Bicalutamide


w206



General information:


Withdrawn ID: w206
Canonical SMILES:
Standard InChI:
Standard InChIKey:
ATC class(es): L02BB03
Molecular Formula: C18H14F4N2O4S
Molweight: 430.373



Withdrawal information:


Withdrawn due to drug safety reasons:Yes
First approved: 1995
First death: 2001
First withdrawn: 2005
Last withdrawn: 2005
Reference: https://www.ncbi.nlm.nih.gov/pubmed/24964168



Side-effects:

Total reported cases (submitted by medical professionals) with Bicalutamide as primary suspect: 1715


Reported final outcomes:
Hospitalization (initial or prolonged): 820
Death: 212
Life-Threatening condition: 161
Disability: 95
Intervention required to prevent permanent impairment/damage: 26


Reported side-effects:

Side-effect Case number
DYSPNOEA78
Malignant neoplasm progression74
PROSTATIC SPECIFIC ANTIGEN INCREASED66
INTERSTITIAL LUNG DISEASE66
DRUG INEFFECTIVE64
FATIGUE61
ANAEMIA59
ASTHENIA54
DEATH50
CARDIAC FAILURE50
THROMBOCYTOPENIA48
NAUSEA47
HOT FLUSH45
DISEASE PROGRESSION45
Off label use44
FALL44
PROSTATE CANCER43
DIARRHOEA42
METASTASES TO BONE41
HAEMATURIA41
DRUG INTERACTION41
CHEST PAIN40
PULMONARY EMBOLISM38
PLATELET COUNT DECREASED38
HEPATIC FUNCTION ABNORMAL37
DIZZINESS36
PYREXIA31
MALAISE30
GYNAECOMASTIA30
Acute kidney injury30
DEHYDRATION29
MYOCARDIAL INFARCTION28
CEREBRAL INFARCTION28
VOMITING27
ELECTROCARDIOGRAM QT PROLONGED27
TORSADE DE POINTES26
CONDITION AGGRAVATED25
ACUTE MYOCARDIAL INFARCTION25
PNEUMONIA24
URINARY RETENTION23
PRURITUS23
NEUTROPENIA23
LOSS OF CONSCIOUSNESS23
DECREASED APPETITE23
ABDOMINAL PAIN23
SYNCOPE22
RENAL FAILURE22
INTERNATIONAL NORMALISED RATIO INCREASED22
HYPOTENSION22
WEIGHT DECREASED21
URINARY TRACT INFECTION21
RECTAL HAEMORRHAGE21
OEDEMA PERIPHERAL21
HEPATIC FAILURE21
HEADACHE21
CONSTIPATION21
ARTHRALGIA21
ATRIAL FIBRILLATION20
SEPSIS19
RESPIRATORY FAILURE19
RASH19
CONFUSIONAL STATE19
CARDIAC FAILURE CONGESTIVE19
MUSCULAR WEAKNESS18
HYPERHIDROSIS18
HAEMOGLOBIN DECREASED18
ALANINE AMINOTRANSFERASE INCREASED18
PULMONARY FIBROSIS17
CEREBROVASCULAR ACCIDENT17
ASPARTATE AMINOTRANSFERASE INCREASED17
ARRHYTHMIA17
PAIN IN EXTREMITY16
LUNG NEOPLASM MALIGNANT16
LIVER DISORDER16
INSOMNIA16
HYPOKALAEMIA16
HYPERTENSION16
RENAL FAILURE ACUTE15
PANCYTOPENIA15
DYSURIA15
BACK PAIN15
MYALGIA14
HYPONATRAEMIA14
HYPERGLYCAEMIA14
ERYTHEMA14
DYSPHAGIA14
WEIGHT INCREASED13
RENAL IMPAIRMENT13
Prostate cancer metastatic13
PAIN13
METASTASES TO LYMPH NODES13
LYMPHADENOPATHY13
TRANSIENT ISCHAEMIC ATTACK12
PLEURAL EFFUSION12
JAUNDICE12
DISSEMINATED INTRAVASCULAR COAGULATION12
COUGH12
CHRONIC OBSTRUCTIVE PULMONARY DISEASE12
CARDIAC ARREST12
BREAST CANCER MALE12
ACUTE CORONARY SYNDROME12
SOMNOLENCE11
RHABDOMYOLYSIS11
Prostate cancer recurrent11
OSTEOPOROSIS11
HYPOGLYCAEMIA11
Hormone-refractory prostate cancer11
GAIT DISTURBANCE11
FEELING ABNORMAL11
DRUG DISPENSING ERROR11
DIABETES MELLITUS11
DEPRESSION11
DEEP VEIN THROMBOSIS11
BONE MARROW FAILURE11
NEPHROTIC SYNDROME10
Hip fracture10
FEBRILE NEUTROPENIA10
ERECTILE DYSFUNCTION10
DISORIENTATION10
CHILLS10
BLOOD ALKALINE PHOSPHATASE INCREASED10
SUBDURAL HAEMATOMA9
ORTHOSTATIC HYPOTENSION9
METASTASES TO LIVER9
LIVER FUNCTION TEST ABNORMAL9
HYDRONEPHROSIS9
HALLUCINATION9
GENERAL PHYSICAL HEALTH DETERIORATION9
GAMMA-GLUTAMYLTRANSFERASE INCREASED9
Colon cancer9
CHOLESTASIS9
CEREBRAL HAEMORRHAGE9
BREAST TENDERNESS9
BRADYCARDIA9
ACUTE HEPATIC FAILURE9
WHITE BLOOD CELL COUNT DECREASED8
Ventricular fibrillation8
URTICARIA8
UNRESPONSIVE TO STIMULI8
THROMBOSIS8
TACHYCARDIA8
SUICIDAL IDEATION8
SPEECH DISORDER8
Proctalgia8
PNEUMONITIS8
PARAESTHESIA8
NEPHROLITHIASIS8
MULTI-ORGAN FAILURE8
METASTASES TO SPINE8
INFECTION8
