Efalizumab


DB00095



General information:


Withdrawn ID: DB00095
ATC class(es): L04AA21



Withdrawal information:


Withdrawn due to drug safety reasons:Yes
First withdrawn: 2009
Reference: https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/fda-statement-voluntary-withdrawal-raptiva-us-market



Side-effects:

Total reported cases (submitted by medical professionals) with Efalizumab as primary suspect: 1599


Reported final outcomes:
Hospitalization (initial or prolonged): 450
Death: 141
Intervention required to prevent permanent impairment/damage: 75
Life-Threatening condition: 69
Disability: 50
Congenital anomaly: 1


Reported side-effects:

Side-effect Case number
PSORIASIS231
HEADACHE77
DEATH72
ARTHRALGIA65
PYREXIA64
WHITE BLOOD CELL COUNT INCREASED63
PRURITUS55
PAIN54
CONDITION AGGRAVATED53
OEDEMA PERIPHERAL44
RASH42
INFLUENZA LIKE ILLNESS35
ARTHRITIS34
THROMBOCYTOPENIA33
PSORIATIC ARTHROPATHY32
SKIN EXFOLIATION28
MYALGIA28
WEIGHT DECREASED27
CHILLS27
NAUSEA26
PLATELET COUNT DECREASED25
DRUG INEFFECTIVE25
BACK PAIN25
URTICARIA24
FATIGUE23
DYSPNOEA23
PNEUMONIA22
LYMPHOCYTE COUNT INCREASED22
INFECTION22
Skin plaque21
DERMATITIS EXFOLIATIVE21
ASTHENIA21
MYOCARDIAL INFARCTION19
MALAISE19
PAIN IN EXTREMITY18
LYMPHOCYTOSIS18
HYPOAESTHESIA18
VOMITING17
MENINGITIS ASEPTIC17
LYMPHADENOPATHY17
HERPES ZOSTER17
CELLULITIS16
PUSTULAR PSORIASIS15
MIGRAINE15
JOINT SWELLING15
HAEMORRHAGE15
ERYTHEMA15
DEPRESSION14
ALANINE AMINOTRANSFERASE INCREASED14
LEUKOCYTOSIS13
INFLAMMATION13
COUGH13
ANAEMIA13
PULMONARY EMBOLISM12
LYMPHOMA12
ERYTHRODERMIC PSORIASIS12
DIZZINESS12
DIARRHOEA12
BLOOD GLUCOSE INCREASED12
STAPHYLOCOCCAL INFECTION11
MUSCULOSKELETAL STIFFNESS11
LIVER FUNCTION TEST ABNORMAL11
INFLUENZA11
SEPSIS10
HYPERTENSION10
HERPES SIMPLEX10
HAEMOLYTIC ANAEMIA10
GAIT DISTURBANCE10
DEEP VEIN THROMBOSIS10
CHEST PAIN10
ALOPECIA10
VISION BLURRED9
SQUAMOUS CELL CARCINOMA9
SKIN LESION9
Skin fissures9
SINUSITIS9
RENAL FAILURE ACUTE9
RENAL FAILURE9
PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY9
NEUTROPHIL COUNT INCREASED9
HEPATIC ENZYME INCREASED9
GUILLAIN-BARRE SYNDROME9
DRUG EXPOSURE DURING PREGNANCY9
COLITIS ULCERATIVE9
CEREBROVASCULAR ACCIDENT9
BLOOD ALKALINE PHOSPHATASE INCREASED9
BLISTER9
BLADDER CANCER9
ASPARTATE AMINOTRANSFERASE INCREASED9
URINARY TRACT INFECTION8
TREATMENT NONCOMPLIANCE8
SYNCOPE8
MUSCULAR WEAKNESS8
HAEMOGLOBIN DECREASED8
FACIAL PALSY8
DIVERTICULITIS8
WHITE BLOOD CELL COUNT DECREASED7
SYSTEMIC LUPUS ERYTHEMATOSUS7
SPLENOMEGALY7
RENAL IMPAIRMENT7
PULMONARY OEDEMA7
PLATELET COUNT INCREASED7
PEMPHIGOID7
PARAESTHESIA7
NIGHT SWEATS7
LUPUS-LIKE SYNDROME7
INTERSTITIAL LUNG DISEASE7
DRUG HYPERSENSITIVITY7
BLOOD PRESSURE INCREASED7
ANAEMIA HAEMOLYTIC AUTOIMMUNE7
ABDOMINAL PAIN7
WEIGHT INCREASED6
THERAPY NON-RESPONDER6
SWELLING FACE6
SWELLING6
Skin burning sensation6
RESPIRATORY FAILURE6
