Indomethacin


w208



General information:


Withdrawn ID: w208
Canonical SMILES:
Standard InChI:
Standard InChIKey:
ATC class(es): C01EB03
M01AB01
M01AB51
M02AA23
S01BC01
Molecular Formula: C19H16ClNO4
Molweight: 357.788



Withdrawal information:


Withdrawn due to drug safety reasons:Yes
First approved: 1965
First withdrawn: 1983
Last withdrawn: 1983
Reference: https://www.ncbi.nlm.nih.gov/pubmed/26100227



Side-effects:

Total reported cases (submitted by medical professionals) with Indomethacin as primary suspect: 1267


Reported final outcomes:
Hospitalization (initial or prolonged): 435
Death: 152
Life-Threatening condition: 103
Intervention required to prevent permanent impairment/damage: 54
Congenital anomaly: 25
Disability: 21


Reported side-effects:

Side-effect Case number
DRUG INEFFECTIVE143
DRUG HYPERSENSITIVITY123
Foetal exposure during pregnancy101
PREMATURE BABY64
RETINOPATHY OF PREMATURITY62
OFF LABEL USE55
RENAL FAILURE ACUTE48
DIZZINESS48
GASTROINTESTINAL HAEMORRHAGE45
OLIGOHYDRAMNIOS43
VOMITING42
NAUSEA38
DRUG EXPOSURE DURING PREGNANCY37
DUCTUS ARTERIOSUS PREMATURE CLOSURE36
NECROTISING COLITIS35
TRICUSPID VALVE INCOMPETENCE29
NEONATAL DISORDER29
HEADACHE29
Exposure during pregnancy29
BRONCHOPULMONARY DYSPLASIA29
DRUG INTERACTION28
ASTHENIA28
MATERNAL EXPOSURE DURING PREGNANCY27
DIARRHOEA27
ANAEMIA27
THROMBOCYTOPENIA26
INTRAVENTRICULAR HAEMORRHAGE NEONATAL26
DYSPNOEA26
HAEMOGLOBIN DECREASED25
GASTROINTESTINAL PERFORATION25
Product use issue24
NEONATAL RESPIRATORY DISTRESS SYNDROME24
GASTRIC ULCER24
CONDITION AGGRAVATED24
RENAL FAILURE23
RASH23
Acute kidney injury23
GASTRIC HAEMORRHAGE22
FATIGUE22
MELAENA21
INTESTINAL PERFORATION21
CAESAREAN SECTION21
ABDOMINAL PAIN21
RENAL IMPAIRMENT20
METABOLIC ACIDOSIS20
MATERNAL DRUGS AFFECTING FOETUS20
BLOOD CREATININE INCREASED20
HYPOTENSION19
HYPERKALAEMIA18
DEATH18
ARTHRALGIA18
PERIVENTRICULAR LEUKOMALACIA17
COMPLETED SUICIDE17
PAIN16
Ductus arteriosus stenosis foetal16
CARDIAC FAILURE16
UPPER GASTROINTESTINAL HAEMORRHAGE15
SEPSIS15
PYREXIA15
MALAISE15
ILEAL PERFORATION15
HYDROPS FOETALIS15
CARDIAC FAILURE CONGESTIVE15
ABDOMINAL DISTENSION15
URTICARIA14
BLOOD UREA INCREASED14
ASCITES14
SEPSIS NEONATAL13
PATENT DUCTUS ARTERIOSUS13
OLIGURIA13
MYOCARDIAL INFARCTION13
GENERAL PHYSICAL HEALTH DETERIORATION13
TREMOR12
RESPIRATORY FAILURE12
PREMATURE DELIVERY12
PLEURAL EFFUSION12
OEDEMA PERIPHERAL12
NECROTISING ENTEROCOLITIS NEONATAL12
INTRAVENTRICULAR HAEMORRHAGE12
HYPOXIA12
HYPERTENSION12
HAEMORRHAGE INTRACRANIAL12
HAEMATOCRIT DECREASED12
FAECES DISCOLOURED12
DYSPEPSIA12
DUODENAL ULCER12
DISSEMINATED INTRAVASCULAR COAGULATION12
ABDOMINAL DISCOMFORT12
RESPIRATORY DISTRESS11
PANCYTOPENIA11
NEPHROPATHY TOXIC11
HYPERHIDROSIS11
HAEMATEMESIS11
Foetal death11
DEHYDRATION11
Contraindicated product administered11
COARCTATION OF THE AORTA11
THERAPY NON-RESPONDER10
SKIN HAEMORRHAGE10
SHOCK10
PERITONITIS10
MIGRAINE10
Low birth weight baby10
Live birth10
Joint swelling10
Foetal renal impairment10
ABDOMINAL PAIN UPPER10
PULMONARY HYPERTENSION9
PALPITATIONS9
Musculoskeletal stiffness9
HYPOKALAEMIA9
HAEMATOCHEZIA9
GOUT9
GASTROINTESTINAL DISORDER9
CONFUSIONAL STATE9
Circulatory collapse9
CHILLS9
BACK PAIN9
TREATMENT FAILURE8
TACHYCARDIA8
SYNCOPE8
STILLBIRTH8
Right ventricular hypertrophy8
PULMONARY HAEMORRHAGE8
PLACENTAL TRANSFUSION SYNDROME8
OEDEMA8
LOSS OF CONSCIOUSNESS8
HYPONATRAEMIA8
GASTRIC PERFORATION8
FEELING ABNORMAL8
CORONARY ARTERY INSUFFICIENCY8
BLOOD POTASSIUM INCREASED8
RIGHT VENTRICULAR FAILURE7
