Cerivastatin
General information:
| Withdrawn ID: | w129 |
|---|---|
| Canonical SMILES: | |
| Standard InChI: | |
| Standard InChIKey: | |
| ATC class(es): | C10AA06 |
| Molecular Formula: | C26H34FNO5 |
| Molweight: | 459.55 |
Withdrawal information:
| Withdrawn due to drug safety reasons: | Yes |
|---|---|
| First approved: | 1997 |
| First death: | 1998 |
| First withdrawn: | 2001 |
| Last withdrawn: | 2001 |
| Reference: | https://www.ncbi.nlm.nih.gov/pubmed/15582059 |
Side-effects:
| Total reported cases (submitted by medical professionals) with Cerivastatin as primary suspect: | 5 |
|---|
Reported final outcomes:
| Life-Threatening condition: | 1 |
|---|---|
| Hospitalization (initial or prolonged): | 1 |
| Disability: | 1 |
Reported side-effects:
| Side-effect | Case number |
|---|---|
| MUSCLE SPASMS | 2 |
| MALAISE | 1 |
| ARTHRALGIA | 1 |
| BLOOD DISORDER | 1 |
| BLOOD PRESSURE DIASTOLIC INCREASED | 1 |
| CHROMATURIA | 1 |
| COAGULOPATHY | 1 |
| CONDITION AGGRAVATED | 1 |
| HEPATIC FIBROSIS | 1 |
| HYPERTENSION | 1 |
| JAUNDICE | 1 |
| LABORATORY TEST ABNORMAL | 1 |
| LIVER DISORDER | 1 |
| UNEVALUABLE EVENT | 1 |
| MENTAL STATUS CHANGES | 1 |
| MUSCLE DISORDER | 1 |
| MUSCULAR WEAKNESS | 1 |
| ORAL PAIN | 1 |
| PAIN IN EXTREMITY | 1 |
| POISONING | 1 |
| RASH | 1 |
| RENAL DISORDER | 1 |
| RHABDOMYOLYSIS | 1 |
| TOOTH FRACTURE | 1 |
Filtered ChEMBL targets:
| Target UniProtKB ID | Activity in nm | Target Name | Target gene |
|---|---|---|---|
| P04035 | 10 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | HMDH_HUMAN |
Toxicity information:
| Toxicity class: | 4 |
|---|---|
| Toxicity type: | muscular |
| LD50: | 416 mg/kg |
External links:
| ChEBML: | CHEMBL1477 |
|---|---|
| DrugBank: | DB00439 |