EYE PAIN8
EPISTAXIS8
DRUG NAME CONFUSION8
CYTOLYTIC HEPATITIS8
CORONARY ARTERY DISEASE8
CIRCULATORY COLLAPSE8
VISION BLURRED7
UROSEPSIS7
TRANSAMINASES INCREASED7
PNEUMONIA BACTERIAL7
PHOTOSENSITIVITY REACTION7
Peripheral swelling7
OXYGEN SATURATION DECREASED7
OEDEMA7
Neuroendocrine carcinoma7
METASTASIS7
HEPATITIS CHOLESTATIC7
Hepatic necrosis7
HEPATIC ENZYME INCREASED7
HEAD INJURY7
HAEMORRHAGE7
Feeling hot7
EYE PRURITUS7
DRUG RESISTANCE7
CUSHING'S SYNDROME7
CONVULSION7
CONGESTIVE CARDIOMYOPATHY7
CHROMATURIA7
CELLULITIS7
CARDIOMYOPATHY7
CARDIOMEGALY7
BREAST PAIN7
BLOOD PRESSURE INCREASED7
BLOOD GLUCOSE INCREASED7
BLOOD CREATINE PHOSPHOKINASE INCREASED7
BLOOD BILIRUBIN INCREASED7
BLISTER7
ATRIOVENTRICULAR BLOCK COMPLETE7
ANXIETY7
ACCIDENTAL OVERDOSE7
VISUAL IMPAIRMENT6
Vertigo6
URINARY INCONTINENCE6
TYPE 2 DIABETES MELLITUS6
Therapy cessation6
SUDDEN DEATH6
SPINAL CORD COMPRESSION6
PULMONARY HYPERTENSION6
Product monitoring error6
PNEUMONIA ASPIRATION6
OVERDOSE6
OESOPHAGEAL CARCINOMA6
MYELODYSPLASTIC SYNDROME6
MUSCLE ATROPHY6
MOOD SWINGS6
MELAENA6
LUNG INFILTRATION6
LUNG DISORDER6
LIBIDO DECREASED6
LEUKOPENIA6
JOINT SWELLING6
JAUNDICE CHOLESTATIC6
INFLAMMATION6
HEPATOTOXICITY6
HEPATIC ENCEPHALOPATHY6
GASTROINTESTINAL HAEMORRHAGE6
Dyspnoea exertional6
Diverticulitis6
DEPRESSED MOOD6
Conjunctival hyperaemia6
CHOLELITHIASIS6
BREAST SWELLING6
BALANCE DISORDER6
ATRIAL FLUTTER6
ANGINA UNSTABLE6
ANGINA PECTORIS6
AGITATION6
AGGRESSION6
Acute respiratory failure6
ACUTE RESPIRATORY DISTRESS SYNDROME6
ACUTE MYELOID LEUKAEMIA6
VENTRICULAR TACHYCARDIA5
VENTRICULAR EXTRASYSTOLES5
Vasculitis5
URINARY TRACT OBSTRUCTION5
Treatment failure5
Therapy partial responder5
SCOTOMA5
Rash pruritic5
Radiation proctitis5
PSORIASIS5
PENILE OEDEMA5
NEURALGIA5
MOOD ALTERED5
MEDICATION ERROR5
LIVER INJURY5
Leukocytosis5
Hypopituitarism5
HYPOAESTHESIA5
HYPERCALCAEMIA5
HOSPITALISATION5
Hepatorenal syndrome5
EXERCISE TOLERANCE DECREASED5
Ejection fraction decreased5
ECZEMA5
Drug-induced liver injury5
Drug reaction with eosinophilia and systemic symptoms5
DRUG ERUPTION5
Discomfort5
DIPLOPIA5
DIABETIC KETOACIDOSIS5
Cystitis radiation5
CYSTITIS5
Cutaneous vasculitis5
Coronary artery occlusion5
Compression fracture5
COMA5
Coagulopathy5
Cerebral ischaemia5
CARDIO-RESPIRATORY ARREST5
BUNDLE BRANCH BLOCK RIGHT5
BUNDLE BRANCH BLOCK LEFT5
BONE PAIN5
Bone lesion5
BLOOD TESTOSTERONE INCREASED5
BLOOD LACTATE DEHYDROGENASE INCREASED5
Biliary colic5
ASCITES5
APLASTIC ANAEMIA5
Anti-androgen withdrawal syndrome5
ANGIOEDEMA5
ABDOMINAL WALL HAEMATOMA5
ABDOMINAL PAIN UPPER5
ABDOMINAL DISTENSION5
ABASIA5
WHITE BLOOD CELL COUNT INCREASED4
Uveitis4
Urine flow decreased4
TREATMENT NONCOMPLIANCE4
THERAPY NON-RESPONDER4
Testicular atrophy4
TACHYPNOEA4
SWOLLEN TONGUE4
SUPRAVENTRICULAR TACHYCARDIA4
STEVENS-JOHNSON SYNDROME4
Spinal compression fracture4
Small intestinal obstruction4
Skin ulcer4
SKIN LESION4
SCHIZOPHRENIA4
RESPIRATORY DISORDER4
RENAL DISORDER4
RADIATION INJURY4
Quality of life decreased4
PULMONARY OEDEMA4
PULMONARY ALVEOLAR HAEMORRHAGE4
PROSTATITIS4
Product use in unapproved indication4
Proctitis4
Presyncope4
Pollakiuria4
Phyllodes tumour4
PHARYNGEAL OEDEMA4
Pancreatitis4
PALPITATIONS4
ORGANISING PNEUMONIA4
ORAL PAIN4
NO THERAPEUTIC RESPONSE4
NEOPLASM PROGRESSION4
Metastases to lung4
MENTAL STATUS CHANGES4
LOBAR PNEUMONIA4
LIP SWELLING4
LIMB DISCOMFORT4
Labelled drug-drug interaction medication error4
Ischaemic stroke4
INFLUENZA LIKE ILLNESS4
Inappropriate antidiuretic hormone secretion4
ILEUS4
HYPOXIA4
HYPERTENSIVE CRISIS4
Hyperadrenalism4
HEPATITIS TOXIC4
HEPATITIS FULMINANT4
HEPATITIS4
Hepatic steatosis4
HAEMOPTYSIS4
HAEMATEMESIS4
