ANURIA	4
Antiphospholipid syndrome	4
Ankle deformity	4
Anger	4
AMENORRHOEA	4
AMAUROSIS	4
Altered state of consciousness	4
ALCOHOL USE	4
AFFECTIVE DISORDER	4
ACUTE PULMONARY OEDEMA	4
ACCIDENTAL OVERDOSE	4
ABSCESS JAW	4
Zinc deficiency	3
Wrist deformity	3
Wound decomposition	3
WOUND COMPLICATION	3
White blood cell count abnormal	3
Walking aid user	3
Vulvovaginal mycotic infection	3
VITAL CAPACITY DECREASED	3
VENTRICULAR DYSFUNCTION	3
VENOUS THROMBOSIS	3
Vasculitis cerebral	3
Varices oesophageal	3
Urticarial vasculitis	3
URINE OUTPUT DECREASED	3
UPPER RESPIRATORY TRACT INFLAMMATION	3
UPPER LIMB FRACTURE	3
Trichodysplasia spinulosa	3
Transitional cell carcinoma	3
TRACHEOSTOMY	3
TRACHEOBRONCHITIS	3
TRACHEITIS	3
Tooth loss	3
THYROID FUNCTION TEST ABNORMAL	3
THYROID CANCER	3
THROMBOCYTOPENIC PURPURA	3
THROAT IRRITATION	3
Thiopurine methyltransferase decreased	3
Therapy partial responder	3
Therapeutic response shortened	3
Therapeutic response changed	3
Therapeutic product ineffective	3
Teratogenicity	3
Swelling of eyelid	3
SUBCUTANEOUS EMPHYSEMA	3
Stress fracture	3
Stillbirth	3
Still's disease	3
Staphylococcal abscess	3
Spinal meningioma benign	3
Soft tissue disorder	3
SMALL FOR DATES BABY	3
Skin swelling	3
Skin laceration	3
Skin erosion	3
Sinus operation	3
SEROMA	3
SENSORY LOSS	3
Sensorimotor disorder	3
Rosacea	3
RETROPERITONEAL ABSCESS	3
Retinal degeneration	3
RETCHING	3
RESUSCITATION	3
RESPIRATORY ARREST	3
RENAL TUBULAR NECROSIS	3
Renal neoplasm	3
RENAL MASS	3
RENAL CELL CARCINOMA STAGE UNSPECIFIED	3
REFUSAL OF TREATMENT BY PATIENT	3
RECTAL CANCER	3
Rebound effect	3
Quadriplegia	3
Puncture site haemorrhage	3
Pulmonary veno-occlusive disease	3
Pulmonary sepsis	3
PULMONARY ALVEOLAR HAEMORRHAGE	3
PSYCHOTIC DISORDER	3
PSOAS ABSCESS	3
Pruritus allergic	3
PROTHROMBIN TIME SHORTENED	3
Prothrombin level decreased	3
PROTEIN TOTAL INCREASED	3
Product label confusion	3
Procedural pain	3
PRE-ECLAMPSIA	3
Pneumonia viral	3
PNEUMONIA LEGIONELLA	3
PNEUMONIA ASPIRATION	3
PNEUMOCYSTIS CARINII PNEUMONIA	3
Pleuropericarditis	3
PLATELET COUNT ABNORMAL	3
PITTING OEDEMA	3
Pigmentation disorder	3
PHLEBITIS	3
Pharyngeal abscess	3
PHARMACEUTICAL PRODUCT COMPLAINT	3
Personality change	3
PERITONITIS BACTERIAL	3
PERFORMANCE STATUS DECREASED	3
Ovarian cyst ruptured	3
OVARIAN CYST	3
OSTEOLYSIS	3
Osteochondrosis	3
ORGAN FAILURE	3
Oral mucosal blistering	3
Oral disorder	3
Ophthalmic herpes zoster	3
Oesophageal atresia	3
Ocular hypertension	3
NORMAL PRESSURE HYDROCEPHALUS	3
NO ADVERSE EFFECT	3
NO ADVERSE DRUG EFFECT	3
NEUROMYOPATHY	3
Nerve injury	3
Nail pitting	3
Nail dystrophy	3
MYELITIS TRANSVERSE	3
MYDRIASIS	3
Mycobacterium avium complex infection	3
MUSCULOSKELETAL CHEST PAIN	3
MUSCLE SPASTICITY	3
MUSCLE ENZYME INCREASED	3
MUSCLE CRAMP	3
Muscle atrophy	3
MULTIPLE SCLEROSIS	3
Mucous stools	3
MOUTH HAEMORRHAGE	3
MICTURITION URGENCY	3
MICROANGIOPATHIC HAEMOLYTIC ANAEMIA	3
METASTASES TO LUNG	3
Metastases to kidney	3
Metastases to adrenals	3
Mental disorder due to a general medical condition	3
Meniscus injury	3
Meningitis pneumococcal	3
Meniere's disease	3
MEGAKARYOCYTES ABNORMAL	3
MEAN CELL HAEMOGLOBIN INCREASED	3
Mammoplasty	3
Malignant neoplasm of conjunctiva	3
Macule	3
MACROCYTOSIS	3
LYMPHOCYTE COUNT INCREASED	3
Lung opacity	3
Loose body in joint	3
LIVER ABSCESS	3
Live birth	3
LIMB INJURY	3
LEUKAEMIA	3
LEG AMPUTATION	3
LEFT VENTRICULAR DYSFUNCTION	3
KLEBSIELLA INFECTION	3
KETOACIDOSIS	3
JUGULAR VEIN DISTENSION	3
ISCHAEMIC HEPATITIS	3
ISCHAEMIA	3
Iron deficiency	3
Iritis	3
Intestinal ulcer	3
INTESTINAL HAEMORRHAGE	3
Intervertebral disc operation	3
Intervertebral disc disorder	3
Intervertebral disc compression	3
INTERNATIONAL NORMALISED RATIO DECREASED	3
INTENTIONAL DRUG MISUSE	3
Injection site warmth	3
Infiltration anaesthesia	3
INFECTED SKIN ULCER	3
Immune-mediated myositis	3
ILEUS PARALYTIC	3
IDIOPATHIC THROMBOCYTOPENIC PURPURA	3
HYPOPHAGIA	3
Hypertrophy	3
HYPERGAMMAGLOBULINAEMIA BENIGN MONOCLONAL	3
Hyperferritinaemia	3
HYPERCOAGULATION	3
HYPERAEMIA	3
Hydrocele	3
HUMERUS FRACTURE	3
Human polyomavirus infection	3
HODGKIN'S DISEASE STAGE III	3
Hip surgery	3
Herpes ophthalmic	3
HERNIA	3
HEPATIC ISCHAEMIA	3
HEPATIC CYST	3
Heavy menstrual bleeding	3
HEARING IMPAIRED	3
HALLUCINATION, VISUAL	3
HALLUCINATION, AUDITORY	3
HAEMORRHAGIC DIATHESIS	3
HAEMORRHAGE INTRACRANIAL	3
HAEMOLYSIS	3
HAEMODIALYSIS	3
HAEMOCHROMATOSIS	3
GLOSSITIS	3
GINGIVAL PAIN	3
GASTROINTESTINAL ULCER	3
Gastrointestinal inflammation	3
Gastrointestinal infection	3
GASTROINTESTINAL CANDIDIASIS	3
GASTRIC ULCER HAEMORRHAGE	3
GALLBLADDER CANCER	3
FUNGAEMIA	3
Folate deficiency	3
FOETAL GROWTH RETARDATION	3
Foetal growth restriction	3
FINGER AMPUTATION	3
FIBRIN D DIMER INCREASED	3
Facial paresis	3
FACIAL PALSY	3
EYE SWELLING	3
Eye operation	3
Exposed bone in jaw	3
EXCORIATION	3
Escherichia sepsis	3
EPSTEIN-BARR VIRUS INFECTION	3
ENTEROCOLITIS HAEMORRHAGIC	3
ENTERITIS	3
Energy increased	3
ENDOMETRIAL CANCER	3
ELECTROCARDIOGRAM ST SEGMENT ABNORMAL	3
Effusion	3
ECTOPIC PREGNANCY	3
DYSPHORIA	3
DYSMORPHISM	3
Dupuytren's contracture	3
Drug use disorder	3
DRUG LEVEL DECREASED	3
Drug effect delayed	3
Drug dose omission	3
DIVERTICULUM	3
DIFFICULTY IN WALKING	3
Diabetic neuropathy	3
Diabetic eye disease	3
DERMATITIS PSORIASIFORM	3
DEMYELINATING POLYNEUROPATHY	3
Cytomegalovirus chorioretinitis	3
CONJUNCTIVAL HYPERAEMIA	3
CONJUNCTIVAL HAEMORRHAGE	3
COLD SWEAT	3
Coeliac disease	3
Coccidioidomycosis	3
Clear cell renal cell carcinoma	3
CHOLECYSTITIS INFECTIVE	3
CERVIX CARCINOMA	3
Cat scratch disease	3
Carditis	3
CARDIOTOXICITY	3
BUNDLE BRANCH BLOCK LEFT	3
BRONCHOPLEURAL FISTULA	3
BREAST MASS	3
Breast cancer stage III	3
Bone marrow infiltration	3
BODY TEMPERATURE DECREASED	3
BLOOD THYROID STIMULATING HORMONE DECREASED	3
BLOOD LACTATE DEHYDROGENASE DECREASED	3
Blood iron abnormal	3
BLOOD IMMUNOGLOBULIN G DECREASED	3
Blood count abnormal	3
BLOOD CHLORIDE INCREASED	3
BLOOD BLISTER	3
BLINDNESS UNILATERAL	3
BLADDER DISORDER	3
Bipolar disorder	3
BILIARY CIRRHOSIS PRIMARY	3
BASOPHIL COUNT INCREASED	3
BACTERIURIA	3
AZOTAEMIA	3
ATROPHY	3
