Isosorbide


1456



General information:


Withdrawn ID: 1456
Canonical SMILES:
Standard InChI:
Standard InChIKey:
ATC class(es): C01DA08
C05AE02
Molecular Formula: C6H10O4
Molweight: 146.141



Withdrawal information:


Withdrawn due to drug safety reasons:No
First approved: 1974



Side-effects:

Total reported cases (submitted by medical professionals) with Isosorbide as primary suspect: 33


Reported final outcomes:
Hospitalization (initial or prolonged): 17
Death: 2
Disability: 2
Life-Threatening condition: 1
Congenital anomaly: 1


Reported side-effects:

Side-effect Case number
HYPOTENSION5
DIZZINESS4
ORTHOSTATIC HYPOTENSION4
Drug hypersensitivity3
Dyspnoea3
HEADACHE3
DRUG INEFFECTIVE3
CHEST PAIN3
SYNCOPE3
Acute kidney injury2
Presyncope2
Completed suicide2
Toxicity to various agents2
Hypersensitivity2
Blood pressure decreased2
Urticaria2
PHARMACEUTICAL PRODUCT COMPLAINT1
Pain1
Precancerous mucosal lesion1
Product dispensing error1
Product solubility abnormal1
Pemphigus1
Pain in extremity1
Off label use1
Overdose1
Osteonecrosis of jaw1
Oliguria1
Oligohydramnios1
Metabolic acidosis1
Respiratory arrest1
Respiratory distress1
RESPIRATORY RATE INCREASED1
Scab1
Shock1
Skin fissures1
Small cell lung cancer1
Staphylococcus test positive1
Subacute cutaneous lupus erythematosus1
Subarachnoid haemorrhage1
Tonsillar ulcer1
Transcription medication error1
Tremor1
Urinary retention1
VICTIM OF CRIME1
Wrong patient received product1
Cellulitis1
HEART RATE IRREGULAR1
Heart rate increased1
Foetal death1
Feeling hot1
Device dislocation1
Depression1
Condition aggravated1
Coma1
Incorrect dose administered1
Cardiac arrest1
BLOOD PRESSURE INCREASED1
BLOOD PRESSURE FLUCTUATION1
BLOOD POTASSIUM DECREASED1
Blood culture positive1
Balance disorder1
ASTHENIA1
No adverse event1
Incorrect product dosage form administered1
Induced labour1
ISCHAEMIA1
Kounis syndrome1
LABORATORY TEST ABNORMAL1
LACUNAR INFARCTION1
Lip swelling1
Loss of consciousness1
Lung disorder1
Maternal exposure during pregnancy1
Medication residue present1
Myalgia1
Myocardial ischaemia1
Nausea1
Nightmare1





Filtered ChEMBL targets:

Target UniProtKB ID Activity in nm Target Name Target gene
P10828 39.8 Thyroid hormone receptor beta THB_HUMAN



Toxicity information:

Toxicity class: 4
Toxicity type: N/A
LD50: 1500 mg/kg



External links:

ChEBML: CHEMBL1200660
DrugBank: