Carisoprodol


w209



General information:


Withdrawn ID: w209
Canonical SMILES:
Standard InChI:
Standard InChIKey:
ATC class(es): M03BA02
M03BA52
M03BA72
Molecular Formula: C12H24N2O4
Molweight: 260.33



Withdrawal information:


Withdrawn due to drug safety reasons:Yes
First approved: 1959
First withdrawn: 2007
Last withdrawn: 2007
Reference: https://www.ncbi.nlm.nih.gov/pubmed/25047350



Side-effects:

Total reported cases (submitted by medical professionals) with Carisoprodol as primary suspect: 844


Reported final outcomes:
Death: 507
Hospitalization (initial or prolonged): 168
Life-Threatening condition: 30
Disability: 10
Intervention required to prevent permanent impairment/damage: 8


Reported side-effects:

Side-effect Case number
COMPLETED SUICIDE254
TOXICITY TO VARIOUS AGENTS147
CARDIAC ARREST135
RESPIRATORY ARREST133
DRUG ABUSE86
DEATH43
CARDIO-RESPIRATORY ARREST37
DRUG INEFFECTIVE35
OVERDOSE33
POISONING32
PHARMACEUTICAL PRODUCT COMPLAINT28
INTENTIONAL DRUG MISUSE26
ROAD TRAFFIC ACCIDENT23
DRUG DEPENDENCE23
INTENTIONAL OVERDOSE22
Angioedema22
UNRESPONSIVE TO STIMULI20
NAUSEA19
DRUG TOXICITY19
Drug hypersensitivity19
MULTIPLE DRUG OVERDOSE INTENTIONAL18
Exposure via ingestion18
DRUG WITHDRAWAL SYNDROME18
VOMITING17
URTICARIA17
MENTAL STATUS CHANGES16
DRUG EFFECT DECREASED16
ACCIDENTAL DEATH16
PAIN15
INCORRECT DOSE ADMINISTERED15
ANXIETY14
Coma13
TACHYPNOEA12
TACHYCARDIA12
SUICIDE ATTEMPT12
SOMNOLENCE12
CARDIAC DISORDER12
AGITATION12
TREMOR11
HEADACHE11
LOSS OF CONSCIOUSNESS10
HYPOTENSION10
HYPERSENSITIVITY10
Haemorrhage10
Retroperitoneal haematoma9
RESPIRATORY DISTRESS9
PULMONARY OEDEMA9
Pneumonia aspiration9
IMPAIRED DRIVING ABILITY9
DYSPNOEA9
Suspected suicide8
RASH8
INSOMNIA8
HYPOXIA8
HYPERHIDROSIS8
FEELING ABNORMAL8
CONVULSION8
ACCIDENTAL OVERDOSE8
WITHDRAWAL SYNDROME7
Tinnitus7
SEROTONIN SYNDROME7
Seizure7
PRURITUS7
METABOLIC ACIDOSIS7
FALL7
DIZZINESS7
DEPRESSION7
DEPRESSED LEVEL OF CONSCIOUSNESS7
THERAPEUTIC RESPONSE DECREASED6
PRODUCT SUBSTITUTION ISSUE6
MUSCLE TWITCHING6
LETHARGY6
Haematoma6
CONDITION AGGRAVATED6
AMNESIA6
Urinary bladder rupture5
SUBSTANCE ABUSE5
SINUS TACHYCARDIA5
Respiratory alkalosis5
Product use in unapproved indication5
PARANOIA5
MYDRIASIS5
MUSCLE SPASMS5
MEMORY IMPAIRMENT5
HAEMOGLOBIN DECREASED5
Haematochezia5
Epistaxis5
DEHYDRATION5
COUGH5
CONFUSIONAL STATE5
ANAPHYLACTIC REACTION5
Wheezing4
VISUAL IMPAIRMENT4
SUBDURAL HAEMATOMA4
Spinal epidural haematoma4
Soft tissue haemorrhage4
SEDATION4
RESTLESSNESS4
PULMONARY EMBOLISM4
PULMONARY CONGESTION4
PALPITATIONS4
MYOCARDIAL INFARCTION4
MIOSIS4
MEDICATION ERROR4
Intentional product misuse4
Hyperventilation4
HALLUCINATION4
GAIT DISTURBANCE4
DRY MOUTH4
Drug level increased4
DRUG ABUSER4
DIARRHOEA4
DEPENDENCE4
Cyanosis4
CHILLS4
CHEST PAIN4
BACK PAIN4
ASTHENIA4
ACUTE HEPATIC FAILURE4
Abdominal pain4
