Acitretin


w197



General information:


Withdrawn ID: w197
Canonical SMILES:
Standard InChI:
Standard InChIKey:
ATC class(es): D05BB02
Molecular Formula: C21H26O3
Molweight: 326.429



Withdrawal information:


Withdrawn due to drug safety reasons:Yes
First approved: 1989
First withdrawn: 1990
Last withdrawn: 1990
Reference: https://www.ncbi.nlm.nih.gov/pubmed/26060704



Side-effects:

Total reported cases (submitted by medical professionals) with Acitretin as primary suspect: 742


Reported final outcomes:
Hospitalization (initial or prolonged): 198
Disability: 35
Death: 29
Congenital anomaly: 20
Life-Threatening condition: 19
Intervention required to prevent permanent impairment/damage: 11


Reported side-effects:

Side-effect Case number
DRUG INEFFECTIVE64
PREGNANCY48
PSORIASIS45
DRUG EXPOSURE DURING PREGNANCY44
OFF LABEL USE41
SKIN EXFOLIATION32
CONDITION AGGRAVATED32
ERYTHEMA30
ALOPECIA29
HEADACHE26
ABORTION INDUCED25
ARTHRALGIA24
DRUG INTERACTION22
HYPERCHOLESTEROLAEMIA19
FATIGUE19
NAUSEA18
DRY SKIN18
MYALGIA17
DRUG EXPOSURE BEFORE PREGNANCY17
RENAL IMPAIRMENT16
PYREXIA16
PAIN15
SQUAMOUS CELL CARCINOMA14
PRURITUS14
DERMATITIS EXFOLIATIVE14
ASTHENIA13
PREGNANCY OF PARTNER12
DYSPNOEA12
DIABETES MELLITUS12
Cushing's syndrome12
BLOOD CREATININE INCREASED12
ALANINE AMINOTRANSFERASE INCREASED12
Treatment failure11
OEDEMA PERIPHERAL11
Maternal exposure before pregnancy11
MALAISE11
BACK PAIN11
Acute kidney injury11
TRANSMISSION OF DRUG VIA SEMEN10
PAIN IN EXTREMITY10
LIP DRY10
HEPATIC ENZYME INCREASED10
ERECTILE DYSFUNCTION10
DEEP VEIN THROMBOSIS10
BLISTER10
ARTHRITIS10
ANAEMIA10
VISION BLURRED9
SEPSIS9
NO ADVERSE EFFECT9
DEPRESSION9
ABDOMINAL PAIN9
VISUAL IMPAIRMENT8
RASH8
PULMONARY EMBOLISM8
Psoriatic arthropathy8
NEUTROPENIA8
NAIL DISORDER8
Maternal exposure during pregnancy8
IMPAIRED HEALING8
HYPERTENSION8
Hospitalisation8
GAMMA-GLUTAMYLTRANSFERASE INCREASED8
GAIT DISTURBANCE8
Exposure during pregnancy8
EOSINOPHILIA8
Drug intolerance8
CEREBROVASCULAR ACCIDENT8
BLOOD TRIGLYCERIDES INCREASED8
TRANSAMINASES INCREASED7
Therapeutic product effect incomplete7
STICKY SKIN7
Product use in unapproved indication7
LYMPHADENOPATHY7
LIVE BIRTH7
HYPOTENSION7
FACE OEDEMA7
EPISTAXIS7
DIZZINESS7
DIARRHOEA7
CHEILITIS7
CARDIAC FAILURE CONGESTIVE7
BLOOD ALKALINE PHOSPHATASE INCREASED7
ASPARTATE AMINOTRANSFERASE INCREASED7
ABORTION SPONTANEOUS7
VISUAL ACUITY REDUCED6
URTICARIA6
THERAPEUTIC RESPONSE DECREASED6
Skin ulcer6
Skin erosion6
SKIN DISORDER6
RENAL FAILURE ACUTE6
RENAL FAILURE6
RASH PUSTULAR6
PUSTULAR PSORIASIS6
PERIPHERAL SENSORY NEUROPATHY6
ONYCHOCLASIS6
MATERNAL DRUGS AFFECTING FOETUS6
Leukocytosis6
HYPERTRIGLYCERIDAEMIA6
HYPERKERATOSIS6
EXOSTOSIS6
ECZEMA6
DRY MOUTH6
