Tolrestat
General information:
| Withdrawn ID: | w86 |
|---|---|
| Canonical SMILES: | |
| Standard InChI: | |
| Standard InChIKey: | |
| ATC class(es): | A10XA01 |
| Molecular Formula: | C16H14F3NO3S |
| Molweight: | 357.347 |
Withdrawal information:
| Withdrawn due to drug safety reasons: | Yes |
|---|---|
| First approved: | 1982 |
| First death: | 1995 |
| First withdrawn: | 1996 |
| Last withdrawn: | 1996 |
| Reference: | https://www.ncbi.nlm.nih.gov/pubmed/21574210 |
Filtered ChEMBL targets:
| Target UniProtKB ID | Activity in nm | Target Name | Target gene |
|---|---|---|---|
| O60218 | 11.6 | Aldo-keto reductase family 1 member B10 | AK1BA_HUMAN |
| P14550 | 720 | Aldo-keto reductase family 1 member A1 | AK1A1_HUMAN |
| P15121 | 10 | Aldo-keto reductase family 1 member B1 | ALDR_HUMAN |
Toxicity information:
| Toxicity type: | hepatic |
|---|
External links:
| ChEBML: | CHEMBL436 |
|---|---|
| DrugBank: | DB02383 |