Glycosylated haemoglobin increased4
Generalised tonic-clonic seizure4
GASTROENTERITIS4
FLUSHING4
FLATULENCE4
ENCEPHALOPATHY4
Emphysema4
ELECTROLYTE IMBALANCE4
Dysstasia4
DYSPHONIA4
DYSARTHRIA4
DRUG PRESCRIBING ERROR4
DRUG INTOLERANCE4
DERMATITIS EXFOLIATIVE4
Dementia4
Coronary artery stenosis4
COLITIS4
Cognitive disorder4
CHEST DISCOMFORT4
BRONCHOSPASM4
BODY TEMPERATURE INCREASED4
BLADDER DISORDER4
Bicytopenia4
Atrioventricular block first degree4
ANAPHYLACTIC REACTION4
Adrenal insufficiency4
ACUTE PULMONARY OEDEMA4
ABNORMAL DREAMS4
WRONG DRUG ADMINISTERED3
WHEEZING3
VISUAL ACUITY REDUCED3
UNEVALUABLE EVENT3
Tubulointerstitial nephritis3
Troponin increased3
TRICUSPID VALVE INCOMPETENCE3
TREMOR3
TOXIC SKIN ERUPTION3
TINNITUS3
THIRST3
Testicular pain3
Tendonitis3
Tendon rupture3
STRESS URINARY INCONTINENCE3
STRESS3
Squamous cell carcinoma3
Spinal osteoarthritis3
SKIN DISCOLOURATION3
SINUS BRADYCARDIA3
Sexual dysfunction3
Road traffic accident3
RESPIRATORY DISTRESS3
RALES3
Pulmonary mass3
PULMONARY HAEMORRHAGE3
PROTHROMBIN TIME PROLONGED3
PRODUCTIVE COUGH3
Product use issue3
Product substitution issue3
Product administration error3
POLYURIA3
POLYNEUROPATHY3
Pneumocystis jirovecii pneumonia3
PITUITARY HAEMORRHAGE3
PEMPHIGOID3
PANCREATITIS ACUTE3
Normochromic anaemia3
NOCTURIA3
NIPPLE PAIN3
NEUTROPHIL COUNT DECREASED3
NASAL CONGESTION3
MYOCARDIAL ISCHAEMIA3
MUSCULOSKELETAL STIFFNESS3
MUSCLE SPASMS3
Multiple organ dysfunction syndrome3
MITRAL VALVE INCOMPETENCE3
Metastases to breast3
Lymphocele3
Lumbar vertebral fracture3
Long QT syndrome3
Leukoencephalopathy3
LEUKOCYTOCLASTIC VASCULITIS3
LEUKAEMIA3
LEFT VENTRICULAR FAILURE3
Intra-abdominal haematoma3
INTENTIONAL DRUG MISUSE3
INFLUENZA3
IMMOBILE3
Hypophagia3
HYPOGONADISM3
HYPOCALCAEMIA3
HYPERSENSITIVITY3
HEPATOMEGALY3
Hepatocellular injury3
HEPATOCELLULAR DAMAGE3
HEPATIC CIRRHOSIS3
Hemiparesis3
HEART RATE INCREASED3
HEART RATE DECREASED3
HAIR GROWTH ABNORMAL3
Haemorrhoids3
HAEMORRHAGIC DIATHESIS3
HAEMORRHAGE URINARY TRACT3
HAEMOLYTIC ANAEMIA3
Glycosuria3
GASTROOESOPHAGEAL REFLUX DISEASE3
Flank pain3
Femur fracture3
Faeces discoloured3
FACIAL PALSY3
Eye infection fungal3
EYE HAEMORRHAGE3
Eye abscess3
Epidural lipomatosis3
EOSINOPHILIC PNEUMONIA3
Dyspnoea at rest3
DYSGEUSIA3
DRY SKIN3
Drug hypersensitivity3
DILATATION VENTRICULAR3
Delusion3
Cytopenia3
COORDINATION ABNORMAL3
Contraindicated product administered3
COCCYDYNIA3
CHOLANGITIS3
Cervical vertebral fracture3
C-REACTIVE PROTEIN INCREASED3
BREAST CANCER3
Brain oedema3
BLOOD SODIUM DECREASED3
Blood magnesium decreased3
BLOOD CREATININE INCREASED3
BILE DUCT OBSTRUCTION3
BILE DUCT CANCER3
ATRIOVENTRICULAR BLOCK3
ANAPHYLACTIC SHOCK3
Anal incontinence3
ANAL FISTULA3
ALOPECIA3
Adverse event3
ABNORMAL BEHAVIOUR3
ABDOMINAL DISCOMFORT3
Wrong technique in product usage process2
Vertebral artery stenosis2
Vascular stent occlusion2
Urine output increased2
URINE OUTPUT DECREASED2
Ureterolithiasis2
URETERIC STENOSIS2
Upper respiratory tract infection2
Transitional cell carcinoma2
TOXIC EPIDERMAL NECROLYSIS2
TONGUE OEDEMA2
Therapy change2
THERAPEUTIC RESPONSE UNEXPECTED2
Testicular swelling2
SYSTEMIC LUPUS ERYTHEMATOSUS2
SWELLING2
Surgery2
SUBILEUS2
STAPHYLOCOCCAL INFECTION2
SMOOTH MUSCLE ANTIBODY POSITIVE2
Small cell carcinoma2
SLEEP APNOEA SYNDROME2
SKIN SWELLING2
SKIN PAPILLOMA2
Skin hyperpigmentation2
Sinus arrhythmia2
SHOCK2
Seizure2
SCROTAL SWELLING2
Sciatica2
Rib fracture2
Retroperitoneal lymphadenopathy2
RESPIRATORY DEPRESSION2
RESPIRATORY ARREST2
RENAL CYST2
Refusal of treatment by relative2
Rectal ulcer2
Raynaud's phenomenon2
RASH PUSTULAR2
RASH ERYTHEMATOUS2
Pustular psoriasis2
PSYCHOTIC DISORDER2
