Triazolam


w68



General information:


Withdrawn ID: w68
Canonical SMILES:
Standard InChI:
Standard InChIKey:
ATC class(es): N05CD05
Molecular Formula: C17H12Cl2N4
Molweight: 343.21



Withdrawal information:


Withdrawn due to drug safety reasons:Yes
First approved: 1982
First withdrawn: 1982
Last withdrawn: 1993
Reference: https://www.ncbi.nlm.nih.gov/pubmed/17502431



Side-effects:

Total reported cases (submitted by medical professionals) with Triazolam as primary suspect: 739


Reported final outcomes:
Hospitalization (initial or prolonged): 302
Death: 63
Life-Threatening condition: 41
Disability: 3
Intervention required to prevent permanent impairment/damage: 2
Congenital anomaly: 1


Reported side-effects:

Side-effect Case number
Drug abuse144
SOPOR138
OVERDOSE108
SUICIDE ATTEMPT100
INTENTIONAL OVERDOSE63
SOMNOLENCE58
LOSS OF CONSCIOUSNESS56
DRUG INEFFECTIVE49
TOXICITY TO VARIOUS AGENTS44
Intentional self-injury41
DEPRESSED LEVEL OF CONSCIOUSNESS38
COMA38
Drug hypersensitivity29
DELIRIUM29
FALL28
CONFUSIONAL STATE28
COMPLETED SUICIDE25
BRADYPHRENIA23
DRUG DEPENDENCE21
DIZZINESS19
BLOOD CREATINE PHOSPHOKINASE INCREASED19
INCORRECT DOSE ADMINISTERED18
DRUG INTERACTION17
ROAD TRAFFIC ACCIDENT16
DISORIENTATION16
Medication error15
Hypokinesia15
ASTHENIA15
AMNESIA15
VOMITING14
MULTIPLE DRUG OVERDOSE INTENTIONAL14
Intentional product misuse14
INSOMNIA14
HALLUCINATION13
DYSARTHRIA13
DEATH13
ANXIETY13
SYNCOPE12
SUICIDAL IDEATION12
RHABDOMYOLYSIS12
BRADYKINESIA12
SPEECH DISORDER11
POISONING11
MULTIPLE DRUG OVERDOSE11
ALTERED STATE OF CONSCIOUSNESS11
OFF LABEL USE10
MIOSIS10
GAIT DISTURBANCE10
BRADYCARDIA10
ABNORMAL BEHAVIOUR10
TREMOR9
STUPOR9
RESTLESSNESS9
RESPIRATORY DEPRESSION9
INTENTIONAL DRUG MISUSE9
DRUG TOXICITY9
AGITATION9
TACHYCARDIA8
PYREXIA8
HYPOTENSION8
HEADACHE8
DEMENTIA8
BLOOD PRESSURE INCREASED8
BLOOD PRESSURE DECREASED8
WITHDRAWAL SYNDROME7
SEDATION7
RESPIRATORY ARREST7
PNEUMONIA ASPIRATION7
HEPATIC FUNCTION ABNORMAL7
DRUG WITHDRAWAL SYNDROME7
DEPRESSION7
DEHYDRATION7
CONDITION AGGRAVATED7
COGNITIVE DISORDER7
CARDIAC ARREST7
APHASIA7
AGGRESSION7
VERTIGO6
PRURITUS6
Product quality issue6
PHARMACEUTICAL PRODUCT COMPLAINT6
PAIN6
MALAISE6
HYPOAESTHESIA6
HYPERTENSION6
GAMMA-GLUTAMYLTRANSFERASE INCREASED6
ELECTROCARDIOGRAM QT PROLONGED6
CONVULSION6
ASPARTATE AMINOTRANSFERASE INCREASED6
SELF-MEDICATION5
RENAL IMPAIRMENT5
NIGHTMARE5
NEUROLEPTIC MALIGNANT SYNDROME5
NAUSEA5
MUSCULAR WEAKNESS5
MEMORY IMPAIRMENT5
Hyporesponsive to stimuli5
HYPOGLYCAEMIA5
HEAD INJURY5
HAEMODIALYSIS5
GLAUCOMA5
DYSSTASIA5
DRUG EFFECT DECREASED5
DIPLOPIA5
DEPENDENCE5
WEIGHT DECREASED4
Sedation complication4
Psychomotor retardation4
Product use in unapproved indication4
PLATELET COUNT DECREASED4
ORTHOSTATIC HYPOTENSION4
JAUNDICE4
INTENTIONAL MISUSE4
HYPOTHERMIA4
HYPERVENTILATION4
HOMICIDE4
HEART RATE INCREASED4
