Dofetilide


w64



General information:


Withdrawn ID: w64
Canonical SMILES:
Standard InChI:
Standard InChIKey:
ATC class(es): C01BD04
Molecular Formula: C19H27N3O5S2
Molweight: 441.565



Withdrawal information:


Withdrawn due to drug safety reasons:Yes
First approved: 1999
First withdrawn: 2004
Last withdrawn: 2004
Reference: https://www.ncbi.nlm.nih.gov/pubmed/12590905



Side-effects:

Total reported cases (submitted by medical professionals) with Dofetilide as primary suspect: 2371


Reported final outcomes:
Hospitalization (initial or prolonged): 727
Death: 262
Life-Threatening condition: 87
Intervention required to prevent permanent impairment/damage: 21
Disability: 17


Reported side-effects:

Side-effect Case number
ATRIAL FIBRILLATION235
ELECTROCARDIOGRAM QT PROLONGED225
DRUG INEFFECTIVE201
DEATH179
DIZZINESS114
DYSPNOEA110
TORSADE DE POINTES101
FATIGUE101
VENTRICULAR TACHYCARDIA100
PALPITATIONS79
ARRHYTHMIA66
HEADACHE65
CONDITION AGGRAVATED64
NAUSEA61
DYSPHAGIA61
DRUG INTERACTION61
CHEST PAIN57
PNEUMONIA54
MALAISE51
CARDIAC ARREST51
ASTHENIA46
URINARY TRACT INFECTION44
HEART RATE INCREASED42
DIARRHOEA42
WEIGHT DECREASED37
FALL36
TACHYCARDIA35
DRUG HYPERSENSITIVITY35
COUGH35
CEREBROVASCULAR ACCIDENT35
CARDIAC FAILURE CONGESTIVE35
Off label use34
VENTRICULAR FIBRILLATION32
LOSS OF CONSCIOUSNESS32
SYNCOPE31
RASH31
HYPERTENSION31
BLOOD PRESSURE INCREASED31
FEELING ABNORMAL30
TREMOR29
INSOMNIA29
HEART RATE IRREGULAR29
DRUG DOSE OMISSION28
CHRONIC OBSTRUCTIVE PULMONARY DISEASE28
CARDIAC DISORDER28
Therapy cessation27
BLOOD POTASSIUM DECREASED27
ARTHRALGIA25
VOMITING24
OEDEMA PERIPHERAL24
CHEST DISCOMFORT24
BRADYCARDIA24
WEIGHT INCREASED23
HYPOTENSION23
HOSPITALISATION23
CARDIAC FAILURE22
ANXIETY22
UNEVALUABLE EVENT21
RENAL IMPAIRMENT21
Product use in unapproved indication21
PAIN IN EXTREMITY21
ELECTROCARDIOGRAM QT CORRECTED INTERVAL PROLONGED21
VENTRICULAR EXTRASYSTOLES20
RENAL FAILURE20
HEART RATE DECREASED20
PARAESTHESIA19
MUSCLE SPASMS19
BRONCHITIS19
BACK PAIN19
VISION BLURRED18
NASOPHARYNGITIS18
MYOCARDIAL INFARCTION18
HYPERHIDROSIS18
DECREASED APPETITE18
BLOOD CREATININE INCREASED18
ATRIAL FLUTTER18
SINUSITIS17
MEMORY IMPAIRMENT17
INFECTION17
HYPOAESTHESIA17
DEPRESSION17
BLOOD MAGNESIUM DECREASED17
NO ADVERSE EVENT16
MYALGIA16
DYSPNOEA EXERTIONAL16
BLOOD PRESSURE DECREASED16
VISUAL IMPAIRMENT15
Product prescribing error15
PAIN15
GAIT DISTURBANCE15
Drug effect incomplete15
DISEASE RECURRENCE15
CONFUSIONAL STATE15
CARDIO-RESPIRATORY ARREST15
Therapeutic product effect incomplete14
PHARMACEUTICAL PRODUCT COMPLAINT14
INCORRECT DOSE ADMINISTERED14
ANAEMIA14
HYPOACUSIS13
DEHYDRATION13
BLOOD UREA INCREASED13
ABDOMINAL PAIN UPPER13
SEPSIS12
RESPIRATORY FAILURE12
Pruritus12
MEDICATION ERROR12
DRUG DISPENSING ERROR12
CARDIAC PACEMAKER INSERTION12
ABDOMINAL PAIN12
SOMNOLENCE11
RENAL FAILURE ACUTE11
PYREXIA11
NEOPLASM MALIGNANT11
INFLUENZA11
HYPERSENSITIVITY11
GASTROOESOPHAGEAL REFLUX DISEASE11
DYSPEPSIA11
CORONARY ARTERY DISEASE11
CONSTIPATION11
BLOOD GLUCOSE INCREASED11