Aspergillus infection	3
Aplasia cutis congenita	3
AORTIC STENOSIS	3
Ankle fracture	3
Ankle arthroplasty	3
ANGINA UNSTABLE	3
AMYLOIDOSIS	3
Amylase increased	3
Alopecia areata	3
Adenocarcinoma gastric	3
ADENOCARCINOMA	3
ACUTE INTERSTITIAL PNEUMONITIS	3
ACUTE GENERALISED EXANTHEMATOUS PUSTULOSIS	3
ACUTE FEBRILE NEUTROPHILIC DERMATOSIS	3
ACIDOSIS	3
Abscess soft tissue	3
ABSCESS INTESTINAL	3
ABNORMAL FAECES	3
ABDOMINAL RIGIDITY	3
ABDOMINAL PAIN LOWER	3
ABDOMINAL ABSCESS	3
Wrist fracture	2
WOUND INFECTION STAPHYLOCOCCAL	2
Whipple's disease	2
Weight bearing difficulty	2
VOCAL CORD PARALYSIS	2
VITAMIN K DEFICIENCY	2
Visceral leishmaniasis	2
Viral pharyngitis	2
VIRAEMIA	2
Verbal abuse	2
VENTRICULAR FIBRILLATION	2
VENOUS THROMBOSIS LIMB	2
VASCULITIS NECROTISING	2
VARICOSE VEIN	2
Vaginal ulceration	2
Vaginal infection	2
Uterine haemorrhage	2
Uterine atony	2
URINE KETONE BODY PRESENT	2
URINE ANALYSIS ABNORMAL	2
Urinary tract obstruction	2
Urinary hesitation	2
Ureaplasma infection	2
UNINTENDED PREGNANCY	2
Underweight	2
Underdose	2
ULTRASOUND SCAN ABNORMAL	2
ULCER HAEMORRHAGE	2
TYPE 1 DIABETES MELLITUS	2
Tubo-ovarian abscess	2
Traumatic lung injury	2
Transaminases abnormal	2
Tracheo-oesophageal fistula	2
Toxic neuropathy	2
TOTAL LUNG CAPACITY DECREASED	2
Tongue oedema	2
TONGUE DISCOLOURATION	2
Toe operation	2
THYROXINE INCREASED	2
Thyroid hormones increased	2
THROMBOTIC THROMBOCYTOPENIC PURPURA	2
Thrombocytosis	2
THREATENED LABOUR	2
Therapy cessation	2
Therapeutic product effect delayed	2
Terminal state	2
Tendon pain	2
Tender joint count increased	2
Taste disorder	2
Talipes	2
Takayasu's arteritis	2
SYSTEMIC LUPUS ERYTHEMATOSUS RASH	2
SYSTEMIC CANDIDA	2
Swollen joint count	2
SUTURE RELATED COMPLICATION	2
SUPRAVENTRICULAR TACHYCARDIA	2
SUPERINFECTION	2
Sudden hearing loss	2
Sudden death	2
Substance-induced psychotic disorder	2
Subdural haemorrhage	2
SUBDURAL HAEMATOMA	2
Subacute cutaneous lupus erythematosus	2
Strongyloidiasis	2
Stress ulcer	2
STRESS SYMPTOMS	2
Stress at work	2
STOMACH DISCOMFORT	2
Stenosis	2
STATUS EPILEPTICUS	2
STAPHYLOCOCCAL BACTERAEMIA	2
SPUTUM PURULENT	2
Splenic infection bacterial	2
Splenic abscess	2
Soft tissue swelling	2
SKIN TOXICITY	2
SKIN ODOUR ABNORMAL	2
SKIN NODULE	2
SKIN HYPERTROPHY	2
Sinus pain	2
Sinus congestion	2
Sinonasal papilloma	2
SHOULDER DYSTOCIA	2
Sexually transmitted disease	2
SEPTIC ARTHRITIS STAPHYLOCOCCAL	2
SENSITIVITY OF TEETH	2
SENSATION OF HEAVINESS	2
SELF-MEDICATION	2
SEBORRHOEIC KERATOSIS	2
SCLERITIS	2
SARS-CoV-2 test negative	2
SARCOMA	2
Salt craving	2
Saccadic eye movement	2
Rotator cuff repair	2
Root canal infection	2
RIGHT VENTRICULAR SYSTOLIC PRESSURE INCREASED	2
Rheumatoid meningitis	2
Rheumatoid factor	2
Rheumatic disorder	2
RETINOPATHY HYPERTENSIVE	2
Retinal vein occlusion	2
RETINAL DISORDER	2
RESTRICTIVE PULMONARY DISEASE	2
RESTRICTIVE CARDIOMYOPATHY	2
RESTLESSNESS	2
Respiratory tract infection viral	2
RESPIRATORY DEPRESSION	2
RENAL TRANSPLANT	2
RENAL CELL CARCINOMA STAGE III	2
Renal aplasia	2
RENAL ABSCESS	2
Rectal adenocarcinoma	2
QRS AXIS ABNORMAL	2
Q fever	2
PYOTHORAX	2
Pyopneumothorax	2
PYELONEPHRITIS ACUTE	2
PURULENCE	2
PULMONARY VASCULITIS	2
Pulmonary thrombosis	2
PULMONARY HAEMORRHAGE	2
PULMONARY EOSINOPHILIA	2
Pseudobulbar palsy	2
PROTHROMBIN TIME ABNORMAL	2
PROSTATITIS	2
Product prescribing issue	2
Product prescribing error	2
Product monitoring error	2
PROCEDURAL COMPLICATION	2
Procalcitonin increased	2
Primary biliary cholangitis	2
Presyncope	2
Presbyopia	2
Presbyacusis	2
PREMATURE SEPARATION OF PLACENTA	2
PREMATURE MENOPAUSE	2
POST-TRAUMATIC STRESS DISORDER	2
POST PROCEDURAL HAEMORRHAGE	2
Porphyria	2
POLYDIPSIA	2
PNEUMONIA PNEUMOCOCCAL	2
PNEUMONIA FUNGAL	2
Pneumocystis jirovecii infection	2
PNEUMOCYSTIS JIROVECI INFECTION	2
PNEUMOCYSTIS CARINII INFECTION	2
Pleural thickening	2
PHOTOPSIA	2
Phobia	2
Phlebectomy	2
PERITONEAL CARCINOMA	2
Peripheral venous disease	2
PERIPHERAL OCCLUSIVE DISEASE	2
Peripheral motor neuropathy	2
Peripheral artery occlusion	2
PERIORBITAL OEDEMA	2
Perineal disorder	2
Perinatal depression	2
Pericardial mass	2
Pelvic prolapse	2
PELVIC FRACTURE	2
PCO2 DECREASED	2
Parotid gland enlargement	2
PANIC ATTACK	2
PANCREATITIS NECROTISING	2
PANCREATITIS CHRONIC	2
Pain of skin	2
OVARIAN EPITHELIAL CANCER	2
Otitis externa	2
Orthosis user	2
Orbital myositis	2
Oral pustule	2
ORAL INTAKE REDUCED	2
Oral fungal infection	2
OPTIC NEUROPATHY	2
OPTIC NEURITIS	2
OPPORTUNISTIC INFECTION	2
Onychomycosis	2
ONYCHOMADESIS	2
Onycholysis	2
OLIGOHYDRAMNIOS	2
OESOPHAGEAL CARCINOMA	2
Occupational exposure to product	2
NO THERAPEUTIC RESPONSE	2
Nikolsky's sign	2
Neurotoxicity	2
Neuropathic arthropathy	2
Nerve root compression	2
Nephropathy toxic	2
NEPHROPATHY	2
NEOPLASM	2
NEONATAL RESPIRATORY DISTRESS SYNDROME	2
Necrotising myositis	2
NECROBIOSIS	2
Neck surgery	2
Nasal ulcer	2
Nasal discomfort	2
Nasal crusting	2
Myopia	2
MYOCLONUS	2
Myocardial ischaemia	2
MUSCLE RUPTURE	2
Muscle abscess	2
MULTI-ORGAN DISORDER	2
MUCOSAL EROSION	2
MOUTH INJURY	2
MONOPARESIS	2
MONOCYTOSIS	2
MONOCYTE PERCENTAGE INCREASED	2
MITRAL VALVE PROLAPSE	2
Migraine with aura	2
METAPLASIA	2
MENTAL IMPAIRMENT	2
Meningomyelocele	2
MENINGITIS TUBERCULOUS	2
MENINGITIS CRYPTOCOCCAL	2
MENINGIOMA	2
MEIGS' SYNDROME	2
MEDIASTINITIS	2
MEAN CELL VOLUME INCREASED	2
Mastoid abscess	2
Mass excision	2
MAJOR DEPRESSION	2
Lymphocytic infiltration	2
LYMPHOCYTE STIMULATION TEST POSITIVE	2
Lymphocyte morphology abnormal	2
LYMPHANGIOMA	2
LYMPH NODE TUBERCULOSIS	2
LYME DISEASE	2
LUNG INJURY	2
LUNG CREPITATION	2
LUMBAR VERTEBRAL FRACTURE	2
Loose tooth	2
LIPIDS INCREASED	2
Ligament sprain	2
Lichenoid keratosis	2
Left ventricular hypertrophy	2
LEFT ATRIAL DILATATION	2
Laryngeal disorder	2
Large intestine polyp	2
LARGE INTESTINAL HAEMORRHAGE	2
Lacrimation increased	2
LABORATORY TEST INTERFERENCE	2
LABILE BLOOD PRESSURE	2
Kidney transplant rejection	2
Joint warmth	2
Joint surgery	2
Joint laxity	2
Joint instability	2
Joint dislocation reduction	2
Iron binding capacity total decreased	2
Intra-abdominal fluid collection	2
International normalised ratio fluctuation	2
