Alosetron


w71



General information:


Withdrawn ID: w71
Canonical SMILES:
Standard InChI:
Standard InChIKey:
ATC class(es): A03AE01
Molecular Formula: C17H18N4O
Molweight: 294.351



Withdrawal information:


Withdrawn due to drug safety reasons:Yes
First approved: 2000
First death: 2000
First withdrawn: 2000
Last withdrawn: 2000
Reference: https://www.ncbi.nlm.nih.gov/pubmed/21574210



Side-effects:

Total reported cases (submitted by medical professionals) with Alosetron as primary suspect: 161


Reported final outcomes:
Hospitalization (initial or prolonged): 40
Disability: 5
Life-Threatening condition: 3
Death: 3
Intervention required to prevent permanent impairment/damage: 2


Reported side-effects:

Side-effect Case number
CONSTIPATION46
ABDOMINAL PAIN42
COLITIS ISCHAEMIC36
ADVERSE EVENT31
VOMITING20
NAUSEA16
DRUG INEFFECTIVE15
DIARRHOEA14
RECTAL HAEMORRHAGE13
HAEMORRHOIDS9
ABDOMINAL PAIN UPPER9
COLITIS8
HAEMATOCHEZIA7
FAECALOMA7
WEIGHT DECREASED6
PYREXIA6
DIVERTICULITIS6
SMALL INTESTINAL OBSTRUCTION5
GASTRITIS5
DIVERTICULUM5
DIARRHOEA HAEMORRHAGIC5
ASTHENIA5
WHITE BLOOD CELL COUNT INCREASED4
MALAISE4
IRRITABLE BOWEL SYNDROME4
HEADACHE4
ANAEMIA4
ABDOMINAL DISTENSION4
SEPTIC SHOCK3
PRURITUS3
PAIN3
INFECTION3
HIATUS HERNIA3
FATIGUE3
DEPRESSION3
CROHN'S DISEASE3
CONDITION AGGRAVATED3
COLONIC STENOSIS3
COLECTOMY3
BACK PAIN3
ANXIETY3
ABDOMINAL PAIN LOWER3
SYNCOPE2
SEPSIS2
RENAL FAILURE CHRONIC2
REFUSAL OF TREATMENT BY PATIENT2
RASH2
PROCEDURAL PAIN2
PNEUMONIA2
PLATELET COUNT INCREASED2
PERITONITIS2
PANCREATITIS2
OEDEMA PERIPHERAL2
OEDEMA2
MYALGIA2
LUNG INFILTRATION2
LOSS OF CONSCIOUSNESS2
LARGE INTESTINE PERFORATION2
INTESTINAL OBSTRUCTION2
INCORRECT DOSE ADMINISTERED2
ILEUS2
ILEOSTOMY2
HYPOKALAEMIA2
GASTROINTESTINAL INJURY2
GASTROINTESTINAL DISORDER2
GASTROENTERITIS2
GASTRIC DISORDER2
FAECAL OCCULT BLOOD POSITIVE2
ENDOMETRIOSIS2
DYSPNOEA2
DIVERTICULUM INTESTINAL2
DISCOMFORT2
DEHYDRATION2
CHILLS2
CARDIAC FAILURE CONGESTIVE2
BLOOD PRESSURE DECREASED2
ANOREXIA2
ANAL SPHINCTER ATONY2
ADHESION2
ABORTION SPONTANEOUS2
ABDOMINAL TENDERNESS2
ABDOMINAL ABSCESS2
VULVOVAGINITIS1
VOLVULUS OF BOWEL1
VAGINAL DISORDER1
UTERINE LEIOMYOMA1
URINE ODOUR ABNORMAL1
URINARY TRACT INFECTION1
Ulcer1
TREMOR1
Therapeutic product effect incomplete1
TACHYCARDIA1
SYSTOLIC HYPERTENSION1
Swelling face1
SURGICAL PROCEDURE REPEATED1
SUPRAVENTRICULAR TACHYCARDIA1
SUPRAPUBIC PAIN1
Stress1
STOOLS WATERY1
STAPHYLOCOCCAL INFECTION1
SMALL INTESTINAL PERFORATION1
SHORT-BOWEL SYNDROME1
RESPIRATORY RATE INCREASED1
RESPIRATORY FAILURE1
RENAL FAILURE1
RENAL CYST1
RED BLOOD CELL SEDIMENTATION RATE INCREASED1
RECTAL TENESMUS1
RECTAL POLYP1
PULSE ABSENT1
PULMONARY EMBOLISM1
PULMONARY CONGESTION1
Product use issue1
Product substitution issue1
Product quality issue1
Product packaging issue1
PROCTALGIA1
PREGNANCY1
POSTOPERATIVE INFECTION1
POSTOPERATIVE ADHESION1
POST PROCEDURAL HAEMORRHAGE1
Post procedural drainage1
POOR QUALITY SLEEP1
POLYP COLORECTAL1
PLEURAL EFFUSION1
PHOTOSENSITIVITY REACTION1