Arthropathy11
SURGERY10
SUPRAVENTRICULAR EXTRASYSTOLES10
STRESS10
SINUS BRADYCARDIA10
RENAL DISORDER10
PULMONARY HYPERTENSION10
Product substitution issue10
OROPHARYNGEAL PAIN10
Nervousness10
MUSCULAR WEAKNESS10
INTERNATIONAL NORMALISED RATIO INCREASED10
Intentional product misuse10
HYPOKALAEMIA10
HOT FLUSH10
HAEMOGLOBIN DECREASED10
GASTROINTESTINAL HAEMORRHAGE10
EJECTION FRACTION DECREASED10
CREATININE RENAL CLEARANCE DECREASED10
CARDIOVERSION10
ABDOMINAL DISCOMFORT10
UPPER RESPIRATORY TRACT INFECTION9
THIRST9
SLEEP APNOEA SYNDROME9
ROAD TRAFFIC ACCIDENT9
Product dose omission9
PRESYNCOPE9
Overdose9
EXTRASYSTOLES9
DRUG INTOLERANCE9
DRUG EFFECT DECREASED9
Burning sensation9
WHEEZING8
VERTIGO8
UNRESPONSIVE TO STIMULI8
Transient ischaemic attack8
SUPRAVENTRICULAR TACHYCARDIA8
Product quality issue8
Product dispensing error8
NEPHROLITHIASIS8
JOINT SWELLING8
INFLUENZA LIKE ILLNESS8
GASTRIC DISORDER8
FLUID RETENTION8
ELECTROCARDIOGRAM ABNORMAL8
Drug ineffective for unapproved indication8
CYSTITIS8
CIRCUMSTANCE OR INFORMATION CAPABLE OF LEADING TO MEDICATION ERROR8
BODY HEIGHT DECREASED8
ARTHRITIS8
ALOPECIA8
VENTRICULAR ARRHYTHMIA7
THERAPY NON-RESPONDER7
PULSE ABSENT7
PULMONARY OEDEMA7
Product use issue7
Peripheral swelling7
OEDEMA7
MENTAL STATUS CHANGES7
Intentional product use issue7
DRUG PRESCRIBING ERROR7
DISTURBANCE IN ATTENTION7
DIABETES MELLITUS7
CARDIAC FLUTTER7
CARDIAC ABLATION7
Balance disorder7
ASPARTATE AMINOTRANSFERASE INCREASED7
ANGINA PECTORIS7
ALANINE AMINOTRANSFERASE INCREASED7
Acute kidney injury7
SWELLING6
Suicide attempt6
SINUS ARRHYTHMIA6
Seizure6
POST PROCEDURAL COMPLICATION6
PLEURAL EFFUSION6
OSTEOARTHRITIS6
NEUROPATHY PERIPHERAL6
LETHARGY6
KNEE ARTHROPLASTY6
ISCHAEMIC CARDIOMYOPATHY6
INTERNATIONAL NORMALISED RATIO DECREASED6
HIP FRACTURE6
HEART RATE ABNORMAL6
HEAD INJURY6
GOUT6
GASTROINTESTINAL TUBE INSERTION6
GASTROINTESTINAL DISORDER6
EPISTAXIS6
Dysphonia6
CHILLS6
CELLULITIS6
CARDIOMEGALY6
BLOOD POTASSIUM INCREASED6
BLOOD CHOLESTEROL INCREASED6
ASTHMA6
Amnesia6
ABDOMINAL DISTENSION6
Urticaria5
Toxicity to various agents5
OBESITY5
MUSCULOSKELETAL PAIN5
MITRAL VALVE INCOMPETENCE5
LUNG NEOPLASM MALIGNANT5
LUNG DISORDER5
Loss of personal independence in daily activities5
LOCALISED INFECTION5
LIVER FUNCTION TEST ABNORMAL5
HAEMORRHOIDS5
Haemorrhage5
HAEMATURIA5
GASTRIC BYPASS5
FLATULENCE5
ELECTROCARDIOGRAM QRS COMPLEX PROLONGED5
DYSURIA5
DISORIENTATION5
CHOLELITHIASIS5
CATARACT5
CARDIOMYOPATHY5
BLOOD TEST ABNORMAL5
BLOOD SODIUM DECREASED5
BLOOD CALCIUM DECREASED5
ATRIAL TACHYCARDIA5
ARRHYTHMIA SUPRAVENTRICULAR5
AORTIC ANEURYSM5
ACCIDENTAL OVERDOSE5
VIRAL INFECTION4
TREATMENT NONCOMPLIANCE4
Tinnitus4
SUDDEN DEATH4
SNEEZING4
SMALL INTESTINAL OBSTRUCTION4
Sinus node dysfunction4
SEDATION4
RIB FRACTURE4
RHINORRHOEA4
RESTLESSNESS4
RECTAL HAEMORRHAGE4
PULMONARY CONGESTION4
Pruritus generalised4
PROSTATE CANCER4
POLLAKIURIA4
PANCREATITIS4
PANCREATIC CARCINOMA4
MUSCLE TWITCHING4
JOINT INJURY4
Intentional overdose4
Inappropriate schedule of drug administration4