Intentional overdose	2
INJURY ASPHYXIATION	2
INJECTION SITE HAEMORRHAGE	2
Inguinal hernia repair	2
INGUINAL HERNIA	2
Infective myositis	2
Infective exacerbation of chronic obstructive airways disease	2
INFECTION IN AN IMMUNOCOMPROMISED HOST	2
INDURATION	2
INCREASED UPPER AIRWAY SECRETION	2
IMPAIRED SELF-CARE	2
Impaired quality of life	2
IMPAIRED DRIVING ABILITY	2
Immunoglobulins decreased	2
Immune thrombocytopenic purpura	2
IMMUNE RECONSTITUTION SYNDROME	2
Immobilisation syndrome	2
Idiopathic pulmonary fibrosis	2
HYPOURICAEMIA	2
Hypothermia	2
Hypopyon	2
Hypopnoea	2
HYPOPHOSPHATAEMIA	2
HYPOMAGNESAEMIA	2
HYPOAESTHESIA ORAL	2
HYPERVENTILATION	2
Hyperuricaemia	2
HYPERTRICHOSIS	2
Hyperphosphataemia	2
Hyperphagia	2
Hypergammaglobulinaemia	2
Human herpesvirus 6 encephalitis	2
HTLV-1 carrier	2
HIRSUTISM	2
HIDRADENITIS	2
Herpes simplex oesophagitis	2
Hepatitis B DNA increased	2
HEPATITIS A	2
HEPATIC INFARCTION	2
Hepatic cytolysis	2
HEMIANOPIA HOMONYMOUS	2
HEART SOUNDS ABNORMAL	2
Head discomfort	2
HAEMORRHAGIC STROKE	2
Haemorrhagic disorder	2
HAEMOGLOBIN ABNORMAL	2
Haemangioma of liver	2
Groin abscess	2
Granulomatosis with polyangiitis	2
Granuloma annulare	2
GRANULOCYTOPENIA	2
GLOMERULONEPHRITIS RAPIDLY PROGRESSIVE	2
GLIOBLASTOMA	2
Gestational diabetes	2
Genital hypoaesthesia	2
Genital herpes simplex	2
Generalised anxiety disorder	2
Gastrointestinal sounds abnormal	2
GASTROINTESTINAL PAIN	2
GASTROINTESTINAL EROSION	2
Gastrointestinal carcinoma	2
GASTRITIS HAEMORRHAGIC	2
Gastritis erosive	2
GASTRIC ULCER PERFORATION	2
Gastrectomy	2
Fournier's gangrene	2
FEMORAL NECK FRACTURE	2
Felty's syndrome	2
FAT NECROSIS	2
Faecal incontinence	2
Facet joint syndrome	2
Eyelid ptosis	2
EYELID OEDEMA	2
EYELID DISORDER	2
Eye abscess	2
EXTRASYSTOLES	2
Extrapyramidal disorder	2
Extranodal marginal zone B-cell lymphoma (MALT type)	2
Exposure via partner	2
Exposure to communicable disease	2
EXERCISE TOLERANCE DECREASED	2
Ewing's sarcoma	2
ESCHAR	2
EROSIVE OESOPHAGITIS	2
Episcleritis	2
Epigastric discomfort	2
Epididymitis	2
Epidermal necrosis	2
EOSINOPHIL COUNT ABNORMAL	2
Enzyme level abnormal	2
Enzyme abnormality	2
ENTEROBACTER INFECTION	2
Endometriosis	2
Emphysematous cystitis	2
Electrocardiogram QT prolonged	2
Ecthyma	2
Dyshidrotic eczema	2
Duodenitis	2
DRY THROAT	2
Drug specific antibody present	2
Drug monitoring procedure not performed	2
DIZZINESS POSTURAL	2
Disease complication	2
DILATATION ATRIAL	2
Diffuse large B-cell lymphoma stage II	2
DIFFUSE ALVEOLAR DAMAGE	2
DIABETIC FOOT	2
Device related infection	2
Device occlusion	2
Dermo-hypodermitis	2
DERMATOMYOSITIS	2
Dependence	2
DELUSION	2
Deep vein thrombosis postoperative	2
DECUBITUS ULCER	2
Cytomegalovirus colitis	2
Cystitis escherichia	2
Cutaneous sarcoidosis	2
CULTURE URINE POSITIVE	2
CRYPTOCOCCOSIS	2
CREATININE RENAL CLEARANCE DECREASED	2
Craniosynostosis	2
CRACKLES LUNG	2
CORYNEBACTERIUM INFECTION	2
Coronavirus infection	2
CORONARY ARTERY STENOSIS	2
CORONARY ARTERY BYPASS	2
Corneal scar	2
CONNECTIVE TISSUE DISORDER	2
CONGENITAL MUSCULOSKELETAL ANOMALY	2
Congenital cardiovascular anomaly	2
Congenital arterial malformation	2
Conduction disorder	2
COMPLICATIONS OF MATERNAL EXPOSURE TO THERAPEUTIC DRUGS	2
COMA HEPATIC	2
Colonic abscess	2
Colon cancer metastatic	2
COLLAGEN DISORDER	2
Clostridium difficile colitis	2
Chronic sinusitis	2
CHRONIC MYELOMONOCYTIC LEUKAEMIA	2
CHRONIC HEPATITIS	2
Chorioretinal scar	2
Chondrodystrophy	2
Cholestatic liver injury	2
CHOLECYSTITIS CHRONIC	2
Cholangiolitis	2
Cheilitis	2
CEREBRAL VENTRICLE DILATATION	2
CEREBRAL VASOCONSTRICTION	2
Cerebral sarcoidosis	2
CEREBRAL PALSY	2
CEREBRAL ISCHAEMIA	2
CEREBRAL ARTERY EMBOLISM	2
Cerebellar syndrome	2
Central nervous system vasculitis	2
Central nervous system lesion	2
Cellulitis gangrenous	2
Cataract operation	2
Cartilage injury	2
Carotid artery stenosis	2
Carotid artery occlusion	2
Carotid artery disease	2
CARDIAC TAMPONADE	2
CARDIAC OUTPUT DECREASED	2
CARDIAC FAILURE ACUTE	2
CARCINOEMBRYONIC ANTIGEN INCREASED	2
Candida osteomyelitis	2
BUTTERFLY RASH	2
BURSITIS INFECTIVE	2
BRONCHOPNEUMOPATHY	2
BRAIN STEM INFARCTION	2
BRAIN NATRIURETIC PEPTIDE INCREASED	2
BONE MARROW DISORDER	2
Body height decreased	2
Blood selenium decreased	2
BLOOD PRESSURE DIASTOLIC INCREASED	2
BLOOD PH INCREASED	2
BLOOD PH DECREASED	2
Blood magnesium increased	2
BLOOD IMMUNOGLOBULIN M INCREASED	2
BLOOD GLUCOSE DECREASED	2
BLOOD CULTURE POSITIVE	2
BLOOD CREATININE ABNORMAL	2
Blood cholesterol abnormal	2
BLOOD CHLORIDE DECREASED	2
BLOOD BICARBONATE DECREASED	2
Blindness transient	2
BLEPHARITIS	2
BLADDER NEOPLASM	2
Bladder irritation	2
BK virus infection	2
BIOPSY LUNG ABNORMAL	2
BILE DUCT CANCER	2
BETA HAEMOLYTIC STREPTOCOCCAL INFECTION	2
BAND NEUTROPHIL PERCENTAGE INCREASED	2
BACTERIA URINE IDENTIFIED	2
Axial spondyloarthritis	2
ATYPICAL MYCOBACTERIAL INFECTION	2
Atrophic vulvovaginitis	2
ATRIOVENTRICULAR BLOCK COMPLETE	2
ATRIOVENTRICULAR BLOCK	2
Atrial thrombosis	2
Aspartate aminotransferase abnormal	2
ASEPTIC NECROSIS BONE	2
Apraxia	2
Appetite disorder	2
APLASIA PURE RED CELL	2
AORTIC VALVE SCLEROSIS	2
AORTIC VALVE INCOMPETENCE	2
ANTINEUTROPHIL CYTOPLASMIC ANTIBODY POSITIVE	2
ANTI-HBS ANTIBODY POSITIVE	2
ANGIOPATHY	2
ANGIONEUROTIC OEDEMA	2
Anal hypoaesthesia	2
Anaemia of chronic disease	2
AMNIOCENTESIS ABNORMAL	2
American trypanosomiasis	2
ALVEOLITIS ALLERGIC	2
Alveolar proteinosis	2
Allergy to metals	2
Age-related macular degeneration	2
AFFECT LABILITY	2
Adrenal disorder	2
Adenocarcinoma of colon	2
Acute hepatitis C	2
Acute abdomen	2
Acne cystic	2
ACINETOBACTER INFECTION	2
ACCELERATED HYPERTENSION	2
ABNORMAL PRODUCT OF CONCEPTION	2
ABNORMAL BEHAVIOUR	2
Abdominal symptom	2
Abdominal hernia	2
Abdominal adhesions	2
YELLOW SKIN	1
XANTHOMA	1
Wrong product administered	1
Wrong dose	1
Wound drainage	1
WOUND DEHISCENCE	1
Withdrawal syndrome	1
WHITE BLOOD CELLS URINE POSITIVE	1
WHITE BLOOD CELL DISORDER	1
WEST NILE VIRAL INFECTION	1
Weight abnormal	1
WEGENER'S GRANULOMATOSIS	1
Waldenstrom's macroglobulinaemia	1
WAIST CIRCUMFERENCE INCREASED	1
Vulvovaginitis	1