Drug-induced liver injury6
CONFUSIONAL STATE6
Cholestasis6
CELLULITIS6
BLOOD GLUCOSE INCREASED6
WEIGHT INCREASED5
WEIGHT DECREASED5
VOMITING5
Suicidal ideation5
STAPHYLOCOCCAL INFECTION5
Skin plaque5
SKIN LESION5
SKIN HAEMORRHAGE5
PULMONARY FIBROSIS5
PREMATURE BABY5
PREGNANCY ON ORAL CONTRACEPTIVE5
PLATELET COUNT DECREASED5
Pityriasis rubra pilaris5
PHOTOSENSITIVITY REACTION5
PARONYCHIA5
PANCREATITIS5
PAIN OF SKIN5
OLIGURIA5
MUSCULAR WEAKNESS5
Lymphoma5
LIVER INJURY5
LIVER FUNCTION TEST ABNORMAL5
HYPERSENSITIVITY5
HYPERLIPIDAEMIA5
HEPATIC FUNCTION ABNORMAL5
HAEMOGLOBIN DECREASED5
Foetal exposure during pregnancy5
Dermatitis exfoliative generalised5
DERMATITIS5
DEPRESSED MOOD5
DEATH5
Crohn's disease5
Cognitive disorder5
CAESAREAN SECTION5
BRADYCARDIA5
BOWEN'S DISEASE5
BONE PAIN5
BLOOD CREATINE PHOSPHOKINASE INCREASED5
BLOOD CHOLESTEROL INCREASED5
BASAL CELL CARCINOMA5
AUTOIMMUNE HEPATITIS5
ATRIAL FIBRILLATION5
ALCOHOL USE5
ACUTE MYOCARDIAL INFARCTION5
UNEVALUABLE EVENT4
Tuberculosis4
THROMBOSIS4
THROMBOCYTOPENIA4
Squamous cell carcinoma of skin4
SKIN INFECTION4
SKIN ATROPHY4
RHABDOMYOLYSIS4
RECTAL HAEMORRHAGE4
PNEUMONIA4
PEMPHIGOID4
OSTEOPENIA4
OSTEONECROSIS4
ONYCHOMADESIS4
OEDEMA4
NASAL DRYNESS4
Mycosis fungoides4
Metabolic acidosis4
MAJOR DEPRESSION4
MADAROSIS4
JOINT SWELLING4
JAUNDICE4
ICHTHYOSIS4
HYPOXIA4
Hyperglycaemia4
HYPERCALCAEMIA4
HEPATITIS4
HAIR COLOUR CHANGES4
Exposure via father4
ERYTHRODERMIC PSORIASIS4
ECTROPION4
Dyspepsia4
Dyslipidaemia4
DRY EYE4
Drug ineffective for unapproved indication4
DRUG DOSE OMISSION4
Differentiation syndrome4
Dermatitis psoriasiform4
DEHYDRATION4
COUGH4
CAPILLARY LEAK SYNDROME4
BLOOD UREA INCREASED4
BLOOD PRESSURE INCREASED4
BLOOD BILIRUBIN INCREASED4
ASCITES4
ANGIOEDEMA4
Acute promyelocytic leukaemia differentiation syndrome4
WOUND INFECTION3
Wound3
WHITE BLOOD CELL COUNT INCREASED3
WHEEZING3
VIth nerve paralysis3
Trisomy 183
TREATMENT NONCOMPLIANCE3
TRANSIENT ISCHAEMIC ATTACK3
Toxic goitre3
TOOTH LOSS3
TACHYCARDIA3
SYSTEMIC LUPUS ERYTHEMATOSUS3
SWELLING FACE3
Superinfection3
SUICIDE ATTEMPT3
STEVENS-JOHNSON SYNDROME3
SPINAL OSTEOARTHRITIS3
SPINAL DISORDER3
SKIN FISSURES3
SKIN CANCER3
SKIN BURNING SENSATION3
Rickets3
RETINAL DETACHMENT3
Retinal artery occlusion3
Respiratory alkalosis3
Rash papular3
PRURITUS GENERALISED3
Product use issue3
Polyneuropathy3
PLEURAL EFFUSION3
PERIORBITAL OEDEMA3
Paraesthesia3
Pancytopenia3
Palmar-plantar erythrodysaesthesia syndrome3
OSTEOPOROSIS3
OSTEOMYELITIS3
NORMAL NEWBORN3
NIGHT BLINDNESS3
Neutrophil count decreased3
MYOCARDIAL INFARCTION3
MUSCULOSKELETAL PAIN3
MUCOSAL DRYNESS3
METASTATIC SQUAMOUS CELL CARCINOMA3
MASTITIS3
LUNG INFILTRATION3
LIPIDS INCREASED3
Lichenoid keratosis3
JOINT RANGE OF MOTION DECREASED3