HYPOTHYROIDISM4
HALLUCINATION4
HAEMATOMA4
HAEMATOCRIT DECREASED4
GLOMERULAR FILTRATION RATE DECREASED4
Extra dose administered4
EAR INFECTION4
DRY MOUTH4
DISEASE PROGRESSION4
Dementia4
DELIRIUM4
CREATININE RENAL CLEARANCE INCREASED4
COMA4
Cerebral haemorrhage4
CARDIAC OPERATION4
BOWEL MOVEMENT IRREGULARITY4
BLOOD PRESSURE INADEQUATELY CONTROLLED4
BLOOD PRESSURE FLUCTUATION4
AORTIC VALVE INCOMPETENCE4
Aortic stenosis4
Angioedema4
Anaphylactic reaction4
Wrong strength3
WHITE BLOOD CELL COUNT DECREASED3
Weight fluctuation3
UPPER LIMB FRACTURE3
THROMBOSIS3
Therapy change3
Therapeutic response unexpected3
THERAPEUTIC PROCEDURE3
SWOLLEN TONGUE3
Staphylococcal infection3
SPINAL COLUMN STENOSIS3
Speech disorder3
SKIN INFECTION3
Skin cancer3
SINUS TACHYCARDIA3
Sinus disorder3
SHOCK3
RESTLESS LEGS SYNDROME3
RESPIRATORY DISORDER3
RENAL FAILURE CHRONIC3
Pulseless electrical activity3
PULMONARY FIBROSIS3
PROTHROMBIN TIME PROLONGED3
Product appearance confusion3
POOR QUALITY DRUG ADMINISTERED3
PNEUMONIA ASPIRATION3
Paranoia3
PANIC ATTACK3
OXYGEN SATURATION DECREASED3
NO ADVERSE DRUG EFFECT3
NASAL CONGESTION3
Musculoskeletal stiffness3
MUSCULOSKELETAL CHEST PAIN3
MUSCLE DISORDER3
LYMPHOMA3
LUNG INFECTION3
LIMB DISCOMFORT3
Laryngitis3
KIDNEY INFECTION3
INTESTINAL OBSTRUCTION3
INTERNATIONAL NORMALISED RATIO ABNORMAL3
Internal haemorrhage3
INFLAMMATION3
IMPLANTABLE DEFIBRILLATOR MALFUNCTION3
IMPLANTABLE DEFIBRILLATOR INSERTION3
Impaired healing3
ILEUS3
HYPOMAGNESAEMIA3
Hypoglycaemia3
HYPERLIPIDAEMIA3
HYPERGLYCAEMIA3
HIP ARTHROPLASTY3
HERNIA3
HEPATIC FAILURE3
HAEMOPTYSIS3
GLYCOSYLATED HAEMOGLOBIN INCREASED3
GLAUCOMA3
GASTROINTESTINAL PAIN3
GASTROENTERITIS VIRAL3
GALLBLADDER DISORDER3
FLUSHING3
FLUID OVERLOAD3
FEELING COLD3
Facial paralysis3
Euphoric mood3
Erythema3
ERECTILE DYSFUNCTION3
EMOTIONAL DISORDER3
DYSSTASIA3
DYSKINESIA3
Dry throat3
DRY SKIN3
Drug-induced liver injury3
DRUG ADMINISTRATION ERROR3
DISCOMFORT3
DILATATION VENTRICULAR3
Dementia Alzheimer's type3
CONTUSION3
Contraindicated product administered3
Completed suicide3
COGNITIVE DISORDER3
COAGULOPATHY3
CARDIAC MURMUR3
Cardiac failure acute3
BREAST PAIN3
Brain injury3
BONE PAIN3
BONE DISORDER3
BLOOD THYROID STIMULATING HORMONE INCREASED3
BLOOD PRESSURE ABNORMAL3
BLOOD MAGNESIUM INCREASED3
Blood disorder3
BLOOD CREATININE DECREASED3
BACTERIAL INFECTION3
BACK DISORDER3
ATRIOVENTRICULAR BLOCK COMPLETE3
ATRIOVENTRICULAR BLOCK3
ANOREXIA3
ANGINA UNSTABLE3
AGITATION3
Ageusia3
ACCIDENT3
ABNORMAL DREAMS3
ABASIA3
Wrong technique in product usage process2
Wrong technique in drug usage process2
WEIGHT LOSS POOR2
VITREOUS FLOATERS2
Ventricular hypokinesia2
Varicose vein2
Urinary tract disorder2
Upper respiratory tract congestion2
Type 2 diabetes mellitus2
TRICUSPID VALVE INCOMPETENCE2
Treatment failure2
Tooth infection2
TOOTH DISORDER2
TONSILLAR DISORDER2
Thyroid function test abnormal2
Thyroid disorder2
Throat irritation2
THROAT CANCER2
THERMAL BURN2
Tachyarrhythmia2
SUDDEN CARDIAC DEATH2
SUBDURAL HAEMATOMA2
SPLENOMEGALY2
SLUGGISHNESS2