HALLUCINATION, VISUAL4
DYSPNOEA4
Dysphagia4
DRUG WITHDRAWAL CONVULSIONS4
DRUG EXPOSURE DURING PREGNANCY4
DISTURBANCE IN ATTENTION4
Decubitus ulcer4
DECREASED APPETITE4
BLOOD LACTATE DEHYDROGENASE INCREASED4
ALCOHOL USE4
ALANINE AMINOTRANSFERASE INCREASED4
ACCIDENTAL OVERDOSE4
Accidental exposure to product by child4
ABDOMINAL PAIN4
Wrong product administered3
WHITE BLOOD CELL COUNT INCREASED3
VENTRICULAR TACHYCARDIA3
TORSADE DE POINTES3
SLEEP DISORDER3
SHOCK3
Rhonchi3
RESPIRATORY FAILURE3
RENAL FAILURE ACUTE3
Psychomotor skills impaired3
Product use issue3
Palpitations3
NON-CARDIOGENIC PULMONARY OEDEMA3
Movement disorder3
Mental impairment3
IRRITABILITY3
INTERSTITIAL LUNG DISEASE3
Intentional product use issue3
INJURY ASPHYXIATION3
INFLUENZA3
Incorrect product administration duration3
Inappropriate schedule of drug administration3
HYPONATRAEMIA3
Hypokalaemia3
HYPERHIDROSIS3
HEART RATE DECREASED3
HAEMORRHAGE SUBCUTANEOUS3
Glossodynia3
GENERAL PHYSICAL HEALTH DETERIORATION3
FRACTURE3
Foreign body in throat3
FEELING ABNORMAL3
ERYTHEMA MULTIFORME3
Drug use disorder3
DRUG SCREEN POSITIVE3
DRUG LEVEL INCREASED3
DRUG ERUPTION3
Disinhibition3
DELUSION3
DECREASED ACTIVITY3
CONTUSION3
Contraindicated product administered3
COMPRESSION FRACTURE3
COMA SCALE ABNORMAL3
CEREBRAL INFARCTION3
CARDIAC FAILURE3
C-REACTIVE PROTEIN INCREASED3
BLOOD PRESSURE SYSTOLIC INCREASED3
Akinesia3
ACCIDENTAL EXPOSURE3
ABDOMINAL PAIN UPPER3
ABDOMINAL DISCOMFORT3
WHITE BLOOD CELL COUNT DECREASED2
VENTRICULAR EXTRASYSTOLES2
URTICARIA2
URINARY TRACT INFECTION2
Unresponsive to stimuli2
UNEVALUABLE EVENT2
TONSILLITIS2
THERAPY NON-RESPONDER2
SUBDURAL HAEMATOMA2
Somnambulism2
SKULL FRACTURE2
SINUS TACHYCARDIA2
Sinus bradycardia2
Seizure2
RETROGRADE AMNESIA2
Rectal haemorrhage2
PULMONARY OEDEMA2
PULMONARY HAEMORRHAGE2
PULMONARY EMBOLISM2
PSYCHOTIC DISORDER2
Psychomotor hyperactivity2
Product dispensing error2
Presyncope2
POST PROCEDURAL COMPLICATION2
PORIOMANIA2
Poor quality drug administered2
PO2 DECREASED2
PNEUMONIA2
PERSONALITY CHANGE2
PARKINSONISM2
Paraesthesia2
PALLOR2
Oesophageal candidiasis2
OEDEMA2
NO ADVERSE EVENT2
NERVOUS SYSTEM DISORDER2
MYOCARDIAL INFARCTION2
MYDRIASIS2
MYALGIA2
MULTI-ORGAN FAILURE2
MENTAL DISORDER2
MALNUTRITION2
LIVER FUNCTION TEST ABNORMAL2
LIVER DISORDER2
Language disorder2
International normalised ratio increased2
Initial insomnia2
Incorrect drug administration duration2
IMPAIRED DRIVING ABILITY2
HYPOTHYROIDISM2
Hyponatraemic syndrome2
HYPERCHOLESTEROLAEMIA2
HYPERCAPNIA2
Hip fracture2
HEPATITIS FULMINANT2
HEPATITIS C2
Hemiparesis2
Heat illness2
GASTROINTESTINAL HAEMORRHAGE2
GASTRITIS2
Feeling jittery2
Fear2
EYELID PTOSIS2
EXTRASYSTOLES2
EUPHORIC MOOD2
ERYTHEMA2
ELECTROENCEPHALOGRAM ABNORMAL2
ELECTROCARDIOGRAM ABNORMAL2
EATING DISORDER2
Dysuria2
DYSLALIA2
DYSGEUSIA2
DYSCALCULIA2