VULVOVAGINAL CANDIDIASIS	1
VULVAL DISORDER	1
VOMITING PROJECTILE	1
Vocal cord thickening	1
Vocal cord disorder	1
Vitritis infective	1
Vitritis	1
VITREOUS HAEMORRHAGE	1
VITH NERVE DISORDER	1
Vitamin D decreased	1
VITAMIN B12 INCREASED	1
VITAMIN B COMPLEX DEFICIENCY	1
VISUAL FIELD DEFECT	1
VIRAL PERICARDITIS	1
VIRAL MYOCARDITIS	1
Viral load increased	1
Violence-related symptom	1
Vestibular neuronitis	1
VENTRICULAR HYPOPLASIA	1
VENTRICULAR EXTRASYSTOLES	1
VENTRICULAR DYSKINESIA	1
VENTRICULAR ARRHYTHMIA	1
VENOUS INSUFFICIENCY	1
Vasodilatation	1
VASCULAR STENOSIS	1
Vascular skin disorder	1
Vascular resistance pulmonary increased	1
Varicella zoster virus infection	1
Vaginal laceration	1
Vaccination failure	1
UTERINE LEIOMYOMA	1
Uterine disorder	1
UTERINE CONTRACTIONS DURING PREGNANCY	1
Uterine carcinoma in situ	1
UROBILIN URINE PRESENT	1
URINE COLOUR ABNORMAL	1
URINE BILIRUBIN INCREASED	1
Urinary tract inflammation	1
URINARY TRACT INFECTION BACTERIAL	1
Urinary tract disorder	1
Urinary tract discomfort	1
URINARY OCCULT BLOOD POSITIVE	1
Urinary bladder suspension	1
Ureteric cancer recurrent	1
Ureteral stent insertion	1
URETERAL DISORDER	1
Upper respiratory tract congestion	1
UNWANTED PREGNANCY	1
UNRESPONSIVE TO VERBAL STIMULI	1
Unintentional use for unapproved indication	1
Umbilical hernia, obstructive	1
UMBILICAL HERNIA	1
UMBILICAL CORD ABNORMALITY	1
ULTRASOUND DOPPLER ABNORMAL	1
Type V hyperlipidaemia	1
Type IV hypersensitivity reaction	1
Type 2 lepra reaction	1
Tympanic membrane perforation	1
TYMPANIC MEMBRANE DISORDER	1
TWIN PREGNANCY	1
TUMOUR INVASION	1
Tumour haemorrhage	1
Tubular breast carcinoma	1
TUBERCULOSIS SKIN TEST POSITIVE	1
Tuberculin test	1
Troponin I increased	1
Trisomy 21	1
TRISOMY 13	1
Trismus	1
TRI-IODOTHYRONINE INCREASED	1
Traumatic haematoma	1
Transplant rejection	1
Transplant dysfunction	1
TRANSITIONAL CELL CANCER OF THE RENAL PELVIS AND URETER	1
Transfusion	1
TRACHEAL HAEMORRHAGE	1
Toxoplasmosis	1
TOXIC ENCEPHALOPATHY	1
Torsade de pointes	1
Tooth repair	1
Tooth injury	1
Tooth discolouration	1
Tonsillitis bacterial	1
Tonsillar hypertrophy	1
TONSIL CANCER	1
Tongue ulceration	1
TONGUE NEOPLASM MALIGNANT STAGE UNSPECIFIED	1
Tongue geographic	1
Tongue dysplasia	1
Tongue dry	1
Tongue discomfort	1
TONGUE CARCINOMA STAGE III	1
TONGUE BLISTERING	1
Tongue biting	1
Toe amputation	1
Tobacco user	1
Tinea infection	1
TINEA BLANCA	1
Tibia fracture	1
THYROXINE DECREASED	1
Thyroiditis subacute	1
Thyroid mass	1
THYROID GLAND CANCER	1
THYROID CYST	1
Thrombophlebitis	1
THROMBOCYTHAEMIA	1
Thinking abnormal	1
Thermal burn	1
Therapy change	1
Thalassaemia	1
TENSION HEADACHE	1
Tendon sheath lesion excision	1
Tendon operation	1
Tender joint count	1
Temporomandibular joint syndrome	1
TEMPORAL ARTERITIS	1
TEETH BRITTLE	1
Tachyphylaxis	1
SYSTOLIC HYPERTENSION	1
SYPHILIS	1
SYNCOPE VASOVAGAL	1
SURGICAL PROCEDURE REPEATED	1
SUPRAVENTRICULAR EXTRASYSTOLES	1
SUPERINFECTION FUNGAL	1
SUBILEUS	1
SUBCUTANEOUS NODULE	1
Subacute hepatic failure	1
STRIDOR	1
STREPTOCOCCAL SEROLOGY POSITIVE	1
STREPTOCOCCAL SEROLOGY	1
Strabismus	1
Stomach mass	1
Stent placement	1
STENOTROPHOMONAS INFECTION	1
STAPHYLOCOCCUS TEST POSITIVE	1
Squamous cell carcinoma of the oral cavity	1
SQUAMOUS CELL CARCINOMA OF SKIN	1
Squamous cell carcinoma of lung	1
SPUTUM RETENTION	1
SPUTUM CULTURE POSITIVE	1
Spontaneous haematoma	1
Spondyloarthropathy	1
SPLEEN DISORDER	1
Spinal X-ray abnormal	1
Spinal pain	1
SPINAL LAMINECTOMY	1
Spinal deformity	1
Spinal cord oedema	1
Spinal cord neoplasm	1
SPINAL CORD DISORDER	1
Spinal cord compression	1
Speech disorder developmental	1
SPECIFIC GRAVITY URINE INCREASED	1
SOLITARY KIDNEY	1
Soft tissue necrosis	1
SNEEZING	1
Small intestinal stenosis	1
SMALL INTESTINAL HAEMORRHAGE	1
Small fibre neuropathy	1
SMALL CELL LUNG CANCER STAGE UNSPECIFIED	1
SMALL CELL LUNG CANCER METASTATIC	1
Small cell lung cancer	1
Sleep disorder due to general medical condition, mixed type	1
SKULL MALFORMATION	1
Skin wound	1
Skin weeping	1
Skin warm	1
Skin turgor decreased	1
SKIN TEST POSITIVE	1
SKIN NEOPLASM EXCISION	1
Skin irritation	1
Skin injury	1
SKIN INFLAMMATION	1
Skin haemorrhage	1
Skin fragility	1
Skin fibrosis	1
Skin depigmentation	1
SKIN CANDIDA	1
Skin bacterial infection	1
Skeletal dysplasia	1
SINUSITIS FUNGAL	1
SINUS POLYP	1
Sinus headache	1
SINUS BRADYCARDIA	1
Single umbilical artery	1
Single functional kidney	1
SILICOSIS	1
SIGNET-RING CELL CARCINOMA	1
SIGMOIDITIS	1
SICK SINUS SYNDROME	1
Shoulder fracture	1
Shoulder deformity	1
SHIFT TO THE LEFT	1
Serositis	1
SEROLOGY POSITIVE	1
SEPSIS SYNDROME	1
Sensitive skin	1
SENSE OF OPPRESSION	1
Sensation of foreign body	1
Selective eating disorder	1
Secondary immunodeficiency	1
SECONDARY AMYLOIDOSIS	1
Scratch	1
Schizophrenia	1
Scaphocephaly	1
SCAN BONE MARROW ABNORMAL	1
Salpingo-oophorectomy unilateral	1
Salpingo-oophorectomy	1
Salmonellosis	1
Salmonella test positive	1
Salmonella sepsis	1
SALIVARY HYPERSECRETION	1
Salivary gland disorder	1
RIGHT VENTRICULAR HYPERTROPHY	1
RIGHT VENTRICULAR HEAVE	1
RHEUMATOID NODULE REMOVAL	1
Rhegmatogenous retinal detachment	1
Reversible cerebral vasoconstriction syndrome	1
Retrognathia	1
RETINAL VEIN THROMBOSIS	1
Retinal vascular thrombosis	1
RETINAL PIGMENT EPITHELIOPATHY	1
Retinal oedema	1
Retinal deposits	1
Reticulocytosis	1
RETICULOCYTE PERCENTAGE INCREASED	1
Respiratory alkalosis	1
RESPIRATION ABNORMAL	1
RENAL TUBULAR DISORDER	1
RENAL TUBULAR ATROPHY	1
RENAL TUBULAR ACIDOSIS	1
RENAL PAIN	1
RENAL ISCHAEMIA	1
RENAL INJURY	1
RENAL INFARCT	1
Renal haemorrhage	1
Renal cyst ruptured	1
Renal cyst infection	1
Renal colic	1
REFUSAL OF TREATMENT BY RELATIVE	1
REFRACTORY ANAEMIA	1
Red blood cell macrocytes present	1
RED BLOOD CELL COUNT ABNORMAL	1
Raynaud's phenomenon	1
Rash morbilliform	1
RADICULITIS BRACHIAL	1
RADIATION INJURY	1
Quality of life decreased	1
Quadriparesis	1
Pyuria	1
Pyomyositis	1
Pyometra	1
PYELOCALIECTASIS	1
PURULENT PERICARDITIS	1
Purpura non-thrombocytopenic	1
PUPILLARY REFLEX IMPAIRED	1
PULSE ABSENT	1
PULMONARY VALVE INCOMPETENCE	1
Pulmonary necrosis	1
Pulmonary infarction	1