Right ventricular dysfunction7
RHEUMATOID ARTHRITIS7
RENAL FAILURE NEONATAL7
PRURITUS7
PLATELET COUNT DECREASED7
PAIN IN EXTREMITY7
HYPOCALCAEMIA7
HYPERGLYCAEMIA7
GASTRITIS7
FOETAL DISTRESS SYNDROME7
DECREASED APPETITE7
CARDIAC ARREST7
APGAR SCORE LOW7
WHITE BLOOD CELL COUNT INCREASED6
WEIGHT DECREASED6
ULCER6
Toxicity to various agents6
THROMBOSIS6
RIGHT ATRIAL DILATATION6
RENAL TUBULAR NECROSIS6
PNEUMOPERITONEUM6
PERICARDIAL EFFUSION6
PARAESTHESIA6
OVERDOSE6
LEUKOCYTOSIS6
LARGE INTESTINAL ULCER6
INTESTINAL ISCHAEMIA6
INFECTION6
Impaired work ability6
HEART RATE INCREASED6
Hand deformity6
DRUG ADMINISTRATION ERROR6
DISEASE RECURRENCE6
DILATATION VENTRICULAR6
DEPRESSED LEVEL OF CONSCIOUSNESS6
CORNEAL PERFORATION6
CONSTIPATION6
Colitis6
COAGULOPATHY6
CHOLESTASIS6
CARDIOMEGALY6
C-REACTIVE PROTEIN INCREASED6
BLOOD PRESSURE DECREASED6
ANXIETY6
AMNESIA6
AGITATION6
WITHDRAWAL SYNDROME5
WEIGHT INCREASED5
THROMBOCYTOPENIA NEONATAL5
SWELLING5
Suspected suicide5
SUICIDAL IDEATION5
Subarachnoid haemorrhage5
SOMNOLENCE5
SEPTIC SHOCK5
Sacroiliitis5
Right ventricular hypertension5
Reversible cerebral vasoconstriction syndrome5
RENAL FAILURE CHRONIC5
RECTAL HAEMORRHAGE5
PURPURA5
Product use in unapproved indication5
PREMATURE RUPTURE OF MEMBRANES5
POLYARTHRITIS5
PNEUMOTHORAX5
PETECHIAE5
PERITONEAL DIALYSIS5
PATENT DUCTUS ARTERIOSUS REPAIR5
OESOPHAGITIS5
NEONATAL ASPHYXIA5
NECK PAIN5
MEMORY IMPAIRMENT5
LETHARGY5
LARGE INTESTINE PERFORATION5
INTERSTITIAL LUNG DISEASE5
HYPERTENSIVE CRISIS5
HYPERSENSITIVITY5
HIATUS HERNIA5
Hepatotoxicity5
HAEMORRHAGE5
Drug intolerance5
DIVERTICULUM5
DEATH NEONATAL5
CONVULSION5
COMA5
CARDIOVASCULAR DISORDER5
BLOOD SODIUM DECREASED5
BLOOD PRESSURE INCREASED5
BLOOD GLUCOSE INCREASED5
Ankylosing spondylitis5
Angioedema5
ACUTE RESPIRATORY DISTRESS SYNDROME5
ACIDOSIS5
VISION BLURRED4
VERTIGO4
URINE OUTPUT DECREASED4
Swollen tongue4
SMALL INTESTINAL PERFORATION4
PSORIASIS4
PREMATURE LABOUR4
POST PROCEDURAL COMPLICATION4
POLLAKIURIA4
PNEUMONIA4
PHARMACEUTICAL PRODUCT COMPLAINT4
PANCREATITIS NECROTISING4
PANCREATITIS4
MYOCLONUS4
MULTI-ORGAN FAILURE4
Joint stiffness4
INTRACRANIAL PRESSURE INCREASED4
Intentional product misuse4
INTENTIONAL OVERDOSE4
INFLAMMATION4
Infantile apnoea4
Hepatitis cholestatic4
HEPATITIS ACUTE4
HEPATIC HAEMORRHAGE4
HEPATIC FAILURE4
HALLUCINATION, VISUAL4
HAEMODIALYSIS4
HAEMATURIA4
GASTROINTESTINAL ULCER HAEMORRHAGE4
GASTROINTESTINAL NECROSIS4
GASTRITIS EROSIVE4
GASTRIC ULCER HAEMORRHAGE4
FOETAL DISORDER4
Fluid retention4
FALL4
EROSIVE OESOPHAGITIS4
EOSINOPHILIA4
DYSARTHRIA4
DUODENITIS4
DRUG SCREEN POSITIVE4
Drug reaction with eosinophilia and systemic symptoms4
DRUG RASH WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS4
DRUG ERUPTION4
Disability4
Crohn's disease4
COUGH4
COGNITIVE DISORDER4
CHEST PAIN4
CEREBRAL VASOCONSTRICTION4
CEREBRAL ISCHAEMIA4
CARDIO-RESPIRATORY ARREST4
BRADYCARDIA FOETAL4
BRADYCARDIA4
BLOOD CREATINE INCREASED4
BACTERAEMIA4
AUTOIMMUNE HEPATITIS4
ANURIA4
WHITE BLOOD CELL COUNT DECREASED3
UNEVALUABLE EVENT3
Tubulointerstitial nephritis3
TREATMENT NONCOMPLIANCE3
TRACHEAL HAEMORRHAGE3
Tinnitus3
Therapeutic product effect decreased3
THERAPEUTIC AGENT TOXICITY3
SYNOVITIS3
SWELLING FACE3
SPEECH DISORDER3
SEROTONIN SYNDROME3
Seizure3
Rheumatoid factor positive3
RHABDOMYOLYSIS3
RENAL TUBULAR DISORDER3
Renal function test abnormal3
RENAL DISORDER3
Pulmonary thrombosis3
PRESCRIBED OVERDOSE3
PHOTOPHOBIA3
PERSISTENT FOETAL CIRCULATION3
PERITONEAL HAEMORRHAGE3
Peripheral swelling3
PEPTIC ULCER3
ORTHOPNOEA3