Ischaemic stroke3
INTERNATIONAL NORMALISED RATIO INCREASED3
Intellectual disability3
INFLUENZA3
HYPOGLYCAEMIA3
HYPOALBUMINAEMIA3
Hidradenitis3
Hepatic lesion3
HEPATIC FAILURE3
Hepatic cirrhosis3
Hair disorder3
HAEMATURIA3
HAEMATOCRIT DECREASED3
GRAND MAL CONVULSION3
Gastrointestinal disorder3
GALLBLADDER ENLARGEMENT3
Febrile neutropenia3
Fall3
ENCEPHALOPATHY3
DYSPNOEA EXERTIONAL3
DYSPHAGIA3
DRUG RESISTANCE3
DISTURBANCE IN ATTENTION3
DISEASE RECURRENCE3
Disease progression3
DIALYSIS3
DECREASED APPETITE3
CYTOLYTIC HEPATITIS3
Cutaneous vasculitis3
Contraindicated product administered3
CONSTIPATION3
CONJUNCTIVITIS3
CHILLS3
Cataract3
CARDIAC FAILURE3
Candida infection3
CALCINOSIS3
C-REACTIVE PROTEIN INCREASED3
BONE DENSITY DECREASED3
BLOOD ALBUMIN DECREASED3
Atrioventricular block complete3
ARTHROPATHY3
ANXIETY3
Adenocarcinoma3
ACUTE HEPATIC FAILURE3
WOUND SECRETION2
Vitamin D deficiency2
VISUAL FIELD DEFECT2
VISUAL DISTURBANCE2
VIIth nerve paralysis2
VENTRICULAR HYPOPLASIA2
Vasculitis2
VASCULAR OPERATION2
Vaginal haemorrhage2
URINE KETONE BODY PRESENT2
Upper limb fracture2
UNINTENDED PREGNANCY2
ULCERATIVE KERATITIS2
ULCER2
Type IIb hyperlipidaemia2
TWIN PREGNANCY2
TRISOMY 212
TRICUSPID VALVE INCOMPETENCE2
Tremor2
Toxicity to various agents2
TOXIC SKIN ERUPTION2
Toxic epidermal necrolysis2
TINNITUS2
Thyroid cancer2
Thirst2
Therapy partial responder2
THERAPEUTIC RESPONSE UNEXPECTED2
TENDONITIS2
TENDON DISORDER2
Tachypnoea2
SYNDACTYLY2
SYNCOPE2
SWELLING2
Surgery2
Superficial inflammatory dermatosis2
SPEECH DISORDER2
SKIN OEDEMA2
SKIN GRAFT2
SHOCK2
Sensory loss2
Sensory disturbance2
Scab2
ROSACEA2
RHINORRHOEA2
RETINOIC ACID SYNDROME2
RETINAL HAEMORRHAGE2
RESPIRATORY FAILURE2
RESPIRATORY DISTRESS2
RENAL TUBULAR NECROSIS2
Renal function test abnormal2
Renal cyst2
Rectal adenocarcinoma2
PYELONEPHRITIS2
Pulmonary mass2
PULMONARY HYPERTENSION2
Product substitution issue2
Product prescribing error2
Polymyalgia rheumatica2
Polyarthritis2
Phototherapy2
PHOTOPHOBIA2
PHLEBITIS2
Peripheral swelling2
Paranoia2
Parakeratosis2
PANCREATITIS ACUTE2
Pancreatic disorder2
Oral candidiasis2
NO ADVERSE EVENT2
NO ADVERSE DRUG EFFECT2
Neuralgia2
NERVOUS SYSTEM DISORDER2
NEOPLASM MALIGNANT2
NECROSIS2
NASOPHARYNGITIS2
NASAL CONGESTION2
NAIL DISCOLOURATION2
NAIL BED INFECTION2
MYOSITIS2
MYELODYSPLASTIC SYNDROME2
MUSCULOSKELETAL STIFFNESS2
MUSCULOSKELETAL DISCOMFORT2
Muscle spasms2
Mouth ulceration2
MOBILITY DECREASED2
MITRAL VALVE DISEASE2
MIGRAINE2
MENINGOCELE2
MEDICATION ERROR2
Malignant melanoma in situ2
Macule2
Lymphocytic infiltration2
LOWER RESPIRATORY TRACT INFECTION2
Loss of consciousness2
Limb discomfort2
Lichen planus2
LIBIDO DECREASED2
LETHARGY2
Keratosis follicular2
KERATOACANTHOMA2
KAPOSI'S SARCOMA2
