Gefitinib


895



General information:


Withdrawn ID: 895
Canonical SMILES:
Standard InChI:
Standard InChIKey:
ATC class(es): L01XE02
Molecular Formula: C22H24ClFN4O3
Molweight: 446.902



Withdrawal information:


Withdrawn due to drug safety reasons:No
First approved: 2003
First withdrawn: 2005



Side-effects:

Total reported cases (submitted by medical professionals) with Gefitinib as primary suspect: 3401


Reported final outcomes:
Hospitalization (initial or prolonged): 1422
Death: 622
Life-Threatening condition: 284
Disability: 185
Intervention required to prevent permanent impairment/damage: 158
Congenital anomaly: 3


Reported side-effects:

Side-effect Case number
MALIGNANT NEOPLASM PROGRESSION489
DIARRHOEA334
INTERSTITIAL LUNG DISEASE269
RASH225
DISEASE PROGRESSION208
LUNG DISORDER167
PNEUMONIA163
Drug resistance157
HEPATIC FUNCTION ABNORMAL152
NAUSEA146
VOMITING143
PYREXIA131
DYSPNOEA127
LIVER DISORDER119
METASTASES TO CENTRAL NERVOUS SYSTEM108
DEHYDRATION89
PLEURAL EFFUSION84
DEATH84
ANAEMIA83
RESPIRATORY FAILURE77
ASTHENIA71
ALANINE AMINOTRANSFERASE INCREASED65
PULMONARY EMBOLISM59
FATIGUE58
ASPARTATE AMINOTRANSFERASE INCREASED56
Acquired gene mutation56
METASTASES TO BONE55
OFF LABEL USE53
DECREASED APPETITE53
COUGH53
ANOREXIA50
PRURITUS46
STOMATITIS45
DERMATITIS ACNEIFORM44
THROMBOCYTOPENIA43
PNEUMONITIS43
METASTASES TO MENINGES43
METASTASES TO LUNG43
DRY SKIN43
ABDOMINAL PAIN42
HYPOXIA40
METASTASES TO LIVER39
GENERAL PHYSICAL HEALTH DETERIORATION38
RENAL FAILURE37
MALAISE37
PLATELET COUNT DECREASED36
HEADACHE36
DIZZINESS36
CONDITION AGGRAVATED36
SEPSIS35
FALL35
DRUG INEFFECTIVE35
OEDEMA PERIPHERAL34
HYPOTENSION34
PARONYCHIA33
DYSPHAGIA33
INFECTION32
HAEMOGLOBIN DECREASED32
CEREBRAL INFARCTION32
SKIN DISORDER31
RENAL FAILURE ACUTE31
DRUG INTERACTION31
BLOOD CREATININE INCREASED31
WHITE BLOOD CELL COUNT DECREASED30
WEIGHT DECREASED30
PAIN30
FEBRILE NEUTROPENIA30
DEPRESSED LEVEL OF CONSCIOUSNESS30
DEEP VEIN THROMBOSIS30
LIVER FUNCTION TEST ABNORMAL29
CARDIAC FAILURE29
URINARY TRACT INFECTION28
RENAL IMPAIRMENT28
HAEMOPTYSIS28
CONSTIPATION28
CONFUSIONAL STATE28
ERYTHEMA27
SKIN ULCER26
PNEUMOTHORAX26
NEUTROPENIA26
LYMPHANGIOSIS CARCINOMATOSA26
GASTROINTESTINAL HAEMORRHAGE26
SKIN TOXICITY25
BLOOD ALKALINE PHOSPHATASE INCREASED25
LUNG INFILTRATION24
HEPATOTOXICITY24
HAEMATEMESIS24
PNEUMONIA ASPIRATION23
INTERNATIONAL NORMALISED RATIO INCREASED23
CYSTITIS HAEMORRHAGIC23
CHEST PAIN23
ALOPECIA23
ACNE23
MYOCARDIAL INFARCTION22
Malignant transformation22
HYPONATRAEMIA22
HYPOKALAEMIA22
EGFR gene mutation22
ATRIAL FIBRILLATION22
ACUTE RESPIRATORY DISTRESS SYNDROME22
TRANSAMINASES INCREASED21
MUSCULAR WEAKNESS21
SOMNOLENCE20
PULMONARY OEDEMA20
PERICARDIAL EFFUSION20
PAIN IN EXTREMITY20
LEUKOPENIA20
DISSEMINATED INTRAVASCULAR COAGULATION20
CELLULITIS20
OXYGEN SATURATION DECREASED19
MUCOSAL INFLAMMATION19
METASTASES TO LYMPH NODES19
HEPATIC ENZYME INCREASED19
ORAL INTAKE REDUCED18
OESOPHAGITIS18
ATELECTASIS18
ACUTE RESPIRATORY FAILURE18
PNEUMONIA BACTERIAL17
OEDEMA17
METASTASIS17
HEPATITIS17
HEART RATE INCREASED17
HAEMATURIA17
COMA17
BLOOD PRESSURE DECREASED17
ABDOMINAL PAIN UPPER17
WHITE BLOOD CELL COUNT INCREASED16
DRUG TOXICITY16
CEREBROVASCULAR ACCIDENT16
SYNCOPE15
STAPHYLOCOCCAL INFECTION15
EPISTAXIS15
CONVULSION15
CHILLS15
BLOOD LACTATE DEHYDROGENASE INCREASED15
BACK PAIN15
Small cell lung cancer14
RESPIRATORY DISTRESS14
PURPURA14
PULMONARY ALVEOLAR HAEMORRHAGE14
PRODUCTIVE COUGH14
PERITONITIS14
MULTI-ORGAN FAILURE14
LUNG NEOPLASM MALIGNANT14
LOSS OF CONSCIOUSNESS14
HERPES ZOSTER14
DEMENTIA14
SKIN EXFOLIATION13
RASH PRURITIC13
PNEUMATOSIS INTESTINALIS13
PANCYTOPENIA13
NEUTROPHIL COUNT DECREASED13
NAIL DISORDER13
LEUKOENCEPHALOPATHY13
GAMMA-GLUTAMYLTRANSFERASE INCREASED13
CYTOLYTIC HEPATITIS13
BONE MARROW FAILURE13
VISION BLURRED12
NON-SMALL CELL LUNG CANCER12
NASOPHARYNGITIS12
MALIGNANT PLEURAL EFFUSION12
LUNG INFECTION12
INTESTINAL OBSTRUCTION12
HYPOMAGNESAEMIA12
HYPOAESTHESIA12
HYPERTENSION12
HEPATIC FAILURE12
ELECTROCARDIOGRAM QT PROLONGED12
ECZEMA12
DRUG INTOLERANCE12
CHEST DISCOMFORT12
CEREBRAL HAEMORRHAGE12
CARDIO-RESPIRATORY ARREST12
CARDIAC ARREST12
C-REACTIVE PROTEIN INCREASED12
TACHYCARDIA11
SPEECH DISORDER11
RENAL DISORDER11
RECTAL HAEMORRHAGE11
PULMONARY HAEMORRHAGE11
PALMAR-PLANTAR ERYTHRODYSAESTHESIA SYNDROME11
MUSCLE SPASMS11
METASTASES TO PLEURA11
HAEMATOCRIT DECREASED11
FOLLICULITIS11
FACE OEDEMA11
DYSPNOEA EXERTIONAL11
DRUG ERUPTION11
CARDIAC FAILURE CONGESTIVE11
ARTHRALGIA11
ANXIETY11
TREMOR10
SEPTIC SHOCK10
RASH PUSTULAR10
PROTHROMBIN TIME PROLONGED10
Product use in unapproved indication10
METASTASES TO SPINE10
METASTASES TO ADRENALS10
LETHARGY10
ILEUS10
GASTRIC ULCER10
ENTEROCOLITIS10
ELECTROLYTE IMBALANCE10
DYSPEPSIA10
DYSGEUSIA10
DUODENAL ULCER10
DISEASE RECURRENCE10
BLOOD UREA INCREASED10
BLOOD PRESSURE INCREASED10
BLOOD GLUCOSE INCREASED10
ASCITES10
ABDOMINAL DISTENSION10
TACHYPNOEA9
SKIN INFECTION9
RASH GENERALISED9
PROTEINURIA9
Product use issue9
PERFORMANCE STATUS DECREASED9
OVERDOSE9
NEUROPATHY PERIPHERAL9
MENTAL STATUS CHANGES9
MELAENA9
LUNG CONSOLIDATION9
INSOMNIA9
GASTROOESOPHAGEAL REFLUX DISEASE9
FRACTURE9
DISORIENTATION9
DERMATITIS9
DEPRESSION9
BRONCHOPNEUMONIA9
BLOOD POTASSIUM INCREASED9
BLISTER9
APHASIA9
TREATMENT NONCOMPLIANCE8
THROMBOSIS8
THERAPY NON-RESPONDER8
SQUAMOUS CELL CARCINOMA8
