Benzbromarone
General information:
| Withdrawn ID: | w211 |
|---|---|
| Canonical SMILES: | |
| Standard InChI: | |
| Standard InChIKey: | |
| ATC class(es): | M04AB03 |
| Molecular Formula: | C17H12Br2O3 |
| Molweight: | 424.088 |
Withdrawal information:
| Withdrawn due to drug safety reasons: | Yes |
|---|---|
| First approved: | 1976 |
| First withdrawn: | 2003 |
| Last withdrawn: | 2003 |
| Reference: | https://www.ncbi.nlm.nih.gov/pubmed/5907884 |
Side-effects:
| Total reported cases (submitted by medical professionals) with Benzbromarone as primary suspect: | 1 |
|---|
Reported final outcomes:
Reported side-effects:
| Side-effect | Case number |
|---|---|
| Contusion | 1 |
| Drug interaction | 1 |
| International normalised ratio increased | 1 |
Filtered ChEMBL targets:
| Target UniProtKB ID | Activity in nm | Target Name | Target gene |
|---|---|---|---|
| O75604 | 631 | Ubiquitin carboxyl-terminal hydrolase 2 | UBP2_HUMAN |
| P02545 | 44.7 | Prelamin-A/C | LMNA_HUMAN |
| P16473 | 3981.1 | Thyrotropin receptor | TSHR_HUMAN |
| P28482 | 10000 | Mitogen-activated protein kinase 1 | MK01_HUMAN |
| P33527 | 190 | Multidrug resistance-associated protein 1 | MRP1_HUMAN |
| P61604 | 9100 | 10 kDa heat shock protein, mitochondrial | CH10_HUMAN |
| Q16665 | 1000 | Hypoxia-inducible factor 1-alpha | HIF1A_HUMAN |
| Q96S37 | 22 | Solute carrier family 22 member 12 | S22AC_HUMAN |
| Q99504 | 8300 |
Toxicity information:
| Toxicity class: | 4 |
|---|---|
| Toxicity type: | hepatic |
| LD50: | 450 mg/kg |
External links:
| ChEBML: | CHEMBL388590 |
|---|---|
| DrugBank: |