JOINT DISLOCATION2
Intracranial pressure increased2
INSOMNIA2
Inflammatory bowel disease2
INFECTION2
IMPAIRED DRIVING ABILITY2
Immune thrombocytopenic purpura2
ILL-DEFINED DISORDER2
HYPOTHYROIDISM2
HYPOAESTHESIA2
Herpes zoster2
HEPATOMEGALY2
HEPATITIS TOXIC2
HEPATITIS CHOLESTATIC2
Hepatitis C2
HEPATIC NECROSIS2
HEPATIC FIBROSIS2
HEART DISEASE CONGENITAL2
Hallucination, visual2
HAEMORRHAGE2
HAEMATOCHEZIA2
HAEMATEMESIS2
Guttate psoriasis2
Glomerular filtration rate decreased2
Genital pain2
Genital burning sensation2
Generalised erythema2
Gastrointestinal tube insertion2
GASTROINTESTINAL HAEMORRHAGE2
GASTRIC MUCOSAL LESION2
FOETAL MALFORMATION2
FOETAL DISORDER2
Foetal death2
FLUID OVERLOAD2
FINGER AMPUTATION2
Feeling hot2
Feeding disorder2
EYELID OEDEMA2
EYE HAEMORRHAGE2
Exfoliative rash2
Erythema annulare2
Epidermal necrosis2
DRUG SCREEN POSITIVE2
DRUG ADMINISTRATION ERROR2
DNA ANTIBODY POSITIVE2
DIVERTICULITIS2
DIABETIC KETOACIDOSIS2
Dermatitis contact2
Dermatitis bullous2
Dermal absorption increased2
Dementia2
DEAFNESS UNILATERAL2
Cutaneous sarcoidosis2
Cushingoid2
Creatinine renal clearance decreased2
Coronary artery disease2
CONVULSION2
COLITIS ULCERATIVE2
CLOSTRIDIUM DIFFICILE COLITIS2
Clear cell renal cell carcinoma2
CHRONIC OBSTRUCTIVE PULMONARY DISEASE2
CHOLELITHIASIS2
CHOLANGITIS2
Choking2
CHAPPED LIPS2
Cerebral infarction2
CATHETER RELATED INFECTION2
Cardio-respiratory arrest2
BLOOD LACTATE DEHYDROGENASE INCREASED2
BLINDNESS UNILATERAL2
BLINDNESS2
Bladder cancer2
BILIARY DILATATION2
BACTERAEMIA2
Atrial septal defect2
Asthma2
Antiphospholipid syndrome2
ANTINUCLEAR ANTIBODY POSITIVE2
ANOREXIA2
ANGIONEUROTIC OEDEMA2
ANGER2
AMNIORRHEXIS2
AMNESIA2
AGITATION2
Adverse reaction2
Adverse event2
Adverse drug reaction2
Acute myeloid leukaemia2
Acrokeratosis paraneoplastica2
Acne2
Acanthosis2
ABORTION2
ABNORMAL BEHAVIOUR2
ABDOMINAL PAIN UPPER2
Xerosis1
Xerophthalmia1
Xanthoma1
WOUND NECROSIS1
Wound dehiscence1
White blood cell count decreased1
Weight gain poor1
Vertigo1
Vertebral foraminal stenosis1
VENTRICULAR TACHYCARDIA1
VENOUS THROMBOSIS LIMB1
VENOUS INSUFFICIENCY1
Venous injury1
Venous haemorrhage1
Vein rupture1
VASOSPASM1
Vasculitis gastrointestinal1
VASCULAR RUPTURE1
VARICOSE VEIN1
Varices oesophageal1
VAGINAL DISCHARGE1
Uterine dilation and curettage1
URINE SODIUM ABNORMAL1
URINE COLOUR ABNORMAL1
URINARY TRACT INFECTION1
URINARY TRACT DISORDER1
URINARY SEDIMENT PRESENT1
URINARY INCONTINENCE1
URETHRAL DISORDER1
UNWANTED PREGNANCY1
Troponin increased1
TRAUMATIC HAEMATOMA1
TRAUMATIC BRAIN INJURY1
Tooth resorption1
TOOTH HYPOPLASIA1
Tongue ulceration1
Tongue oedema1
THROMBOTIC THROMBOCYTOPENIC PURPURA1
THROAT TIGHTNESS1
Therapy non-responder1
Therapy interrupted1