SKIN LESION8
RESPIRATORY ARREST8
REFUSAL OF TREATMENT BY PATIENT8
RADIATION PNEUMONITIS8
PULMONARY MASS8
PULMONARY FIBROSIS8
PNEUMOCYSTIS JIROVECI PNEUMONIA8
PALPITATIONS8
NEOPLASM PROGRESSION8
LUNG NEOPLASM8
LUNG CARCINOMA CELL TYPE UNSPECIFIED RECURRENT8
JAUNDICE8
HYPERSENSITIVITY8
HEMIPLEGIA8
HAIR TEXTURE ABNORMAL8
HAEMORRHAGE8
FEMUR FRACTURE8
EPILEPSY8
DYSURIA8
DELIRIUM8
COAGULOPATHY8
CEREBRAL ISCHAEMIA8
CARDIOMEGALY8
BRONCHITIS8
BRADYCARDIA8
BLOOD ALBUMIN DECREASED8
Acute kidney injury8
ABSCESS8
ABDOMINAL DISCOMFORT8
WEIGHT INCREASED7
TOXIC EPIDERMAL NECROLYSIS7
SHOCK7
POLLAKIURIA7
MOUTH ULCERATION7
METABOLIC ACIDOSIS7
HYPOGLYCAEMIA7
HYPOCALCAEMIA7
HYPERBILIRUBINAEMIA7
GAIT DISTURBANCE7
FAECES DISCOLOURED7
Drug-induced liver injury7
BODY TEMPERATURE INCREASED7
BLOOD SODIUM DECREASED7
BLOOD CREATINE PHOSPHOKINASE INCREASED7
BLOOD BILIRUBIN INCREASED7
AMNESIA7
ALTERED STATE OF CONSCIOUSNESS7
ACUTE MYOCARDIAL INFARCTION7
TUMOUR HAEMORRHAGE6
Toxicity to various agents6
Therapy cessation6
THERAPEUTIC RESPONSE DECREASED6
SWELLING6
RHABDOMYOLYSIS6
RESPIRATORY RATE INCREASED6
RECALL PHENOMENON6
RASH MACULO-PAPULAR6
PLEURISY6
PANCREATITIS ACUTE6
ORGANISING PNEUMONIA6
ORAL PAIN6
NON-SMALL CELL LUNG CANCER RECURRENT6
No adverse event6
NERVOUS SYSTEM DISORDER6
NEPHROTIC SYNDROME6
Multiple organ dysfunction syndrome6
MARKEDLY REDUCED DIETARY INTAKE6
LYMPHADENOPATHY MEDIASTINAL6
LUNG ADENOCARCINOMA6
LOWER RESPIRATORY TRACT INFECTION6
LARGE INTESTINE PERFORATION6
IMPAIRED HEALING6
HAEMATOCHEZIA6
Gene mutation6
FEELING ABNORMAL6
ENCEPHALOPATHY6
EMPHYSEMA6
DYSARTHRIA6
DERMATITIS EXFOLIATIVE6
DEAFNESS6
CONJUNCTIVITIS6
COGNITIVE DISORDER6
CIRCULATORY COLLAPSE6
CHRONIC OBSTRUCTIVE PULMONARY DISEASE6
CHEST X-RAY ABNORMAL6
CEREBRAL ATROPHY6
CARCINOEMBRYONIC ANTIGEN INCREASED6
BRAIN OEDEMA6
BONE LESION6
BACTERIAL INFECTION6
ASPIRATION6
ARTHRITIS6
AGITATION6
ACTIVITIES OF DAILY LIVING IMPAIRED6
ACTIVATED PARTIAL THROMBOPLASTIN TIME PROLONGED6
ABASIA6
VISUAL ACUITY REDUCED5
VERTIGO5
VENTRICULAR EXTRASYSTOLES5
URTICARIA5
URINE OUTPUT DECREASED5
UPPER RESPIRATORY TRACT INFECTION5
UPPER GASTROINTESTINAL HAEMORRHAGE5
Treatment failure5
TONGUE DISORDER5
Therapy partial responder5
SUBILEUS5
STEVENS-JOHNSON SYNDROME5
SMALL INTESTINAL OBSTRUCTION5
SINUS TACHYCARDIA5
RESPIRATORY DISORDER5
RASH PAPULAR5
RASH ERYTHEMATOUS5
RADIATION INJURY5
PSEUDOMONAS INFECTION5
POLYNEUROPATHY5
PLEURITIC PAIN5
PLATELET COUNT INCREASED5
PARAESTHESIA5
PANCREATITIS5
ODYNOPHAGIA5
NEUROLOGICAL SYMPTOM5
MYELODYSPLASTIC SYNDROME5
MYALGIA5
MUCOUS MEMBRANE DISORDER5
MENTAL DISORDER5
MEDICATION ERROR5
LYMPHOPENIA5
LUNG CANCER METASTATIC5
LOWER GASTROINTESTINAL HAEMORRHAGE5
LIVER INJURY5
KLEBSIELLA INFECTION5
INTESTINAL ISCHAEMIA5
INFLUENZA LIKE ILLNESS5
HYPERHIDROSIS5
HYDRONEPHROSIS5
HICCUPS5
HAEMORRHAGE SUBCUTANEOUS5
GASTROENTERITIS5
GASTRITIS5
GASTRIC ULCER HAEMORRHAGE5
GASTRIC CANCER5
FLATULENCE5
FEMORAL NECK FRACTURE5
EYE PAIN5
EYE DISORDER5
DRUG HYPERSENSITIVITY5
DIABETES MELLITUS5
CREATININE RENAL CLEARANCE DECREASED5
CHOLESTASIS5
CHOLELITHIASIS5
Breast cancer5
BLOOD URINE PRESENT5
BLOOD CULTURE POSITIVE5
BLINDNESS5
ACUTE MYELOID LEUKAEMIA5
ABNORMAL BEHAVIOUR5
XERODERMA4
VASCULITIS4
URINARY RETENTION4
ULCER4
TOXIC SKIN ERUPTION4
SWELLING FACE4
SURGERY4
SUBDURAL HAEMATOMA4
Squamous cell carcinoma of lung4
SKIN REACTION4
SCAB4
RETINAL HAEMORRHAGE4
RETINAL DETACHMENT4
RECURRENT CANCER4
PULMONARY TOXICITY4
PULMONARY CONGESTION4
POST PROCEDURAL COMPLICATION4
PNEUMATOSIS4
PETECHIAE4
ORAL CANDIDIASIS4
ONYCHOMADESIS4
ONYCHOCLASIS4
NON-SMALL CELL LUNG CANCER METASTATIC4
NEOPLASM MALIGNANT4
NAIL INFECTION4
MYOCARDIAL ISCHAEMIA4
MUSCLE DISORDER4
MOUTH HAEMORRHAGE4
METASTATIC NEOPLASM4
MENINGITIS4
MEMORY IMPAIRMENT4
MANIA4
MALNUTRITION4
LYMPHADENOPATHY4
LEUKOCYTOSIS4
LACUNAR INFARCTION4
LACRIMATION INCREASED4
INTRACRANIAL PRESSURE INCREASED4
INGUINAL HERNIA4
INGROWING NAIL4
INFECTIOUS PLEURAL EFFUSION4
IMPETIGO4
HYPOTHYROIDISM4
HYPOTHERMIA4
HYPOPHAGIA4
HYPOALBUMINAEMIA4
HYPERKALAEMIA4
HYPERGLYCAEMIA4
Hepatocellular injury4
HEPATITIS FULMINANT4
HAIR GROWTH ABNORMAL4
HAEMOLYSIS4
HAEMODIALYSIS4
GRAND MAL CONVULSION4
GASTROINTESTINAL ULCER4
GASTROINTESTINAL DISORDER4
GASTRITIS EROSIVE4
FUNGAL INFECTION4
FEELING HOT4
ESCHERICHIA INFECTION4
EATING DISORDER4
DYSPHONIA4
DUODENAL ULCER HAEMORRHAGE4
DRY EYE4
DIVERTICULAR PERFORATION4
DEMYELINATION4
DECUBITUS ULCER4
CYSTITIS4
CYANOSIS4
CULTURE URINE POSITIVE4
COORDINATION ABNORMAL4
CONTUSION4
COLON CANCER4
COLITIS ISCHAEMIC4
CHROMATURIA4
CATARACT4
BURNING SENSATION4
BLOOD POTASSIUM DECREASED4
BLOOD MAGNESIUM DECREASED4
BLOOD CREATINE INCREASED4
Bladder cancer4
BALANCE DISORDER4
ARRHYTHMIA4
ADENOCARCINOMA4
ACUTE PROMYELOCYTIC LEUKAEMIA4
WHEEZING3
VULVOVAGINAL DISCOMFORT3
VOCAL CORD PARALYSIS3
Visual impairment3
VISUAL DISTURBANCE3
VIRAL INFECTION3
VENA CAVA THROMBOSIS3
URINE KETONE BODY PRESENT3
THROAT IRRITATION3
THERAPEUTIC RESPONSE UNEXPECTED3
TENDERNESS3
SUICIDE ATTEMPT3
SUFFOCATION FEELING3
SUDDEN DEATH3
SUBDURAL HAEMORRHAGE3
STRIDOR3
SKIN NECROSIS3
SKIN FISSURES3
SKIN DISCOLOURATION3
Seizure3
SEBORRHOEIC DERMATITIS3
Schizophrenia3
RETINAL ARTERY OCCLUSION3
RENAL FUNCTION TEST ABNORMAL3
REFUSAL OF TREATMENT BY RELATIVE3
RED BLOOD CELL COUNT DECREASED3
RECTAL CANCER3
RADIATION SKIN INJURY3
PYODERMA3
PULMONARY HYPERTENSION3
PSEUDOMEMBRANOUS COLITIS3