SLEEP DISORDER2
SKIN EXFOLIATION2
Skin discolouration2
Skin burning sensation2
SICK SINUS SYNDROME2
Sciatica2
Retching2
RESPIRATORY TRACT INFECTION2
RESPIRATORY RATE INCREASED2
RESPIRATORY DISTRESS2
RESPIRATORY ARREST2
RENAL FUNCTION TEST ABNORMAL2
Renal cancer2
Pulmonary toxicity2
PULMONARY THROMBOSIS2
PULMONARY EMBOLISM2
PSYCHOTIC DISORDER2
Prostatic disorder2
PROSTATE INFECTION2
PRODUCTIVE COUGH2
Product use complaint2
Product dose omission issue2
Product commingling2
Procedural pain2
Prescribed overdose2
Pneumonia viral2
PLATELET COUNT DECREASED2
PLANTAR FASCIITIS2
PHOTOSENSITIVITY REACTION2
PHARYNGITIS2
Pharyngeal oedema2
PERIPHERAL VASCULAR DISORDER2
Pericardial effusion2
Paralysis2
PANCREATITIS ACUTE2
ORGAN FAILURE2
ORAL PAIN2
Onychomycosis2
OESOPHAGEAL DISORDER2
OESOPHAGEAL CARCINOMA2
OESOPHAGEAL CANDIDIASIS2
NO THERAPEUTIC RESPONSE2
NIGHTMARE2
NIGHT SWEATS2
NEUTROPENIA2
NECK PAIN2
Neck injury2
Near death experience2
MYOCARDIAL ISCHAEMIA2
Muscle strain2
MOVEMENT DISORDER2
Mood altered2
MIGRAINE WITH AURA2
METASTATIC NEOPLASM2
METABOLIC ACIDOSIS2
MENTAL IMPAIRMENT2
MEDICATION RESIDUE2
MASTECTOMY2
LOSS OF LIBIDO2
LONG QT SYNDROME2
Liver disorder2
LISTLESS2
Lipoma2
Limb injury2
Leukaemia2
Left ventricular dysfunction2
Labelled drug-drug interaction medication error2
KNEE OPERATION2
JAW DISORDER2
Irritable bowel syndrome2
INTESTINAL ISCHAEMIA2
Intervertebral disc disorder2
INTERVERTEBRAL DISC DEGENERATION2
INTERSTITIAL LUNG DISEASE2
International normalised ratio fluctuation2
Intentional underdose2
INNER EAR DISORDER2
INCREASED TENDENCY TO BRUISE2
Increased appetite2
IMPLANTABLE DEFIBRILLATOR REPLACEMENT2
Impaired work ability2
Impaired driving ability2
Illness2
HYPOVOLAEMIA2
Hypothermia2
HYPERTHYROIDISM2
HYPERKALAEMIA2
HUNGER2
Humerus fracture2
HERPES ZOSTER2
Hepatotoxicity2
Hepatic steatosis2
HEPATIC CIRRHOSIS2
HELICOBACTER GASTRITIS2
Head discomfort2
HAEMATOCHEZIA2
GLOMERULONEPHRITIS2
Gastritis2
GANGRENE2
Gamma-glutamyltransferase increased2
Gait inability2
FUNGAL INFECTION2
Foreign body2
FEELING HOT2
FAECES PALE2
EYE INFECTION2
Exercise tolerance decreased2
Essential hypertension2
Encephalopathy2
EMOTIONAL DISTRESS2
ELECTROCARDIOGRAM T WAVE ABNORMAL2
Electrocardiogram ST segment elevation2
ELECTROCARDIOGRAM QT INTERVAL ABNORMAL2
EAR PAIN2
DYSLIPIDAEMIA2
DYSGEUSIA2
Dry eye2
Drug effective for unapproved indication2
DIVERTICULITIS2
DIABETES MELLITUS NON-INSULIN-DEPENDENT2
DEVICE MALFUNCTION2
Depressed level of consciousness2
Dental caries2
Deep vein thrombosis2
DEAFNESS2
CYANOSIS2
COVID-192
CONVULSION2
Contraindicated drug administered2
CONDUCTION DISORDER2
COLONIC POLYP2
COLITIS2
COLD SWEAT2
CHRONIC OBSTRUCTIVE AIRWAYS DISEASE EXACERBATED2
CHRONIC OBSTRUCTIVE AIRWAYS DISEASE2
Choking2
Carpal tunnel syndrome2
CARDIAC VALVE DISEASE2
CARDIAC PACEMAKER MALFUNCTION2
CARDIAC FIBRILLATION2
Cardiac failure chronic2
BUNDLE BRANCH BLOCK2
BRONCHOSPASM2
BREAST CANCER FEMALE2
BREAST CANCER2
BLOOD URIC ACID INCREASED2
BLOOD UREA NITROGEN/CREATININE RATIO INCREASED2