RASH GENERALISED6
PULMONARY FIBROSIS6
POLYNEUROPATHY6
PHOTOSENSITIVITY REACTION6
PHARYNGOLARYNGEAL PAIN6
OCULAR HYPERAEMIA6
NASOPHARYNGITIS6
METASTASES TO LIVER6
LUNG DISORDER6
LOSS OF CONSCIOUSNESS6
JAUNDICE6
HEPATIC STEATOSIS6
GUTTATE PSORIASIS6
GAMMA-GLUTAMYLTRANSFERASE INCREASED6
ECZEMA6
CONTUSION6
CHRONIC LYMPHOCYTIC LEUKAEMIA6
CEREBRAL ISCHAEMIA6
BLOOD CREATININE INCREASED6
B-CELL LYMPHOMA6
TUBERCULOSIS5
TRANSIENT ISCHAEMIC ATTACK5
STOMATITIS5
SEPTIC SHOCK5
RHABDOMYOLYSIS5
PERIPHERAL T-CELL LYMPHOMA UNSPECIFIED5
PANCYTOPENIA5
NEUTROPHIL COUNT DECREASED5
NEUTROPENIA5
NEOPLASM MALIGNANT5
MUSCLE SPASMS5
MULTI-ORGAN FAILURE5
MENINGITIS VIRAL5
MALIGNANT MELANOMA5
LUNG INFILTRATION5
INJECTION SITE PAIN5
HYPOTENSION5
HEPATOTOXICITY5
HAEMATOCRIT DECREASED5
GOUT5
GENERAL PHYSICAL HEALTH DETERIORATION5
FUNGAL INFECTION5
FALL5
EPISTAXIS5
DEHYDRATION5
COLON CANCER5
CHOLELITHIASIS5
CARDIAC FAILURE CONGESTIVE5
AUTOIMMUNE DISORDER5
ARTHROPATHY5
ARRHYTHMIA5
ANOREXIA5
AMNESIA5
ACUTE FEBRILE NEUTROPHILIC DERMATOSIS5
ACNE5
ABDOMINAL PAIN UPPER5
ABASIA5
VIRAL INFECTION4
UPPER RESPIRATORY TRACT INFECTION4
TRANSAMINASES INCREASED4
TENDERNESS4
SUDDEN DEATH4
SUBDURAL HAEMATOMA4
SPEECH DISORDER4
SKIN IRRITATION4
RASH PUSTULAR4
PROTHROMBIN TIME PROLONGED4
PREGNANCY4
POLYARTHRITIS4
PERICARDITIS4
PANCREATITIS4
PAIN OF SKIN4
ORAL CANDIDIASIS4
MOUTH HAEMORRHAGE4
MOLLUSCUM CONTAGIOSUM4
MEDICATION ERROR4
LYMPHOCYTE MORPHOLOGY ABNORMAL4
LUNG NEOPLASM MALIGNANT4
LOWER RESPIRATORY TRACT INFECTION4
LETHARGY4
INSOMNIA4
INFECTIOUS MONONUCLEOSIS4
IMMUNOSUPPRESSION4
HYPOTHYROIDISM4
HYPERKERATOSIS4
HEPATOSPLENOMEGALY4
HEPATIC FAILURE4
HEPATIC CIRRHOSIS4
HAEMOCHROMATOSIS4
FLUSHING4
FEELING HOT4
ERYSIPELAS4
EOSINOPHILIA4
ENCEPHALITIS4
DYSARTHRIA4
DIPLOPIA4
DIFFICULTY IN WALKING4
DIABETES MELLITUS NON-INSULIN-DEPENDENT4
CONVULSION4
COLITIS4
CHOLESTASIS4
CERVICAL DYSPLASIA4
CARDIOMEGALY4
CARDIAC DISORDER4
BRONCHITIS4
BLOOD CREATINE PHOSPHOKINASE INCREASED4
BLOOD CHOLESTEROL INCREASED4
BACTERIAL INFECTION4
APHTHOUS STOMATITIS4
ANXIETY4
ANAPHYLACTIC REACTION4
ACUTE MYOCARDIAL INFARCTION4
ACTIVATED PARTIAL THROMBOPLASTIN TIME PROLONGED4
ABORTION SPONTANEOUS4
VISUAL IMPAIRMENT3
VERTIGO3
TOXIC EPIDERMAL NECROLYSIS3
TINNITUS3
THERAPEUTIC RESPONSE DECREASED3
STREPTOCOCCAL INFECTION3
STOMACH DISCOMFORT3
STAPHYLOCOCCAL SEPSIS3
SOMNOLENCE3
SKIN HAEMORRHAGE3
SKIN DISORDER3
RETROPERITONEAL FIBROSIS3
RESPIRATORY DISORDER3
RED BLOOD CELL SEDIMENTATION RATE INCREASED3
RED BLOOD CELL COUNT DECREASED3
RECTAL HAEMORRHAGE3
RASH PAPULAR3
RASH MACULAR3
RASH ERYTHEMATOUS3
PRURITUS GENERALISED3
PROTEIN TOTAL INCREASED3
PROSTATE CANCER3
POST PROCEDURAL COMPLICATION3
PNEUMONITIS3
PNEUMONIA FUNGAL3
PLEURAL EFFUSION3
PHOTOPHOBIA3
PHARYNGEAL OEDEMA3
PARALYSIS3
PAPILLOMA VIRAL INFECTION3
ORAL MUCOSAL BLISTERING3
OEDEMA3
NODULE3
NO THERAPEUTIC RESPONSE3
NEUROLOGICAL SYMPTOM3