Prostate cancer3
PRINZMETAL ANGINA3
PRESCRIBED OVERDOSE3
POST PROCEDURAL VOMITING3
PORTAL VEIN THROMBOSIS3
PHARYNGOLARYNGEAL PAIN3
PERSONALITY CHANGE3
PERITONEAL DISORDER3
PERICARDIAL EFFUSION MALIGNANT3
PCO2 DECREASED3
PARANEOPLASTIC SYNDROME3
OTITIS MEDIA3
OCCULT BLOOD POSITIVE3
OCCULT BLOOD3
NUCLEAR MAGNETIC RESONANCE IMAGING BRAIN ABNORMAL3
NIGHT SWEATS3
NEUROPATHY3
Neuroendocrine tumour of the lung3
NECROSIS3
Nail toxicity3
MUSCULOSKELETAL PAIN3
MOBILITY DECREASED3
MICTURITION URGENCY3
Metastases to breast3
MEDICAL DEVICE COMPLICATION3
LUNG ADENOCARCINOMA STAGE IV3
LOBAR PNEUMONIA3
LEUKAEMIA3
LARGE INTESTINAL ULCER3
ISCHAEMIC STROKE3
INTESTINAL PERFORATION3
INTESTINAL HAEMORRHAGE3
Intentional product use issue3
INFLAMMATION3
INCREASED BRONCHIAL SECRETION3
INCONTINENCE3
INAPPROPRIATE ANTIDIURETIC HORMONE SECRETION3
IMPAIRED SELF-CARE3
IMMUNODEFICIENCY3
HYPOACUSIS3
HYPERTRANSAMINASAEMIA3
HYPERCALCAEMIA3
HYDROCEPHALUS3
HIATUS HERNIA3
HEPATITIS TOXIC3
HEPATIC CYST3
HENOCH-SCHONLEIN PURPURA3
Hemiparesis3
HEART RATE IRREGULAR3
HAEMOTHORAX3
GINGIVITIS3
GINGIVAL BLEEDING3
GASTROINTESTINAL PERFORATION3
GASTROINTESTINAL NECROSIS3
GASTROINTESTINAL MOTILITY DISORDER3
FLANK PAIN3
FEELING COLD3
FEEDING DISORDER3
FAECAL INCONTINENCE3
EYE PRURITUS3
EYE DISCHARGE3
EXCESSIVE GRANULATION TISSUE3
EROSIVE DUODENITIS3
EOSINOPHILIC PNEUMONIA3
ENCEPHALITIS3
EMBOLISM3
EMBOLIC STROKE3
DRY MOUTH3
Drug tolerance3
DRUG DOSE OMISSION3
DIFFUSE ALVEOLAR DAMAGE3
CYSTITIS INTERSTITIAL3
Cutaneous symptom3
CRYPTOGENIC ORGANIZING PNEUMONIA3
CRANIAL NERVE DISORDER3
CORNEAL DISORDER3
COMPUTERISED TOMOGRAM ABNORMAL3
COLITIS ULCERATIVE3
COLITIS3
CHRONIC OBSTRUCTIVE AIRWAYS DISEASE EXACERBATED3
CHOLECYSTITIS3
CEREBRAL ARTERY EMBOLISM3
CEREBELLAR INFARCTION3
CATHETER RELATED INFECTION3
CALCULUS URETERIC3
CACHEXIA3
BONE PAIN3
BLOOD PRESSURE SYSTOLIC INCREASED3
BLOOD PRESSURE DIASTOLIC DECREASED3
BLOOD CALCIUM DECREASED3
BLINDNESS TRANSIENT3
BACTERAEMIA3
B-cell lymphoma3
AZOTAEMIA3
ATRIAL FLUTTER3
APPENDICITIS3
AORTIC DISSECTION3
ANURIA3
ANAPHYLACTIC SHOCK3
ANAPHYLACTIC REACTION3
AMMONIA INCREASED3
ALVEOLITIS3
ADVERSE EVENT3
ADRENAL INSUFFICIENCY3
XEROSIS2
WOUND INFECTION STAPHYLOCOCCAL2
VENTRICULAR FIBRILLATION2
Venous thrombosis limb2
VENOOCCLUSIVE LIVER DISEASE2
VASCULITIS NECROTISING2
VAGINAL PAIN2
VAGINAL HAEMORRHAGE2
URINARY INCONTINENCE2
Ureteric stenosis2
UNRESPONSIVE TO STIMULI2
Ulcerative keratitis2
TUMOUR LYSIS SYNDROME2
TRANSIENT ISCHAEMIC ATTACK2
TOOTH INFECTION2
TONGUE NEOPLASM MALIGNANT STAGE UNSPECIFIED2
THROMBOPHLEBITIS2
Symmetrical drug-related intertriginous and flexural exanthema2
SUPRAVENTRICULAR TACHYCARDIA2
SUPERIOR VENA CAVA SYNDROME2
SUBCUTANEOUS EMPHYSEMA2
SUBCUTANEOUS ABSCESS2
STREPTOCOCCAL BACTERAEMIA2
STAPHYLOCOCCAL BACTERAEMIA2
SPLENIC INFARCTION2
SPINAL OSTEOARTHRITIS2
SPINAL DISORDER2
SPINAL COMPRESSION FRACTURE2
SOFT TISSUE INFECTION2
SKIN INDURATION2
SKIN HYPERPIGMENTATION2
SKIN EROSION2
SKIN CHAPPED2
SKIN ATROPHY2
SERRATIA INFECTION2
SCREAMING2
SALIVARY HYPERSECRETION2
RHINORRHOEA2
RETINAL VEIN THROMBOSIS2
RESTLESSNESS2
RESPIRATORY ACIDOSIS2
RENAL TUBULAR NECROSIS2
RENAL CYST2
REFRACTORY ANAEMIA WITH AN EXCESS OF BLASTS2
REFLUX OESOPHAGITIS2
RED BLOOD CELLS URINE POSITIVE2
RASH MACULAR2
Radiation necrosis2
PYOTHORAX2
Pyogenic granuloma2
PURULENT DISCHARGE2
PURULENCE2
PULMONARY HILUM MASS2
Pulmonary artery thrombosis2
Psoriasis2
PRURITUS GENERALISED2
PROTHROMBIN LEVEL DECREASED2
PROTEIN TOTAL DECREASED2
Product dose omission2
Primary effusion lymphoma2
PRESYNCOPE2
Posterior reversible encephalopathy syndrome2
POST PROCEDURAL NAUSEA2
POST PROCEDURAL HAEMATOMA2
POLYP2
PO2 DECREASED2
PNEUMOPERITONEUM2
PNEUMONIA FUNGAL2
PNEUMOMEDIASTINUM2
Plasma cell myeloma2
PITTING OEDEMA2
PIGMENTATION DISORDER2
PHARYNGITIS2
PERITONITIS SCLEROSING2
PERITONEAL INFECTION2
Peripheral swelling2
PERICARDITIS2
PERIANAL ABSCESS2
Peptic ulcer2
PEMPHIGUS2
PATHOLOGICAL FRACTURE2
PATHOGEN RESISTANCE2
PAROSMIA2
PARKINSONISM2
PAPILLOEDEMA2
PANIC ATTACK2
PANCREATIC INSUFFICIENCY2
PALLOR2
PAIN OF SKIN2
OVARIAN MASS2
OSTEONECROSIS2
OSTEOARTHRITIS2
ORTHOSTATIC HYPOTENSION2
ORTHOPNOEA2
Oropharyngeal pain2
ORAL DISORDER2
Oncologic complication2
OESOPHAGITIS ULCERATIVE2
OESOPHAGEAL ULCER2
OESOPHAGEAL FISTULA2
OESOPHAGEAL CARCINOMA2
NEUTROPHILIA2
NEUROTOXICITY2
Neuroendocrine carcinoma2
NEPHROLITHIASIS2
NEOPLASM RECURRENCE2
NASAL CONGESTION2
NAIL DISCOLOURATION2
MYOCARDITIS2
Myelosuppression2
MUSCULOSKELETAL STIFFNESS2
MUSCLE TWITCHING2
MULTIPLE MYELOMA2
MOVEMENT DISORDER2
Metastases to the mediastinum2
Metastases to soft tissue2
Metastases to heart2
METASTASES TO CHEST WALL2
MENTAL IMPAIRMENT2
MEGACOLON2
MASS2
LYMPHOMA2
Lymphangitis2
LUNG INJURY2
LUNG INFECTION PSEUDOMONAL2
LOCALISED OEDEMA2
LOCALISED INFECTION2
LOCAL SWELLING2
Liver function test increased2
LIVER ABSCESS2
LIVEDO RETICULARIS2
LIPASE INCREASED2
LIP SWELLING2
LIMB INJURY2
KERATITIS2
IRON DEFICIENCY2
INTESTINAL DILATATION2
Intentional product misuse2
Injury2
INFARCTION2
INCREASED UPPER AIRWAY SECRETION2
IMMUNE SYSTEM DISORDER2
ILEUS PARALYTIC2
ILEAL PERFORATION2
HYPOVOLAEMIA2
HYPOTRICHOSIS2
HYPOPROTEINAEMIA2
HYPERTHYROIDISM2
HYPERTENSIVE CRISIS2
Hypersensitivity vasculitis2
HYPERKERATOSIS2
HOSPITALISATION2
HIRSUTISM2
HIP FRACTURE2
HILAR LYMPHADENOPATHY2
HERPES VIRUS INFECTION2
HER2 gene amplification2
