Hexachlorophene
General information:
| Withdrawn ID: | w1 |
|---|---|
| Canonical SMILES: | |
| Standard InChI: | |
| Standard InChIKey: | |
| ATC class(es): | D08AE01 |
| Molecular Formula: | C13H6Cl6O2 |
| Molweight: | 406.904 |
Withdrawal information:
| Withdrawn due to drug safety reasons: | Yes |
|---|---|
| First approved: | 1949 |
| First withdrawn: | 1972 |
| Last withdrawn: | 1988 |
| Reference: | https://www.ncbi.nlm.nih.gov/pubmed/1117313 |
Side-effects:
| Total reported cases (submitted by medical professionals) with Hexachlorophene as primary suspect: | 3 |
|---|
Reported final outcomes:
| Disability: | 1 |
|---|---|
| Hospitalization (initial or prolonged): | 1 |
Reported side-effects:
| Side-effect | Case number |
|---|---|
| NERVOUS SYSTEM DISORDER | 1 |
| Hypersensitivity | 1 |
| Drug hypersensitivity | 1 |
| DEPRESSION | 1 |
Filtered ChEMBL targets:
| Target UniProtKB ID | Activity in nm | Target Name | Target gene |
|---|---|---|---|
| O15118 | 3162.3 | NPC intracellular cholesterol transporter 1 | NPC1_HUMAN |
| P02545 | 446.7 | Prelamin-A/C | LMNA_HUMAN |
| P03372 | 2161.56 | Estrogen receptor | ESR1_HUMAN |
| P11021 | 9100 | Endoplasmic reticulum chaperone BiP | BIP_HUMAN |
| P14174 | 5550 | Macrophage migration inhibitory factor | MIF_HUMAN |
| P16050 | 5011.9 | Polyunsaturated fatty acid lipoxygenase ALOX15 | LOX15_HUMAN |
| P16473 | 10000 | Thyrotropin receptor | TSHR_HUMAN |
| P24557 | 3087 | Thromboxane-A synthase | THAS_HUMAN |
| P25929 | 9796 | Neuropeptide Y receptor type 1 | NPY1R_HUMAN |
| P42858 | 5623.4 | Huntingtin | HD_HUMAN |
| P55072 | 5488 | Transitional endoplasmic reticulum ATPase | TERA_HUMAN |
| P61604 | 1300 | 10 kDa heat shock protein, mitochondrial | CH10_HUMAN |
| Q16637 | 2818.4 | Survival motor neuron protein | SMN_HUMAN |
| Q6IQ20 | 1600 | N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D | NAPEP_HUMAN |
| Q92731 | 98.27 | Estrogen receptor beta | ESR2_HUMAN |
| Q99714 | 7943.3 | 3-hydroxyacyl-CoA dehydrogenase type-2 | HCD2_HUMAN |
Toxicity information:
| Toxicity class: | 3 |
|---|---|
| Toxicity type: | neurological |
| LD50: | 100 mg/kg |
External links:
| ChEBML: | CHEMBL496 |
|---|---|
| DrugBank: | DB00756 |