Therapeutic product effect decreased1
TENDERNESS1
Temperature intolerance1
Telangiectasia1
Taste disorder1
TALIPES1
Systemic inflammatory response syndrome1
Synovitis1
SUDDEN ONSET OF SLEEP1
Subcorneal pustular dermatosis1
SUBARACHNOID HAEMORRHAGE1
Spinal ligament ossification1
SPINA BIFIDA1
SPIDER NAEVUS1
SPERMATOZOA PROGRESSIVE MOTILITY DECREASED1
SPERMATOGENESIS ABNORMAL1
SPERM COUNT DECREASED1
SOMNOLENCE1
SODIUM RETENTION1
Social avoidant behaviour1
SMOOTH MUSCLE ANTIBODY POSITIVE1
Small intestinal perforation1
Sleep disorder1
Skin warm1
Skin swelling1
Skin squamous cell carcinoma metastatic1
SKIN REACTION1
Skin irritation1
Skin injury1
SKIN INFLAMMATION1
SKIN HYPERTROPHY1
Skin fragility1
SKIN DISCOLOURATION1
SKIN DEPIGMENTATION1
Skin degenerative disorder1
SKIN CHAPPED1
SKIN CANDIDA1
Skin abrasion1
SINUSITIS BACTERIAL1
SINUS BRADYCARDIA1
SINGLE UMBILICAL ARTERY1
SIMILAR REACTION ON PREVIOUS EXPOSURE TO DRUG1
Shoulder arthroplasty1
Sexual dysfunction1
SELF-MEDICATION1
Sebaceous hyperplasia1
Scrotal erythema1
SCOLIOSIS1
RHONCHI1
RETINAL VASCULAR THROMBOSIS1
Retinal disorder1
RETINAL ARTERY THROMBOSIS1
Retinal artery embolism1
RESTRICTIVE PULMONARY DISEASE1
RESORPTION BONE INCREASED1
RENAL HAEMORRHAGE1
RENAL DISORDER1
Renal artery thrombosis1
Rehabilitation therapy1
RED BLOOD CELLS URINE1
RECURRENT CANCER1
Rash pruritic1
Rash morbilliform1
RASH FOLLICULAR1
RALES1
PYOGENIC GRANULOMA1
PURULENCE1
Purpura1
PULMONARY THROMBOSIS1
Pulmonary sarcoidosis1
Pulmonary oedema1
PULMONARY CONGESTION1
PUBIC PAIN1
PSYCHOTIC DISORDER1
Psoriasis area severity index increased1
PSEUDARTHROSIS1
PROTHROMBIN LEVEL INCREASED1
PROTEINURIA1
PROTEIN URINE PRESENT1
PROLONGED PREGNANCY1
PRODUCTIVE COUGH1
Product use complaint1
Product storage error1
PROCTOSTOMY1
PROCTITIS1
PRESBYOPIA1
PREMATURE RUPTURE OF MEMBRANES1
PREGNANCY WITH INJECTABLE CONTRACEPTIVE1
PREGNANCY WITH CONTRACEPTIVE DEVICE1
PREGNANCY TEST POSITIVE1
POTENTIATING DRUG INTERACTION1
Postoperative wound complication1
POSTOPERATIVE THROMBOSIS1
Post procedural sepsis1
Post inflammatory pigmentation change1
Portal vein thrombosis1
Portal hypertension1
POLLAKIURIA1
PNEUMONITIS1
PLANTAR FASCIITIS1
Pigmentation disorder1
Photopsia1
Pharyngeal oedema1
PERSECUTORY DELUSION1
Peripheral sensorimotor neuropathy1
PERIPHERAL ISCHAEMIA1
Peripheral coldness1
PERICARDITIS1
Pericardial effusion1
Periarthritis1
PEPTIC ULCER1
PENIS CARCINOMA1
Patient dissatisfaction with treatment1
Paternal exposure timing unspecified1
PATERNAL DRUGS AFFECTING FOETUS1
Parkinsonism1
Paralysis1
Papilloedema1
PANCREATITIS CHRONIC1
Palpitations1
Palmoplantar keratoderma1
OSTEOCHONDROSIS1
ORTHOPNOEA1
ORAL MUCOSA EROSION1
Oral lichen planus1
ORAL INTAKE REDUCED1
Onychomalacia1
Onychalgia1