NEONATAL RESPIRATORY FAILURE3
Neck mass3
Neck deformity3
Nasopharyngitis3
MYDRIASIS3
MUSCLE RIGIDITY3
Mood swings3
MITRAL VALVE INCOMPETENCE3
Leukocytoclastic vasculitis3
Left ventricular dysfunction3
LABORATORY TEST ABNORMAL3
Knee arthroplasty3
INTUSSUSCEPTION3
INTERNATIONAL NORMALISED RATIO INCREASED3
HYPOGLYCAEMIA3
HYDROCEPHALUS3
Hip arthroplasty3
HEPATIC NECROSIS3
HAEMORRHAGIC DIATHESIS3
HAEMOLYTIC ANAEMIA3
HAEMODYNAMIC INSTABILITY3
GINGIVAL BLEEDING3
GENERALISED OEDEMA3
GASTROOESOPHAGEAL REFLUX DISEASE3
GASTROINTESTINAL ULCER3
GASTRIC MUCOSAL LESION3
GASTRIC DISORDER3
GAIT DISTURBANCE3
FLUSHING3
EYE SWELLING3
ERYTHEMA3
EPISTAXIS3
ENTERITIS3
DYSSTASIA3
DUODENAL ULCER PERFORATION3
DUODENAL PERFORATION3
Dry mouth3
DRUG TOXICITY3
Drug effect incomplete3
Drug administered to patient of inappropriate age3
Drug abuse3
DISORIENTATION3
DIALYSIS3
DECREASED ACTIVITY3
Cushing's syndrome3
Congenital tricuspid valve incompetence3
CONGENITAL ATRIAL SEPTAL DEFECT3
CONGENITAL ANOMALY3
CHEST DISCOMFORT3
CARDIAC DISORDER3
BURSITIS3
BRAIN NATRIURETIC PEPTIDE INCREASED3
Bone density abnormal3
BLOOD ALBUMIN DECREASED3
BLISTER3
BACTERIAL SEPSIS3
Ataxia3
APHASIA3
Anti-cyclic citrullinated peptide antibody positive3
ANGIONEUROTIC OEDEMA3
ANAEMIA NEONATAL3
ACUTE ABDOMEN3
ABORTION SPONTANEOUS3
WHEEZING2
VOMITING NEONATAL2
VENTRICULAR TACHYCARDIA2
VENOUS THROMBOSIS2
VARICELLA2
VAGINAL HAEMORRHAGE2
Uveitis2
URINE COLOUR ABNORMAL2
URINARY TRACT INFECTION2
ULCERATIVE KERATITIS2
TYPE 1 DIABETES MELLITUS2
TROPONIN T INCREASED2
Trisomy 212
TOXIC SKIN ERUPTION2
TORSADE DE POINTES2
Therapeutic response decreased2
Therapeutic product effect incomplete2
Tachypnoea2
Supraventricular tachycardia2
Substance-induced psychotic disorder2
STREPTOCOCCAL SEPSIS2
STOMACH DISCOMFORT2
Sputum discoloured2
SMALL INTESTINAL STENOSIS2
SMALL INTESTINAL OBSTRUCTION2
SMALL INTESTINAL HAEMORRHAGE2
SMALL FOR DATES BABY2
Skin oedema2
Skin lesion2
SKIN DISCOLOURATION2
SINUS BRADYCARDIA2
Self-medication2
Right atrial enlargement2
Retinal haemorrhage2
Respiratory arrest2
RECTAL CANCER2
RASH ERYTHEMATOUS2
Pyelonephritis2
Pulmonary embolism2
PULMONARY DYSMATURITY SYNDROME2
PULMONARY CONGESTION2
PULMONARY ARTERY DILATATION2
PULMONARY ALVEOLAR HAEMORRHAGE2
PSYCHOMOTOR HYPERACTIVITY2
PRURITUS GENERALISED2
Pruritus allergic2
PROTHROMBIN TIME SHORTENED2
PROTEINURIA2
PROTEIN TOTAL DECREASED2
Post procedural haemorrhage2
Post procedural haematoma2
Portal vein thrombosis2
PHARYNGEAL OEDEMA2
Periorbital oedema2
Partial seizures2
Papule2
PALLOR2
OXYGEN SATURATION DECREASED2
Osteomyelitis2
Osteoarthritis2
OESOPHAGEAL ULCER2
OCCULT BLOOD POSITIVE2
NEUTROPHIL COUNT DECREASED2
Neuralgia2
NEPHROPATHY2
NEPHROLITHIASIS2
NEONATAL HYPOTENSION2
NECROTISING FASCIITIS2
MYOCARDIAL ISCHAEMIA2
Muscle spasms2
Multiple organ dysfunction syndrome2
METASTASES TO BONE2
MENINGITIS ASEPTIC2
LYMPHADENOPATHY2
LUNG DISORDER2
LOWER GASTROINTESTINAL HAEMORRHAGE2
Liver function test abnormal2
Lip swelling2
Large intestinal stenosis2
JUVENILE ARTHRITIS2
JOINT RANGE OF MOTION DECREASED2
JAUNDICE NEONATAL2
Irritability2
Iron deficiency anaemia2
Intra-abdominal haematoma2
INTESTINAL INFARCTION2
Internal haemorrhage2
INCREASED VENTRICULAR AFTERLOAD2
INCORRECT DOSE ADMINISTERED2
IgA nephropathy2
HYPOVOLAEMIC SHOCK2
Hypovolaemia2
HYPOPERFUSION2
HYPOGLYCAEMIA NEONATAL2
HYPOAESTHESIA2
HYPERVENTILATION2
HYPERBILIRUBINAEMIA2
HOT FLUSH2
HEPATOSPLENOMEGALY2
HEPATIC HAEMATOMA2
HEPATIC FUNCTION ABNORMAL2
HEPATIC ENZYME INCREASED2
HEMIPARESIS2
HELICOBACTER INFECTION2