DRUG WITHDRAWAL SYNDROME NEONATAL2
Drug intolerance2
Drug ineffective for unapproved indication2
DRUG DISPENSING ERROR2
DRUG ADMINISTRATION ERROR2
Drowning2
DIALYSIS2
DIABETES MELLITUS2
Depressed mood2
Dementia Alzheimer's type2
DEEP VEIN THROMBOSIS2
DEAFNESS2
Cranial nerve disorder2
CHOLESTASIS2
CHILLS2
Chest pain2
CEREBROVASCULAR STENOSIS2
CEREBRAL ATROPHY2
CARDIO-RESPIRATORY ARREST2
CARBON MONOXIDE POISONING2
CAESAREAN SECTION2
BREAST CANCER2
BRAIN OEDEMA2
BRAIN INJURY2
BLOOD TRIGLYCERIDES INCREASED2
BLOOD SODIUM DECREASED2
BLOOD CREATININE INCREASED2
BLOOD CHLORIDE DECREASED2
BLOOD ALKALINE PHOSPHATASE INCREASED2
BLISTER2
BEDRIDDEN2
BACK PAIN2
ASPHYXIA2
APRAXIA2
APNOEA2
Antipsychotic drug level increased2
ANOREXIA2
ALCOHOL INTERACTION2
Accidental exposure to product2
Wrong patient received medication1
WRONG DRUG ADMINISTERED1
Wheezing1
Weight increased1
Vulvovaginal candidiasis1
VOMITING NEONATAL1
VISUAL FIELD DEFECT1
Vision blurred1
VICTIM OF HOMICIDE1
VICTIM OF CHILD ABUSE1
Ventricular arrhythmia1
UTERINE CANCER1
URINE OUTPUT DECREASED1
URINARY RETENTION1
URINARY INCONTINENCE1
Upper airway obstruction1
TRISOMY 211
TREATMENT NONCOMPLIANCE1
TREATMENT FAILURE1
TOXIC EPIDERMAL NECROLYSIS1
TOOTH INFECTION1
TONIC CONVULSION1
TIBIA FRACTURE1
THYROIDECTOMY1
Thyroid disorder1
THYMUS DISORDER1
THERMAL BURN1
THERAPY REGIMEN CHANGED1
THERAPEUTIC RESPONSE UNEXPECTED WITH DRUG SUBSTITUTION1
Therapeutic response unexpected1
Therapeutic response increased1
TESTICULAR PAIN1
TEMPORAL LOBE EPILEPSY1
SURGERY1
Substance dependence1
SUBARACHNOID HAEMORRHAGE1
STRESS1
STOMATITIS1
STATUS EPILEPTICUS1
STARING1
SPINAL FRACTURE1
Spinal compression fracture1
Sphincter of Oddi dysfunction1
Social problem1
SNORING1
SMALL FOR DATES BABY1
Slow speech1
SLOW RESPONSE TO STIMULI1
SLEEP PHASE RHYTHM DISTURBANCE1
Sleep apnoea syndrome1
Skin ulcer1
SKIN INFLAMMATION1
SKIN EXFOLIATION1
SKIN DISCOLOURATION1
SEROTONIN SYNDROME1
Sense of oppression1
SCAR1
SCAB1
Sarcopenia1
Respiratory tract infection1
RESPIRATORY RATE INCREASED1
RESPIRATORY DISORDER1
RENAL HAEMORRHAGE1
RENAL FAILURE1
Renal disorder1
Renal cell carcinoma1
Regressive behaviour1
Reduced facial expression1
Red blood cell count decreased1
RASH PAPULAR1
RASH MACULO-PAPULAR1
Quadriplegia1
PYROMANIA1
PURPURA1
Pupil fixed1
Pulse absent1
Pulmonary tuberculosis1
PULMONARY INFARCTION1
Pulmonary congestion1
PRURITUS GENERALISED1
Product use complaint1
Product solubility abnormal1
Product physical issue1
Prescribed overdose1
Pre-existing condition improved1
Poor quality sleep1
Polyneuropathy1
POISONING DELIBERATE1
PNEUMONIA STAPHYLOCOCCAL1
PLEURAL EFFUSION1
PLEURAL DISORDER1
PHYSICAL ASSAULT1
PHARYNGOLARYNGEAL PAIN1
PHARYNGEAL OEDEMA1
PETECHIAE1
PERSONALITY CHANGE DUE TO A GENERAL MEDICAL CONDITION1
Persecutory delusion1
Peripheral circulatory failure1
Pericarditis constrictive1