ONCOLOGIC COMPLICATION1
Oligomenorrhoea1
Oesophageal ulcer1
Oesophageal stenosis1
Oesophageal perforation1
OESOPHAGEAL HAEMORRHAGE1
OEDEMA MUCOSAL1
OCULAR NEOPLASM1
Ocular hyperaemia1
NORMOCHROMIC NORMOCYTIC ANAEMIA1
Nonspecific reaction1
Noninfective gingivitis1
Non-alcoholic fatty liver1
NO THERAPEUTIC RESPONSE1
Neutrophilia1
Neutropenic sepsis1
NEUROPATHY PERIPHERAL1
NEURODEGENERATIVE DISORDER1
Neuroborreliosis1
Nephrotic syndrome1
Nephropathy toxic1
NEPHROLITHIASIS1
NEOPLASM SKIN1
Neoplasm progression1
NEOPLASM1
NEONATAL RESPIRATORY DISTRESS SYNDROME1
NEONATAL PNEUMONIA1
NEONATAL DISORDER1
Necrolytic migratory erythema1
NECK PAIN1
NAIL PSORIASIS1
Nail dystrophy1
Nail discomfort1
MYOPATHY1
MYOCARDITIS1
MYOCARDIAL ISCHAEMIA1
Musculoskeletal disorder1
Muscle rupture1
Muscle rigidity1
MUSCLE CONTRACTURE1
Multiple fractures1
MULTIPLE DRUG OVERDOSE1
MULTIPLE CONGENITAL ABNORMALITIES1
MULTI-ORGAN FAILURE1
MUCOUS MEMBRANE DISORDER1
Mucosal inflammation1
Mucosal haemorrhage1
MOVEMENT DISORDER1
MOROSE1
MOOD SWINGS1
Mixed liver injury1
MICROCYTIC ANAEMIA1
MICROALBUMINURIA1
METASTASES TO LYMPH NODES1
METASTASES TO LIVER1
METABOLIC DISORDER1
Mesenteric abscess1
MENTAL IMPAIRMENT1
MENTAL DISORDER1
Meningoencephalitis viral1
Memory impairment1
Mean cell volume increased1
Mass1
Malignant neoplasm progression1
MALIGNANT MELANOMA1
Malignant mediastinal neoplasm1
Maculopathy1
MACULAR DEGENERATION1
Lung disorder1
LUNG CONSOLIDATION1
Lumbar spinal stenosis1
Lower limb fracture1
LOWER GASTROINTESTINAL HAEMORRHAGE1
Low density lipoprotein increased1
Loss of personal independence in daily activities1
LOCALISED INFECTION1
Local swelling1
Liver function test increased1
Lipids abnormal1
Lip swelling1
Lip exfoliation1
Lip disorder1
LIP BLISTER1
Limb operation1
LIMB MALFORMATION1
Limb fracture1
LIGAMENT CALCIFICATION1
Leukopenia1
LEUKOCYTURIA1
Leptospirosis1
LEARNING DISABILITY1
Latent tuberculosis1
LACRIMATION INCREASED1
Knee deformity1
Knee arthroplasty1
KLEBSIELLA INFECTION1
Ketoacidosis1
KERATOCONUS1
Keratitis-ichthyosis-deafness syndrome1
Keratitis1
Joint injury1
JOINT CONTRACTURE1
Jejunal perforation1
JAUNDICE CHOLESTATIC1
Irritable bowel syndrome1
Irritability1
Intraocular lens implant1
INTESTINAL ISCHAEMIA1
INTERVERTEBRAL DISC PROTRUSION1
INTERSTITIAL LUNG DISEASE1
INTERMITTENT CLAUDICATION1
Intercepted drug dispensing error1
Intentional self-injury1
Intentional product misuse1
INTENTIONAL OVERDOSE1
INJURY1
Injection site swelling1
Injection site papule1
Injection site haemorrhage1
Ingrowing nail1
INFLAMMATION1
INFERTILITY1
Induration1
INDUCED LABOUR1
INCREASED TENDENCY TO BRUISE1
INCORRECT DOSE ADMINISTERED1
Inappropriate schedule of drug administration1
Inappropriate prescribing1