BLOOD TRIGLYCERIDES INCREASED2
BLOOD THYROID STIMULATING HORMONE DECREASED2
BLOOD PHOSPHORUS INCREASED2
BLOOD IRON DECREASED2
BLOOD GLUCOSE FLUCTUATION2
BLOOD GLUCOSE DECREASED2
BLOOD ELECTROLYTES DECREASED2
BLOOD CREATINE INCREASED2
BLOOD COUNT ABNORMAL2
BLOOD CHLORIDE DECREASED2
BLOOD ALKALINE PHOSPHATASE INCREASED2
Blister2
Bladder disorder2
BIPOLAR DISORDER2
BEDRIDDEN2
BACTERAEMIA2
Apparent death2
Aphonia2
Aphasia2
Aortic disorder2
ANTINUCLEAR ANTIBODY POSITIVE2
Anosmia2
AGGRESSION2
ADVERSE EVENT2
ADVERSE DRUG REACTION2
Acute pulmonary oedema2
ACTIVITIES OF DAILY LIVING IMPAIRED2
ABNORMAL BEHAVIOUR2
Abdominal hernia2
Wrong product administered1
Wrong drug administered1
Wrong dosage form1
Wound infection1
Wound complication1
Wound1
WHITE BLOOD CELL COUNT INCREASED1
WEIGHT ABNORMAL1
Walking aid user1
VULVOVAGINAL CANDIDIASIS1
Vulval cancer1
VULVAL ABSCESS1
Vomiting projectile1
Volume blood decreased1
Vocal cord paralysis1
VOCAL CORD INFLAMMATION1
Vitreous detachment1
VITAMIN B1 INCREASED1
Visual field defect1
Visual acuity reduced1
Viral upper respiratory tract infection1
Vestibular neuronitis1
Ventricular tachyarrhythmia1
VENTRICULAR FAILURE1
Venous injury1
VASCULITIS1
VASCULAR GRAFT1
VASCULAR DEMENTIA1
VAGINAL HAEMORRHAGE1
UROSEPSIS1
Urobilinogen urine increased1
URINE OUTPUT INCREASED1
Urine bilirubin increased1
Urinary tract infection fungal1
Urinary incontinence1
Ureteric obstruction1
Upper-airway cough syndrome1
Upper respiratory fungal infection1
UNEXPECTED THERAPEUTIC DRUG EFFECT1
Underweight1
UMBILICAL HERNIA1
Ulcer1
Troponin increased1
Trigger finger1
Trichorrhexis1
Traumatic intracranial haemorrhage1
TRAUMATIC BRAIN INJURY1
Transferrin decreased1
Transaminases increased1
Tracheostomy1
Tooth fracture1
TOOTH EXTRACTION1
Tooth abscess1
Tonsil cancer1
Tinea pedis1
Tibia fracture1
THYROXINE INCREASED1
Thyrotoxic crisis1
Thyroid cancer metastatic1
THROMBOCYTOPENIA1
Throat tightness1
THINKING ABNORMAL1
Therapeutic response shortened1
Therapeutic response changed1
Therapeutic product effect delayed1
TERMINAL INSOMNIA1
Tenoplasty1
Tendon rupture1
TENDON INJURY1
Tendon disorder1
Tachypnoea1
Systemic mycosis1
SYSTEMIC LUPUS ERYTHEMATOSUS1
Symptom recurrence1
SWEAT GLAND DISORDER1
Suspected suicide1
Suspected counterfeit product1
Suicidal ideation1
Subarachnoid haemorrhage1
Stridor1
Stress cardiomyopathy1
Stress at work1
STREPTOCOCCAL BACTERAEMIA1
STOMACH DISCOMFORT1
STENT PLACEMENT1
Sputum discoloured1
SPLENORENAL SHUNT1
Spinal stenosis1
Spinal operation1
SPINAL FUSION SURGERY1
Spinal fracture1
Soft tissue mass1
Soft tissue injury1
Snoring1
SMALL INTESTINAL HAEMORRHAGE1
Sleep phase rhythm disturbance1
Skin plaque1
Skin irritation1
Skin abrasion1
Sinus congestion1
Serum ferritin increased1
Sensory loss1
SENSORY DISTURBANCE1
Sensation of foreign body1
SENSATION OF BLOOD FLOW1
Seasonal allergy1
Scar1
ROTATOR CUFF SYNDROME1
Rosacea1
Right atrial dilatation1
Rhonchi1
RHINITIS SEASONAL1
Rheumatoid arthritis1
RHEUMATIC HEART DISEASE1
Retroperitoneal haematoma1
Retinal detachment1
