agomelatine

General information:

Withdrawn ID:	EMA1
Canonical SMILES:
Standard InChI:
Standard InChIKey:
ATC class(es):	N06AX22
Molecular Formula:	C15H17NO2
Molweight:	243.301

Withdrawal information:

Withdrawn due to drug safety reasons:	No

Side-effects:

Total reported cases (submitted by medical professionals) with agomelatine as primary suspect:	7

Reported final outcomes:

Death:	1
Hospitalization (initial or prolonged):	1

Reported side-effects:

Side-effect	Case number
Electrocardiogram QT prolonged	3
Coma	2
Condition aggravated	2
SOMNOLENCE	2
DRUG INTERACTION	2
Respiratory disorder neonatal	1
Insomnia	1
Intentional overdose	1
IRRITABILITY	1
Migraine	1
MYOCLONUS	1
Night sweats	1
Overdose	1
Prescribed underdose	1
HYPONATRAEMIA	1
Selective eating disorder	1
Sleep disorder	1
SUICIDAL IDEATION	1
SYNCOPE	1
Transaminases increased	1
Weight decreased	1
Drug ineffective	1
Alanine aminotransferase increased	1
AMNESIA	1
Aspartate aminotransferase increased	1
Bradycardia neonatal	1
CONFUSIONAL STATE	1
Diarrhoea	1
Dizziness	1
Drug administered to patient of inappropriate age	1
INAPPROPRIATE ANTIDIURETIC HORMONE SECRETION	1
FATIGUE	1
Foetal exposure during pregnancy	1
Hepatic failure	1
Hepatotoxicity	1
HYPOKALAEMIA	1
Agitation	1
HYPOTENSION	1

Filtered ChEMBL targets:

Target UniProtKB ID	Activity in nm	Target Name	Target gene
P28335	630	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN
P48039	0.06	Melatonin receptor type 1A	MTR1A_HUMAN
P49286	0.06918	Melatonin receptor type 1B	MTR1B_HUMAN

Toxicity information:

Toxicity class:	4
Toxicity type:	N/A
LD50:	1000 mg/kg

External links:

ChEBML:	CHEMBL10878
DrugBank:	DB06594