Inability to afford medication1
IMPULSIVE BEHAVIOUR1
IMPAIRED WORK ABILITY1
IMPAIRED GASTRIC EMPTYING1
Ileus1
ILEOSTOMY1
IIIRD NERVE PARALYSIS1
Idiopathic intracranial hypertension1
Hypovolaemia1
HYPOTRICHOSIS1
HYPOPLASTIC LEFT HEART SYNDROME1
Hyponatraemia1
Hypomenorrhoea1
HYPOKALAEMIA1
Hypoaesthesia oral1
Hyperthyroidism1
HYPERTENSIVE ENCEPHALOPATHY1
Hyperpyrexia1
Hyperplasia1
Hyperhidrosis1
Hypereosinophilic syndrome1
Hyperaemia1
HIV infection1
Hip fracture1
High density lipoprotein decreased1
HIATUS HERNIA1
HEPATOSPLENOMEGALY1
Hepatocellular injury1
Hepatocellular carcinoma1
HEPATITIS VIRAL1
Hepatitis B1
HEPATITIS ACUTE1
HEPATIC STEATOSIS1
Hepatic enzyme abnormal1
HEPATIC CONGESTION1
HEART RATE IRREGULAR1
Head discomfort1
HALLUCINATION, AUDITORY1
Hallucination1
Hairy cell leukaemia1
HAEMORRHOID OPERATION1
Haemorrhage subcutaneous1
HAEMOLYTIC ANAEMIA1
HAEMODIALYSIS1
HAEMATOMA1
Granuloma annulare1
GRANULOMA1
GRAFT LOSS1
Gout1
GLUCOSE URINE PRESENT1
GLAUCOMA1
Gingival pain1
GINGIVAL HYPERPLASIA1
Gingival bleeding1
GESTATIONAL DIABETES1
Genital herpes1
GENERALISED OEDEMA1
GASTROINTESTINAL PAIN1
Gastric ulcer1
GASTRIC HAEMORRHAGE1
GASTRIC DISORDER1
GAMMOPATHY1
Gallbladder operation1
GALLBLADDER DISORDER1
Fungal skin infection1
Fungal infection1
Freezing phenomenon1
FRACTURE1
Flushing1
Fine motor skill dysfunction1
Fibromyalgia1
FEMUR FRACTURE1
Femoral neck fracture1
Feeling cold1
Feeling abnormal1
FAECAL INCONTINENCE1
FACIAL PALSY1
EYE SWELLING1
EYE PRURITUS1
Eye prosthesis insertion1
Eye irritation1
Exposure via body fluid1
EXOPHTHALMOS1
EXCORIATION1
EXCESSIVE GRANULATION TISSUE1
Erythema multiforme1
ERYSIPELAS1
Erosive oesophagitis1
Epiphyses premature fusion1
Eosinophilic cellulitis1
ENTHESOPATHY1
Enterocolitis1
Endometrial cancer1
ENANTHEMA1
Emotional distress1
EMBOLIC STROKE1
EATING DISORDER1
EAR INFECTION1
DYSURIA1
DYSPNOEA PAROXYSMAL NOCTURNAL1
Duodenitis1
Drug tolerance1
Drug reaction with eosinophilia and systemic symptoms1
Drug prescribing error1
DRUG LEVEL INCREASED1
DRUG HYPERSENSITIVITY1
DRUG ERUPTION1
Drug effect incomplete1
DRUG DISPENSING ERROR1
DISORIENTATION1
DISEASE COMPLICATION1
Diplopia1
DILATATION ATRIAL1
Diffuse alopecia1
DIARRHOEA HAEMORRHAGIC1
DIABETIC RETINOPATHY1
DIABETIC FOOT INFECTION1
DIABETES MELLITUS INSULIN-DEPENDENT1
Device ineffective1
DERMATITIS ATOPIC1
Dermatitis allergic1
DEREALISATION1
DEPRESSED LEVEL OF CONSCIOUSNESS1
Dementia Alzheimer's type1
DELIRIUM TREMENS1
DELUSION1
DELAYED PUBERTY1
DELAYED MENARCHE1
Decreased immune responsiveness1
Deafness transitory1
DEAFNESS NEUROSENSORY1
Cystoid macular oedema1
Cutaneous T-cell lymphoma1
Cryoglobulinaemia1
CREPITATIONS1
Corneal transplant1
Corneal perforation1
Contusion1
CONTRAINDICATION TO MEDICAL TREATMENT1