Product dose omission2
Poor peripheral circulation2
Polyarthritis2
POISONING2
PNEUMOTHORAX2
PLEURAL DISORDER2
Plasma cell myeloma2
Pituitary tumour benign2
Perineal pain2
PERFORMANCE STATUS DECREASED2
PENILE PAIN2
Paraparesis2
Pancreatic carcinoma2
Pain in jaw2
OSTEOPENIA2
Osteonecrosis of jaw2
OSTEONECROSIS2
Osteomyelitis2
Osteoarthritis2
ORCHIDECTOMY2
Oesophageal haemorrhage2
Ocular icterus2
Ocular hyperaemia2
NO ADVERSE EVENT2
Neuroendocrine carcinoma metastatic2
Necrosis2
NECK PAIN2
Musculoskeletal pain2
MOUTH ULCERATION2
Mobility decreased2
Metastatic neoplasm2
Metastases to spinal cord2
Metastases to soft tissue2
Metastases to pelvis2
Metastases to central nervous system2
Meningioma2
Malnutrition2
LYMPHOMA2
Lymphocytosis2
Loss of personal independence in daily activities2
Loss of libido2
LOCAL SWELLING2
Liver transplant2
Liver function test increased2
Lethargy2
LEFT VENTRICULAR DYSFUNCTION2
Left atrial dilatation2
Lacunar infarction2
Jaw fracture2
INTRAVENTRICULAR HAEMORRHAGE2
INTRACARDIAC THROMBUS2
INTERNATIONAL NORMALISED RATIO ABNORMAL2
INTERCEPTED DRUG DISPENSING ERROR2
Intentional product misuse2
Injection site pain2
Incorrect dose administered2
ILL-DEFINED DISORDER2
HYPOTRICHOSIS2
Hypersomnia2
Hyperkalaemia2
Hydroureter2
HERPES SIMPLEX2
Hepatocellular carcinoma2
HEPATITIS ACUTE2
HEPATIC LESION2
HEPATIC ENZYME ABNORMAL2
Hepatic cancer2
Haemorrhage subcutaneous2
HAEMODIALYSIS2
HAEMATOCRIT DECREASED2
HAEMATOCHEZIA2
Guillain-Barre syndrome2
GLUCOSE TOLERANCE IMPAIRED2
GINGIVAL BLEEDING2
GENERALISED OEDEMA2
Gastric cancer2
Formication2
Fibroadenoma of breast2
Feeding disorder2
Fat tissue increased2
FACIAL BONES FRACTURE2
Escherichia urinary tract infection2
ERYTHROPENIA2
EOSINOPHILIA2
EOSINOPHIL COUNT INCREASED2
ELECTROCARDIOGRAM T WAVE INVERSION2
Electrocardiogram ST segment elevation2
ELECTROCARDIOGRAM ABNORMAL2
ECCHYMOSIS2
DYSPEPSIA2
DRY MOUTH2
DRY EYE2
Disuse syndrome2
DISTURBANCE IN ATTENTION2
Disease recurrence2
DERMATITIS BULLOUS2
Depressive symptom2
DEPRESSED LEVEL OF CONSCIOUSNESS2
DEMENTIA ALZHEIMER'S TYPE2
CYANOSIS2
CONTUSION2
CONJUNCTIVITIS2
Conjunctival ulcer2
COMPLETED SUICIDE2
Chronic respiratory failure2
Cholecystitis acute2
Cholangitis sclerosing2
Cerebral thrombosis2
Cerebral haematoma2
Cataract2
Carotid artery stenosis2
CARDIOVASCULAR DISORDER2
Cardiac stress test abnormal2
Cardiac failure acute2
CARDIAC DISORDER2
Cardiac death2
Calculus urinary2
BRONCHITIS CHRONIC2
BRONCHITIS2
BRONCHIECTASIS2
BREAST ENLARGEMENT2
BREAST DISCOMFORT2
Bone marrow oedema2
BONE DISORDER2
Blood urea increased2
Blood testosterone decreased2
BLOOD PRESSURE DECREASED2
BLOOD POTASSIUM INCREASED2
Blood potassium decreased2
BLOOD PH INCREASED2
BLOOD GLUCOSE FLUCTUATION2
BLOOD CHOLESTEROL INCREASED2
Blood calcium decreased2
Bladder outlet obstruction2
AZOTAEMIA2
Atrioventricular block second degree2
Atrial tachycardia2
Atelectasis2
ASPHYXIA2
Aphasia2
AORTIC STENOSIS2
Aortic aneurysm2
ANTI-NEUTROPHIL CYTOPLASMIC ANTIBODY POSITIVE VASCULITIS2
ANOREXIA2
Androgens increased2
Anaesthesia2
AMNESIA2
ALCOHOL USE2
AGRANULOCYTOSIS2
Adverse drug reaction2
ACUTE PSYCHOSIS2
Acute left ventricular failure2
Acquired gene mutation2
ABSCESS2
ABDOMINAL PAIN LOWER2
YELLOW SKIN1
WRONG TECHNIQUE IN DRUG USAGE PROCESS1
WOUND HAEMORRHAGE1
Wound1
Withdrawal syndrome1
WHITE BLOOD CELL DISORDER1
WEIGHT LOSS POOR1
WEBER-CHRISTIAN DISEASE1
Walking disability1
VITREOUS DISORDER1
Vitiligo1
Vitamin D deficiency1
Viral upper respiratory tract infection1
Viral infection1
Vipoma1
Vertebral artery occlusion1
VENTRICULAR DYSFUNCTION1
VENOUS THROMBOSIS LIMB1
VASCULITIC RASH1
VASCULAR PURPURA1
Vascular pseudoaneurysm1