WRONG TECHNIQUE IN DRUG USAGE PROCESS3
Urinary bladder haemorrhage3
STUPOR3
SPEECH DISORDER3
SELF-MEDICATION3
REFUSAL OF TREATMENT BY PATIENT3
PUPILLARY REFLEX IMPAIRED3
Pulmonary alveolar haemorrhage3
PSYCHOTIC DISORDER3
Product use issue3
PRODUCT QUALITY ISSUE3
PERIORBITAL OEDEMA3
PANIC ATTACK3
NERVOUSNESS3
MUSCULOSKELETAL STIFFNESS3
MALAISE3
Lactic acidosis3
Ischaemic stroke3
INTERNATIONAL NORMALISED RATIO INCREASED3
Hypokalaemia3
Hyperreflexia3
HEPATOMEGALY3
HEART RATE INCREASED3
HALLUCINATION, VISUAL3
Haemothorax3
HAEMATOCRIT DECREASED3
GRAND MAL CONVULSION3
FACIAL BONES FRACTURE3
EYE MOVEMENT DISORDER3
DYSKINESIA3
Drug resistance3
DRUG INTERACTION3
Delusion3
CONTUSION3
CEREBRAL INFARCTION3
Cerebral haemorrhage3
Bronchopneumonia3
BRAIN OEDEMA3
BRAIN INJURY3
BLOOD PRESSURE INCREASED3
ASPIRATION3
ARTHRALGIA3
Anion gap abnormal3
Acute kidney injury3
ABDOMINAL PAIN UPPER3
WEIGHT DECREASED2
VICTIM OF HOMICIDE2
URINARY RETENTION2
URINARY INCONTINENCE2
Ulcer2
THERAPEUTIC RESPONSE UNEXPECTED WITH DRUG SUBSTITUTION2
SYNCOPE2
Subarachnoid haemorrhage2
STOMACH DISCOMFORT2
SPINAL FRACTURE2
Spinal cord compression2
SKULL FRACTURE2
Shock haemorrhagic2
Seizure like phenomena2
RIB FRACTURE2
RHABDOMYOLYSIS2
Reye's syndrome2
Retroperitoneal haemorrhage2
Respiratory failure2
RESPIRATORY DEPRESSION2
RENAL IMPAIRMENT2
PULMONARY MICROEMBOLI2
PULMONARY HYPERTENSION2
Pruritus generalised2
PROTHROMBIN TIME PROLONGED2
PNEUMONIA2
Peripheral swelling2
OEDEMA PERIPHERAL2
OCULOCEPHALOGYRIC REFLEX ABSENT2
NO THERAPEUTIC RESPONSE2
MYALGIA2
MUSCLE RIGIDITY2
MULTIPLE DRUG OVERDOSE2
MULTI-ORGAN FAILURE2
MOVEMENT DISORDER2
MENTAL DISORDER2
Menometrorrhagia2
Melaena2
LEGAL PROBLEM2
Kounis syndrome2
Injury2
INCORRECT ROUTE OF DRUG ADMINISTRATION2
Hypoxic-ischaemic encephalopathy2
Hypocalcaemia2
Hepatotoxicity2
HEPATIC NECROSIS2
Hepatic fibrosis2
HEAD INJURY2
Haemoptysis2
Haematemesis2
General physical health deterioration2
GAZE PALSY2
Gastrointestinal disorder2
FEELING JITTERY2
FATIGUE2
Extradural haematoma2
Electrocardiogram QT prolonged2
ECONOMIC PROBLEM2
DYSARTHRIA2
Duodenal ulcer2
DRUG SCREEN POSITIVE2
DRUG INTOLERANCE2
DISORIENTATION2
Diplegia2
DELIRIUM2
DAYDREAMING2
CONSTIPATION2
CONGESTIVE CARDIOMYOPATHY2
Coagulopathy2
Bradycardia2
BLOOD GLUCOSE INCREASED2
BLOOD CREATINE PHOSPHOKINASE INCREASED2
Bezoar2
Balance disorder2
ATAXIA2
ASTHMA2
ASPARTATE AMINOTRANSFERASE INCREASED2
Arterial rupture2
Anion gap increased2
ANAPHYLACTOID REACTION2
ANAEMIA2
Akathisia2
Aggression2
ACCIDENTAL EXPOSURE2
ACCIDENT2
ABNORMAL BEHAVIOUR2
Abdominal discomfort2
Xanthoma1
WISDOM TEETH REMOVAL1
Wheelchair user1
VISUAL ACUITY REDUCED1
VISION BLURRED1
VERTIGO1
Vascular stent occlusion1
Vascular pseudoaneurysm1
Vascular access site haemorrhage1
Vanishing bile duct syndrome1
Uterine haemorrhage1
Urinary tract infection1
Urinary sediment present1