PHOTODERMATOSIS1
PERITONEAL EFFUSION1
PERIPHERAL VASCULAR DISORDER1
PARAESTHESIA1
PAINFUL DEFAECATION1
OVERDOSE1
OSTEONECROSIS1
Osteomyelitis1
OSTEOARTHRITIS1
Off label use1
OESOPHAGITIS1
Oesophageal disorder1
OEDEMA MUCOSAL1
ODYNOPHAGIA1
OBSTRUCTION1
NEUTROPHIL PERCENTAGE INCREASED1
NEUTROPHIL COUNT INCREASED1
NERVOUSNESS1
NEPHROLITHIASIS1
Neck pain1
MUSCULOSKELETAL STIFFNESS1
MUSCLE STRAIN1
MUSCLE CRAMP1
MULTI-ORGAN FAILURE1
MUCOUS STOOLS1
MUCOUS MEMBRANE DISORDER1
MONONUCLEOSIS SYNDROME1
MONOCYTE COUNT INCREASED1
METABOLIC ACIDOSIS1
MESENTERIC VASCULAR INSUFFICIENCY1
MEGACOLON1
MEAN CELL VOLUME DECREASED1
MEAN CELL HAEMOGLOBIN INCREASED1
MATERNAL EXPOSURE DURING PREGNANCY1
MATERNAL DRUGS AFFECTING FOETUS1
MASS1
MALNUTRITION1
LYMPHOCYTE COUNT DECREASED1
LOWER GASTROINTESTINAL HAEMORRHAGE1
LOOSE STOOLS1
LEUKOCYTOSIS1
LETHARGY1
LARGE INTESTINAL ULCER1
KNEE ARTHROPLASTY1
INTESTINAL RESECTION1
INTESTINAL ANASTOMOSIS1
INTERVERTEBRAL DISC DEGENERATION1
INSOMNIA1
INGUINAL HERNIA1
INFLAMMATION1
IMPAIRED GASTRIC EMPTYING1
Immunosuppression1
ILEUS PARALYTIC1
Hypoxia1
HYPONATRAEMIA1
HYDRONEPHROSIS1
HERNIA1
HEPATITIS1
HEPATIC LESION1
HEART RATE INCREASED1
Hallucination1
HAEMORRHOIDAL HAEMORRHAGE1
HAEMATURIA1
HAEMATOCRIT DECREASED1
HAEMATEMESIS1
GASTROINTESTINAL PAIN1
GASTROINTESTINAL NECROSIS1
GASTROINTESTINAL HAEMORRHAGE1
Gastrointestinal erosion1
GASTRIC ULCER1
Gallbladder disorder1
FUNGAL SKIN INFECTION1
FUNGAEMIA1
Foot fracture1
FIBROSIS1
FEMALE GENITAL-DIGESTIVE TRACT FISTULA1
FEELING ABNORMAL1
Fall1
FAECES HARD1
FAECES DISCOLOURED1
Facial operation1
Expired product administered1
EXCORIATION1
ERYTHEMA1
ENTEROVESICAL FISTULA1
ENTEROCOLITIS HAEMORRHAGIC1
ELECTROLYTE IMBALANCE1
DYSPEPSIA1
DYSGEUSIA1
Drug effect incomplete1
DRUG EFFECT DECREASED1
Drug dispensing error1
Drug administration error1
DIZZINESS1
DIVERTICULUM INTESTINAL HAEMORRHAGIC1
DISEASE RECURRENCE1
DIABETIC ENTEROPATHY1
Delirium1
DECREASED APPETITE1
DEATH1
CULTURE POSITIVE1
Cranial nerve disorder1
CORONARY ARTERIAL STENT INSERTION1
Confusional state1
COMPUTERISED TOMOGRAM ABNORMAL1
COMPLICATIONS OF MATERNAL EXPOSURE TO THERAPEUTIC DRUGS1
COLITIS ULCERATIVE1
COLECTOMY TOTAL1
COLECTOMY PARTIAL1
Coeliac disease1
CLOSTRIDIAL INFECTION1
CHRONIC OBSTRUCTIVE PULMONARY DISEASE1
CHROMATURIA1
CHOLECYSTECTOMY1
CELLULITIS1
CARDIOVASCULAR INSUFFICIENCY1
CARDIAC ARREST1
CARBON DIOXIDE INCREASED1
BODY TEMPERATURE INCREASED1
BLOOD UREA DECREASED1
Blood potassium decreased1
BLOOD GLUCOSE INCREASED1
ATRIAL FIBRILLATION1
ASCITES1
ARTHRALGIA1
ARTERIAL INSUFFICIENCY1
APPENDICITIS PERFORATED1
APNOEA1
ANAL FISSURE1
ADVERSE REACTION1
ADENOMYOSIS1
ACUTE RESPIRATORY DISTRESS SYNDROME1
ACNE1
ABNORMAL DREAMS1





Filtered ChEMBL targets:

Target UniProtKB ID Activity in nm Target Name Target gene
P46098 0.5 5-hydroxytryptamine receptor 3A 5HT3A_HUMAN
Q12809 2300 Potassium voltage-gated channel subfamily H member 2 KCNH2_HUMAN



Toxicity information:

Toxicity type: gastrointestinal



External links:

ChEBML: CHEMBL1110
DrugBank: DB00969