Vascular graft thrombosis1
Vascular graft1
VARICES OESOPHAGEAL1
Vaginal haemorrhage1
Uterine contractions abnormal1
Urine odour abnormal1
Urinary tract toxicity1
Urinary tract disorder1
Urinary casts1
Urinary bladder toxicity1
Urethral stenosis1
Urethral fistula1
URETHRAL DISORDER1
Ureteric rupture1
Ureteric obstruction1
Upper limb fracture1
UPPER GASTROINTESTINAL HAEMORRHAGE1
Underdose1
ULCER1
Tunnel vision1
Tumour marker increased1
Tumour lysis syndrome1
Tumour invasion1
TUMOUR HAEMORRHAGE1
TUMOUR FLARE1
TRANSURETHRAL PROSTATECTOMY1
Tracheobronchitis1
TP53 gene mutation1
Toxicity to various agents1
Toxic encephalopathy1
TOOTH FRACTURE1
Tooth extraction1
TONGUE ULCERATION1
TONGUE NEOPLASM MALIGNANT STAGE UNSPECIFIED1
TONGUE DISORDER1
Tobacco user1
Thrombosis in device1
Thrombophlebitis migrans1
Thrombophlebitis1
THERAPEUTIC RESPONSE UNEXPECTED WITH DRUG SUBSTITUTION1
Therapeutic response decreased1
Therapeutic product effect incomplete1
Tendon pain1
Systolic dysfunction1
SYRINGOMYELIA1
SYNCOPE VASOVAGAL1
SWELLING FACE1
Suicide attempt1
SUDDEN HEARING LOSS1
Subdural haemorrhage1
Subcutaneous abscess1
SUBARACHNOID HAEMORRHAGE1
Sternal fracture1
Squamous cell carcinoma of head and neck1
Sputum discoloured1
SPUTUM CULTURE POSITIVE1
SPLENOMEGALY1
Splenic rupture1
SPLEEN DISORDER1
Spinal stenosis1
Spinal pain1
Spinal cord oedema1
Spinal column stenosis1
Sleep disorder due to general medical condition, insomnia type1
SLEEP DISORDER1
SKULL FRACTURED BASE1
SKIN TEST NEGATIVE1
SKIN REACTION1
Skin necrosis1
SKIN IRRITATION1
Skin injury1
SKIN INFECTION1
Skin fissures1
Skin disorder1
SKIN DESQUAMATION1
Skin cancer1
Shoulder deformity1
Shock symptom1
Shift to the left1
SERUM FERRITIN INCREASED1
Septic shock1
SENSORY LOSS1
SENSORY DISTURBANCE1
Senile dementia1
SEMEN VOLUME DECREASED1
Self-medication1
Sedation1
Second primary malignancy1
Scrotal pain1
Scrotal oedema1
Scrotal inflammation1
Scab1
Salmonella test positive1
SALIVARY HYPERSECRETION1
RHINORRHOEA1
RHEUMATOID ARTHRITIS1
Retinitis1
RETINAL VEIN OCCLUSION1
Retching1
RESUSCITATION1
Restless legs syndrome1
Respiratory tract infection1
Respiratory syncytial virus test positive1
Respiratory symptom1
RESPIRATORY RATE INCREASED1
RESPIRATORY RATE DECREASED1
RESPIRATORY ALKALOSIS1
Respiratory acidosis1
RESPIRATION ABNORMAL1
RENAL PAIN1
Renal mass1
RENAL FUNCTION TEST ABNORMAL1
RENAL FAILURE CHRONIC1
RENAL COLIC1
Renal cell carcinoma1
Renal aneurysm1
RELAPSING POLYCHONDRITIS1
Refusal of treatment by patient1
RED BLOOD CELL SEDIMENTATION RATE INCREASED1
RED BLOOD CELL COUNT DECREASED1
Rectourethral fistula1
RECTAL TENESMUS1
Rectal fissure1
Rectal discharge1
Rectal adenocarcinoma1
Reaction to excipient1
RASH SCALY1
RASH PAPULAR1
Rash maculo-papular1
RASH GENERALISED1
RADIOTHERAPY TO BONE1
RADICULAR PAIN1
RADICAL PROSTATECTOMY1
Radiation pneumonitis1
Radiation fibrosis1
Radiation associated haemorrhage1
Purulent discharge1
PURPURA NON-THROMBOCYTOPENIC1
PUPILLARY LIGHT REFLEX TESTS ABNORMAL1
Pulmonary thrombosis1
PULMONARY INFARCTION1
Pulmonary eosinophilia1
PRURITUS GENERALISED1
Prostatomegaly1
PROSTATIC SPECIFIC ANTIGEN ABNORMAL1
PROSTATIC SPECIFIC ANTIGEN1
Prostatic operation1
Prostatic obstruction1
Prostate cancer stage I1
Progesterone increased1
Product used for unknown indication1
Product prescribing issue1
Product prescribing error1
Product dose omission issue1
Product dispensing error1
PROCTITIS ULCERATIVE1
POSTRENAL FAILURE1
Post procedural pulmonary embolism1
POST PROCEDURAL HAEMORRHAGE1
POST PROCEDURAL COMPLICATION1
PORTAL HYPERTENSION1
Poor quality sleep1
Poor personal hygiene1
POLYMYOSITIS1
POLYMYALGIA RHEUMATICA1
POLYDIPSIA1
Polycythaemia1