HEART DISEASE CONGENITAL2
HALLUCINATION, AUDITORY2
Hallucination2
Haemoptysis2
HAEMOGLOBIN ABNORMAL2
HAEMATOMA2
GROUP B STREPTOCOCCUS NEONATAL SEPSIS2
GASTROENTERITIS SALMONELLA2
Gastroenteritis2
GALLBLADDER DISORDER2
FOETAL GROWTH RETARDATION2
FOETAL CARDIAC DISORDER2
FLATULENCE2
FIBROSIS2
Fibromuscular dysplasia2
Femoral pulse abnormal2
Febrile neutropenia2
FALSE POSITIVE INVESTIGATION RESULT2
FAECAL OCCULT BLOOD POSITIVE2
FACE OEDEMA2
EROSIVE DUODENITIS2
Enthesopathy2
Ear pain2
DYSPNOEA EXERTIONAL2
DYSKINESIA2
Drug tolerance2
DRUG RESISTANCE2
DRUG PRESCRIBING ERROR2
DRUG LEVEL INCREASED2
Drug ineffective for unapproved indication2
DRUG DISPENSING ERROR2
DIVERTICULUM INTESTINAL2
Discomfort2
Diplopia2
DELUSION2
CULTURE STOOL POSITIVE2
CSF PRESSURE INCREASED2
Contusion2
CONTINUOUS HAEMODIAFILTRATION2
Congenital cardiovascular anomaly2
CONCOMITANT DISEASE PROGRESSION2
COMPLICATIONS OF MATERNAL EXPOSURE TO THERAPEUTIC DRUGS2
Colitis microscopic2
CLONUS2
CLEFT LIP AND PALATE2
CHRONIC RESPIRATORY DISEASE2
Chorioamniotic separation2
CHOLECYSTECTOMY2
CEREBROVASCULAR ACCIDENT2
CEREBRAL HAEMORRHAGE NEONATAL2
Cellulitis2
CARDIAC HYPERTROPHY2
CARDIAC FAILURE CHRONIC2
CANDIDA SEPSIS2
BRADYCARDIA NEONATAL2
BLOOD URINE PRESENT2
BLOOD URIC ACID INCREASED2
BLOOD PRESSURE SYSTOLIC INCREASED2
BLOOD PHOSPHORUS INCREASED2
BLOOD MAGNESIUM INCREASED2
BLOOD LACTATE DEHYDROGENASE INCREASED2
BLOOD CULTURE POSITIVE2
Blood creatine phosphokinase increased2
AZOTAEMIA2
ATRIAL FLUTTER2
ATRIAL FIBRILLATION2
ASPARTATE AMINOTRANSFERASE INCREASED2
ARTHRITIS BACTERIAL2
APLASTIC ANAEMIA2
AORTIC DISORDER2
ANAPHYLACTIC SHOCK2
ALANINE AMINOTRANSFERASE INCREASED2
AGRANULOCYTOSIS2
AGGRESSION2
ADVERSE DRUG REACTION2
ADRENAL HAEMORRHAGE2
ACUTE MYOCARDIAL INFARCTION2
ABNORMAL BEHAVIOUR2
ABDOMINAL RIGIDITY2
ABDOMINAL PAIN LOWER2
X-RAY ABNORMAL1
WRONG TECHNIQUE IN DRUG USAGE PROCESS1
Wound secretion1
White blood cell analysis abnormal1
Weight gain poor1
WATER INTOXICATION1
VOLVULUS1
VITREOUS FLOATERS1
VITAMIN C DEFICIENCY1
VISUAL IMPAIRMENT1
VISUAL FIELD DEFECT1
VISUAL ACUITY REDUCED1
VENTRICULAR HYPERTROPHY1
VENTRICULAR FIBRILLATION1
Ventricular dysfunction1
VENTRICULAR ARRHYTHMIA1
VENOUS PRESSURE JUGULAR INCREASED1
VASCULAR RESISTANCE SYSTEMIC INCREASED1
VARICES OESOPHAGEAL1
Uterine rupture1
URINARY RETENTION1
URINARY INCONTINENCE1
Ureaplasma test positive1
Underweight1
UNDERDOSE1
Ultrasound foetal abnormal1
Ulcer haemorrhage1
Twin reversed arterial perfusion sequence malformation1
TWIN PREGNANCY1
TROPONIN INCREASED1
TROPONIN I INCREASED1
Toxic epidermal necrolysis1
TOOTHACHE1
Tooth injury1
Tongue disorder1
TIC1
THERAPEUTIC RESPONSE UNEXPECTED1
Tetany1
Tenosynovitis1
Tendonitis1
TENDON INJURY1
TEMPERATURE REGULATION DISORDER1
Systolic dysfunction1
SYSTEMIC INFLAMMATORY RESPONSE SYNDROME1
SYSTEMIC CANDIDA1
Suspiciousness1
SURGERY1
Superior vena cava syndrome1
SUICIDAL BEHAVIOUR1
SUFFOCATION FEELING1
SUBDURAL HAEMORRHAGE1
Subcutaneous abscess1
STRESS ULCER1
Stress1
Stomatitis1
Staphylococcus test positive1
STAPHYLOCOCCAL SEPSIS1
Staphylococcal scalded skin syndrome1
STAPHYLOCOCCAL INFECTION1
Sputum increased1
Spondylolisthesis1
SPINAL CORD HAEMORRHAGE1
Soliloquy1
Sleep deficit1
Sleep apnoea syndrome1
Skin wrinkling1
Skin necrosis1
Sjogren's syndrome1
SHOCK HAEMORRHAGIC1
Shift to the left1
SERUM FERRITIN DECREASED1
Septic embolus1
SENSATION OF PRESSURE1
SENSATION OF HEAVINESS1
Scar1
Sacroiliac joint dysfunction1
ROAD TRAFFIC ACCIDENT1
RHONCHI1
Retinopathy congenital1
Retinal pigmentation1
Retching1