HEPATITIS ACUTE2
HEPATIC LESION2
HEPATIC FIBROSIS2
HEPATIC ENZYME ABNORMAL2
HEART RATE DECREASED2
HALLUCINATION2
HAIR COLOUR CHANGES2
HAEMORRHAGE INTRACRANIAL2
HAEMOLYTIC ANAEMIA2
HAEMOGLOBIN INCREASED2
GROWTH OF EYELASHES2
GRANULOCYTE COUNT DECREASED2
GLOMERULONEPHRITIS RAPIDLY PROGRESSIVE2
GLOMERULONEPHRITIS MEMBRANOUS2
GINGIVAL DISORDER2
Generalised erythema2
GASTROINTESTINAL TOXICITY2
Gastritis haemorrhagic2
GASTRIC PERFORATION2
FURUNCLE2
FUNGAL SKIN INFECTION2
FUNGAL RASH2
FREQUENT BOWEL MOVEMENTS2
FLUID OVERLOAD2
FLUID INTAKE REDUCED2
FISTULA2
FAECES HARD2
FACIAL PARESIS2
FACIAL PAIN2
Extremity necrosis2
EXTRAPYRAMIDAL DISORDER2
Erythema multiforme2
ERYSIPELAS2
EROSIVE OESOPHAGITIS2
EPIDERMAL NECROSIS2
Eosinophil count increased2
ENTEROCOLITIS INFECTIOUS2
ENTEROCOLITIS HAEMORRHAGIC2
ELECTROCARDIOGRAM ST SEGMENT DEPRESSION2
ECZEMA ASTEATOTIC2
DYSSTASIA2
DYSKINESIA2
DUODENAL ULCER PERFORATION2
DUODENAL STENOSIS2
DRUG EXPOSURE DURING PREGNANCY2
Drug effect incomplete2
DIVERTICULUM INTESTINAL2
Diverticulitis2
Discomfort2
DIPLOPIA2
DIFFICULTY IN WALKING2
Device related infection2
DERMATOSIS2
DERMATITIS ALLERGIC2
DEMENTIA ALZHEIMER'S TYPE2
DEAFNESS BILATERAL2
Cytopenia2
CYST2
CSF PROTEIN INCREASED2
CREPITATIONS2
CRACKLES LUNG2
COVID-192
CORONARY ARTERY OCCLUSION2
CORONARY ARTERY DISEASE2
CORONARY ARTERY ATHEROSCLEROSIS2
CORNEAL EROSION2
CONCOMITANT DISEASE AGGRAVATED2
COLLAPSE OF LUNG2
CLOSTRIDIAL INFECTION2
Cholecystitis acute2
CHOLANGITIS2
CHOKING2
CHEILITIS2
CEREBRAL VENTRICLE DILATATION2
CEREBRAL DISORDER2
CENTRAL NERVOUS SYSTEM LESION2
CELL MARKER INCREASED2
CATHETER RELATED COMPLICATION2
CARDIOPULMONARY FAILURE2
CARDIAC FAILURE ACUTE2
Cardiac disorder2
CANDIDIASIS2
Candida infection2
CANCER PAIN2
CAESAREAN SECTION2
BUNDLE BRANCH BLOCK LEFT2
BRONCHOSTENOSIS2
Bronchospasm2
Bronchopulmonary aspergillosis2
BRONCHOPLEURAL FISTULA2
Breast cancer female2
BRAIN NEOPLASM2
BLOOD URIC ACID INCREASED2
BLOOD OSMOLARITY DECREASED2
BLOOD GLUCOSE DECREASED2
BLOOD CREATININE DECREASED2
BLOOD AMYLASE INCREASED2
BLINDNESS UNILATERAL2
BLEPHARITIS2
BLADDER PAIN2
BILE DUCT OBSTRUCTION2
BEDRIDDEN2
Basal cell carcinoma2
ATRIOVENTRICULAR BLOCK COMPLETE2
ASTHMA2
Arteriosclerosis coronary artery2
ARTERIAL THROMBOSIS LIMB2
APLASTIC ANAEMIA2
AORTIC VALVE SCLEROSIS2
Amylase increased2
ALVEOLITIS ALLERGIC2
Agranulocytosis2
AGEUSIA2
ACUTE LYMPHOCYTIC LEUKAEMIA2
ACUTE LUNG INJURY2
ACUTE FEBRILE NEUTROPHILIC DERMATOSIS2
ACINETOBACTER INFECTION2
ACIDOSIS2
ACCIDENTAL OVERDOSE2
ABSCESS LIMB2
ABSCESS BACTERIAL2
ABDOMINAL PAIN LOWER2
ABDOMINAL MASS2
ABDOMINAL ABSCESS2
Wrong technique in product usage process1
WRONG TECHNIQUE IN DRUG USAGE PROCESS1
WOUND INFECTION PSEUDOMONAS1
WOUND HAEMORRHAGE1
WOUND DEHISCENCE1
WOUND1
White matter lesion1
WHITE BLOOD CELLS URINE POSITIVE1
VULVOVAGINITIS1
Vulvovaginal pain1
Vulvovaginal candidiasis1
VITREOUS FLOATERS1
VISUAL FIELD DEFECT1
Viral rash1
VIITH NERVE PARALYSIS1
VERTEBRAL ARTERY OCCLUSION1
VENTRICULAR TACHYCARDIA1
VENTRICULAR SEPTAL DEFECT1
VENTRICULAR HYPERTROPHY1
VENTRICULAR DYSFUNCTION1
VENOUS THROMBOSIS1
VENA CAVA INJURY1
VASCULAR NEOPLASM1
VAGINAL SWELLING1
VAGINAL DISORDER1
VAGINAL DISCHARGE1
VAGINAL CANDIDIASIS1
VAGINAL BURNING SENSATION1
UTERINE HAEMORRHAGE1
UTERINE DISORDER1
UROGENITAL HAEMORRHAGE1
UROBILINOGEN URINE INCREASED1
URINE ANALYSIS ABNORMAL1
URINE ABNORMALITY1
URINARY TRACT DISORDER1
URINARY BLADDER HAEMORRHAGE1
Urethritis1
URETHRAL OBSTRUCTION1
URETERIC OBSTRUCTION1
Ureteric compression1
Upper respiratory tract congestion1
UNEVALUABLE EVENT1
Underdose1
ULTRASOUND ABDOMEN ABNORMAL1
Tyrosine kinase mutation1
TUNNEL VISION1
Tumour rupture1
Tumour pruritus1
TUMOUR NECROSIS1
Tumour marker increased1
TUMOUR EMBOLISM1
Tumour compression1
TUMOUR ASSOCIATED FEVER1
TUBULOINTERSTITIAL NEPHRITIS1
TUBERCULOSIS1
TROPONIN T INCREASED1
TROPONIN INCREASED1
TRISMUS1
TRIGEMINAL NEURALGIA1
TRICUSPID VALVE INCOMPETENCE1
TRANSMISSION OF DRUG VIA SEMEN1
TRACHEOBRONCHITIS1
TRACHEAL OEDEMA1
TRACHEAL DISORDER1
TOXIC DILATATION OF COLON1
Total lung capacity decreased1
TORTICOLLIS1
TORSADE DE POINTES1
Toothache1
Tooth erosion1
TONGUE OEDEMA1
TONGUE HAEMORRHAGE1
Tongue erythema1
TONGUE COATED1
Tongue blistering1
TOE AMPUTATION1
TINNITUS1
Thyroid mass1
Thyroid disorder1
THROMBOTIC THROMBOCYTOPENIC PURPURA1
THROMBOTIC MICROANGIOPATHY1
THROMBOCYTOPENIC PURPURA1
THROMBOCYTHAEMIA1
THROAT TIGHTNESS1
Therapeutic response changed1
THERAPEUTIC AGENT TOXICITY1
Tetany1
TERMINAL STATE1
Tendon rupture1
Temperature intolerance1
Tachyarrhythmia1
SYSTEMIC LUPUS ERYTHEMATOSUS1
SYSTEMIC INFLAMMATORY RESPONSE SYNDROME1
SYNOVITIS1
SYNCOPE VASOVAGAL1
SWOLLEN TONGUE1
SURGICAL PROCEDURE REPEATED1
SUPRAVENTRICULAR EXTRASYSTOLES1
SUPERIOR VENA CAVAL OCCLUSION1
SUPERINFECTION1
SUICIDAL IDEATION1
Subcorneal pustular dermatosis1
SUBARACHNOID HAEMORRHAGE1
Subacute cutaneous lupus erythematosus1
STUPOR1
STRESS SYMPTOMS1
Stress cardiomyopathy1
STRESS1
STRANGURY1
STOOLS WATERY1
STOOL ANALYSIS ABNORMAL1
STOMATITIS NECROTISING1
STOMACH DISCOMFORT1
Steroid withdrawal syndrome1
STENOTROPHOMONAS INFECTION1
STATUS EPILEPTICUS1
Staring1
Staphylococcal skin infection1
STAPHYLOCOCCAL IMPETIGO1
STAPHYLOCOCCAL ABSCESS1
SPUTUM RETENTION1
SPUTUM PURULENT1
SPONDYLOSIS1
Spleen disorder1
Spinal pain1
SPINAL LAMINECTOMY1
Spinal fracture1
SPINAL CORD INFARCTION1
Spinal column stenosis1