Pneumonia viral1
Pneumonia pseudomonal1
PNEUMONIA PRIMARY ATYPICAL1
Pneumonia mycoplasmal1
PNEUMOCYSTIS JIROVECI PNEUMONIA1
Pleuritic pain1
PLATELET DISORDER1
Platelet count increased1
Pituitary tumour1
Pigmentation disorder1
Pharyngeal abscess1
PERITONITIS1
PERIPHERAL COLDNESS1
Peripheral artery thrombosis1
Peripheral arterial occlusive disease1
Periorbital cellulitis1
Pericarditis constrictive1
Pericarditis1
Pericardial effusion1
PERICARDIAL DISEASE1
PENILE HAEMORRHAGE1
Pelvic pain1
Pelvic abscess1
Pathological fracture1
Parotitis1
PARKINSON'S DISEASE1
Paraneoplastic syndrome1
Paraesthesia oral1
PANNICULITIS1
PANIC DISORDER1
Pancreatic mass1
PANCREATIC ENZYMES INCREASED1
Pancreatic carcinoma recurrent1
Palpable purpura1
Palmoplantar keratoderma1
PALMAR-PLANTAR ERYTHRODYSAESTHESIA SYNDROME1
Palmar fasciitis1
PAIN OF SKIN1
Packed red blood cell transfusion1
Otitis media1
Osteosclerosis1
Osteosarcoma1
Orthostatic intolerance1
Orthopnoea1
Oropharyngeal pain1
Orchitis noninfective1
ORAL INTAKE REDUCED1
ORAL DISORDER1
ORAL DISCOMFORT1
OPTIC NEUROPATHY1
Optic ischaemic neuropathy1
Open globe injury1
OESTROGEN RECEPTOR ASSAY POSITIVE1
Oestradiol increased1
Oesophageal varices haemorrhage1
OESOPHAGEAL ULCER1
Oesophageal obstruction1
Oesophageal adenocarcinoma1
Oedema mouth1
Ocular discomfort1
NORMOCHROMIC NORMOCYTIC ANAEMIA1
Nodule1
NEUTROPHIL COUNT1
Neuroendocrine carcinoma of prostate1
Nerve compression1
Nephropathy toxic1
NEPHRITIS INTERSTITIAL1
NEOPLASM RECURRENCE1
NASOPHARYNGITIS1
NASAL DRYNESS1
Nail dystrophy1
NAIL DISORDER1
Myositis1
Myopathy toxic1
MYOPATHY1
Mycosis fungoides1
MYCOPLASMA INFECTION1
MUSCULAR DYSTROPHY1
Muscle twitching1
MUSCLE TIGHTNESS1
MUSCLE SPASTICITY1
MUSCLE RIGIDITY1
Muscle oedema1
MUSCLE CONTRACTURE1
Multiple-drug resistance1
MULTIPLE MYELOMA1
MULTI-ORGAN DISORDER1
MUCOUS STOOLS1
Mucosal discolouration1
Mouth injury1
MOTOR DYSFUNCTION1
Monoplegia1
Mixed liver injury1
Mitral valve stenosis1
Miosis1
Migraine1
MICTURITION URGENCY1
Metastases to thorax1
Metastases to retroperitoneum1
Metastases to prostate1
Metastases to kidney1
Metastases to chest wall1
Metastases to bone marrow1
METASTASES TO BLADDER1
METABOLIC SYNDROME1
Metabolic alkalosis1
MENTAL IMPAIRMENT1
Memory impairment1
Mass1
Malignant transformation1
Macular oedema1
MACULAR DEGENERATION1
Lymphocytic infiltration1
LYMPHOCYTE STIMULATION TEST POSITIVE1
Lymphadenopathy mediastinal1
Lymphadenectomy1
LUNG INFECTION1
LUNG CYST1
Lumbar spinal stenosis1
LOWER RESPIRATORY TRACT INFECTION1
LOOSE TOOTH1
LOCALISED OEDEMA1
LIPASE INCREASED1
Ligament disorder1
Lichenoid keratosis1
LICHEN PLANUS1
Left ventricular hypertrophy1
Left ventricular dilatation1
Laryngeal squamous cell carcinoma1
Large intestine polyp1
Large intestinal haemorrhage1
Lacrimation increased1
Laceration1
JOINT STIFFNESS1
JOINT EFFUSION1
Ischaemic cardiomyopathy1
Ischaemia1
Iron deficiency anaemia1
Iron deficiency1
INTRAOCULAR PRESSURE INCREASED1
Intracranial pressure increased1
Intracranial mass1
Intracranial aneurysm1
INTRACARDIAC MASS1
Intra-abdominal haemorrhage1
INTESTINAL SPASM1
Intestinal obstruction1
Intestinal metastasis1
Intestinal mass1
Intestinal adenocarcinoma1
Intervertebral disc space narrowing1
Intervertebral disc disorder1
Intervertebral disc degeneration1
INTERNATIONAL NORMALISED RATIO DECREASED1
INSULIN RESISTANCE1
Injury1
Injection site reaction1
INJECTION SITE RASH1
Injection site infection1
Injection site haemorrhage1
Injection site bruising1
Infectious colitis1
INCREASED APPETITE1
INCORRECT ROUTE OF DRUG ADMINISTRATION1
Incontinence1
Incoherent1
INAPPROPRIATE SCHEDULE OF DRUG ADMINISTRATION1
IMPAIRED DRIVING ABILITY1