PULMONARY HYPERTENSIVE CRISIS	1
Pulmonary congestion	1
PULMONARY CALCIFICATION	1
Pulmonary arterial pressure increased	1
Pterygium	1
Pseudomonas test positive	1
Pseudomonas bronchitis	1
PSEUDOMONAL SEPSIS	1
PROTHROMBIN TIME	1
PROTHROMBIN LEVEL ABNORMAL	1
PROTEUS TEST POSITIVE	1
PROTEUS INFECTION	1
PROTEIN URINE	1
PROTEIN C DECREASED	1
Prostatic specific antigen	1
PROSTATIC ADENOMA	1
Prostate infection	1
Prostate cancer recurrent	1
PROLONGED PREGNANCY	1
Progesterone receptor assay positive	1
Product quality issue	1
PRODUCT OUTER PACKAGING ISSUE	1
Product name confusion	1
Product dose omission in error	1
Product dose omission	1
Product dispensing error	1
PRODUCT COUNTERFEIT	1
Product administered at inappropriate site	1
PRIMARY PROGRESSIVE MULTIPLE SCLEROSIS	1
PRIMARY MEDIASTINAL LARGE B-CELL LYMPHOMA RECURRENT	1
Pressure of speech	1
PREGNANCY TEST POSITIVE	1
PREGNANCY TEST FALSE POSITIVE	1
PREGNANCY ON ORAL CONTRACEPTIVE	1
Pregnancy on contraceptive	1
Precancerous skin lesion	1
POSTOPERATIVE WOUND COMPLICATION	1
Postoperative respiratory failure	1
Postoperative respiratory distress	1
POSTOPERATIVE INFECTION	1
Postoperative abscess	1
Post procedural sepsis	1
POST PROCEDURAL DISCHARGE	1
Post inflammatory pigmentation change	1
POSITIVE ROMBERGISM	1
Portal fibrosis	1
PORPHYRINS URINE INCREASED	1
PORPHYRIA NON-ACUTE	1
POOR PERIPHERAL CIRCULATION	1
POLYSEROSITIS	1
Polyomavirus test positive	1
Polymerase chain reaction positive	1
POLYMENORRHOEA	1
Polycythaemia	1
Poikiloderma	1
PO2 INCREASED	1
Pneumothorax spontaneous	1
Pneumonia streptococcal	1
Pneumonia pseudomonal	1
PNEUMONIA NECROTISING	1
PNEUMONIA MYCOPLASMAL	1
Pneumonia influenzal	1
PNEUMONIA HAEMOPHILUS	1
Pneumonia cryptococcal	1
PNEUMONIA ASPERGILLUS	1
Pneumatosis intestinalis	1
PLEURITIC PAIN	1
PLEOCYTOSIS	1
Platelet disorder	1
Plasmacytoma	1
Plasma cell myeloma	1
PLACENTA PRAEVIA	1
PITYRIASIS ROSEA	1
Physical examination of joints abnormal	1
PHONOPHOBIA	1
PHLEBITIS SUPERFICIAL	1
PHARYNGEAL ERYTHEMA	1
PHARYNGEAL CANCER STAGE UNSPECIFIED	1
Phagocytosis	1
Phaeohyphomycosis	1
PETIT MAL EPILEPSY	1
Persistent depressive disorder	1
PERONEAL NERVE INJURY	1
Periumbilical abscess	1
PERITONEAL ABSCESS	1
PERIRECTAL ABSCESS	1
PERIPORTAL SINUS DILATATION	1
Peripheral ischaemia	1
Peripheral embolism	1
Periodontitis	1
Perforated ulcer	1
Percussion test abnormal	1
PENIS DISORDER	1
PENILE PAIN	1
Pemphigoid	1
Pelvi-ureteric obstruction	1
Peau d'orange	1
PARVOVIRUS B19 SEROLOGY POSITIVE	1
PARTIAL SEIZURES WITH SECONDARY GENERALISATION	1
Paronychia	1
Parkinson's disease	1
PARESIS	1
Paraplegia	1
Paranasal sinus hypersecretion	1
Paradoxical embolism	1
Paradoxical drug reaction	1
Pancreatitis relapsing	1
PANCREATIC NEOPLASM	1
PANCREATIC DISORDER	1
Pancreatic cyst	1
PANCREATIC CARCINOMA RESECTABLE	1
PALPABLE PURPURA	1
Palmar-plantar erythrodysaesthesia syndrome	1
Palate injury	1
Painful respiration	1
Painful defaecation	1
Oxygen saturation increased	1
Overwork	1
Overlap syndrome	1
OVARIAN FAILURE	1
Ovarian disorder	1
Ovarian cancer recurrent	1
Ovarian adenoma	1
Otitis media acute	1
Osteomyelitis bacterial	1
OROPHARYNGEAL SWELLING	1
Oral pigmentation	1
Oral mucosa erosion	1
Oral lichenoid reaction	1
Oral lichen planus	1
Oral infection	1
ORAL CAVITY FISTULA	1
OPTIC ISCHAEMIC NEUROPATHY	1
OPTIC ATROPHY	1
OPEN WOUND	1
OPEN ANGLE GLAUCOMA	1
Oestrogen receptor assay positive	1
OESTRIOL ABNORMAL	1
OESTRADIOL INCREASED	1
OESOPHAGITIS ULCERATIVE	1
OESOPHAGEAL ULCER	1
OESOPHAGEAL HAEMORRHAGE	1
OEDEMATOUS PANCREATITIS	1
Oedema mucosal	1
OCULOMUCOCUTANEOUS SYNDROME	1
OCULAR NEOPLASM	1
Obstructive pancreatitis	1
Obstruction	1
Nystagmus	1
NUCLEAR MAGNETIC RESONANCE IMAGING BRAIN ABNORMAL	1
NUCLEAR MAGNETIC RESONANCE IMAGING	1
Normocytic anaemia	1
Normal newborn	1
Nonspecific reaction	1
Non-small cell lung cancer	1
NON-HODGKIN'S LYMPHOMA STAGE III	1
Non-alcoholic fatty liver	1
Nodal osteoarthritis	1
Nocturnal dyspnoea	1
Nocardiosis	1
NO ADVERSE REACTION	1
NO ADVERSE DRUG REACTION	1
NITRITE URINE	1
NIGHT BLINDNESS	1
Neutrophilic dermatosis	1
NEUTROPHIL PERCENTAGE DECREASED	1
NEUROPATHY	1
Neurological symptom	1
NEUROLOGICAL EXAMINATION ABNORMAL	1
Neuroendocrine carcinoma of the skin	1
Neuroendocrine carcinoma	1
Neurodermatitis	1
NEUROBORRELIOSIS	1
NEURITIS	1
Neuralgic amyotrophy	1
NEURAL TUBE DEFECT	1
NEPHROCALCINOSIS	1
Neoplasm skin	1
NEOPLASM RECURRENCE	1
Needle issue	1
Necrotising scleritis	1
Necrotising retinitis	1
NECROTISING OESOPHAGITIS	1
Near death experience	1
Natural killer cell count decreased	1
Nasal oedema	1
Nasal injury	1
Nasal inflammation	1
Nail operation	1
Nail bed inflammation	1
Naevus flammeus	1
Myomectomy	1
MYOCARDITIS RHEUMATIC	1
MYOCARDIAL RUPTURE	1
MYELOFIBROSIS	1
MYELITIS	1
MYCOPLASMA INFECTION	1
Mycobacterium marinum infection	1
Mycobacterium kansasii infection	1
Mycobacterium chelonae infection	1
Mycobacterium abscessus infection	1
MYASTHENIC SYNDROME	1
Muscle tone disorder	1
Muscle tightness	1
Muscle relaxant therapy	1
MUSCLE HYPERTROPHY	1
Muscle haemorrhage	1
Muscle discomfort	1
Murphy's sign positive	1
Multiple drug therapy	1
MULTIPLE CONGENITAL ABNORMALITIES	1
Mucosal pain	1
Mucormycosis	1
Mouth swelling	1
Mood altered	1
Mononeuropathy	1
MONOCYTOPENIA	1
MONOCYTE PERCENTAGE DECREASED	1
MONOCYTE COUNT DECREASED	1
Monoclonal gammopathy	1
MONARTHRITIS	1
Molluscum contagiosum	1
MITRAL VALVE REPLACEMENT	1
Mitochondrial toxicity	1
MISSED LABOUR	1
MILIA	1
Microsporidia infection	1
Microcephaly	1
Methaemoglobinaemia	1
Metatarsalgia	1
METASTATIC NEOPLASM	1
Metastatic bronchial carcinoma	1
METASTASES TO SMALL INTESTINE	1
METASTASES TO BONE	1
Metaplastic breast carcinoma	1
METABOLIC DISORDER	1
Metabolic alkalosis	1
MESOTHELIOMA	1
Menstruation normal	1
Menopausal symptoms	1
Meniscal degeneration	1
Meningorrhagia	1
Meningitis eosinophilic	1
Meningitis chemical	1
MENINGISM	1
Meningeal disorder	1
MELANOSIS	1
Melanocytic naevus	1
Medical device site joint infection	1
Medical device implantation	1
Mediastinum neoplasm	1
MEDIASTINAL DISORDER	1
MEASLES	1
Maternal exposure during breast feeding	1
Mastocytosis	1
Mastitis	1
Mania	1