NEPHROTIC SYNDROME3
NECK PAIN3
MYOCARDITIS3
MYCOSIS FUNGOIDES3
METASTASES TO LUNG3
MENORRHAGIA3
MENINGITIS CRYPTOCOCCAL3
MASS3
LEUKAEMIA3
JOINT EFFUSION3
INCORRECT DOSE ADMINISTERED3
IMPAIRED WORK ABILITY3
IMMUNOGLOBULINS INCREASED3
IMMUNE SYSTEM DISORDER3
HYPOXIA3
HYPOKALAEMIA3
HYPERSENSITIVITY3
HYPERAESTHESIA3
HEPATITIS3
HEART RATE INCREASED3
HEARING IMPAIRED3
GRANULOMA3
GLYCOSYLATED HAEMOGLOBIN INCREASED3
GENERALISED ERYTHEMA3
GASTROINTESTINAL HAEMORRHAGE3
FEELING COLD3
FEELING ABNORMAL3
FACTOR VIII INHIBITION3
ENDOCARDITIS3
DYSSTASIA3
DRUG TOXICITY3
DRUG INTERACTION3
DISEASE RECURRENCE3
DIARRHOEA HAEMORRHAGIC3
DERMATITIS PSORIASIFORM3
DERMATITIS3
DECREASED APPETITE3
DEAFNESS3
CYTOLYTIC HEPATITIS3
CYST3
CONJUNCTIVITIS3
CHRONIC OBSTRUCTIVE PULMONARY DISEASE3
CHRONIC INFLAMMATORY DEMYELINATING POLYRADICULONEUROPATHY3
CASTLEMAN'S DISEASE3
CARDIAC ARREST3
C-REACTIVE PROTEIN INCREASED3
BREAST CANCER FEMALE3
BONE MARROW FAILURE3
BODY TEMPERATURE INCREASED3
BLOOD POTASSIUM DECREASED3
BLOOD BILIRUBIN INCREASED3
ASTHMA3
ASCITES3
APPENDICITIS3
ANTINUCLEAR ANTIBODY POSITIVE3
ANGIONEUROTIC OEDEMA3
ANGINA PECTORIS3
ALVEOLITIS ALLERGIC3
ADVERSE DRUG REACTION3
ADENOCARCINOMA3
ABSCESS3
WOUND2
VITILIGO2
VITAMIN B12 DEFICIENCY2
VISUAL DISTURBANCE2
VIRAL UPPER RESPIRATORY TRACT INFECTION2
VENOUS INSUFFICIENCY2
UVEITIS2
URINARY TRACT OBSTRUCTION2
UNEVALUABLE EVENT2
TOXIC SKIN ERUPTION2
TOOTH INFECTION2
THROMBOCYTHAEMIA2
TENOSYNOVITIS2
Sunburn2
STREPTOCOCCAL SEPSIS2
STEVENS-JOHNSON SYNDROME2
SPUTUM CULTURE POSITIVE2
SMALL CELL LUNG CANCER STAGE UNSPECIFIED2
Sleep disorder2
SKIN REACTION2
SKIN PAPILLOMA2
SKIN INFECTION2
SKIN GRAFT2
SKIN DISCOLOURATION2
SKIN CHAPPED2
SKIN CANCER2
SERUM SICKNESS2
SCAR2
SCAB2
SALMONELLOSIS2
SACROILIITIS2
RENAL DISORDER2
RENAL CELL CARCINOMA STAGE UNSPECIFIED2
REFUSAL OF TREATMENT BY PATIENT2
PURPURA2
PROTEIN S DEFICIENCY2
PROLACTINOMA2
POLYCYTHAEMIA VERA2
PNEUMONIA BACTERIAL2
PLEURAL ADHESION2
PLANTAR FASCIITIS2
PETECHIAE2
PAPILLOEDEMA2
PAIN IN JAW2
OVERDOSE2
OVARIAN CANCER2
OSTEONECROSIS2
ONYCHOMADESIS2
OCULAR MYASTHENIA2
NON-HODGKIN'S LYMPHOMA2
NEUROPATHY2
NEURITIS2
NEPHROLITHIASIS2
NASAL CONGESTION2
MYCOBACTERIUM AVIUM COMPLEX INFECTION2
MUSCULOSKELETAL PAIN2
MUSCULOSKELETAL CHEST PAIN2
MUSCLE TIGHTNESS2
MULTIPLE SCLEROSIS2
MOTOR DYSFUNCTION2
MOBILITY DECREASED2
METASTATIC NEOPLASM2
METASTATIC MALIGNANT MELANOMA2
METASTASES TO LYMPH NODES2
MENTAL STATUS CHANGES2
MENTAL DISORDER2
LYMPHOCYTE COUNT DECREASED2
LYMPHADENITIS2
LOCAL SWELLING2
LIVER DISORDER2
LICHEN PLANUS2
LEUKOPENIA2
LEIOMYOSARCOMA2
LABORATORY TEST ABNORMAL2
JOINT STIFFNESS2
JAW DISORDER2
IRON DEFICIENCY ANAEMIA2
INTESTINAL POLYP2
INJECTION SITE REACTION2
INJECTION SITE IRRITATION2
INJECTION SITE HAEMORRHAGE2
IMPETIGO2
HYPERTRIGLYCERIDAEMIA2
HYPERPYREXIA2
HYPERNATRAEMIA2
HYPERHIDROSIS2
HUMAN PAPILLOMA VIRUS TEST POSITIVE2
HOT FLUSH2