RESTLESSNESS1
Respiratory tract haemorrhage1
Respiratory rate decreased1
Respiratory moniliasis1
RESPIRATORY DISORDER NEONATAL1
Respiratory disorder1
RESPIRATORY ACIDOSIS1
Renal tubular acidosis1
Renal injury1
RENAL CYST1
Renal cell carcinoma1
REFLUX OESOPHAGITIS1
Red blood cell sedimentation rate increased1
Rebound effect1
Reaction to excipient1
Rash pruritic1
RASH MORBILLIFORM1
RASH MACULO-PAPULAR1
RASH MACULAR1
Rash generalised1
Pyoderma gangrenosum1
PYELONEPHRITIS ACUTE1
Pulse abnormal1
Pulmonary vascular disorder1
PULMONARY HYPOPLASIA1
Pulmonary haemorrhage neonatal1
PULMONARY FIBROSIS1
Pulmonary artery thrombosis1
Pulmonary arterial hypertension1
PSYCHOTIC DISORDER1
PSYCHOTIC BEHAVIOUR1
PSYCHOMOTOR SKILLS IMPAIRED1
Psychiatric symptom1
Psoriatic arthropathy1
PROTHROMBIN TIME PROLONGED1
PROTEIN URINE PRESENT1
Prostatic specific antigen increased1
Prostate cancer recurrent1
Product substitution issue1
PRODUCT QUALITY ISSUE1
Product physical issue1
PROCEDURAL VOMITING1
Preterm premature rupture of membranes1
PRESYNCOPE1
PREMATURE SEPARATION OF PLACENTA1
PREGNANCY1
Pre-eclampsia1
POSTOPERATIVE INFECTION1
Porencephaly1
Poor quality sleep1
POOR QUALITY DRUG ADMINISTERED1
POLYURIA1
POLYP1
POLYHYDRAMNIOS1
POEMS SYNDROME1
PO2 DECREASED1
Pneumonia cytomegaloviral1
Pneumonia aspiration1
PLEURITIC PAIN1
Pleural thickening1
PLEURAL FIBROSIS1
PLATELET COUNT INCREASED1
PLACENTAL DISORDER1
Placenta accreta1
PITTING OEDEMA1
Phonophobia1
Pharyngeal haematoma1
PHARMACEUTICAL PRODUCT COUNTERFEIT1
PERIPHERAL VASCULAR DISORDER1
PERIPHERAL ISCHAEMIA1
PERICARDIAL DISEASE1
Peptic ulcer haemorrhage1
PAROSMIA1
Paraspinal abscess1
Paranoia1
PANIC REACTION1
Panic attack1
PANCREATITIS ACUTE1
PANCREATIC ATROPHY1
Palatal oedema1
PALATAL DISORDER1
PAINFUL RESPIRATION1
Osteosclerosis1
Osteoporotic fracture1
Osteopenia1
OSTEONECROSIS1
ORAL DYSAESTHESIA1
Oesophageal spasm1
Oesophageal pain1
OESOPHAGEAL DISORDER1
OCULOMUCOCUTANEOUS SYNDROME1
OCCULT BLOOD NEGATIVE1
Obstructive sleep apnoea syndrome1
Obstructive defaecation1
Nuchal rigidity1
NON-CARDIAC CHEST PAIN1
NODAL RHYTHM1
NODAL ARRHYTHMIA1
NO THERAPEUTIC RESPONSE1
No adverse event1
Nightmare1
Night sweats1
NEUTROPENIC SEPSIS1
NEUTROPENIA NEONATAL1
NEUROPATHY PERIPHERAL1
Neurological symptom1
NERVOUSNESS1
Nerve injury1
NEPHRITIS1
NEONATAL TACHYCARDIA1
NEONATAL MULTI-ORGAN FAILURE1
Neonatal intestinal perforation1
NEONATAL INFECTION1
Neonatal hypoxia1
NEONATAL CARDIAC FAILURE1
NEONATAL APNOEIC ATTACK1
NEONATAL ANURIA1
NECROSIS1
NAEVUS FLAMMEUS1
Myxoedema coma1
Myositis1
MYELODYSPLASTIC SYNDROME1
MYCOSIS FUNGOIDES1
MYALGIA1
Musculoskeletal pain1
Musculoskeletal discomfort1
MUSCULAR WEAKNESS1
Muscle twitching1
MULTIPLE DRUG OVERDOSE1
MULTIPLE CONGENITAL ABNORMALITIES1
Multiple allergies1
MUCOSAL INFLAMMATION1
MUCORMYCOSIS1
MOVEMENT DISORDER1
Mouth ulceration1
Mouth swelling1
Mood altered1
Mobility decreased1
MITRAL VALVE PROLAPSE1
MITRAL VALVE DISEASE1
MIOSIS1
Metastases to liver1
Metamorphopsia1
Metabolic surgery1
Mental status changes1
MEDICATION ERROR1
MECONIUM PERITONITIS1
Maternal exposure timing unspecified1
Mass1
MARKEDLY REDUCED DIETARY INTAKE1
MAJOR DEPRESSION1
Lymphoedema1
LYMPHOCYTE MORPHOLOGY ABNORMAL1
LYMPH NODE TUBERCULOSIS1
LYMPH NODE CALCIFICATION1
LUNG INFILTRATION1
Lower respiratory tract infection1
Logorrhoea1
Localised oedema1
Liver transplant1
Liver injury1
LIVER DISORDER1
LISTERIOSIS1
LIMB DISCOMFORT1
LIGAMENT SPRAIN1
LEUKOPENIA NEONATAL1
Leukopenia1
LEUKOCYTURIA1
Leptotrichia infection1
LEIOMYOMA1