Resuscitation1
Respiratory tract congestion1
Respiratory syncytial virus infection1
RESPIRATORY DEPRESSION1
Renal surgery1
RENAL MASS1
RENAL CYST1
RENAL CELL CARCINOMA1
Reflux laryngitis1
RED CELL DISTRIBUTION WIDTH INCREASED1
Red blood cell count decreased1
Reaction to drug excipients1
RASH PRURITIC1
Rash papular1
RASH MACULO-PAPULAR1
Rash generalised1
RADICAL PROSTATECTOMY1
Quality of life decreased1
QRS AXIS ABNORMAL1
PYURIA1
Purpura1
PULMONARY SARCOIDOSIS1
Pulmonary mass1
PULMONARY ARTERIAL WEDGE PRESSURE INCREASED1
PSORIASIS1
Pruritus genital1
PROTHROMBIN TIME ABNORMAL1
Protein total increased1
PROTEIN TOTAL DECREASED1
PROSTATOMEGALY1
PROSTATITIS1
PROSTATIC OPERATION1
PROSTATECTOMY1
Product storage error1
Product size issue1
Product packaging issue1
Product outer packaging issue1
Product name confusion1
Product monitoring error1
Product lot number issue1
Product label confusion1
Product formulation issue1
Product dose omission in error1
Product dosage form confusion1
Product dispensing issue1
Product communication issue1
PRIMARY HYPOTHYROIDISM1
Precancerous cells present1
Pre-existing condition improved1
Posterior reversible encephalopathy syndrome1
POST-TRAUMATIC STRESS DISORDER1
POST PROCEDURAL HAEMORRHAGE1
Polydipsia1
PNEUMONIA STAPHYLOCOCCAL1
Pneumonia pseudomonas aeruginosa1
PLEURISY1
Platelet count increased1
Pituitary tumour benign1
PITTING OEDEMA1
Photophobia1
PHARYNGOLARYNGEAL PAIN1
Pharyngeal neoplasm1
Pharyngeal mass1
Pharyngeal disorder1
pH urine increased1
Petechiae1
Personality change1
PERIRECTAL ABSCESS1
Peripheral ischaemia1
PERIPHERAL ARTERIAL OCCLUSIVE DISEASE1
Pericarditis infective1
PERICARDITIS1
Pericardial haemorrhage1
PENILE HAEMORRHAGE1
Paroxysmal arrhythmia1
PAROTITIS1
Parkinsonism1
PARKINSON'S DISEASE1
Paraesthesia oral1
Panic reaction1
Pancreatic disorder1
PALLOR1
Pacemaker generated rhythm1
OTITIS EXTERNA1
OSTEOPENIA1
OSTEONECROSIS1
Osteomyelitis1
ORTHOSTATIC HYPOTENSION1
ORTHOPEDIC PROCEDURE1
Oropharyngeal candidiasis1
ORAL INTAKE REDUCED1
Oral herpes1
Oral candidiasis1
OESTRADIOL DECREASED1
Oesophagitis1
Oesophageal perforation1
Oesophageal pain1
Oesophageal motility disorder1
Ocular hyperaemia1
OBSTRUCTIVE UROPATHY1
Obstructive sleep apnoea syndrome1
Obsessive-compulsive disorder1
Nonspecific reaction1
NON-SMALL CELL LUNG CANCER STAGE IIIA1
NON-HODGKIN'S LYMPHOMA1
Non-high-density lipoprotein cholesterol decreased1
NODAL RHYTHM1
Nodal arrhythmia1
Nipple pain1
NIGHT BLINDNESS1
NEUROPATHY1
NEUROLOGICAL SYMPTOM1
Neuroendocrine carcinoma1
Neuralgia1
Nervous system disorder1
Neoplasm1
NECROTISING FASCIITIS1
Nail injury1
N-terminal prohormone brain natriuretic peptide increased1
MYOCLONUS1
MYCETOMA MYCOTIC1
Myasthenia gravis1
MUSCULOSKELETAL DISORDER1
Muscle swelling1
MUSCLE SPASTICITY1
Muscle rupture1
Muscle contractions involuntary1
Multiple organ dysfunction syndrome1
Mood swings1
MITRAL VALVE REPLACEMENT1
Mitral valve disease1
Mitral valve calcification1
Migraine1
Middle insomnia1
Micturition urgency1
Micturition disorder1