HERPES ZOSTER OPHTHALMIC2
HERPES VIRUS INFECTION2
HEPATOMEGALY2
HEPATITIS CHOLESTATIC2
HEPATITIS C2
HEPATITIS B2
HEPATITIS A2
HEMIPARESIS2
HEMIANOPIA2
HAEMOPTYSIS2
GROIN INFECTION2
GRAND MAL CONVULSION2
GLUCOSE URINE PRESENT2
GINGIVAL BLEEDING2
GASTROINTESTINAL CARCINOMA2
GASTROENTERITIS2
GALLBLADDER DISORDER2
FIBROMYALGIA2
EYE SWELLING2
EYE REDNESS2
EYE PAIN2
Exposure during pregnancy2
ESCHERICHIA URINARY TRACT INFECTION2
ERYTHEMA NODOSUM2
ERECTILE DYSFUNCTION2
EPSTEIN-BARR VIRUS INFECTION2
EPILEPSY2
EOSINOPHIL COUNT DECREASED2
ENTEROCOCCAL INFECTION2
EMBOLISM2
EJECTION FRACTION DECREASED2
ECCHYMOSIS2
EAR INFECTION2
DYSPHAGIA2
DYSPEPSIA2
DRY SKIN2
DIVERTICULUM2
DISORIENTATION2
DISEASE PROGRESSION2
DIFFUSE LARGE B-CELL LYMPHOMA2
DIABETES MELLITUS2
DERMATOMYOSITIS2
CYTOMEGALOVIRUS INFECTION2
CRYPTOCOCCOSIS2
CROHN'S DISEASE2
CORONARY ARTERY DISEASE2
CORONARY ARTERY ATHEROSCLEROSIS2
CORNEAL DISORDER2
CONFUSIONAL STATE2
COMA2
COAGULOPATHY2
CHROMATURIA2
CHOLECYSTITIS2
CHEST X-RAY ABNORMAL2
CHEST DISCOMFORT2
CEREBRAL INFARCTION2
CEREBRAL HAEMORRHAGE2
CEREBELLAR INFARCTION2
CARPAL TUNNEL SYNDROME2
CARDIOMYOPATHY2
CARDIAC VALVE VEGETATION2
CARDIAC FAILURE2
BURNING SENSATION2
BURKITT'S LYMPHOMA2
BOVINE TUBERCULOSIS2
BONE PAIN2
BONE MARROW DISORDER2
BODY TINEA2
BLOOD URINE PRESENT2
BLOOD UREA INCREASED2
BLOOD TRIGLYCERIDES INCREASED2
BLOOD SODIUM DECREASED2
BLOOD LACTATE DEHYDROGENASE INCREASED2
BENIGN FAMILIAL PEMPHIGUS2
BASAL CELL CARCINOMA2
AUTOIMMUNE HEPATITIS2
ATRIAL FIBRILLATION2
ATELECTASIS2
ARTHROPOD BITE2
ARTHRITIS BACTERIAL2
ARTERIOSCLEROSIS2
ARTERIAL THROMBOSIS2
ANOGENITAL WARTS2
ANGIOEDEMA2
ANEURYSM2
AMENORRHOEA2
AGITATION2
ACUTE RESPIRATORY DISTRESS SYNDROME2
ACUTE PULMONARY OEDEMA2
ACCIDENTAL OVERDOSE2
ABNORMAL BEHAVIOUR2
XEROPHTHALMIA1
XANTHOMA1
WRONG TECHNIQUE IN DRUG USAGE PROCESS1
WOUND INFECTION1
WOUND DEHISCENCE1
WHITE BLOOD CELL DISORDER1
Weight fluctuation1
VULVAR DYSPLASIA1
VITAMIN B1 DEFICIENCY1
VISCERAL LEISHMANIASIS1
VIRAL LOAD INCREASED1
VESTIBULAR ATAXIA1
VENTRICULAR HYPOKINESIA1
VENTRICULAR FIBRILLATION1
VENOUS THROMBOSIS1
VENOOCCLUSIVE LIVER DISEASE1
VASCULITIS1
VASCULAR NEOPLASM1
VARICELLA1
VAGINAL ULCERATION1
VAGINAL MUCOSAL BLISTERING1
Vaginal haemorrhage1
UTERINE CYST1
URTICARIA THERMAL1
URTICARIA GENERALISED1
UROSEPSIS1
URINE ANALYSIS ABNORMAL1
URINARY INCONTINENCE1
URINARY BLADDER POLYP1
URETERIC DILATATION1
ULCERATIVE KERATITIS1
TYPE 2 DIABETES MELLITUS1
TUMOUR FLARE1
TUBULOINTERSTITIAL NEPHRITIS1
TROPONIN INCREASED1
TREMOR1
Treatment failure1
TOOTHACHE1
TOOTH DISORDER1
Tooth abscess1
TONGUE ULCERATION1
TONGUE INJURY1
TONGUE ERUPTION1
TONGUE BLISTERING1
TINEA INFECTION1
THYROID NEOPLASM1
THYROID ADENOMA1
THROMBOSIS1
THORACIC OUTLET SYNDROME1
THIRST1
TESTIS CANCER1
TERATOMA1
TENDONITIS1
TENDON RUPTURE1
TENDON DISORDER1
TEMPOROMANDIBULAR JOINT SYNDROME1
TEMPORAL ARTERITIS1
TEMPERATURE INTOLERANCE1