LEFT VENTRICULAR HYPERTROPHY1
Left ventricular failure1
LEFT ATRIAL DILATATION1
Large intestine polyp1
LARGE INTESTINAL HAEMORRHAGE1
Langerhans' cell histiocytosis1
Lactic acidosis1
LABILE BLOOD PRESSURE1
Klebsiella test positive1
Keratorhexis1
Jejunal perforation1
Jaundice acholuric1
JAUNDICE1
ISCHAEMIA1
Iridocele1
INTESTINAL ULCER PERFORATION1
Intestinal stenosis1
INTESTINAL HAEMORRHAGE1
Intestinal fistula1
INTESTINAL DIAPHRAGM DISEASE1
Intestinal atresia1
Intervertebral disc disorder1
International normalised ratio decreased1
INTERCOSTAL RETRACTION1
INTENTIONAL MISUSE1
INTENTIONAL DRUG MISUSE1
INJURY1
INFANTILE SPASMS1
INDUCED LABOUR1
Increased ventricular preload1
INCORRECT ROUTE OF DRUG ADMINISTRATION1
Incorrect drug administration duration1
Inappropriate schedule of drug administration1
Illness1
ILIAC ARTERY OCCLUSION1
Ileal ulcer1
Idiopathic angioedema1
Hysterectomy1
HYPOXIC ENCEPHALOPATHY1
HYPOTONIA1
HYPOTHYROIDISM1
HYPOTHERMIA1
HYPOPROTEINAEMIA1
Hypoplastic left heart syndrome1
Hypophagia1
HYPOALBUMINAEMIA1
Hypervigilance1
HYPERURICAEMIA1
HYPERTROPHIC CARDIOMYOPATHY1
Hypertensive cardiomyopathy1
Hypersensitivity vasculitis1
HYPERREFLEXIA1
HYPERPROTEINAEMIA1
Hyperlipidaemia1
Hyperinsulinaemic hypoglycaemia1
HYPERGAMMAGLOBULINAEMIA1
Hypercholesterolaemia1
Hyperchlorhydria1
HYPERALDOSTERONISM1
HYDRONEPHROSIS1
HIP SURGERY1
Hip fracture1
HERPES ZOSTER1
HERNIA1
Hepatomegaly1
Hepatocellular injury1
HEPATITIS1
Hepatic fibrosis1
Hepatic cirrhosis1
Henoch-Schonlein purpura1
HELLP SYNDROME1
HELICOBACTER TEST POSITIVE1
HEART SOUNDS ABNORMAL1
Heart rate decreased1
Hallucinations, mixed1
HAEMORRHAGIC ANAEMIA1
HAEMORRHAGE URINARY TRACT1
HAEMORRHAGE NEONATAL1
HAEMOLYSIS1
HAEMATOCRIT INCREASED1
Haemarthrosis1
GROWTH RETARDATION1
GRANULOMA1
GRAND MAL CONVULSION1
Gouty arthritis1
GLUCOSE URINE PRESENT1
GITELMAN'S SYNDROME1
Gingival pain1
GINGIVAL HYPERTROPHY1
GINGIVAL DISCOLOURATION1
Genital ulceration1
GENERAL PHYSICAL CONDITION ABNORMAL1
Gene mutation1
Gastrooesophageal cancer1
Gastrointestinal tract irritation1
GASTROINTESTINAL TRACT ADENOMA1
Gastrointestinal pain1
GASTROINTESTINAL OEDEMA1
GASTROINTESTINAL MUCOSAL DISORDER1
GASTROINTESTINAL INFECTION1
GASTROINTESTINAL HYPOMOTILITY1
GASTROINTESTINAL FISTULA1
GASTROINTESTINAL EROSION1
Gastrointestinal bacterial overgrowth1
Gastroduodenal ulcer1
GASTRITIS HAEMORRHAGIC1
GASTRIC VARICES HAEMORRHAGE1
Gastric bypass1
Gallbladder operation1
FREQUENT BOWEL MOVEMENTS1
FRACTURE1
Folliculitis1
FOETAL MOVEMENTS DECREASED1
Foetal growth restriction1
FLUID OVERLOAD1
Fibromyalgia1
Femoral pulse decreased1
Feeling hot1
Failure to thrive1
EYELID PTOSIS1
EYELID OEDEMA1
EYE DISORDER1
EXTUBATION1
Exposure via ingestion1
EXERCISE TOLERANCE DECREASED1
ESCHERICHIA URINARY TRACT INFECTION1
ERYTHEMA OF EYELID1
ERYTHEMA MULTIFORME1
Epilepsy1
EPIGASTRIC DISCOMFORT1
EOSINOPHILS URINE PRESENT1
Enterocolitis1
ENTEROBACTER SEPSIS1
ENTERITIS NECROTICANS1
ENDOTRACHEAL INTUBATION1
ENDOTHELIN INCREASED1
ENCEPHALOPATHY NEONATAL1
ELECTROLYTE IMBALANCE1
ELECTROENCEPHALOGRAM ABNORMAL1
ELECTROCARDIOGRAM T WAVE INVERSION1
ELECTROCARDIOGRAM REPOLARISATION ABNORMALITY1
ELECTROCARDIOGRAM QRS COMPLEX PROLONGED1
Eczema1
DYSURIA1
DYSTROPHIA MYOTONICA1
DYSTONIA1
DYSPHAGIA1
Dyslexia1
DYSGEUSIA1
DUODENOGASTRIC REFLUX1
DUODENAL ULCER HAEMORRHAGE1
DUODENAL STENOSIS1
Dry eye1
Drug screen false positive1
Drug effective for unapproved indication1
DRUG EFFECT DECREASED1
DIZZINESS POSTURAL1
DIVERTICULITIS1
DIVERTICULAR HERNIA1
DISSEMINATED INTRAVASCULAR COAGULATION IN NEWBORN1