SOFT TISSUE DISORDER1
SMALL INTESTINAL STENOSIS1
Small intestinal perforation1
SMALL INTESTINAL HAEMORRHAGE1
Small cell lung cancer metastatic1
SKIN ULCER HAEMORRHAGE1
Skin swelling1
SKIN PAPILLOMA1
SKIN NODULE1
Skin mass1
Skin irritation1
SKIN INFLAMMATION1
Skin hypopigmentation1
Skin haemorrhage1
SKIN GRAFT1
SKIN CANDIDA1
SKIN CANCER METASTATIC1
SKIN BLEEDING1
SINUS CONGESTION1
SINUS BRADYCARDIA1
SICCA SYNDROME1
SHOULDER PAIN1
SHIFT TO THE LEFT1
SEROMA1
SEPSIS SYNDROME1
SENSORY LOSS1
Selective IgG subclass deficiency1
SECRETION DISCHARGE1
Secondary hypothyroidism1
Second primary malignancy1
Scratch1
SCOTOMA1
Scar1
SCAN ABDOMEN ABNORMAL1
ROSACEA1
Road traffic accident1
RIGHT VENTRICULAR FAILURE1
RIB FRACTURE1
RHINITIS1
RHABDOMYOSARCOMA1
REVERSIBLE ISCHAEMIC NEUROLOGICAL DEFICIT1
RETROPERITONEAL HAEMORRHAGE1
RETROPERITONEAL FIBROSIS1
RETINAL VEIN OCCLUSION1
RETINAL DISORDER1
RETCHING1
RESTLESS LEGS SYNDROME1
RESPIRATION ABNORMAL1
RENAL TUBULAR ACIDOSIS1
Renal injury1
RENAL FAILURE CHRONIC1
RENAL ATROPHY1
REFLUX GASTRITIS1
Red blood cell sedimentation rate increased1
Rectal ulcer1
RASH VESICULAR1
RASH RUBELLIFORM1
RALES1
RADIATION OESOPHAGITIS1
RADIATION MYELOPATHY1
RADIATION FIBROSIS - LUNG1
Punctate keratitis1
PULSE ABSENT1
PULMONARY TUBERCULOSIS1
PULMONARY RADIATION INJURY1
PULMONARY INFARCTION1
PULMONARY FUNCTION TEST DECREASED1
Pulmonary cavitation1
PULMONARY BULLA1
Pulmonary air leakage1
PSYCHOTIC DISORDER1
Psychiatric symptom1
PSEUDODEMENTIA1
PRURITUS GENITAL1
PROTHROMBIN LEVEL INCREASED1
Prostatic specific antigen increased1
Prostatic calcification1
Prostate ablation1
PROPIONIBACTERIUM INFECTION1
Product substitution issue1
Product storage error1
Product dose omission issue1
PROCTITIS ULCERATIVE1
PROCEDURAL SITE REACTION1
Procedural intestinal perforation1
PROCEDURAL HYPOTENSION1
PROCEDURAL HYPERTENSION1
PRIDE syndrome1
PRESBYOPIA1
Prerenal failure1
PREMATURE LABOUR1
Premature delivery1
PREMATURE BABY1
POSTURING1
POSTRENAL FAILURE1
Post thrombotic syndrome1
POST PROCEDURAL HAEMORRHAGE1
POST PROCEDURAL DIARRHOEA1
PORTAL HYPERTENSIVE GASTROPATHY1
Poor quality sleep1
POOR PERIPHERAL CIRCULATION1
Polymyalgia rheumatica1
Pneumonia viral1
PNEUMONIA STAPHYLOCOCCAL1
PNEUMONIA PNEUMOCOCCAL1
PNEUMONIA KLEBSIELLA1
Pneumocystis jirovecii pneumonia1
PNEUMATOSIS CYSTOIDES INTESTINALIS1
Pleural infection1
Pleural fistula1
Pleural disorder1
PIK3CA-activated mutation1
PHOTOSENSITIVITY REACTION1
Photopsia1
PHARYNX DISCOMFORT1
PHARYNGEAL INFLAMMATION1
PHARYNGEAL HAEMORRHAGE1
PHARYNGEAL FISTULA1
PERITONEAL CARCINOMA1
Peripheral vascular disorder1
PERIPHERAL ISCHAEMIA1
Perineal abscess1
PERICARDITIS MALIGNANT1
PERICARDITIS CONSTRICTIVE1
PERICARDIAL HAEMORRHAGE1
PERFORATED ULCER1
PEPTIC ULCER PERFORATION, OBSTRUCTIVE1
PEMPHIGOID1
PELVIC FRACTURE1
PCO2 INCREASED1
PARKINSON'S DISEASE1
PARAPLEGIA1
PARANEOPLASTIC PEMPHIGUS1
PARANEOPLASTIC CEREBELLAR DEGENERATION1
Pancreatic mass1
Pancreatic enlargement1
Palmoplantar keratoderma1
PALMAR ERYTHEMA1
OVERGROWTH BACTERIAL1
OVARIAN CANCER1
OSTEOSYNTHESIS1
Osteonecrosis of jaw1
OSTEOMYELITIS1
OROPHARYNGEAL BLISTERING1
ORAL MUCOSAL PETECHIAE1
OPTIC NEUROPATHY1
OPTIC NEURITIS1
OPTIC NERVE DISORDER1
OPTIC ATROPHY1
OPERATIVE HAEMORRHAGE1
ONYCHOMYCOSIS1
OESOPHAGEAL VARICES HAEMORRHAGE1
OESOPHAGEAL SPASM1
OESOPHAGEAL OEDEMA1
Oesophageal intramural haematoma1
OESOPHAGEAL HAEMORRHAGE1
OESOPHAGEAL DISORDER1
Oesophageal compression1
OEDEMA MOUTH1
OEDEMA GENITAL1
Ocular toxicity1
OCULAR HYPERAEMIA1
OBSTRUCTIVE UROPATHY1
OBSTRUCTIVE AIRWAYS DISORDER1
OBSTRUCTION1
NYSTAGMUS1
NORMOCHROMIC NORMOCYTIC ANAEMIA1
NON-HODGKIN'S LYMPHOMA1
NO THERAPEUTIC RESPONSE1
NO ADVERSE EFFECT1
NEUTROPHIL TOXIC GRANULATION PRESENT1
NEUTROPHIL PERCENTAGE INCREASED1
Neutrophil count increased1
NEUTROPENIC SEPSIS1
NEUTROPENIC COLITIS1
NEUROPATHIC PAIN1
Neurological decompensation1
Neuritis1
NEURALGIA1
NERVE ROOT LESION1
Nerve root compression1
NEPHROSCLEROSIS1
NEPHROPATHY TOXIC1
NEPHROPATHY1
NEPHRITIS1
NECROTISING FASCIITIS1
Nasal dryness1
Nasal discomfort1
NAIL DYSTROPHY1
Nail bed inflammation1
NAIL BED INFECTION1
MYRINGITIS1
Myelofibrosis1
MYELITIS TRANSVERSE1
MYDRIASIS1
MYCOPLASMA INFECTION1
Mycobacterium tuberculosis complex test positive1
MYCOBACTERIAL INFECTION1
MYCETOMA MYCOTIC1
MYASTHENIA GRAVIS1
Musculoskeletal disorder1
MUSCLE RIGIDITY1
Muscle fatigue1
MUSCLE ATROPHY1
Multiple fractures1
MUCOSAL ULCERATION1
Mucosal toxicity1
Mucinous breast carcinoma1
MOOD ALTERED1
Monoplegia1
MONOPARESIS1
MONOCYTE PERCENTAGE INCREASED1
MONOCYTE COUNT INCREASED1
MILIA1
MICTURITION DISORDER1
MICROGNATHIA1
Metastases to thyroid1
Metastases to stomach1
Metastases to skin1
Metastases to retroperitoneum1
Metastases to prostate1
Metastases to peritoneum1
Metastases to pelvis1
METASTASES TO OESOPHAGUS1
METASTASES TO NECK1
Metastases to muscle1
Metastases to kidney1
METASTASES TO BONE MARROW1
Metastases to abdominal cavity1
MESENTERIC VASCULAR INSUFFICIENCY1
MESENTERIC OCCLUSION1
Meningioma1
MENINGEAL DISORDER1
MEDICATION RESIDUE1
MEDIASTINAL FIBROSIS1
Mediastinal disorder1
MARROW HYPERPLASIA1
MALIGNANT NEOPLASM OF CHOROID1
Malignant ascites1
MACULOPATHY1
MACULAR OEDEMA1
LYMPHOPROLIFERATIVE DISORDER1
LYMPHOCYTE PERCENTAGE DECREASED1
LYMPHOCYTE COUNT DECREASED1
Lymphadenitis1
Lymph node fibrosis1
Lymph node calcification1
Lung opacity1
Lung cyst1