Mandibular mass	1
MALLORY-WEISS SYNDROME	1
Malignant neoplasm of pleura	1
Malignant melanoma in situ	1
MALIGNANT ASCITES	1
Macular oedema	1
Macular detachment	1
Macroglossia	1
Lymphoid hyperplasia of intestine	1
Lymphoedema	1
Lymphocytic leukaemia	1
LYMPHOCYTE PERCENTAGE INCREASED	1
LYMPHOCYTE PERCENTAGE	1
Lymphangitis	1
Lymphadenitis	1
Lupus vulgaris	1
LUPUS NEPHRITIS	1
LUPUS HEPATITIS	1
LUNG SQUAMOUS CELL CARCINOMA STAGE UNSPECIFIED	1
Lung squamous cell carcinoma stage III	1
LUNG INFECTION PSEUDOMONAL	1
Lung adenocarcinoma stage III	1
LOWER GASTROINTESTINAL HAEMORRHAGE	1
Low birth weight baby	1
LOOSE STOOLS	1
Local reaction	1
LOBAR PNEUMONIA	1
LIVER PALPABLE SUBCOSTAL	1
Listeriosis	1
LIPOMATOSIS	1
Lipoma	1
Lipids abnormal	1
Lip squamous cell carcinoma	1
Lip oedema	1
LIP NEOPLASM MALIGNANT STAGE UNSPECIFIED	1
Lip haemorrhage	1
LIP EROSION	1
Lip dry	1
Lip disorder	1
Lip and/or oral cavity cancer	1
LINEAR IGA DISEASE	1
Limb mass	1
LIMB MALFORMATION	1
Ligament rupture	1
Life support	1
LICHEN SCLEROSUS	1
Leukocoria	1
LEUKAEMIA CUTIS	1
LENTIGO MALIGNA STAGE I	1
Lens discolouration	1
LEIOMYOSARCOMA	1
Leiomyoma	1
LEGIONELLA SEROLOGY POSITIVE	1
Laryngeal squamous cell carcinoma	1
Laryngeal oedema	1
LARGE INTESTINE CARCINOMA	1
LACUNAR INFARCTION	1
LABYRINTHITIS	1
Kyphosis	1
Knee operation	1
Knee deformity	1
KIDNEY FIBROSIS	1
KETONURIA	1
Junctional ectopic tachycardia	1
Joint deposit	1
Joint crepitation	1
Job dissatisfaction	1
JESSNER'S LYMPHOCYTIC INFILTRATION	1
Jaw fistula	1
JAUNDICE NEONATAL	1
Ischaemic skin ulcer	1
ISCHAEMIC CARDIOMYOPATHY	1
Iridocyclitis	1
Invasive ductal breast carcinoma	1
INTRAVENTRICULAR HAEMORRHAGE	1
INTRACRANIAL ANEURYSM	1
INTRACARDIAC THROMBUS	1
Intestinal resection	1
Intestinal polyp	1
Intestinal intraepithelial lymphocytes increased	1
INTESTINAL DILATATION	1
Intervertebral disc displacement	1
Internal haemorrhage	1
Internal fixation of fracture	1
Interferon gamma release assay positive	1
Intercepted product dispensing error	1
Insurance issue	1
Insulin resistance	1
Injection site infection	1
Injection site extravasation	1
Inhibitory drug interaction	1
Ingrowing nail	1
INFUSION SITE EXTRAVASATION	1
INFLUENZA SEROLOGY POSITIVE	1
Inflammatory pain	1
INFECTIVE TENOSYNOVITIS	1
INFECTIOUS PERITONITIS	1
Infection parasitic	1
Infection masked	1
Increased tendency to bruise	1
INCONTINENCE	1
Incisional hernia	1
Incisional drainage	1
Incision site infection	1
Incision site haemorrhage	1
Incision site complication	1
Incision site abscess	1
Inappropriate schedule of drug administration	1
Implant site pain	1
Immunosuppressant drug level increased	1
IMMUNOLOGY TEST ABNORMAL	1
Immune-mediated necrotising myopathy	1
Immature respiratory system	1
ILEUS	1
Ileostomy	1
Ileal stenosis	1
IIIrd nerve paresis	1
ICTERUS INDEX INCREASED	1
ICHTHYOSIS	1
Hypotonia	1
HYPOSPADIAS	1
Hypophonesis	1
Hypofibrinogenaemia	1
Hypocapnia	1
Hypertonia neonatal	1
Hypertensive heart disease	1
HYPERSOMNIA	1
Hypersensitivity pneumonitis	1
HYPERNATRAEMIA	1
Hyperleukocytosis	1
Hyperlactacidaemia	1
Hyperkinetic heart syndrome	1
HYPEREOSINOPHILIC SYNDROME	1
Hypercorticoidism	1
Hyperchlorhydria	1
Hypercapnia	1
Hyperbaric oxygen therapy	1
HYPERAMYLASAEMIA	1
Hyperaldosteronism	1
Hyperadrenocorticism	1
Hunger	1
Human herpesvirus 8 infection	1
Human herpesvirus 6 infection reactivation	1
Human herpesvirus 6 infection	1
HUMAN HERPES VIRUS 8 TEST POSITIVE	1
Human chorionic gonadotropin negative	1
HORSESHOE KIDNEY	1
HODGKIN'S DISEASE	1
HOARSENESS	1
HLA marker study positive	1
HISTOPLASMOSIS DISSEMINATED	1
HISTOLOGY ABNORMAL	1
HISTAMINE INTOLERANCE	1
Herpes zoster oticus	1
HERPES OESOPHAGITIS	1
HERNIA CONGENITAL	1
HEPATOJUGULAR REFLUX	1
HEPATITIS CHRONIC ACTIVE	1
HEPATITIS C POSITIVE	1
Hepatitis B surface antigen positive	1
Hepatic vein thrombosis	1
Hepatic pain	1
Hepatic mass	1
HEPATIC INFECTION FUNGAL	1
Hepatic hypertrophy	1
Hepatic haematoma	1
Hepatic enzyme	1
HEPATIC CANCER METASTATIC	1
HEPATIC ATROPHY	1
HEPARIN-INDUCED THROMBOCYTOPENIA	1
Henoch-Schonlein purpura	1
HELLP syndrome	1
Heat stroke	1
Heart valve incompetence	1
Heart disease congenital	1
Head titubation	1
HEAD DEFORMITY	1
HAPTOGLOBIN DECREASED	1
Hand-foot-and-mouth disease	1
Hand dermatitis	1
Halo vision	1
Hair follicle tumour benign	1
HAIR DISORDER	1
HAIR COLOUR CHANGES	1
HAEMORRHAGIC OVARIAN CYST	1
Haemorrhagic necrotic pancreatitis	1
HAEMORRHAGIC CEREBRAL INFARCTION	1
Haemorrhage subcutaneous	1
Haemorrhage in pregnancy	1
Haemodilution	1
Haematotoxicity	1
HAEMATOMA INFECTION	1
Haematology test abnormal	1
HAEMATOCRIT INCREASED	1
Haematocrit abnormal	1
Haemarthrosis	1
Haemangioma congenital	1
HAEMANGIOMA	1
H1N1 influenza	1
Guttate psoriasis	1
Growth retardation	1
GRAVITATIONAL OEDEMA	1
GRANULOMATOUS LIVER DISEASE	1
GRAFT LOSS	1
Graft dysfunction	1
GOITRE	1
GLYCOPEPTIDE ANTIBIOTIC RESISTANT ENTEROCOCCAL INFECTION	1
GLOMERULOSCLEROSIS	1
Glomerulonephritis membranous	1
GLOMERULONEPHRITIS	1
Glomerular filtration rate abnormal	1
Gingivitis ulcerative	1
Gingival ulceration	1
GINGIVAL SWELLING	1
Gingival recession	1
GINGIVAL DISORDER	1
Gingival discolouration	1
Genotype drug resistance test positive	1
GENITAL ULCERATION	1
Generalised tonic-clonic seizure	1
General physical condition abnormal	1
Gastrointestinal wall thickening	1
GASTROINTESTINAL STOMA COMPLICATION	1
GASTROINTESTINAL PERFORATION	1
Gastrointestinal oedema	1
GASTROINTESTINAL NEOPLASM	1
Gastrointestinal necrosis	1
GASTROINTESTINAL MUCOSAL DISORDER	1
Gastrointestinal mucosa hyperaemia	1
Gastrointestinal motility disorder	1
Gastrointestinal melanoma	1
GASTROENTERITIS VIRAL	1
GASTROENTERITIS STAPHYLOCOCCAL	1
GASTROENTERITIS ROTAVIRUS	1
GASTROENTERITIS BACTERIAL	1
GASTRODUODENITIS	1
GASTRODUODENAL ULCER	1
GASTRITIS BACTERIAL	1
GASTRIC VARICES	1
GASTRIC PERFORATION	1
GASTRIC CANCER RECURRENT	1
GANGRENE	1
Gamma-glutamyltransferase decreased	1
GAMMA-GLUTAMYLTRANSFERASE	1
Gallbladder empyema	1
GAIT SPASTIC	1
FUNGUS URINE TEST POSITIVE	1
FUNGUS SEROLOGY TEST POSITIVE	1
Fungal skin infection	1
Functional gastrointestinal disorder	1
Fulminant type 1 diabetes mellitus	1