DISEASE PROGRESSION1
DILATATION ATRIAL1
DIFFICULTY IN WALKING1
DIABETES MELLITUS INADEQUATE CONTROL1
Diabetes mellitus1
Device related infection1
Developmental glaucoma1
DEVELOPMENTAL DELAY1
Detachment of retinal pigment epithelium1
DERMATITIS EXFOLIATIVE1
Dermatitis bullous1
Depression1
Depersonalisation1
Delirium1
Deep vein thrombosis1
DEAFNESS1
CYTOLYTIC HEPATITIS1
Cytogenetic abnormality1
Cystitis1
CYANOSIS NEONATAL1
CRYSTAL ARTHROPATHY1
CREPITATIONS1
CREATININE URINE INCREASED1
CORONARY ARTERY STENOSIS1
CORONARY ARTERY DISEASE1
Corneal transplant1
CORNEAL DISORDER1
Coordination abnormal1
CONVULSION NEONATAL1
Conjunctivitis1
Conjunctival hyperaemia1
Congestive cardiomyopathy1
COMPARTMENT SYNDROME1
COLONIC STENOSIS1
COLONIC POLYP1
Colitis ulcerative1
COLITIS COLLAGENOUS1
COLD SWEAT1
Coeliac disease1
Clostridium difficile infection1
Claustrophobia1
Circulatory failure neonatal1
Chylothorax1
CHRONIC OBSTRUCTIVE PULMONARY DISEASE1
Chronic kidney disease1
CHRONIC INFLAMMATORY DEMYELINATING POLYRADICULONEUROPATHY1
Chromosomal mutation1
Chromaturia1
Choking sensation1
Choking1
CEREBRAL INFARCTION1
Cerebral haematoma1
Central serous chorioretinopathy1
Cell death1
CATHETER SEPSIS1
CATHETER RELATED INFECTION1
CATHETER RELATED COMPLICATION1
Carpal tunnel syndrome1
CAROTID ARTERY OCCLUSION1
Cardiopulmonary failure1
Cardiac murmur1
CARDIAC INDEX DECREASED1
Cardiac failure acute1
CACHEXIA1
BURSITIS INFECTIVE STAPHYLOCOCCAL1
BURNING SENSATION1
Bronchospasm1
Bronchitis1
Breathing-related sleep disorder1
BREATH SOUNDS ABNORMAL1
Brain oedema1
BRADYARRHYTHMIA1
BOWEL MOVEMENT IRREGULARITY1
Bone marrow oedema1
BONE MARROW FAILURE1
BONE MARROW DEPRESSION1
Bone lesion1
Bone erosion1
Bone density decreased1
Blood urea abnormal1
BLOOD TRIGLYCERIDES INCREASED1
BLOOD TESTOSTERONE DECREASED1
BLOOD PRESSURE SYSTOLIC DECREASED1
Blood pressure fluctuation1
BLOOD PRESSURE DIASTOLIC INCREASED1
BLOOD POTASSIUM DECREASED1
Blood glucose abnormal1
Blood creatinine abnormal1
BLOOD CHOLESTEROL INCREASED1
Blood caffeine increased1
BLOOD ALDOSTERONE INCREASED1
Bilirubin conjugated increased1
Basal cell carcinoma1
BARTTER'S SYNDROME1
BACTERIAL INFECTION1
BACTERIAL FOOD POISONING1
Back injury1
Bacillus bacteraemia1
BABINSKI REFLEX TEST1
Autoinflammatory disease1
Autoimmune pancreatitis1
ATRIOVENTRICULAR BLOCK FIRST DEGREE1
Atrioventricular block complete1
ATRIAL TACHYCARDIA1
Atrial septal defect1
ATRIAL NATRIURETIC PEPTIDE INCREASED1
ATELECTASIS1
Asthma1
Arthropathy1
Arthritis gonococcal1
ARTERIAL OCCLUSIVE DISEASE1
ARRHYTHMIA SUPRAVENTRICULAR1
ARRHYTHMIA NEONATAL1
ARRHYTHMIA1
Apparent death1
APNOEIC ATTACK1
APLASIA PURE RED CELL1
Aphthous ulcer1
Aorticopulmonary septal defect1
Aortic thrombosis1
Aortic stenosis1
AORTIC OCCLUSION1
AORTIC DISSECTION1
ANTICONVULSANT DRUG LEVEL DECREASED1
ANTERIOR CHAMBER DISORDER1
ANOREXIA1
Anorectal discomfort1
Ankle fracture1
ANION GAP INCREASED1
ANGIOPATHY1
ANGINA PECTORIS1
Anencephaly1
Anastomotic ulcer haemorrhage1
Anaphylactic reaction1
ANAEMIA MACROCYTIC1
Amniotic fluid volume decreased1
Amniotic cavity infection1
AMNIOCENTESIS ABNORMAL1
Alopecia1
ALCOHOL USE1
Age-related macular degeneration1
Affective disorder1
ADHESION1
Acute pulmonary oedema1
ACUTE PRERENAL FAILURE1
Acute generalised exanthematous pustulosis1
ACTIVATED PARTIAL THROMBOPLASTIN TIME PROLONGED1
ACQUIRED OESOPHAGEAL WEB1
ACQUIRED HAEMOPHILIA1
ACCIDENTAL OVERDOSE1
Abscess1
ABORTION INDUCED1
Abnormal loss of weight1
ABDOMINAL WALL ABSCESS1
ABDOMINAL TENDERNESS1
Abdominal abscess1