TACHYCARDIA1
T-CELL LYMPHOMA1
SYSTEMIC INFLAMMATORY RESPONSE SYNDROME1
SYNOVITIS1
SYNCOPE VASOVAGAL1
SWEAT GLAND INFECTION1
SUPRAVENTRICULAR TACHYCARDIA1
SUPRAVENTRICULAR EXTRASYSTOLES1
Suicide attempt1
SUICIDAL IDEATION1
SUBDURAL EMPYEMA1
SUBCUTANEOUS HAEMATOMA1
SUBCUTANEOUS ABSCESS1
STRESS1
STAPHYLOCOCCAL PHARYNGITIS1
SQUAMOUS CELL CARCINOMA OF THE CERVIX1
SPLENIC LESION1
SPLENIC INFARCTION1
SPLENIC HAEMORRHAGE1
SPINAL OSTEOARTHRITIS1
SPINAL FUSION SURGERY1
SOFT TISSUE DISORDER1
SMEAR CERVIX ABNORMAL1
SMALL INTESTINAL PERFORATION1
SMALL INTESTINAL OBSTRUCTION1
SKIN ULCER1
SKIN HYPERPIGMENTATION1
SINUS DISORDER1
SINUS CONGESTION1
SIGMOIDITIS1
SIALOADENITIS1
SHOULDER PAIN1
SENSORY DISTURBANCE1
SENSATION OF FOREIGN BODY1
Self esteem decreased1
Seizure1
SEGMENTED HYALINISING VASCULITIS1
SEBORRHOEIC KERATOSIS1
SCHIZOPHRENIA1
SARCOIDOSIS1
SALIVARY HYPERSECRETION1
SALIVARY GLAND ADENOMA1
ROSACEA1
Road traffic accident1
RHEUMATOID FACTOR INCREASED1
RHEUMATOID ARTHRITIS1
RHEUMATIC FEVER1
RETINAL DETACHMENT1
RETCHING1
RESPIRATORY TRACT INFECTION1
RESPIRATORY DISTRESS1
RESORPTION BONE INCREASED1
RENAL MASS1
RENAL INFARCT1
RENAL FAILURE CHRONIC1
RENAL CYST1
RED BLOOD CELL COUNT INCREASED1
RED BLOOD CELL ABNORMALITY1
RECTAL CANCER METASTATIC1
Rebound psoriasis1
RASH PRURITIC1
RALES1
PUPILLARY REFLEX IMPAIRED1
PULMONARY TUBERCULOSIS1
PULMONARY MASS1
PULMONARY GRANULOMA1
PSYCHOMOTOR HYPERACTIVITY1
PSEUDOMONAS INFECTION1
PSEUDOLYMPHOMA1
PROTHROMBIN TIME SHORTENED1
PROSTATITIS1
PROSTATIC SPECIFIC ANTIGEN INCREASED1
PRODUCTIVE COUGH1
PRODUCT QUALITY ISSUE1
Primary amyloidosis1
PREGNANCY OF PARTNER1
POST PROCEDURAL INFECTION1
PORTAL HYPERTENSION1
POLYCYTHAEMIA1
POLYCHONDRITIS1
POLYARTERITIS NODOSA1
PNEUMONITIS CRYPTOCOCCAL1
PNEUMONIA STAPHYLOCOCCAL1
PNEUMONIA PRIMARY ATYPICAL1
PNEUMONIA NECROTISING1
PNEUMONIA CRYPTOCOCCAL1
PNEUMONIA BLASTOMYCES1
PLEURAL DISORDER1
PLATELET AGGREGATION1
PLASMACYTOMA1
PLASMABLASTIC LYMPHOMA1
PLANTAR ERYTHEMA1
PITYRIASIS ROSEA1
PITUITARY TUMOUR1
PIGMENT NEPHROPATHY1
PHONOPHOBIA1
PHARYNGITIS STREPTOCOCCAL1
PHARYNGITIS1
PHARMACEUTICAL PRODUCT COMPLAINT1
PETIT MAL EPILEPSY1
PERTUSSIS1
PERIVASCULAR DERMATITIS1
PERITONITIS1
PERIPHERAL SENSORY NEUROPATHY1
PERIORBITAL OEDEMA1
PERIORBITAL CELLULITIS1
PERIODONTITIS1
PERICARDIAL EFFUSION1
PEPTIC ULCER1
PCO2 DECREASED1
PATELLOFEMORAL PAIN SYNDROME1
PAROTITIS1
PARONYCHIA1
PARAPSORIASIS1
PARAPARESIS1
PARANASAL SINUS DISCOMFORT1
PARAKERATOSIS1
PAPILLARY THYROID CANCER1
PANNICULITIS1
PANIC REACTION1
PANCREATITIS CHRONIC1
PANCREATITIS ACUTE1
PALPITATIONS1
PALLOR1
OXYGEN SATURATION DECREASED1
OVARIAN ENLARGEMENT1
OVARIAN CYST1
OTITIS EXTERNA1
OSTEOPOROSIS1
OSTEOARTHRITIS1
ORGANISING PNEUMONIA1
ORAL VIRAL INFECTION1
ORAL INTAKE REDUCED1
ORAL FUNGAL INFECTION1
OPTIC NEUROPATHY1
ONYCHOLYSIS1
ONCOCYTOMA1
OESOPHAGEAL CARCINOMA1
NUCLEAR MAGNETIC RESONANCE IMAGING BRAIN ABNORMAL1