Patient elopement1
Paralysis1
PARAESTHESIA ORAL1
Panic disorder1
PANCYTOPENIA1
Pancreatitis1
PAIN IN EXTREMITY1
Oxygen saturation decreased1
OVARIAN CANCER METASTATIC1
OSTEOARTHRITIS1
Oropharyngeal pain1
Oropharyngeal discomfort1
Organ donor1
ORAL MUCOSAL PETECHIAE1
OPTIC NEURITIS1
OPIATES POSITIVE1
Open fracture1
OLIGOHYDRAMNIOS1
OEDEMA PERIPHERAL1
OCULOCEPHALOGYRIC REFLEX ABSENT1
OCULAR HYPERAEMIA1
OBSTRUCTIVE AIRWAYS DISORDER1
Obsessive-compulsive disorder1
Nocturia1
NIGHT SWEATS1
Neutrophil count increased1
NEUROPATHY PERIPHERAL1
Neoplasm progression1
Neoplasm malignant1
NEONATAL DISORDER1
Negative thoughts1
Neck pain1
NASOPHARYNGITIS1
MYOGLOBINURIA1
MYOGLOBIN URINE PRESENT1
MYOCLONIC EPILEPSY1
MYCOSIS FUNGOIDES1
Myasthenia gravis crisis1
Myasthenia gravis1
MUSCLE SPASMS1
Muscle injury1
MUSCLE ATROPHY1
MURDER1
MULTI-ORGAN DISORDER1
MUCOSAL EROSION1
Mood altered1
METASTASES TO SPINE1
METASTASES TO BLADDER1
MENIERE'S DISEASE1
Maternal exposure timing unspecified1
MATERNAL DRUGS AFFECTING FOETUS1
MALIGNANT NEOPLASM PROGRESSION1
LYMPHOMA1
LYMPHOCYTIC INFILTRATION1
Lymphocyte count increased1
LUNG INFILTRATION1
LUNG DISORDER1
LOGORRHOEA1
LIPASE INCREASED1
LIP DRY1
Large intestine polyp1
Laceration1
Labelled drug-drug interaction medication error1
Judgement impaired1
JOB DISSATISFACTION1
IRRITABLE BOWEL SYNDROME1
INTRAOCULAR PRESSURE INCREASED1
INTRACRANIAL HYPOTENSION1
INTRACARDIAC THROMBUS1
Intellectual disability1
INSULIN AUTOIMMUNE SYNDROME1
Injury1
INFLAMMATION1
INFECTION1
INFANTILE APNOEIC ATTACK1
Infant sedation1
Incorrect dosage administered1
Incontinence1
IMPAIRED HEALING1
Illness anxiety disorder1
IATROGENIC INJURY1
Hypoxic-ischaemic encephalopathy1
HYPOTONIA1
Hyporeflexia1
HYPOPROTEINAEMIA1
HYPOPITUITARISM1
Hypoglycaemia neonatal1
HYPOAESTHESIA ORAL1
HYPERTONIC BLADDER1
Hypersomnia1
Hyperpyrexia1
HYPERGASTRINAEMIA1
Hyperammonaemia1
Hot flush1
HOSPITALISATION1
Hepatitis B reactivation1
Hepatitis alcoholic1
HEPATITIS1
HEPATIC STEATOSIS1
HEPATIC NEOPLASM MALIGNANT1
HEPATIC HAEMORRHAGE1
Hepatic enzyme increased1
HEMIPLEGIA1
Helicobacter infection1
HAEMORRHAGE1
Haemoglobin decreased1
Haematocrit decreased1
GRAND MAL CONVULSION1
GLOSSOPTOSIS1
GINGIVAL PAIN1
Genital haemorrhage1
Generalised tonic-clonic seizure1
GAZE PALSY1
Gastrointestinal disorder1
GASTRITIS EROSIVE1
GASTRITIS ATROPHIC1
GASTRIC ULCER HAEMORRHAGE1
Gastric perforation1
GASTRIC DISORDER1
Gastric cancer1
Fungal infection1
FRACTURED COCCYX1
FOREIGN BODY ASPIRATION1
FOOT FRACTURE1
FOOD INTERACTION1
FOAMING AT MOUTH1
Fibula fracture1
FIBROMYALGIA1
Fibroma1
Feeling guilty1
FEELING DRUNK1
FEEDING DISORDER NEONATAL1
FATIGUE1
FAMILY STRESS1
Faeces pale1
FAECALOMA1
FAECAL INCONTINENCE1
FACE OEDEMA1
Eye irritation1
Eye contusion1
EROSIVE OESOPHAGITIS1
Epilepsy1
ELECTROLYTE IMBALANCE1
Electrocardiogram ST segment elevation1
