Bithionol

General information:

Withdrawn ID:	w65
Canonical SMILES:
Standard InChI:
Standard InChIKey:
ATC class(es):	D10AB01
	P02BX01
Molecular Formula:	C12H6Cl4O2S
Molweight:	356.052

Withdrawal information:

Withdrawn due to drug safety reasons:	Yes
First approved:	1960
First withdrawn:	1967
Last withdrawn:	1967
Reference:	https://www.ncbi.nlm.nih.gov/pubmed/21133325

Filtered ChEMBL targets:

Target UniProtKB ID	Activity in nm	Target Name	Target gene
O15244	1900	Solute carrier family 22 member 2	S22A2_HUMAN
O15245	2230	Solute carrier family 22 member 1	S22A1_HUMAN
O75751	5500	Solute carrier family 22 member 3	S22A3_HUMAN
P02545	3162.3	Prelamin-A/C	LMNA_HUMAN
P02766	62	Transthyretin	TTHY_HUMAN
P03372	3940.88	Estrogen receptor	ESR1_HUMAN
P18054	707.9	Polyunsaturated fatty acid lipoxygenase ALOX12	LOX12_HUMAN
P24557	1840	Thromboxane-A synthase	THAS_HUMAN
P42858	10000	Huntingtin	HD_HUMAN
P61604	2800	10 kDa heat shock protein, mitochondrial	CH10_HUMAN
Q07820	1898.89	Induced myeloid leukemia cell differentiation protein Mcl-1	MCL1_HUMAN
Q16665	5011.9	Hypoxia-inducible factor 1-alpha	HIF1A_HUMAN
Q86VL8	6600	Multidrug and toxin extrusion protein 2	S47A2_HUMAN
Q92731	8147.15	Estrogen receptor beta	ESR2_HUMAN
Q96FL8	5200	Multidrug and toxin extrusion protein 1	S47A1_HUMAN

Toxicity information:

Toxicity class:	1
Toxicity type:	dermatological
LD50:	4.15 mg/kg

External links:

ChEBML:	CHEMBL290106
DrugBank:	DB04813