NO REACTION ON PREVIOUS EXPOSURE TO DRUG1
NEUTROPHILIA1
NEUTROPHIL PERCENTAGE INCREASED1
NERVOUS SYSTEM DISORDER1
NERVE ROOT LESION1
NERVE COMPRESSION1
NEPHROPATHY1
NEOPLASM RECURRENCE1
NECROTISING ULCERATIVE PERIODONTITIS1
NECROSIS1
NECK MASS1
NAIL DISORDER1
NAIL BED INFECTION1
MYOSITIS1
MYOPATHY1
MYOCARDIAL ISCHAEMIA1
MYELITIS1
Musculoskeletal discomfort1
MUSCLE TWITCHING1
MUSCLE STRAIN1
MUSCLE RUPTURE1
MUSCLE INJURY1
MUSCLE HAEMORRHAGE1
MUSCLE FATIGUE1
MUSCLE CRAMP1
MUSCLE ATROPHY1
MULTIPLE-DRUG RESISTANCE1
MUCOSAL HAEMORRHAGE1
MOVEMENT DISORDER1
MOUTH ULCERATION1
MONOCYTE PERCENTAGE INCREASED1
MONOCYTE COUNT INCREASED1
MITRAL VALVE PROLAPSE1
MITRAL VALVE INCOMPETENCE1
MITRAL VALVE CALCIFICATION1
MILLER FISHER SYNDROME1
MICTURITION DISORDER1
METASTATIC RENAL CELL CARCINOMA1
METASTATIC BRONCHIAL CARCINOMA1
METASTASES TO BONE1
METABOLIC DISORDER1
METABOLIC ACIDOSIS1
MENTAL DISORDER DUE TO A GENERAL MEDICAL CONDITION1
Menstruation irregular1
MENSTRUAL DISORDER1
MENINGITIS STAPHYLOCOCCAL1
MENINGITIS BACTERIAL1
MALIGNANT PLEURAL EFFUSION1
MALIGNANT FIBROUS HISTIOCYTOMA1
LYMPHOPENIA1
LYMPHOCYTIC LYMPHOMA1
LYMPHOCYTIC INFILTRATION1
LYMPHOCYTE PERCENTAGE DECREASED1
LYMPHOCYTE COUNT ABNORMAL1
LYMPHADENOPATHY MEDIASTINAL1
LYME DISEASE1
LUPUS NEPHRITIS1
LUNG NEOPLASM1
LUNG INFECTION PSEUDOMONAL1
LUNG INFECTION1
LUNG CARCINOMA CELL TYPE UNSPECIFIED RECURRENT1
LUNG CANCER METASTATIC1
LUNG ADENOCARCINOMA1
Lower limb fracture1
LOW DENSITY LIPOPROTEIN INCREASED1
LOBAR PNEUMONIA1
LIVER ABSCESS1
LIPOMA1
LIPASE INCREASED1
LIP SWELLING1
LIMB INJURY1
LIGHT CHAIN ANALYSIS INCREASED1
Laryngitis1
LACTIC ACIDOSIS1
LACRIMATION INCREASED1
KERATITIS HERPETIC1
KAPOSI'S SARCOMA1
JAUNDICE CHOLESTATIC1
ISCHAEMIC STROKE1
ISCHAEMIC CEREBRAL INFARCTION1
IRRITABILITY1
IODINE ALLERGY1
INTRACRANIAL PRESSURE INCREASED1
INTRACRANIAL ANEURYSM1
INTESTINAL OBSTRUCTION1
INTESTINAL ISCHAEMIA1
INTESTINAL HAEMORRHAGE1
INTESTINAL FUNCTIONAL DISORDER1
INTESTINAL FISTULA1
INTERVERTEBRAL DISCITIS1
INTERVERTEBRAL DISC PROTRUSION1
INTERVERTEBRAL DISC INJURY1
INTERVERTEBRAL DISC DISORDER1
INTERNATIONAL NORMALISED RATIO INCREASED1
INTERNATIONAL NORMALISED RATIO DECREASED1
INJURY1
INJECTION SITE WARMTH1
INJECTION SITE SWELLING1
INJECTION SITE ERYTHEMA1
INJECTION SITE CELLULITIS1
INJECTION SITE BURNING1
INGUINAL MASS1
IMMUNOGLOBULINS1
ILL-DEFINED DISORDER1
ILEUS1
IDIOPATHIC THROMBOCYTOPENIC PURPURA1
IDIOPATHIC CAPILLARITIS1
ICHTHYOSIS ACQUIRED1
HYPOREFLEXIA1
HYPONATRAEMIA1
HYPOGLYCAEMIA1
HYPOGEUSIA1
HYPOGAMMAGLOBULINAEMIA1
HYPOCHROMIC ANAEMIA1
HYPOCAPNIA1
HYPERVISCOSITY SYNDROME1
HYPERURICAEMIA1
HYPERTROPHIC CARDIOMYOPATHY1
HYPERTHERMIA1
HYPERTENSIVE CARDIOMYOPATHY1
HYPERKALAEMIA1
HYPERGAMMAGLOBULINAEMIA BENIGN MONOCLONAL1
HYPERGAMMAGLOBULINAEMIA1
HYPERCHOLESTEROLAEMIA1
HYPERCALCAEMIA1
HORDEOLUM1
HOMOCYSTINAEMIA1
HODGKIN'S DISEASE1
HIP ARTHROPLASTY1