Full blood count decreased	1
Full blood count abnormal	1
Fractured sacrum	1
Formication	1
Forearm fracture	1
FORCED EXPIRATORY VOLUME DECREASED	1
FOOT AMPUTATION	1
Food aversion	1
FOOD ALLERGY	1
FONTANELLE DEPRESSED	1
Follicular lymphoma	1
FOLLICLE CENTRE LYMPHOMA, FOLLICULAR GRADE I, II, III STAGE I	1
Follicle centre lymphoma, follicular grade I, II, III recurrent	1
Follicle centre lymphoma, follicular grade I, II, III	1
FOETAL MALFORMATION	1
Foetal heart rate abnormal	1
Foetal exposure timing unspecified	1
FOETAL DISORDER	1
FLUID OVERLOAD	1
Flank pain	1
Fistula discharge	1
Fistula	1
FIBRINOLYSIS INCREASED	1
Fibrinolysis	1
Feeling of despair	1
FEELING OF BODY TEMPERATURE CHANGE	1
Feeling jittery	1
Fear of disease	1
Fear	1
FASCIITIS	1
Fallot's tetralogy	1
FAILURE TO THRIVE	1
Faeces hard	1
FAECALOMA	1
FAECAL VOLUME INCREASED	1
Faecal calprotectin increased	1
FACTOR XII DEFICIENCY	1
Facial pain	1
EYELID FUNCTION DISORDER	1
Eye movement disorder	1
Eye irritation	1
Eye injury	1
Eye infection viral	1
EYE INFECTION BACTERIAL	1
EXTRAOCULAR MUSCLE PARESIS	1
Extra dose administered	1
Exposure via breast milk	1
Exposure during breast feeding	1
Expired product administered	1
EXCESSIVE GRANULATION TISSUE	1
Escherichia test positive	1
ERYTHROPENIA	1
Erythrodermic psoriasis	1
ERYTHEMA ANNULARE	1
EROSIVE DUODENITIS	1
ERB'S PALSY	1
Epstein-Barr virus infection reactivation	1
EOSINOPHIL PERCENTAGE ABNORMAL	1
Enthesophyte	1
Enterovirus infection	1
ENTEROCOLITIS BACTERIAL	1
ENTEROCOCCUS TEST POSITIVE	1
Enterococcal sepsis	1
Enterobacter test positive	1
Enterobacter sepsis	1
ENDOSCOPY UPPER GASTROINTESTINAL TRACT ABNORMAL	1
Endoscopy abnormal	1
Endoscopic ultrasound abnormal	1
ENDOPHTHALMITIS	1
ENDOMETRIAL HYPERPLASIA	1
Endocarditis noninfective	1
End stage renal disease	1
Encopresis	1
Encephalitis fungal	1
Encephalitis brain stem	1
Emotional poverty	1
EMOTIONAL DISORDER	1
Embolism	1
EMBOLIC STROKE	1
ELECTROMYOGRAM ABNORMAL	1
ELECTROENCEPHALOGRAM ABNORMAL	1
ELECTROCARDIOGRAM T WAVE PEAKED	1
ELECTROCARDIOGRAM ST-T SEGMENT ELEVATION	1
ELECTROCARDIOGRAM ST SEGMENT DEPRESSION	1
ELECTROCARDIOGRAM P PULMONALE	1
Elbow operation	1
Ejection fraction decreased	1
EJECTION FRACTION	1
Ectropion	1
Echocardiogram abnormal	1
Ear pruritus	1
EAR HAEMORRHAGE	1
Ear discomfort	1
Ear congestion	1
DYSPNOEA PAROXYSMAL NOCTURNAL	1
DYSPLASTIC NAEVUS SYNDROME	1
Dyspareunia	1
Dyslalia	1
DYSKINESIA OESOPHAGEAL	1
DYSGLOBULINAEMIA	1
DYSCALCULIA	1
DUODENAL NEOPLASM	1
Drug specific antibody	1
DRUG SCREEN POSITIVE	1
Drug prescribing error	1
Drug metabolite level high	1
Drug level fluctuating	1
Drug level below therapeutic	1
Drug level above therapeutic	1
Drug level abnormal	1
Drug half-life increased	1
Drug dispensing error	1
Drug administration error	1
DROWNING	1
DOUGLAS' POUCH EFFUSION	1
Diverticulum oesophageal	1
Diverticulum intestinal haemorrhagic	1
Disease susceptibility	1
Disease risk factor	1
Diplegia	1
DIFFUSE AXONAL INJURY	1
Diaphragmatic hernia	1
Diaphragm muscle weakness	1
DIABETES MELLITUS INSULIN-DEPENDENT	1
DIABETES INSIPIDUS	1
Device issue	1
Device dislocation	1
Dermatitis exfoliative generalised	1
Dermatitis acneiform	1
Dermal cyst	1
Dental necrosis	1
Dental care	1
Decreased vibratory sense	1
Death neonatal	1
Deafness unilateral	1
Deafness transitory	1
CYTOMEGALOVIRUS GASTROENTERITIS	1
CYTOMEGALOVIRUS ANTIGEN POSITIVE	1
CYTOMEGALOVIRUS ANTIBODY POSITIVE	1
Cystoid macular oedema	1
CYSTITIS HAEMORRHAGIC	1
Cutaneous T-cell lymphoma	1
Cutaneous symptom	1
Cushingoid	1
CULTURE POSITIVE	1
Cubital tunnel syndrome	1
CSF TEST ABNORMAL	1
CSF PROTEIN INCREASED	1
CSF PRESSURE INCREASED	1
CRYPTOGENIC ORGANIZING PNEUMONIA	1
Cryptitis	1
Critical illness	1
CREUTZFELDT-JAKOB DISEASE	1
CREATINE PHOSPHOKINASE DECREASED	1
Craniocerebral injury	1
CRANIAL NERVE PARALYSIS	1
Cranial nerve injury	1
Coxsackie viral infection	1
Counterfeit product administered	1
Costochondritis	1
CORONARY ARTERY OCCLUSION	1
CORONARY ARTERY ATHEROSCLEROSIS	1
CORONARY ARTERIAL STENT INSERTION	1
CORNEAL ULCER	1
Corneal infection	1
Corneal erosion	1
CORNEAL EPITHELIUM DISORDER	1
CORNEAL ABSCESS	1
COPROPORPHYRINOGEN INCREASED	1
COORDINATION ABNORMAL	1
COOMBS DIRECT TEST POSITIVE	1
Contrast media allergy	1
Contraindicated drug administered	1
Conjunctival oedema	1
CONJUNCTIVAL DISORDER	1
Congenital spinal cord anomaly	1
Congenital scoliosis	1
Congenital neurological disorder	1
CONGENITAL HAND MALFORMATION	1
CONGENITAL DIAPHRAGMATIC HERNIA	1
Congenital cystic kidney disease	1
Congenital choroid plexus cyst	1
Congenital aortic anomaly	1
Concussion	1
CONCOMITANT DISEASE PROGRESSION	1
Concomitant disease aggravated	1
COMPUTERISED TOMOGRAM NORMAL	1
Complications of transplanted lung	1
Complications of transplanted kidney	1
Completed suicide	1
Complement fixation abnormal	1
COMPLEMENT FACTOR DECREASED	1
COMPLEMENT FACTOR C4 DECREASED	1
Compartment syndrome	1
COLITIS ISCHAEMIC	1
Colectomy	1
COAGULATION TIME PROLONGED	1
COAGULATION FACTOR VII LEVEL DECREASED	1
COAGULATION FACTOR V LEVEL DECREASED	1
Coagulation factor decreased	1
Clostridium test positive	1
CLOSTRIDIUM COLITIS	1
Cleft palate	1
CIRRHOSIS ALCOHOLIC	1
CILIARY HYPERAEMIA	1
Chylothorax	1
Chronic hepatitis B	1
Chronic graft versus host disease in intestine	1
CHROMOSOME ANALYSIS ABNORMAL	1
CHOROID MELANOMA	1
Chondrocalcinosis pyrophosphate	1
Cholelithiasis obstructive	1
Cholangitis acute	1
CHLORACNE	1
CHLAMYDIA SEROLOGY POSITIVE	1
Chillblains	1
Chapped lips	1
CERVIX NEOPLASM	1
CERVIX DYSTOCIA	1
CERVICOBRACHIAL SYNDROME	1
Cervical spinal stenosis	1
CERVICAL ROOT PAIN	1
CERVICAL MYELOPATHY	1
Cerebral toxoplasmosis	1
CEREBRAL HAEMATOMA	1
CEREBRAL ATROPHY	1
CEREBRAL ARTERY OCCLUSION	1
CEREBRAL ARTERITIS	1
CEREBELLAR INFARCTION	1
Central nervous system lymphoma	1
Central nervous system infection	1
Cell death	1
CD4/CD8 RATIO INCREASED	1
CD4 lymphocytes decreased	1
CAVERNOUS SINUS THROMBOSIS	1
Catheter site infection	1
CATHETER SITE DISCHARGE	1
Catheter site cellulitis	1
Catheter site abscess	1
Cataract nuclear	1
CAROTID ARTERY ANEURYSM	1
Carotid arteriosclerosis	1