ELECTROCARDIOGRAM ST SEGMENT DEPRESSION1
Dyskinesia1
DURAL TEAR1
DRY MOUTH1
Dry eye1
DRUG SCREEN NEGATIVE1
Drug screen false positive1
Drug reaction with eosinophilia and systemic symptoms1
DRUG PRESCRIBING ERROR1
Drug effective for unapproved indication1
DRUG EFFECT PROLONGED1
DRUG EFFECT INCREASED1
Drug effect incomplete1
Dreamy state1
DIVERTICULUM INTESTINAL HAEMORRHAGIC1
DISSOCIATIVE DISORDER1
DISSEMINATED INTRAVASCULAR COAGULATION1
Disorganised speech1
Disease recurrence1
Disease progression1
DIFFICULTY IN WALKING1
DIARRHOEA1
Diabetes insipidus1
DERMATITIS EXFOLIATIVE1
DERMATITIS CONTACT1
Delayed recovery from anaesthesia1
Decreased interest1
DEAFNESS TRANSITORY1
Daydreaming1
CYANOSIS1
Crying1
Cough1
CORONARY ARTERY BYPASS1
CORNEAL REFLEX DECREASED1
Coordination abnormal1
CONJUNCTIVAL EROSION1
CONGESTIVE CARDIOMYOPATHY1
Concomitant disease aggravated1
COMMUNICATION DISORDER1
Cold sweat1
CLOSTRIDIUM COLITIS1
CIRCULATORY COLLAPSE1
Chromaturia1
CHOLECYSTITIS ACUTE1
Cholangitis1
CHOKING SENSATION1
CHEST X-RAY ABNORMAL1
CHEST DISCOMFORT1
CHEMICAL POISONING1
Cervical vertebral fracture1
CEREBRAL THROMBOSIS1
Cerebral ischaemia1
CEREBRAL HAEMORRHAGE1
Cerebral calcification1
Cerebellar atrophy1
CELLULITIS1
CATHETER RELATED INFECTION1
Cataract1
CARDIOVASCULAR DISORDER1
CARDIAC DISORDER1
CANDIDA SEPSIS1
Bundle branch block right1
Bronchospasm1
BRONCHOPNEUMONIA1
Bronchitis1
Breath sounds abnormal1
BRAIN STEM SYNDROME1
BRAIN STEM INFARCTION1
Brain death1
BRAIN CONTUSION1
Bradyarrhythmia1
BODY TEMPERATURE DECREASED1
BLOOD URIC ACID DECREASED1
BLOOD UREA INCREASED1
BLOOD THYROID STIMULATING HORMONE INCREASED1
Blood pressure diastolic decreased1
BLOOD PRESSURE ABNORMAL1
Blood potassium decreased1
Blood oestrogen increased1
Blood glucose increased1
BLOOD GASES ABNORMAL1
BLOOD CHOLINESTERASE INCREASED1
BLOOD CHOLESTEROL INCREASED1
Blood catecholamines increased1
BLOOD CAFFEINE INCREASED1
BLOOD BILIRUBIN UNCONJUGATED INCREASED1
BLOOD BILIRUBIN INCREASED1
BLOOD AMYLASE INCREASED1
BLOOD ALBUMIN DECREASED1
BLINDNESS1
Blepharospasm1
BILIRUBIN CONJUGATED INCREASED1
Balance disorder1
Bacterial prostatitis1
Attention deficit/hyperactivity disorder1
Atrioventricular block second degree1
ATRIAL FIBRILLATION1
Ataxia1
ASTHMA1
ASTHENOPIA1
ASTERIXIS1
ASPIRATION1
ARTHRITIS1
ARTERIAL STENT INSERTION1
ARRHYTHMIA1
APHAGIA1
Anoxia1
Ankle fracture1
Angle closure glaucoma1
ANGINA PECTORIS1
Anger1
ANEURYSM RUPTURED1
Anal incontinence1
ANAEMIA1
AMMONIA INCREASED1
Alcohol abuse1
Akathisia1
ACUTE RESPIRATORY FAILURE1
ACUTE PULMONARY OEDEMA1
ACUTE PRERENAL FAILURE1
Acute kidney injury1
Acidosis1
ACCIDENTAL DRUG INTAKE BY CHILD1
Abulia1
ABORTION SPONTANEOUS1
ABNORMAL DREAMS1
Abdominal tenderness1





Toxicity information:

Toxicity class: 4
Toxicity type: neurological
LD50: 770 mg/kg



External links:

ChEBML: CHEMBL646
DrugBank: DB00897