HIGH DENSITY LIPOPROTEIN DECREASED1
HERPES ZOSTER DISSEMINATED1
HERPES SEPSIS1
HERPES OESOPHAGITIS1
HEPATOCELLULAR INJURY1
HEPATOCELLULAR DAMAGE1
HEPATITIS TOXIC1
HEPATITIS NON-A NON-B NON-C1
HEPATITIS CHRONIC ACTIVE1
HEPATITIS C TEST NEGATIVE1
HEPATITIS ACUTE1
HEPATIC NEOPLASM MALIGNANT1
HEPATIC NECROSIS1
HEPATIC MASS1
HEPATIC LESION1
HEPATIC FIBROSIS1
HEMIPLEGIA1
HALLUCINATION1
HAIR FOLLICLE TUMOUR BENIGN1
HAIR COLOUR CHANGES1
HAEMORRHOIDS1
HAEMOPHILUS INFECTION1
HAEMOGLOBIN INCREASED1
HAEMODIALYSIS1
HAEMATURIA1
HAEMATOCRIT INCREASED1
HAEMATOCHEZIA1
HAEMATEMESIS1
Haemarthrosis1
GUN SHOT WOUND1
GRANULOMATOUS LIVER DISEASE1
GRANULOMA ANNULARE1
GLOSSODYNIA1
GLOSSITIS1
GLOMERULONEPHRITIS MEMBRANOUS1
GLOMERULONEPHRITIS MEMBRANOPROLIFERATIVE1
GLOMERULONEPHRITIS1
GLAUCOMA1
GINGIVITIS1
GINGIVAL DISORDER1
GENITAL ULCERATION1
GENERALISED OEDEMA1
GASTROOESOPHAGEAL REFLUX DISEASE1
GASTROINTESTINAL EROSION1
GASTROINTESTINAL BACTERIAL INFECTION1
GASTROENTERITIS VIRAL1
GASTRITIS HAEMORRHAGIC1
GASTRITIS EROSIVE1
GASTRITIS1
GASTRIC ULCER1
GASTRIC DISORDER1
GAMMOPATHY1
FOOD POISONING1
FOLLICULITIS1
FOETAL GROWTH RETARDATION1
FLUID RETENTION1
FLATULENCE1
FIBROUS HISTIOCYTOMA1
FIBROSIS1
FACIAL PARESIS1
Facial pain1
EYELID PTOSIS1
EYE OEDEMA1
EYE INFECTION STAPHYLOCOCCAL1
EXPOSURE TO CONTAMINATED AIR1
EXANTHEM1
EUPHORIC MOOD1
ESCHERICHIA SEPSIS1
ERYTHEMA MULTIFORME1
ERYSIPELOID1
EPSTEIN-BARR VIRUS TEST POSITIVE1
EPSTEIN-BARR VIRUS ANTIGEN POSITIVE1
EPIGASTRIC DISCOMFORT1
EPIDEMIC NEPHROPATHY1
ENTEROCUTANEOUS FISTULA1
ENTEROBACTER INFECTION1
ENDOMETRITIS1
ENDOMETRIAL CANCER1
ENCEPHALOPATHY1
ENCEPHALITIS HERPES1
EMPHYSEMA1
Emotional distress1
EMOTIONAL DISORDER1
ELECTROLYTE IMBALANCE1
ELECTROCARDIOGRAM QT PROLONGED1
ECZEMA HERPETICUM1
ECONOMIC PROBLEM1
EAR PAIN1
EAR HAEMORRHAGE1
DYSURIA1
DYSPNOEA EXERTIONAL1
DYSPHASIA1
DYSLEXIA1
DYSHIDROSIS1
DYSGRAPHIA1
DYSCALCULIA1
DUODENAL ULCER1
DRY MOUTH1
DRUG INTOLERANCE1
DRUG ERUPTION1
DRUG EFFECT DECREASED1
Drug dose omission1
DNA ANTIBODY POSITIVE1
DIZZINESS POSTURAL1
DIVERTICULUM INTESTINAL1
DIVERTICULAR PERFORATION1
DISSEMINATED INTRAVASCULAR COAGULATION1
DISSEMINATED CRYPTOCOCCOSIS1
DISEASE COMPLICATION1
Discomfort1
Disability1
DIASTOLIC DYSFUNCTION1
DIALYSIS1
DIABETIC COMPLICATION1
Diabetic coma1
DERMATITIS ATOPIC1
DERMATITIS ALLERGIC1
DEPRESSED LEVEL OF CONSCIOUSNESS1
DEMYELINATION1
DEMYELINATING POLYNEUROPATHY1
DEMENTIA1
DECREASED ACTIVITY1
DEAFNESS NEUROSENSORY1
DEAFNESS BILATERAL1
DACTYLITIS1
CYTOMEGALOVIRUS COLITIS1
CYANOSIS1
CUTANEOUS LUPUS ERYTHEMATOSUS1
CULTURE URINE POSITIVE1
CULTURE STOOL POSITIVE1
CULTURE POSITIVE1
CSF PROTEIN INCREASED1
CSF CELL COUNT INCREASED1
CRYPTOCOCCAL CUTANEOUS INFECTION1
CRANIAL NERVE DISORDER1
CORONARY ARTERY OCCLUSION1
CORONARY ARTERY BYPASS1
CORNEAL TRANSPLANT1
COORDINATION ABNORMAL1
COOMBS TEST POSITIVE1
CONTRAINDICATION TO MEDICAL TREATMENT1