CARDIOPULMONARY FAILURE	1
CARDIAC VALVE DISEASE	1
CARDIAC STRESS TEST ABNORMAL	1
Cardiac granuloma	1
Cardiac flutter	1
CARDIAC FAILURE HIGH OUTPUT	1
Cardiac discomfort	1
Cardiac death	1
Cardiac asthma	1
CARDIAC ANEURYSM	1
Carbon monoxide diffusing capacity decreased	1
Carbon dioxide decreased	1
CARBOHYDRATE ANTIGEN 19-9 INCREASED	1
CARBOHYDRATE ANTIGEN 15-3 INCREASED	1
CARBOHYDRATE ANTIGEN 125	1
Caplan's syndrome	1
Cancer surgery	1
CALCINOSIS	1
BURSA INJURY	1
Burnout syndrome	1
Bunion operation	1
Bundle branch block right	1
Budd-Chiari syndrome	1
Bruxism	1
Bronchitis haemophilus	1
Bronchitis bacterial	1
Bronchiolitis	1
BRONCHIAL ULCERATION	1
BRONCHIAL INFECTION	1
Bronchial disorder	1
BRONCHIAL CARCINOMA	1
Breath odour	1
Breast prosthesis user	1
Breast neoplasm	1
BREAST INFECTION	1
Breast haemorrhage	1
BREAST DISCHARGE	1
Breast cyst excision	1
BREAST CANCER STAGE II	1
BREAST CANCER RECURRENT	1
Breast cancer metastatic	1
BREAST CANCER IN SITU	1
Brain stem glioma	1
BRAIN NEOPLASM MALIGNANT	1
BRAIN HERNIATION	1
BRAIN DEATH	1
BOWEN'S DISEASE	1
BOWEL SOUNDS ABNORMAL	1
Bowel movement irregularity	1
Bone tuberculosis	1
Bone marrow oedema	1
Bone loss	1
BONE LESION	1
BONE INFECTION	1
Bone infarction	1
Bone graft	1
Bone deformity	1
Bone abscess	1
Body mass index increased	1
Blue toe syndrome	1
Bloody discharge	1
BLOOD URINE	1
BLOOD TESTOSTERONE INCREASED	1
Blood testosterone decreased	1
BLOOD SODIUM INCREASED	1
BLOOD SODIUM ABNORMAL	1
Blood prolactin decreased	1
BLOOD PRESSURE ORTHOSTATIC DECREASED	1
BLOOD PRESSURE INADEQUATELY CONTROLLED	1
BLOOD POTASSIUM ABNORMAL	1
BLOOD PHOSPHORUS INCREASED	1
Blood phosphorus decreased	1
Blood lactic acid increased	1
BLOOD IRON INCREASED	1
BLOOD IMMUNOGLOBULIN M DECREASED	1
BLOOD IMMUNOGLOBULIN G INCREASED	1
BLOOD IMMUNOGLOBULIN A INCREASED	1
BLOOD FOLATE INCREASED	1
BLOOD FIBRINOGEN DECREASED	1
Blood creatine decreased	1
BLOOD CHOLINESTERASE DECREASED	1
BLOOD CALCIUM INCREASED	1
Blood alkaline phosphatase decreased	1
BLOOD ALBUMIN INCREASED	1
Blepharospasm	1
Blastomycosis	1
Blast cells	1
Bladder transitional cell carcinoma	1
Bladder obstruction	1
Bladder injury	1
BLADDER CANCER RECURRENT	1
Bite	1
BIOPSY SKIN ABNORMAL	1
Biopsy kidney abnormal	1
Biopsy intestine abnormal	1
Biliary fibrosis	1
BILIARY DILATATION	1
BILIARY CIRRHOSIS	1
Bile duct stenosis	1
BILE DUCT OBSTRUCTION	1
BILATERAL HYDRONEPHROSIS	1
BENIGN LUNG NEOPLASM	1
BENIGN INTRACRANIAL HYPERTENSION	1
BENIGN HYDATIDIFORM MOLE	1
Benign breast neoplasm	1
BASOPHIL PERCENTAGE	1
Basedow's disease	1
BASE EXCESS DECREASED	1
Barrett's oesophagus	1
Bacterial sepsis	1
BACTERIA URINE	1
BACTERIA SPUTUM IDENTIFIED	1
AXILLARY PAIN	1
Aversion	1
AUTONOMIC NERVOUS SYSTEM IMBALANCE	1
Autoimmune haemolytic anaemia	1
Auditory disorder	1
ATRIOVENTRICULAR BLOCK FIRST DEGREE	1
ATRIAL TACHYCARDIA	1
Atrial septal defect	1
Atlantoaxial subluxation	1
ATHEROSCLEROSIS OBLITERANS	1
ATHEROSCLEROSIS	1
ASTERIXIS	1
ASPIRATION	1
Aspartate aminotransferase decreased	1
ASBESTOSIS	1
Arthroscopy	1
Arterial stenosis	1
ARTERIAL RUPTURE	1
ARTERIAL OCCLUSIVE DISEASE	1
ARRESTED LABOUR	1
Aptyalism	1
APPLICATION SITE PAIN	1
APPLICATION SITE DERMATITIS	1
Appendix disorder	1
Appendicectomy	1
Apoptosis	1
APNOEA	1
Aphonia	1
APGAR SCORE LOW	1
Apathy	1
Aortic valve stenosis	1
Aortic valve disease mixed	1
AORTIC THROMBOSIS	1
Aortic bruit	1
AORTIC ATHEROSCLEROSIS	1
Aortic aneurysm	1
Anxiety disorder	1
ANTITHROMBIN III DECREASED	1
Antinuclear antibody increased	1
ANTICONVULSANT DRUG LEVEL ABOVE THERAPEUTIC	1
Anticipatory anxiety	1
Anti-neutrophil cytoplasmic antibody positive vasculitis	1
ANTI-HBC IGG ANTIBODY POSITIVE	1
ANTI FACTOR XII ANTIBODY POSITIVE	1
ANTI FACTOR VIII ANTIBODY POSITIVE	1
Anterior spinal artery syndrome	1
Anorectal agenesis	1
Ankle operation	1
Animal scratch	1
ANGLE CLOSURE GLAUCOMA	1
ANGIOMYOLIPOMA	1
ANGIOIMMUNOBLASTIC T-CELL LYMPHOMA	1
ANGIOGRAM PERIPHERAL ABNORMAL	1
Anencephaly	1
Anembryonic gestation	1
ANDROGENS INCREASED	1
Androgenetic alopecia	1
Anaplastic thyroid cancer	1
ANAPHYLACTOID SHOCK	1
Anaphylactoid reaction	1
Anal squamous cell carcinoma	1
Anal incontinence	1
ANAL HAEMORRHAGE	1
Anal fissure	1
Anal atresia	1
Anal abscess	1
ANAEMIA POSTOPERATIVE	1
Amoebiasis	1
AMNIOTIC INFECTION SYNDROME OF BLANE	1
Amniotic fluid volume decreased	1
AMNIORRHEXIS	1
Amnestic disorder	1
Alveolar osteitis	1
ALPHA 1 FOETOPROTEIN INCREASED	1
ALPHA 1 FOETOPROTEIN ABNORMAL	1
Alopecia universalis	1
ALOPECIA TOTALIS	1
Allergic sinusitis	1
Allergic oedema	1
Allergic granulomatous angiitis	1
ALANINE AMINOTRANSFERASE DECREASED	1
AKINESIA	1
Agitation neonatal	1
Aggression	1
Adrenocortical insufficiency acute	1
Adrenal neoplasm	1
Adrenal insufficiency	1
Adrenal adenoma	1
Administration site extravasation	1
Adenovirus infection	1
Addison's disease	1
ACUTE MYELOMONOCYTIC LEUKAEMIA	1
Acute motor-sensory axonal neuropathy	1
ACUTE LYMPHOCYTIC LEUKAEMIA	1
Acute lung injury	1
Acute leukaemia	1
ACUTE CORONARY SYNDROME	1
Actinomycosis	1
Acquired porphyria	1
ACQUIRED METHAEMOGLOBINAEMIA	1
Acquired haemophilia	1
ACID FAST BACILLI INFECTION	1
ACETABULUM FRACTURE	1
Accidental exposure to product by child	1
Accidental exposure to product	1
ACCIDENTAL DRUG INTAKE BY CHILD	1
Acarodermatitis	1
Acanthosis	1
ABORTION THREATENED	1
Abortion late	1
ABORTION INCOMPLETE	1
ABORTION EARLY	1
Abnormal dreams	1
Abdominal neoplasm	1
ABDOMINAL MASS	1

Filtered ChEMBL targets:

Target UniProtKB ID	Activity in nm	Target Name	Target gene
O15118	562.3	NPC intracellular cholesterol transporter 1	NPC1_HUMAN
O75496	3162.3	Geminin	GEMI_HUMAN
P02545	3.2	Prelamin-A/C	LMNA_HUMAN
P04637	10000	Cellular tumor antigen p53	P53_HUMAN
P40225	7943.3	Thrombopoietin	TPO_HUMAN
P42858	316.2	Huntingtin	HD_HUMAN
P51151	730.8	Ras-related protein Rab-9A	RAB9A_HUMAN
Q02127	800	Dihydroorotate dehydrogenase (quinone), mitochondrial	PYRD_HUMAN
Q16637	7079.5	Survival motor neuron protein	SMN_HUMAN
Q6W5P4	79.4	Neuropeptide S receptor	NPSR1_HUMAN

Toxicity information:

Toxicity class:	3
Toxicity type:	N/A
LD50:	235 mg/kg

External links:

ChEBML:	CHEMBL960
DrugBank:	DB01097