Immunosuppression1
Immunodeficiency1
Immune-mediated adverse reaction1
Immune thrombocytopenic purpura1
IMMUNE SYSTEM DISORDER1
Idiopathic interstitial pneumonia1
Hypovolaemia1
HYPOVENTILATION1
HYPOTONIA1
HYPOTHYROIDISM1
HYPOTHERMIA1
Hypomagnesaemia1
Hypokinesia1
Hypoglycaemic encephalopathy1
HYPOAESTHESIA ORAL1
Hyperuricaemia1
HYPERTROPHIC CARDIOMYOPATHY1
Hypertransaminasaemia1
Hypertonic bladder1
HYPERTENSIVE CARDIOMYOPATHY1
Hypersensitivity vasculitis1
HYPERPROLACTINAEMIA1
HYPEROSMOLAR STATE1
Hyperosmolar hyperglycaemic state1
Hypernatraemia1
HYPERGLYCAEMIC HYPEROSMOLAR NONKETOTIC SYNDROME1
HYPERCREATINAEMIA1
Hypercorticoidism1
Hypercholesterolaemia1
Hyperbilirubinaemia1
HYDROCEPHALUS1
HY'S LAW CASE1
Humerus fracture1
Hospice care1
HORMONE THERAPY1
HISTIOCYTOSIS HAEMATOPHAGIC1
HEPATITIS C POSITIVE1
HEPATITIS B1
HEPATITIS A POSITIVE1
Hepatic rupture1
Hepatic pain1
HEPATIC NEOPLASM MALIGNANT NON-RESECTABLE1
HEPATIC NEOPLASM MALIGNANT1
Heparin-induced thrombocytopenia1
HEART VALVE INSUFFICIENCY1
HEARING IMPAIRED1
Head discomfort1
Hair disorder1
Hair colour changes1
Haemorrhagic erosive gastritis1
Haemophilia1
Haemodynamic instability1
Haematotoxicity1
HAEMATOMA1
HAEMANGIOMA1
Groin pain1
Grip strength decreased1
GRANULOCYTOPENIA1
GRAND MAL CONVULSION1
GOUT1
Glucose tolerance decreased1
GINGIVITIS1
Generalised erythema1
Gastrointestinal wall thickening1
GASTROINTESTINAL NECROSIS1
Gastrointestinal inflammation1
Gastrointestinal disorder1
GASTRITIS1
Gastric varices haemorrhage1
GASTRIC ULCER PERFORATION1
GASTRIC ULCER HAEMORRHAGE1
GASTRIC ULCER1
GASTRIC POLYPS1
Gastric perforation1
Gastric haemorrhage1
Gallbladder polyp1
Gait inability1
FUNGAL INFECTION1
Frequent bowel movements1
Free prostate-specific antigen decreased1
FRACTURE1
FOOT FRACTURE1
Fluid retention1
FEMORAL NECK FRACTURE1
Fear of death1
FEAR1
FAILURE TO THRIVE1
Faeces pale1
FAECAL INCONTINENCE1
Facial paralysis1
Face injury1
EYELID PTOSIS1
Eyelid oedema1
Eye swelling1
Eye infection1
EXTRADURAL HAEMATOMA1
Exostosis1
EXOCRINE PANCREATIC FUNCTION TEST ABNORMAL1
Exfoliative rash1
Ex-tobacco user1
Essential tremor1
Escherichia sepsis1
ERYTHRODERMIC PSORIASIS1
Erythema multiforme1
EPSTEIN-BARR VIRUS ANTIGEN POSITIVE1
EPILEPSY1
EPIGLOTTIC OEDEMA1
EOSINOPHIL PERCENTAGE INCREASED1
Enterovesical fistula1
ENDOTRACHEAL INTUBATION1
Endothelial dysfunction1
Endocarditis1
ENCEPHALITIS1
Emotional disorder1
EMBOLISM ARTERIAL1
Embolic stroke1
ELECTROCARDIOGRAM T WAVE AMPLITUDE DECREASED1
Electrocardiogram T wave abnormal1
ELECTROCARDIOGRAM ST SEGMENT DEPRESSION1
Electrocardiogram QRS complex prolonged1
Ectopic ACTH syndrome1
Echocardiogram abnormal1
EAR PAIN1
Ear congestion1
Dysphemia1
DYSKINESIA1
DYSGLOBULINAEMIA1
DUPUYTREN'S CONTRACTURE1
DUODENAL ULCER HAEMORRHAGE1
Drug level increased1
Drug level decreased1
Drug ineffective for unapproved indication1
DRUG EXPOSURE DURING PREGNANCY1
Drug dose omission1
Drug administration error1
Diverticulum intestinal1
Disturbance in social behaviour1
DISABILITY1
Dilated cardiomyopathy1
DIFFUSE ALVEOLAR DAMAGE1
DIFFICULT TO WEAN FROM VENTILATOR1
DIALYSIS1
DIABETIC NEPHROPATHY1
DIABETIC HYPEROSMOLAR COMA1
Diabetic coma1
Diabetes with hyperosmolarity1
DIABETES MELLITUS NON-INSULIN-DEPENDENT1
Device related sepsis1
Device related infection1
Device occlusion1
Device leakage1
DESMOID TUMOUR1
DERMATITIS ATOPIC1
Dermatitis allergic1
Dermatitis1
DELIRIUM1
Dehydroepiandrosterone increased1
DECREASED ACTIVITY1
CYTOMEGALOVIRUS TEST POSITIVE1
CYTOMEGALOVIRUS INFECTION1
CYSTOSCOPY ABNORMAL1
Cystitis haemorrhagic1
CYST1
CSF test abnormal1
Critical illness1
Craniocerebral injury1
COVID-19 pneumonia1
CORYNEBACTERIUM INFECTION1