LUNG CREPITATION1
Lung carcinoma cell type unspecified stage 01
Lung adenocarcinoma recurrent1
LUNG ADENOCARCINOMA METASTATIC1
LUNG ABSCESS1
Lower limb fracture1
Low density lipoprotein increased1
LOOSE STOOLS1
Long QT syndrome1
Logorrhoea1
LIP ULCERATION1
LIP HAEMORRHAGE1
LIP EXFOLIATION1
LIP EROSION1
Ligament sprain1
Leukodystrophy1
LEUKOCYTOCLASTIC VASCULITIS1
Leukaemoid reaction1
Leukaemia recurrent1
LARYNGITIS1
LARYNGEAL OEDEMA1
LARYNGEAL GRANULOMA1
LARGE INTESTINAL HAEMORRHAGE1
Language disorder1
LACERATION1
KERATOCONJUNCTIVITIS SICCA1
KAOLIN CEPHALIN CLOTTING TIME PROLONGED1
JOINT INJURY1
JOINT EFFUSION1
JEJUNAL STENOSIS1
JAUNDICE CHOLESTATIC1
Irritable bowel syndrome1
Irritability1
IRON BINDING CAPACITY TOTAL DECREASED1
Invasive ductal breast carcinoma1
INTUBATION1
INTRAVENTRICULAR HAEMORRHAGE1
INTRACRANIAL ANEURYSM1
Intra-abdominal fluid collection1
INTERVERTEBRAL DISC DEGENERATION1
Intentional self-injury1
INJURY ASPHYXIATION1
INJECTION SITE HAEMORRHAGE1
INITIAL INSOMNIA1
INGUINAL HERNIA, OBSTRUCTIVE1
INGROWN HAIR1
Influenza1
INFLAMMATORY MARKER INCREASED1
INFECTIVE SPONDYLITIS1
INFECTION PROPHYLAXIS1
INFECTED EPIDERMAL CYST1
INCREASED APPETITE1
INCORRECT DOSE ADMINISTERED1
INCOHERENT1
Incision site ulcer1
INADEQUATE ANALGESIA1
IMPLANT SITE REACTION1
IMPLANT SITE EROSION1
IMPLANT SITE ABSCESS1
IMPAIRED WORK ABILITY1
Impaired quality of life1
Immune thrombocytopenic purpura1
Illness1
Ileostomy1
ILEAL ULCER1
IGA NEPHROPATHY1
IATROGENIC INJURY1
HYPOVENTILATION1
Hypothalamic pituitary adrenal axis suppression1
Hypophysitis1
HYPOPHOSPHATAEMIA1
Hypokinesia1
Hypoaesthesia oral1
HYPERURICAEMIA1
HYPERTROPHIC OBSTRUCTIVE CARDIOMYOPATHY1
HYPERTRICHOSIS1
HYPERTONIC BLADDER1
HYPERTHERMIA1
HYPERSOMNIA1
Hyperpyrexia1
Hyperplasia1
HYPERNATRAEMIA1
HYPERMETROPIA1
HYPERLIPIDAEMIA1
HYPERCOAGULATION1
HYPERAMYLASAEMIA1
Hyperammonaemia1
Hydrothorax1
HYDROPNEUMOTHORAX1
HUNGER1
HOT FLUSH1
Hordeolum1
HOARSENESS1
Herpes simplex1
HEPATOSPLENOMEGALY1
Hepatocellular carcinoma1
HEPATITIS B1
HEPATITIS A1
HEPATIC STEATOSIS1
Hepatic pain1
HEPATIC NEOPLASM1
HEPATIC NECROSIS1
HEPATIC CONGESTION1
HEPATIC CIRRHOSIS1
Hepatic cancer1
HEMIANOPIA HOMONYMOUS1
HEAD DISCOMFORT1
HANGNAIL1
HAIR DISORDER1
Haemorrhoids1
HAEMORRHOIDAL HAEMORRHAGE1
HAEMORRHAGIC STROKE1
HAEMORRHAGIC INFARCTION1
HAEMOPHILUS INFECTION1
HAEMOLYTIC URAEMIC SYNDROME1
HAEMATOTOXICITY1
HAEMATOMA1
HAEMANGIOMA OF LIVER1
GUN SHOT WOUND1
GUILLAIN-BARRE SYNDROME1
GRUNTING1
GRIP STRENGTH DECREASED1
GRANULOMA SKIN1
GRANULOMA1
GOUT1
Glycosylated haemoglobin increased1
Glutamate dehydrogenase increased1
GLUCOSE TOLERANCE IMPAIRED1
GLUCOSE TOLERANCE DECREASED1
GLOSSODYNIA1
Glaucoma1
GINGIVITIS ULCERATIVE1
GINGIVAL RECESSION1
Genital ulceration1
GENITAL RASH1
GENITAL PAIN FEMALE1
Generalised tonic-clonic seizure1
Generalised oedema1
GENERAL PHYSICAL CONDITION ABNORMAL1
GENERAL NUTRITION DISORDER1
GENE MUTATION IDENTIFICATION TEST POSITIVE1
Gene mutation identification test negative1
GAZE PALSY1
Gastrointestinal ulcer haemorrhage1
Gastrointestinal polyp haemorrhage1
GASTROINTESTINAL INFECTION1
Gastrointestinal carcinoma1
GASTROENTERITIS ROTAVIRUS1
GASTROENTERITIS RADIATION1
Gastroenteritis Escherichia coli1
GASTRIC ULCER PERFORATION1
Gastric mucosal lesion1
GASTRIC HAEMORRHAGE1
GASTRIC DISORDER1
Gastric dilatation1
GAS GANGRENE1
GAMMOPATHY1
GALLBLADDER POLYP1
GALLBLADDER DISORDER1
Gallbladder cancer1
FUNGUS URINE TEST POSITIVE1
FULL BLOOD COUNT DECREASED1
FOREIGN BODY TRAUMA1
Forced vital capacity decreased1
Forced expiratory volume decreased1
FOOD POISONING1
FLUSHING1
FLUID RETENTION1
FLUID IMBALANCE1
FIBROSIS1
FIBROMYALGIA1
Fibrin D dimer increased1
FAT EMBOLISM1
Fanconi syndrome acquired1
FAMILY STRESS1
FAILURE TO THRIVE1
Facial paralysis1
FACIAL PALSY1
FACIAL BONES FRACTURE1
EYELID PAIN1
EYELID OEDEMA1
EYELID IRRITATION1
EYELID EXFOLIATION1
EYELID EROSION1
EYELID DISORDER1
EYELID BLEEDING1
EYELASH DISCOLOURATION1
Eye inflammation1
EYE INFECTION1
Eye burns1
Eye abscess1
Extravasation blood1
EXTRAVASATION1
EXTRADURAL HAEMATOMA1
EXSANGUINATION1
Exposure during pregnancy1
EXCORIATION1
ESCHERICHIA URINARY TRACT INFECTION1
ESCHERICHIA BACTERAEMIA1
ERYTHEMA OF EYELID1
Eructation1
ERECTILE DYSFUNCTION1
EPIDIDYMITIS1
EOSINOPHILIA1
EOSINOPHIL PERCENTAGE DECREASED1
ENZYME ABNORMALITY1
ENTEROCOCCAL INFECTION1
ENTEROBACTER INFECTION1
ENTERAL NUTRITION1
Endocarditis1
ENANTHEMA1
Emotional disorder1
ELECTROENCEPHALOGRAM ABNORMAL1
ELECTROCARDIOGRAM T WAVE ABNORMAL1
ELECTROCARDIOGRAM ST-T SEGMENT ABNORMAL1
ELECTROCARDIOGRAM ST-T CHANGE1
ELECTROCARDIOGRAM ST SEGMENT ELEVATION1
ELECTROCARDIOGRAM ST SEGMENT ABNORMAL1
ELECTROCARDIOGRAM R ON T PHENOMENON1
Electrocardiogram QT shortened1
ELECTROCARDIOGRAM QRS COMPLEX PROLONGED1
ELECTROCARDIOGRAM CHANGE1
Ejection fraction decreased1
ECZEMA INFECTED1
ECONOMIC PROBLEM1
ECHOCARDIOGRAM ABNORMAL1
ECCHYMOSIS1
Eastern Cooperative Oncology Group performance status1
EAR PAIN1
EAR CONGESTION1
DYSTONIA1
DYSPNOEA EXACERBATED1
DYSPNOEA AT REST1
Dysphemia1
DYSPHASIA1
DUODENITIS1
DUODENAL PERFORATION1
DRUG WITHDRAWAL SYNDROME1
Drug tolerance increased1
Drug resistance mutation1
DRUG LEVEL INCREASED1
Drug level decreased1
DRUG INTERACTION POTENTIATION1
Drug effect less than expected1
DRUG EFFECT DECREASED1
Dropped head syndrome1
Dose calculation error1
DIVERTICULUM OESOPHAGEAL1
DIVERTICULUM1