Urinary casts present1
Urethral haemorrhage1
UNEMPLOYMENT1
TRICUSPID VALVE INCOMPETENCE1
TREATMENT NONCOMPLIANCE1
Transient ischaemic attack1
Toxic encephalopathy1
TOOTHACHE1
TOOTH REPAIR1
TOOTH LOSS1
TOOTH INFECTION1
TOOTH FRACTURE1
TOOTH EXTRACTION1
TOOTH EROSION1
TOOTH DISORDER1
Tonic clonic movements1
Thrombocytopenia1
Therapy cessation1
Therapeutic response unexpected1
Tetany1
Tendon rupture1
Systolic hypertension1
Systemic mastocytosis1
Swollen tongue1
SWELLING FACE1
SUICIDAL IDEATION1
SUDDEN ONSET OF SLEEP1
SUBDURAL HAEMORRHAGE1
SUBCUTANEOUS ABSCESS1
Subclavian steal syndrome1
STRESS1
Stevens-Johnson syndrome1
STERNAL FRACTURE1
Staphylococcal infection1
Spinal operation1
SPINAL CORD DISORDER1
SOCIAL PHOBIA1
SLEEP ATTACKS1
Skin injury1
SHOCK1
Septic shock1
Second degree chemical burn of skin1
SCAR1
RHEUMATOID ARTHRITIS1
Respiratory rate increased1
RESPIRATORY DISORDER1
Respiratory acidosis1
RENAL FAILURE ACUTE1
RENAL FAILURE1
RENAL DISORDER1
RED BLOOD CELLS CSF POSITIVE1
REACTION TO DRUG EXCIPIENTS1
RASH GENERALISED1
Radius fracture1
Quadriparesis1
PYREXIA1
PURPURA1
Pupillary light reflex tests abnormal1
Pulse pressure decreased1
PULMONARY HAEMORRHAGE1
PSYCHOMOTOR HYPERACTIVITY1
PROTEIN TOTAL DECREASED1
PRODUCT COMPOUNDING QUALITY ISSUE1
Product availability issue1
Procedural haemorrhage1
POOR QUALITY DRUG ADMINISTERED1
POOR PERSONAL HYGIENE1
Polymedication1
POLLAKIURIA1
Pneumonitis1
Plicated tongue1
PLEURAL ADHESION1
Platelet dysfunction1
Platelet disorder1
Plasmapheresis1
Peritoneal adhesions1
PERIORBITAL HAEMATOMA1
Pericardial haemorrhage1
Pemphigoid1
Pelvic haemorrhage1
PATHOGEN RESISTANCE1
Paraparesis1
PANNICULITIS1
PANCREATITIS1
Pain in extremity1
Oropharyngeal pain1
Off label use1
Oesophageal obstruction1
NONSPECIFIC REACTION1
Neuropathy peripheral1
Neuroleptic malignant syndrome1
NEURALGIA1
NEPHRITIS1
Neoplasm malignant1
NECK PAIN1
NECK INJURY1
Myopathy1
Myoclonus1
MYOCARDIAL FIBROSIS1
Muscular weakness1
Multiple sclerosis relapse1
Multiple organ dysfunction syndrome1
MULTIPLE INJURIES1
MULTIPLE DRUG OVERDOSE ACCIDENTAL1
Mouth ulceration1
MOBILITY DECREASED1
Metabolic encephalopathy1
METABOLIC DISORDER1
MENTAL IMPAIRMENT1
MENTAL DISORDER DUE TO A GENERAL MEDICAL CONDITION1
MARITAL PROBLEM1
MAJOR DEPRESSION1
Lung consolidation1
Lower gastrointestinal haemorrhage1
LOSS OF EMPLOYMENT1
LIP SWELLING1
Kussmaul respiration1
Knee arthroplasty1
Jejunal ulcer1
ISCHAEMIC HEPATITIS1
Irritability1
INFUSION RELATED REACTION1
Incorrect drug administration duration1
Incision site haemorrhage1
INAPPROPRIATE SCHEDULE OF DRUG ADMINISTRATION1
IMPRISONMENT1
IMPAIRED WORK ABILITY1
ILEUS1
Hypovolaemia1
Hypoventilation1
HYPOPHAGIA1
Hypokinesia1
Hypoglycaemia1
Hypoacusis1
HYPERSOMNIA1
Hyperphosphataemia1
Hyperchloraemia1
HERPES ZOSTER1
HEPATITIS C1
HEPATIC STEATOSIS1
HEPATIC FAILURE1
HEPATIC CONGESTION1
Hemiparesis1