METASTASES TO LARGE INTESTINE1
METAMORPHOPSIA1
Metabolic surgery1
Metabolic function test abnormal1
Metabolic encephalopathy1
MENTAL DISORDER1
Meningitis1
Meniere's disease1
MELAENA1
MEGAKARYOCYTES DECREASED1
Medication residue present1
Medication monitoring error1
MEDICAL DEVICE COMPLICATION1
Mean cell volume abnormal1
Mean cell haemoglobin concentration increased1
Mean cell haemoglobin concentration abnormal1
MARKEDLY REDUCED DIETARY INTAKE1
MANIA1
Malnutrition1
Macular degeneration1
Lymphoedema1
LYMPHATIC SYSTEM NEOPLASM1
LYMPHADENOPATHY MEDIASTINAL1
Lymphadenopathy1
LUNG CANCER METASTATIC1
Loose tooth1
Logorrhoea1
LOCALISED OSTEOARTHRITIS1
LIVER INJURY1
Liver abscess1
Lip ulceration1
Lip swelling1
Ligament rupture1
Ligament injury1
Lichen planus1
Leukocytosis1
LEG AMPUTATION1
LEFT VENTRICULAR HYPERTROPHY1
Left ventricular enlargement1
Left ventricular end-diastolic pressure increased1
Left ventricular dilatation1
Left atrial dilatation1
Laryngitis fungal1
Laryngeal cancer1
Large intestine polyp1
LARGE INTESTINE PERFORATION1
LACTIC ACIDOSIS1
LACRIMATION INCREASED1
Laboratory test abnormal1
Joint range of motion decreased1
Jaundice hepatocellular1
Irritability1
INTRAOCULAR PRESSURE INCREASED1
Intracranial aneurysm1
Intestinal perforation1
INTERVERTEBRAL DISC PROTRUSION1
INTERVERTEBRAL DISC COMPRESSION1
INTERMITTENT CLAUDICATION1
Intercepted product dispensing error1
Intercepted product administration error1
Intercepted drug prescribing error1
Intercepted drug dispensing error1
INTENTIONAL DRUG MISUSE1
Intentional dose omission1
Injury1
INFLUENZA IMMUNISATION1
INCORRECT STORAGE OF DRUG1
Incorrect product storage1
INCISIONAL HERNIA1
INCISION SITE HAEMATOMA1
INCISION SITE COMPLICATION1
Inappropriate schedule of product administration1
IMPLANT SITE REACTION1
ILL-DEFINED DISORDER1
IDIOPATHIC THROMBOCYTOPENIC PURPURA1
Idiopathic pulmonary fibrosis1
Hypoxic-ischaemic encephalopathy1
HYPOXIA1
HYPOTONIA1
HYPONATRAEMIA1
Hypokinesia1
HYPOAESTHESIA ORAL1
HYPERVENTILATION1
Hypertrophic cardiomyopathy1
HYPERTENSIVE CRISIS1
Hypersomnia1
HYPERCHOLESTEROLAEMIA1
Hyperaesthesia1
Hydronephrosis1
Hydrocephalus1
Hostility1
Hordeolum1
HISTONE ANTIBODY POSITIVE1
HIP SWELLING1
High density lipoprotein decreased1
Hiatus hernia1
HERPES SIMPLEX1
HEPATITIS1
HEPATIC NEOPLASM1
HEPATIC FUNCTION ABNORMAL1
HEPATIC ENZYME INCREASED1
HEPATIC ENCEPHALOPATHY1
Hemiparesis1
Helicobacter test positive1
Helicobacter infection1
HEAT STROKE1
HEART VALVE STENOSIS1
HEART VALVE REPLACEMENT1
Heart valve incompetence1
Heart injury1
Hearing impaired1
Head and neck cancer1
Hangover1
HALLUCINATION, VISUAL1
Hair texture abnormal1
Hair colour changes1
HAEMOTHORAX1
HAEMORRHAGIC STROKE1
Haemorrhagic diathesis1
Haemorrhage intracranial1
HAEMOLYTIC ANAEMIA1
HAEMOLYSIS1
HAEMOGLOBIN INCREASED1
Haemoglobin abnormal1
HAEMATOCRIT INCREASED1
Haematocrit abnormal1
HAEMATEMESIS1
HAEMANGIOMA OF LIVER1
GYNAECOMASTIA1
GRAVITATIONAL OEDEMA1
GINGIVITIS1
GINGIVAL RECESSION1
Gingival disorder1
GINGIVAL BLEEDING1
GENITAL INFECTION FEMALE1
General symptom1