DIVERTICULITIS INTESTINAL HAEMORRHAGIC1
DISTURBANCE IN ATTENTION1
DISABILITY1
DIPLEGIA1
DILATATION INTRAHEPATIC DUCT ACQUIRED1
DIASTOLIC DYSFUNCTION1
Diarrhoea infectious1
DIALYSIS1
DIABETIC KETOACIDOSIS1
DIABETIC FOOT1
DIABETES INSIPIDUS1
DEVICE MIGRATION1
DERMATOMYOSITIS1
Dermatitis bullous1
Dermal cyst1
Depressed mood1
DENTAL PLAQUE1
DENTAL CARIES1
Degenerative bone disease1
Defaecation urgency1
DECREASED ACTIVITY1
Decorticate posture1
Deafness unilateral1
Cytotoxic cardiomyopathy1
CYTOMEGALOVIRUS INFECTION1
Cytomegalovirus gastrointestinal ulcer1
CYTOMEGALOVIRUS COLITIS1
Cystitis pseudomonal1
CYSTITIS NONINFECTIVE1
CYSTITIS BACTERIAL1
Cutaneous vasculitis1
CUTANEOUS LUPUS ERYTHEMATOSUS1
CULTURE WOUND1
CULTURE POSITIVE1
CSF CELL COUNT INCREASED1
CRYSTALLURIA1
CRYSTAL URINE1
CRYPTORCHISM1
Crohn's disease1
CREUTZFELDT-JAKOB DISEASE1
CRANIAL NEUROPATHY1
CORONARY ARTERY THROMBOSIS1
CORONARY ARTERY STENOSIS1
Coronary artery aneurysm1
CORNEAL ABRASION1
CONTRACTED BLADDER1
CONJUNCTIVITIS VIRAL1
CONJUNCTIVITIS BACTERIAL1
CONJUNCTIVAL ULCER1
CONJUNCTIVAL IRRITATION1
CONGENITAL DIAPHRAGMATIC HERNIA1
CONGENITAL ANOMALY1
Computerised tomogram thorax abnormal1
COMPLEX PARTIAL SEIZURES1
COMPLETED SUICIDE1
COLOSTOMY1
COLORECTAL CANCER1
COLONIC OBSTRUCTION1
Colon neoplasm1
COLON CANCER METASTATIC1
COLITIS PSEUDOMEMBRANOUS1
COLITIS EROSIVE1
Colectomy1
Coagulation test abnormal1
CLOSTRIDIUM COLITIS1
CLONUS1
CLEFT LIP AND PALATE1
Cleft lip1
CHRONIC OBSTRUCTIVE AIRWAYS DISEASE1
Chronic kidney disease1
Chronic gastritis1
CHEMICAL CYSTITIS1
CHAPPED LIPS1
CEREBROVASCULAR DISORDER1
CEREBROSPINAL FLUID LEAKAGE1
CEREBROSCLEROSIS1
CEREBRAL THROMBOSIS1
Cerebral radiation injury1
Cerebral haematoma1
CEREBRAL DECOMPRESSION1
Cerebral cyst1
Cerebellar syndrome1
Cerebellar ataxia1
CENTRAL PONTINE MYELINOLYSIS1
CENTRAL NERVOUS SYSTEM NEOPLASM1
Central nervous system necrosis1
CELLULITIS LARYNGEAL1
CATHETER SITE RELATED REACTION1
CATHETER SITE PAIN1
CATHETER SITE HAEMATOMA1
CATHETER SITE ERYTHEMA1
CAROTID ARTERY OCCLUSION1
Cardiovascular insufficiency1
CARDIOTOXICITY1
Cardiomyopathy1
CARDIOGENIC SHOCK1
CARDIAC VALVE DISEASE1
Cardiac tamponade1
CARDIAC MURMUR1
CARDIAC HYPERTROPHY1
Cardiac flutter1
Cardiac failure chronic1
CARCINOMA1
CARCINOID TUMOUR OF THE SMALL BOWEL1
CARCINOID SYNDROME1
CARBOHYDRATE ANTIGEN 27.29 INCREASED1
CAPILLARY LEAK SYNDROME1
CANDIDA PNEUMONIA1
Cancer with a high tumour mutational burden1
Calculus urinary1
CAECITIS1
BUNDLE BRANCH BLOCK RIGHT1
BULLOUS LUNG DISEASE1
BULLOUS IMPETIGO1
BRONCHOALVEOLAR LAVAGE ABNORMAL1
Bronchitis chronic1
BRONCHIECTASIS1
BRONCHIAL INFECTION1
BRONCHIAL CARCINOMA1
BRAIN STEM HAEMORRHAGE1
BRAIN NATRIURETIC PEPTIDE INCREASED1
Brain injury1
BRAIN HYPOXIA1
BRAIN HERNIATION1
BRAIN DAMAGE1
BRAIN CONTUSION1
BRAIN CANCER METASTATIC1
Brain abscess1
BRADYPNOEA1
BRADYARRHYTHMIA1
BOWEL SOUNDS ABNORMAL1
BONE MARROW DISORDER1
BONE MARROW DEPRESSION1
BODY TINEA1
BLOOD VISCOSITY INCREASED1
Blood uric acid decreased1
Blood triglycerides increased1
Blood sodium abnormal1
BLOOD PRESSURE FLUCTUATION1
BLOOD PRESSURE DIASTOLIC INCREASED1
BLOOD PRESSURE ABNORMAL1
Blood potassium abnormal1
BLOOD PH INCREASED1
BLOOD PH DECREASED1
BLOOD PH ABNORMAL1
Blood glucose abnormal1
Blood disorder1
BLOOD CREATININE ABNORMAL1
BLOOD CHOLESTEROL INCREASED1
BLOOD CHLORIDE DECREASED1
BLOOD BILIRUBIN DECREASED1
BLOOD BICARBONATE INCREASED1
BLOOD BETA-D-GLUCAN INCREASED1
Blood albumin increased1
Blister infected1
BLADDER TAMPONADE1
BLADDER HYPERTROPHY1
BK virus infection1
BIOPSY STOMACH ABNORMAL1
BIOPSY KIDNEY ABNORMAL1
BILIARY DILATATION1
BILIARY CANCER METASTATIC1
BILE DUCT STENOSIS1
Beta haemolytic streptococcal infection1
Benign prostatic hyperplasia1
BENIGN INTRACRANIAL HYPERTENSION1
BARRETT'S OESOPHAGUS1
BALANITIS1
BACTERIA STOOL IDENTIFIED1
BACTERIA SPUTUM IDENTIFIED1
AXILLARY PAIN1
AUTONOMIC NEUROPATHY1
Autoimmune haemolytic anaemia1
Atypical pneumonia1
ATROPHY1
ATRIOVENTRICULAR BLOCK THIRD DEGREE1
ATRIOVENTRICULAR BLOCK1
Atrial thrombosis1
Atheroembolism1
Ataxia1
ASTIGMATISM1
Aspergilloma1
Aspartate aminotransferase1
ARTHROPATHY1
Arthritis bacterial1
ARTERIOSPASM CORONARY1
ARTERIAL RUPTURE1
ARACHNOID CYST1
APPENDICITIS PERFORATED1
APHTHOUS STOMATITIS1
APATHY1
Apallic syndrome1
Aortic valve disease mixed1
Aortic disorder1
AORTIC ATHEROSCLEROSIS1
ANXIETY DISORDER1
ANTIPHOSPHOLIPID ANTIBODIES POSITIVE1
ANTIBODY TEST ABNORMAL1
ANORECTAL DISORDER1
ANOMALY OF EXTERNAL EAR CONGENITAL1
ANGIOPATHY1
ANGIOEDEMA1
ANGINA UNSTABLE1
ANGINA PECTORIS1
ANGER1
Anaplastic lymphoma kinase gene mutation1
ANAPHYLACTOID REACTION1
Anal incontinence1
ANAL FISTULA1
ANAL FISSURE1
ANAL DISCOMFORT1
ANAEMIA OF MALIGNANT DISEASE1
ANAEMIA HAEMOLYTIC AUTOIMMUNE1
Amyotrophic lateral sclerosis1
AMYLOIDOSIS1
AMENORRHOEA1
ALOPECIA SCARRING1
ALLERGY TEST POSITIVE1
AGGRESSION1
AFFECT LABILITY1
ADVERSE DRUG REACTION1
ADJUSTMENT DISORDER1
ACUTE PRERENAL FAILURE1
Acute monocytic leukaemia1
ACUTE LEUKAEMIA1
ACUTE HEPATIC FAILURE1
Acute haemorrhagic conjunctivitis1
ACUTE ABDOMEN1
ACTIVATED PARTIAL THROMBOPLASTIN TIME SHORTENED1
ACQUIRED OESOPHAGEAL WEB1
ACCIDENTAL NEEDLE STICK1
Accidental exposure to product packaging1
ACCIDENTAL EXPOSURE1
ABNORMAL DREAMS1
ABNORMAL CHEST SOUND1
ABDOMINAL SYMPTOM1
ABDOMINAL RIGIDITY1
ABDOMINAL INFECTION1
ABDOMINAL HAEMATOMA1
ABDOMINAL COMPARTMENT SYNDROME1





