Flunitrazepam
General information:
| Withdrawn ID: | w230 |
|---|---|
| Canonical SMILES: | |
| Standard InChI: | |
| Standard InChIKey: | |
| ATC class(es): | N05CD03 |
| Molecular Formula: | C16H12FN3O3 |
| Molweight: | 313.283 |
Withdrawal information:
| Withdrawn due to drug safety reasons: | Yes |
|---|---|
| First approved: | 1975 |
| First withdrawn: | 1996 |
| Last withdrawn: | 1996 |
| Reference: | https://dij.sagepub.com/content/35/1/293.full.pdf |
Side-effects:
| Total reported cases (submitted by medical professionals) with Flunitrazepam as primary suspect: | 9 |
|---|
Reported final outcomes:
| Hospitalization (initial or prolonged): | 5 |
|---|---|
| Life-Threatening condition: | 1 |
Reported side-effects:
| Side-effect | Case number |
|---|---|
| Overdose | 4 |
| Altered state of consciousness | 2 |
| Drug withdrawal syndrome | 2 |
| Toxicity to various agents | 2 |
| Hallucination, visual | 2 |
| Delirium | 2 |
| Coma | 2 |
| Dehydration | 1 |
| COORDINATION ABNORMAL | 1 |
| Delusion | 1 |
| Disorientation | 1 |
| DIZZINESS | 1 |
| DRUG ABUSER | 1 |
| Drug dependence | 1 |
| Drug eruption | 1 |
| DRUG INTERACTION | 1 |
| DRUG LEVEL INCREASED | 1 |
| ASTHENIA | 1 |
| Hallucination, auditory | 1 |
| GENERAL PHYSICAL HEALTH DETERIORATION | 1 |
| Generalised tonic-clonic seizure | 1 |
| Heart rate abnormal | 1 |
| Hepatic function abnormal | 1 |
| Hyporeflexia | 1 |
| Hypotension | 1 |
| Inflammation | 1 |
| Intentional overdose | 1 |
| LOSS OF CONSCIOUSNESS | 1 |
| Neuroleptic malignant syndrome | 1 |
| NYSTAGMUS | 1 |
| Oxygen saturation decreased | 1 |
| Pneumonia aspiration | 1 |
| Respiratory disorder | 1 |
| Rhabdomyolysis | 1 |
| Suicide attempt | 1 |
Filtered ChEMBL targets:
| Target UniProtKB ID | Activity in nm | Target Name | Target gene |
|---|---|---|---|
| P18507 | 1.4 | Gamma-aminobutyric acid receptor subunit gamma-2 | GBRG2_HUMAN |
Toxicity information:
| Toxicity class: | 6 |
|---|---|
| Toxicity type: | multiple |
| LD50: | 8687 mg/kg |
External links:
| ChEBML: | CHEMBL13280 |
|---|---|
| DrugBank: | DB01544 |