Filtered ChEMBL targets:

Target UniProtKB ID Activity in nm Target Name Target gene
B2RXH2 10000 Lysine-specific demethylase 4E KDM4E_HUMAN
P00403 70 Cytochrome c oxidase subunit 2 COX2_HUMAN
P09917 7000 Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN
P10145 50 Interleukin-8 IL8_HUMAN
P10275 0.14 Androgen receptor ANDR_HUMAN
P23219 5 Prostaglandin G/H synthase 1 PGH1_HUMAN
P35354 10 Prostaglandin G/H synthase 2 PGH2_HUMAN
P42330 100 Aldo-keto reductase family 1 member C3 AK1C3_HUMAN
P42345 4645.1 Serine/threonine-protein kinase mTOR MTOR_HUMAN
P51151 6309.6 Ras-related protein Rab-9A RAB9A_HUMAN
Q16665 6309.6 Hypoxia-inducible factor 1-alpha HIF1A_HUMAN
Q6W5P4 1584.9 Neuropeptide S receptor NPSR1_HUMAN
Q6XQN6 0.15 Nicotinate phosphoribosyltransferase PNCB_HUMAN
Q9Y5Y4 50 Prostaglandin D2 receptor 2 PD2R2_HUMAN



Toxicity information:

Toxicity class: 3
Toxicity type: multiple; gastrointestinal
LD50: 125 mg/kg



External links:

ChEBML: CHEMBL6
DrugBank: DB00328