Filtered ChEMBL targets:

Target UniProtKB ID Activity in nm Target Name Target gene
O14578 1300 Citron Rho-interacting kinase CTRO_HUMAN
O14976 7 Cyclin-G-associated kinase GAK_HUMAN
O43293 5700 Death-associated protein kinase 3 DAPK3_HUMAN
O43353 530 Receptor-interacting serine/threonine-protein kinase 2 RIPK2_HUMAN
O94768 3800 Serine/threonine-protein kinase 17B ST17B_HUMAN
O94804 470 Serine/threonine-protein kinase 10 STK10_HUMAN
P00533 0.1 Epidermal growth factor receptor EGFR_HUMAN
P02545 0.8 Prelamin-A/C LMNA_HUMAN
P04626 24 Receptor tyrosine-protein kinase erbB-2 ERBB2_HUMAN
P06239 630 Tyrosine-protein kinase Lck LCK_HUMAN
P07948 990 Tyrosine-protein kinase Lyn LYN_HUMAN
P08581 4372 Hepatocyte growth factor receptor MET_HUMAN
P08631 4400 Tyrosine-protein kinase HCK HCK_HUMAN
P10721 4300 Mast/stem cell growth factor receptor Kit KIT_HUMAN
P12931 3800 Proto-oncogene tyrosine-protein kinase Src SRC_HUMAN
P15056 2000 Serine/threonine-protein kinase B-raf BRAF_HUMAN
P15735 6400 Phosphorylase b kinase gamma catalytic chain, liver/testis isoform PHKG2_HUMAN
P21709 4000 Ephrin type-A receptor 1 EPHA1_HUMAN
P22830 6682 Ferrochelatase, mitochondrial HEMH_HUMAN
P29322 1800 Ephrin type-A receptor 8 EPHA8_HUMAN
P31152 3100 Mitogen-activated protein kinase 4 MK04_HUMAN
P35968 48.5 Vascular endothelial growth factor receptor 2 VGFR2_HUMAN
P36888 1000 Receptor-type tyrosine-protein kinase FLT3 FLT3_HUMAN
P42681 6000 Tyrosine-protein kinase TXK TXK_HUMAN
P42685 2000 Tyrosine-protein kinase FRK FRK_HUMAN
P45984 1400 Mitogen-activated protein kinase 9 MK09_HUMAN
P49674 430 Casein kinase I isoform epsilon KC1E_HUMAN
P51451 1200 Tyrosine-protein kinase Blk BLK_HUMAN
P53779 2300 Mitogen-activated protein kinase 10 MK10_HUMAN
P54762 7300 Ephrin type-B receptor 1 EPHB1_HUMAN
Q04206 55 Transcription factor p65 TF65_HUMAN
Q07912 2300 Activated CDC42 kinase 1 ACK1_HUMAN
Q09013 6900 Myotonin-protein kinase DMPK_HUMAN
Q13882 980 Protein-tyrosine kinase 6 PTK6_HUMAN
Q15303 476 Receptor tyrosine-protein kinase erbB-4 ERBB4_HUMAN
Q16659 1600 Mitogen-activated protein kinase 6 MK06_HUMAN
Q16816 3700 Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform PHKG1_HUMAN
Q86V86 5800 Serine/threonine-protein kinase pim-3 PIM3_HUMAN
Q9BUB5 290 MAP kinase-interacting serine/threonine-protein kinase 1 MKNK1_HUMAN
Q9H0K1 2100 Serine/threonine-protein kinase SIK2 SIK2_HUMAN
Q9H1R3 1900 Myosin light chain kinase 2, skeletal/cardiac muscle MYLK2_HUMAN
Q9H2G2 920 STE20-like serine/threonine-protein kinase SLK_HUMAN
Q9HBH9 360 MAP kinase-interacting serine/threonine-protein kinase 2 MKNK2_HUMAN
Q9UEE5 2000 Serine/threonine-protein kinase 17A ST17A_HUMAN
Q9UF33 590 Ephrin type-A receptor 6 EPHA6_HUMAN
Q9UNQ0 3190 Broad substrate specificity ATP-binding cassette transporter ABCG2 ABCG2_HUMAN
Q9Y572 2664 Receptor-interacting serine/threonine-protein kinase 3 RIPK3_HUMAN
Q9Y616 1500 Interleukin-1 receptor-associated kinase 3 IRAK3_HUMAN



Toxicity information:

Toxicity type: N/A



External links:

ChEBML: CHEMBL939
DrugBank: DB07998, DB00317