CONSTIPATION1
CONJUNCTIVITIS BACTERIAL1
CONJUNCTIVAL DISCOLOURATION1
CLOSTRIDIUM DIFFICILE COLITIS1
CLOSTRIDIUM COLITIS1
CLOSTRIDIAL INFECTION1
CHRONIC TONSILLITIS1
CHRONIC MYELOID LEUKAEMIA1
CHOLINERGIC SYNDROME1
CHOLANGITIS1
CHEILITIS1
Chapped lips1
CERVIX CARCINOMA1
CERUMEN IMPACTION1
CEREBROVASCULAR DISORDER1
CEREBRAL THROMBOSIS1
CEREBRAL DISORDER1
CEREBRAL ASPERGILLOSIS1
CENTRAL NERVOUS SYSTEM INFLAMMATION1
CD4 LYMPHOCYTES DECREASED1
CATHETER RELATED INFECTION1
CATARACT1
CARDIOVASCULAR DISORDER1
CARDIO-RESPIRATORY ARREST1
CARDIAC MURMUR1
CARCINOEMBRYONIC ANTIGEN INCREASED1
CAPILLARY LEAK SYNDROME1
CANDIDIASIS1
CALCULUS URETERIC1
BURNS SECOND DEGREE1
BUDD-CHIARI SYNDROME1
BRONCHOPNEUMONIA1
BREAST PAIN1
BREAST NEOPLASM1
BREAST MASS1
BREAST CYST1
BREAST CANCER1
BRAIN MASS1
BRAIN DAMAGE1
BONE NEOPLASM1
BODY TEMPERATURE DECREASED1
BLOOD URIC ACID INCREASED1
BLOOD THYROID STIMULATING HORMONE INCREASED1
BLOOD PRESSURE SYSTOLIC INCREASED1
BLOOD PRESSURE DIASTOLIC INCREASED1
BLOOD PRESSURE ABNORMAL1
BLOOD POTASSIUM INCREASED1
BLOOD MAGNESIUM DECREASED1
BLOOD IRON INCREASED1
BLOOD HOMOCYSTEINE INCREASED1
BLOOD GLUCOSE DECREASED1
BLOOD FIBRINOGEN INCREASED1
BLOOD ELECTROLYTES DECREASED1
BLOOD DISORDER1
BLOOD CULTURE POSITIVE1
BLOOD CREATINE INCREASED1
BLOOD CALCIUM INCREASED1
BLOOD BLISTER1
BLOOD BICARBONATE INCREASED1
BLOOD AMYLASE INCREASED1
BLOOD ALBUMIN DECREASED1
BLINDNESS UNILATERAL1
BLEPHARITIS1
BLASTOMYCOSIS1
BIOPSY BONE MARROW ABNORMAL1
BILIARY DILATATION1
BETA GLOBULIN INCREASED1
BERYLLIOSIS1
BENCE JONES PROTEINURIA1
BEDRIDDEN1
BASOPHIL COUNT INCREASED1
BALANCE DISORDER1
BACTERIAL SEPSIS1
BACTERIAL RHINITIS1
BACTERIA URINE1
B-CELL SMALL LYMPHOCYTIC LYMPHOMA1
AUTOIMMUNE THROMBOCYTOPENIA1
AURICULAR SWELLING1
ASPIRATION1
ASPARTATE AMINOTRANSFERASE1
ARTHRITIS REACTIVE1
ARTERIOSCLEROSIS CORONARY ARTERY1
ARTERIAL THROMBOSIS LIMB1
ARTERIAL OCCLUSIVE DISEASE1
APRAXIA1
APPENDICITIS PERFORATED1
APLASIA PURE RED CELL1
APHASIA1
AORTIC VALVE DISEASE1
AORTIC THROMBOSIS1
AORTIC EMBOLUS1
ANTIPHOSPHOLIPID SYNDROME1
ANTINUCLEAR ANTIBODY INCREASED1
ANTIBODY TEST POSITIVE1
ANTI-SS-A ANTIBODY POSITIVE1
ANTI-PLATELET ANTIBODY POSITIVE1
ANKYLOSING SPONDYLITIS1
Ankle fracture1
ANISOCYTOSIS1
ANGIOPATHY1
ANGINA UNSTABLE1
ANGER1
ANASTOMOTIC LEAK1
ANAL FISTULA1
ANAEMIA MEGALOBLASTIC1
AMYOTROPHIC LATERAL SCLEROSIS1
ALCOHOLISM1
ALCOHOL USE1
ALCOHOL POISONING1
ALCOHOL ABUSE1
ALANINE AMINOTRANSFERASE DECREASED1
AGRANULOCYTOSIS1
ADRENOCORTICAL INSUFFICIENCY ACUTE1
ADRENALITIS1
ADRENAL INSUFFICIENCY1
ACUTE MYELOID LEUKAEMIA1
ACUTE LYMPHOCYTIC LEUKAEMIA1
ACUTE LEUKAEMIA1
ACUTE HEPATIC FAILURE1
ACTINOMYCOSIS1
ACNE CONGLOBATA1
ACCIDENT AT HOME1
Acarodermatitis1
ABDOMINAL STRANGULATED HERNIA1
ABDOMINAL INFECTION1
ABDOMINAL DISTENSION1
ABDOMINAL DISCOMFORT1
ABDOMINAL ABSCESS1





Toxicity information:



External links:

ChEBML: CHEMBL1201575