HALLUCINATIONS, MIXED1
Haemorrhagic ovarian cyst1
Haemorrhage intracranial1
Haemodynamic instability1
Haematuria1
Glucose urine present1
Glossodynia1
GINGIVITIS1
Gingival swelling1
Generalised tonic-clonic seizure1
Gastrointestinal haemorrhage1
GASTROENTERITIS VIRAL1
GASTROENTERITIS1
Gastric ulcer1
Gastric disorder1
FURUNCLE1
FOREIGN BODY ASPIRATION1
Foot fracture1
FLUSHING1
Fixed eruption1
Femoral nerve palsy1
FEAR1
FACIAL PALSY1
Exposure via inhalation1
Exposure during pregnancy1
EXCORIATION1
EOSINOPHIL COUNT INCREASED1
Enterocolitis haemorrhagic1
ENDODONTIC PROCEDURE1
Encephalopathy1
Embolism1
ELECTROENCEPHALOGRAM ABNORMAL1
Electrocardiogram QRS complex prolonged1
EJACULATION FAILURE1
Dysuria1
DYSPHONIA1
Dysphagia1
Dyspepsia1
DYSGEUSIA1
Dysacusis1
DRY SKIN1
DRUG TOLERANCE INCREASED1
DRUG TOLERANCE1
Drug prescribing error1
DRUG ERUPTION1
Drug effect incomplete1
Drug dose omission1
DRUG DIVERSION1
DROWNING1
DISTURBANCE IN ATTENTION1
DISCOMFORT1
Diarrhoea haemorrhagic1
DEVICE MISUSE1
DEPERSONALISATION1
DENTAL CARIES1
DEMENTIA1
DECREASED APPETITE1
DEATH OF RELATIVE1
Deafness1
CYSTITIS ESCHERICHIA1
Crying1
Coronary artery occlusion1
COORDINATION ABNORMAL1
Conjunctivitis1
Compartment syndrome1
Coma scale abnormal1
COGNITIVE DISORDER1
Clonus1
Circumstance or information capable of leading to medication error1
CIRCULATORY COLLAPSE1
Cholestasis1
CHOKING1
CHEST INJURY1
CHEST DISCOMFORT1
CEREBRAL ISCHAEMIA1
Cardiomegaly1
Cardiac tamponade1
Cardiac operation1
BURNING SENSATION1
BRUXISM1
Bronchospasm1
BRAIN HERNIATION1
BRAIN CONTUSION1
BONE DISORDER1
Blood pressure decreased1
BLOOD LACTIC ACID DECREASED1
BLOOD CALCIUM DECREASED1
BLOOD BILIRUBIN INCREASED1
BLOOD ALKALINE PHOSPHATASE INCREASED1
BLOOD ALBUMIN DECREASED1
BLADDER DISORDER1
BELLIGERENCE1
BACK DISORDER1
AUTOIMMUNE THYROIDITIS1
Auditory perseveration1
ARTIFICIAL CROWN PROCEDURE1
Arthritis1
Arteriospasm coronary1
Arterial spasm1
Arterial occlusive disease1
Arterial haemorrhage1
Arrhythmia1
APHASIA1
ANOREXIA1
Ankle fracture1
Aneurysm ruptured1
ANAEMIA POSTOPERATIVE1
Altered state of consciousness1
ALCOHOL PROBLEM1
ALANINE AMINOTRANSFERASE INCREASED1
Agranulocytosis1
AGORAPHOBIA1
ADVERSE REACTION1
Acute respiratory failure1
ACUTE CORONARY SYNDROME1
ACTIVATED PARTIAL THROMBOPLASTIN TIME PROLONGED1
Accidental poisoning1
Accidental exposure to product by child1
ACCIDENT AT WORK1
Abdominal wall haematoma1
Abdominal pain lower1
Abasia1





Filtered ChEMBL targets:

Target UniProtKB ID Activity in nm Target Name Target gene
P02545 5.6 Prelamin-A/C LMNA_HUMAN
P16473 631 Thyrotropin receptor TSHR_HUMAN
P51151 6309.6 Ras-related protein Rab-9A RAB9A_HUMAN
Q9NUW8 794.3 Tyrosyl-DNA phosphodiesterase 1 TYDP1_HUMAN



Toxicity information:

Toxicity class: 4
Toxicity type: multiple
LD50: 800 mg/kg



External links:

ChEBML: CHEMBL1233
DrugBank: DB00395