Contraindicated product prescribed1
Contraindicated drug prescribed1
CONGENITAL HAND MALFORMATION1
CONGENITAL FOOT MALFORMATION1
Congenital dyskeratosis1
CONGENITAL AORTIC ANOMALY1
Colon cancer1
Colitis1
COLECTOMY1
CIRCUMSTANCE OR INFORMATION CAPABLE OF LEADING TO MEDICATION ERROR1
Cholecystitis acute1
Cholecystitis1
Cholecystectomy1
CHEST PAIN1
Chest discomfort1
CHANGE OF BOWEL HABIT1
Cerebral venous thrombosis1
CEREBRAL CYST1
CEREBRAL ARTERY THROMBOSIS1
Cauda equina syndrome1
Cataract operation1
CAROTID ARTERY STENOSIS1
CARDIOMYOPATHY1
CARDIOMEGALY1
CARDIAC MURMUR1
CARDIAC ENZYMES INCREASED1
CARDIAC DISORDER1
CARCINOMA1
CALCIFICATION OF MUSCLE1
Burning sensation1
Bronchopulmonary aspergillosis1
Bronchitis1
Bronchiectasis1
BREECH PRESENTATION1
BREECH DELIVERY1
BREAST NEOPLASM1
BREAST CANCER RECURRENT1
BREAST CANCER METASTATIC1
Breast cancer1
Bradycardia foetal1
Bowenoid papulosis1
BOWEL SOUNDS ABNORMAL1
Botryomycosis1
Bone hypertrophy1
Bone disorder1
BODY MASS INDEX DECREASED1
BODY HEIGHT DECREASED1
BLOOD URINE PRESENT1
Blood uric acid increased1
Blood test abnormal1
BLOOD SODIUM INCREASED1
BLOOD PRESSURE FLUCTUATION1
BLOOD PARATHYROID HORMONE INCREASED1
BLOOD PARATHYROID HORMONE DECREASED1
Blood insulin decreased1
Blood glucose decreased1
BLOOD FOLLICLE STIMULATING HORMONE INCREASED1
BLOOD DISORDER1
BLOOD CALCIUM DECREASED1
Blood blister1
BLOOD AMYLASE INCREASED1
BLEPHARITIS1
Biopsy liver abnormal1
BILIARY TRACT DISORDER1
Biliary colic1
Bicytopenia1
Benign intracranial hypertension1
Bedridden1
BASILAR ARTERY OCCLUSION1
BASEDOW'S DISEASE1
BALANCE DISORDER1
BACTERIAL TEST POSITIVE1
Bacterial disease carrier1
AXILLARY MASS1
Atelectasis1
ATAXIA1
ASPIRATION1
Arthritis bacterial1
Arteritis1
ARTERIAL THROMBOSIS1
Arrhythmia1
Areflexia1
Aphonia1
APATHY1
AORTIC STENOSIS1
Antipsychotic drug level increased1
Antiphospholipid antibodies positive1
ANTINUCLEAR ANTIBODY INCREASED1
ANTIBODY TEST POSITIVE1
ANOSMIA1
ANOMALY OF MIDDLE EAR CONGENITAL1
ANODONTIA1
Anion gap increased1
Angle closure glaucoma1
ANGINA PECTORIS1
ANDROGENETIC ALOPECIA1
Anaphylactic reaction1
Anaemia macrocytic1
ALDOLASE INCREASED1
ALCOHOL WITHDRAWAL SYNDROME1
Acute lung injury1
ACUTE GENERALISED EXANTHEMATOUS PUSTULOSIS1
ACTIVITIES OF DAILY LIVING IMPAIRED1
ACOUSTIC STIMULATION TESTS ABNORMAL1
ACHROMOTRICHIA ACQUIRED1
ACCIDENTAL EXPOSURE1
Abscess intestinal1
Abdominal distension1
Abdominal discomfort1
Abdominal adhesions1
ABASIA1





Filtered ChEMBL targets:

Target UniProtKB ID Activity in nm Target Name Target gene
Q16637 3162.3 Survival motor neuron protein SMN_HUMAN



Toxicity information:

Toxicity class: 5
Toxicity type: reproductive
LD50: 4000 mg/kg



External links:

ChEBML: CHEMBL1131
DrugBank: DB00459