Coronary artery thrombosis1
Coronary artery bypass1
Concomitant disease progression1
Concomitant disease aggravated1
Complication associated with device1
COLONIC POLYP1
Colonic abscess1
Colon neoplasm1
COLLAGEN DISORDER1
COLD SWEAT1
COAGULATION TEST ABNORMAL1
Clostridium difficile infection1
CLOSTRIDIUM DIFFICILE COLITIS1
Clavicle fracture1
Claudication of jaw muscles1
CIRCUMSTANCE OR INFORMATION CAPABLE OF LEADING TO MEDICATION ERROR1
Chronic myeloid leukaemia1
Choroidal detachment1
Cholelithiasis obstructive1
Choking1
Chest injury1
CHEMOTHERAPY1
Cervix oedema1
Cervical spinal stenosis1
Cerebrovascular disorder1
Cerebral vascular occlusion1
Cerebral artery occlusion1
Cerebral artery embolism1
Cerebral arteriosclerosis1
CEREBELLAR SYNDROME1
CEREBELLAR INFARCTION1
Cerebellar haemorrhage1
Cellulitis of male external genital organ1
Cataract nuclear1
CARPAL TUNNEL SYNDROME1
Carotid artery occlusion1
Carotid arteriosclerosis1
Cardiac output decreased1
CARDIAC NEOPLASM MALIGNANT1
CARDIAC MURMUR1
Cardiac hypertrophy1
Cardiac failure chronic1
CARCINOID TUMOUR1
Calculus bladder1
CALCINOSIS1
Cachexia1
BURNING SENSATION1
BRONCHIAL OBSTRUCTION1
Breath sounds abnormal1
Breast mass1
Breast hyperplasia1
Breast disorder1
Breakthrough pain1
BRAIN STEM HAEMORRHAGE1
Brain natriuretic peptide increased1
BOWEL MOVEMENT IRREGULARITY1
Blood urine present1
BLOOD URINE1
BLOOD THYROID STIMULATING HORMONE INCREASED1
Blood thyroid stimulating hormone decreased1
BLOOD PRESSURE SYSTOLIC INCREASED1
Blood pressure diastolic decreased1
Blood pressure abnormal1
Blood luteinising hormone increased1
BLOOD IRON INCREASED1
BLOOD IMMUNOGLOBULIN M INCREASED1
Blood follicle stimulating hormone increased1
Blood creatine increased1
Blood cortisol decreased1
Blood corticotrophin decreased1
Blood chloride decreased1
BLOOD CALCIUM INCREASED1
BLOOD BLISTER1
BLOOD BILIRUBIN UNCONJUGATED INCREASED1
BLOOD ANTIDIURETIC HORMONE INCREASED1
BLOOD AMYLASE INCREASED1
Blood alcohol increased1
BLINDNESS TRANSIENT1
BLINDNESS1
Bladder transitional cell carcinoma1
Bladder sphincter atony1
BLADDER PAIN1
Bladder neck obstruction1
Bladder cancer1
BILIRUBIN CONJUGATED INCREASED1
Biliary dyskinesia1
BILIARY CIRRHOSIS PRIMARY1
BENIGN PROSTATIC HYPERPLASIA1
Bedridden1
BASEDOW'S DISEASE1
BALANITIS1
BACTERIAL INFECTION1
BACTERAEMIA1
Back injury1
Autonomic nervous system imbalance1
Autoimmune hepatitis1
ASTHMA1
Asterixis1
Aspiration1
ARTHRITIS1
Arteriosclerosis coronary artery1
Arterial injury1
APPLICATION SITE PAIN1
APPLICATION SITE HAEMATOMA1
Appetite disorder1
Aphthous stomatitis1
Aortic valve stenosis1
Aortic valve sclerosis1
AORTIC VALVE INCOMPETENCE1
Aortic dissection1
Aortic disorder1
Aortic arteriosclerosis1
Ankle fracture1
Angioplasty1
ANGIONEUROTIC OEDEMA1
Androgens abnormal1
Androgen deficiency1
Anal fissure1
Anaesthetic complication1
ANAEMIA POSTOPERATIVE1
ANAEMIA MACROCYTIC1
ANAEMIA HAEMOLYTIC AUTOIMMUNE1
AMYOTROPHIC LATERAL SCLEROSIS1
Alveolitis allergic1
Altered state of consciousness1
Allergic reaction to excipient1
Alcohol abuse1
Affect lability1
ADRENAL HAEMORRHAGE1
ADMINISTRATION SITE REACTION1
ADENOTONSILLECTOMY1
Adenocarcinoma of colon1
Adenocarcinoma1
Acute interstitial pneumonitis1
Accidental exposure to product1
ACCIDENTAL EXPOSURE1
Accident1
Abscess sterile1
ABNORMAL FAECES1
ABDOMINAL TENDERNESS1
Abdominal lymphadenopathy1
Abdominal injury1
Abdominal hernia1
Abdominal adhesions1
Abdominal abscess1





Filtered ChEMBL targets:

Target UniProtKB ID Activity in nm Target Name Target gene
P10275 19 Androgen receptor ANDR_HUMAN



Toxicity information:

Toxicity type: cardiovascular



External links:

ChEBML: CHEMBL409
DrugBank: DB01128