Calcifediol


1390



General information:


Withdrawn ID: 1390
Canonical SMILES:
Standard InChI:
Standard InChIKey:
ATC class(es): A11CC06
Molecular Formula: C27H44O2
Molweight: 400.637



Withdrawal information:


Withdrawn due to drug safety reasons:No
First approved: 1980



Side-effects:

Total reported cases (submitted by medical professionals) with Calcifediol as primary suspect: 38


Reported final outcomes:
Death: 35
Hospitalization (initial or prolonged): 8
Life-Threatening condition: 0


Reported side-effects:

Side-effect Case number
Death51
Nausea3
Fatigue3
Hypersensitivity3
Dyspnoea3
Cardiac failure congestive3
Asthenia3
COVID-192
Abdominal pain upper2
Headache2
Hospitalisation2
Erythema2
Acute kidney injury2
Dry skin2
Insomnia2
Dizziness2
Dialysis2
Pruritus2
Therapy cessation2
Sepsis2
Renal failure2
Respiratory failure2
Rash2
Bone pain1
Atrial fibrillation1
Facial spasm1
Facial paralysis1
Bacterial infection1
Blood calcium decreased1
Accidental exposure to product by child1
Epigastric discomfort1
Blood parathyroid hormone decreased1
Dyspepsia1
Dysgeusia1
Drug intolerance1
Disturbance in attention1
Diabetes mellitus inadequate control1
Adverse drug reaction1
Culture urine positive1
Anxiety1
Contusion1
Confusional state1
Hypercalcaemia1
Chronic obstructive pulmonary disease1
Chest pain1
Cerebral haemorrhage1
Amnesia1
Cardiac arrest1
Tachypnoea1
Myocardial infarction1
Oedema1
Pain1
Pain in extremity1
Pleural effusion1
Pneumonia aspiration1
Renal impairment1
Sleep talking1
Subarachnoid haemorrhage1
Myalgia1
Tongue discolouration1
Transient ischaemic attack1
Troponin increased1
Ulcer1
Unevaluable event1
Urinary tract infection1
Vascular purpura1
Vertigo positional1
Influenza like illness1
Gastric ulcer haemorrhage1
Haemoglobin decreased1
Head injury1
Vomiting1
Hypertension1
Hypotension1
Impaired gastric emptying1
Influenza1
Feeling abnormal1
Internal haemorrhage1
Irritability1
Lactic acidosis1
Laryngeal oedema1
Left ventricular failure1
Monoparesis1
Muscle spasms1
Muscular weakness1





Filtered ChEMBL targets:

Target UniProtKB ID Activity in nm Target Name Target gene
P36956 1176 Sterol regulatory element-binding protein 1 SRBP1_HUMAN



Toxicity information:

Toxicity class: 2
Toxicity type: N/A
LD50: 42 mg/kg



External links:

ChEBML: CHEMBL1040
DrugBank: DB00146