General physical health deterioration1
Gastrostomy1
GASTROOESOPHAGEAL CANCER1
Gastrointestinal necrosis1
GASTROINTESTINAL FUNGAL INFECTION1
Gastroenteritis norovirus1
Gastroenteritis1
Gastric ulcer perforation1
Gastric banding1
FULL BLOOD COUNT DECREASED1
FRIEDREICH'S ATAXIA1
FRACTURE1
Foot fracture1
FOOD POISONING1
Food allergy1
Follicle centre lymphoma, follicular grade I, II, III recurrent1
FIBROMYALGIA1
Feelings of worthlessness1
Feeling jittery1
Feeding disorder1
Familial amyotrophic lateral sclerosis1
Faeces discoloured1
FACIAL PALSY1
Facial bones fracture1
Eyelid pain1
Eye swelling1
Eye pain1
Eye movement disorder1
Eye inflammation1
Eye haemorrhage1
Eye disorder1
EXPOSURE TO TOXIC AGENT1
Expired product administered1
Exostosis1
ESCHERICHIA URINARY TRACT INFECTION1
Eructation1
EPIGASTRIC DISCOMFORT1
ENTEROVESICAL FISTULA1
Enterocolitis infectious1
Enterocolitis1
Energy increased1
Electrolyte imbalance1
Electrocardiogram U-wave prominent1
ELECTROCARDIOGRAM U-WAVE ABNORMALITY1
ELECTROCARDIOGRAM ST-T CHANGE1
Electrocardiogram ST segment depression1
ELECTROCARDIOGRAM REPOLARISATION ABNORMALITY1
Electrocardiogram QT interval1
ELECTROCARDIOGRAM QT CORRECTED INTERVAL1
ELECTROCARDIOGRAM QRS COMPLEX ABNORMAL1
Electrocardiogram Q wave abnormal1
Electrocardiogram PR prolongation1
Electrocardiogram P wave abnormal1
ELECTROCARDIOGRAM NORMAL1
ECHOCARDIOGRAM ABNORMAL1
ECCHYMOSIS1
Eating disorder1
Ear disorder1
Ear discomfort1
Dyspnoea paroxysmal nocturnal1
Dysphoria1
Dysarthria1
Drug resistance1
Drug monitoring procedure not performed1
DRUG LEVEL INCREASED1
DRUG LEVEL DECREASED1
Drug dependence1
Drug clearance decreased1
Dressler's syndrome1
Diverticulum intestinal haemorrhagic1
DIVERTICULUM1
DIAPHRAGMATIC DISORDER1
Diabetic ulcer1
Diabetic complication1
DIABETES MELLITUS INADEQUATE CONTROL1
Device use issue1
Device related infection1
DERMAL CYST1
Depressed mood1
Dependence on respirator1
DECUBITUS ULCER1
DEAFNESS NEUROSENSORY1
CYTOMEGALOVIRUS INFECTION1
CYTOMEGALOVIRUS HEPATITIS1
CYSTITIS RADIATION1
CYSTITIS HAEMORRHAGIC1
Cyst rupture1
Cyst1
Cutaneous vasculitis1
Cutaneous T-cell lymphoma1
Cutaneous lupus erythematosus1
Crepitations1
CREATINE URINE INCREASED1
COVID-19 pneumonia1
CORONARY ARTERY OCCLUSION1
CORONARY ARTERY BYPASS1
CORONARY ARTERY ATHEROSCLEROSIS1
Coordination abnormal1
Contraindication to medical treatment1
Contraindicated drug prescribed1
Conjunctivitis1
Concussion1
Clostridium difficile infection1
CLOSTRIDIUM DIFFICILE COLITIS1
Clavicle fracture1
Chronic respiratory failure1
CHRONIC LYMPHOCYTIC LEUKAEMIA1
Chronic leukaemia1
Chronic kidney disease1
CHOROID MELANOMA1
Chondropathy1
CHOLINERGIC SYNDROME1
Cholecystitis acute1
CHOLECYSTITIS1
Cholangiocarcinoma1
CHEST WALL PAIN1
Cervical vertebral fracture1
Cerebrovascular disorder1
Cerebral palsy1
CEREBRAL INFARCTION1
CATHETERISATION CARDIAC ABNORMAL1
Catheterisation cardiac1
CATATONIA1
CAROTID BRUIT1
Carotid artery occlusion1
CAROTID ARTERY DISEASE1
Cardiac pacemaker replacement1
CARDIAC NEOPLASM UNSPECIFIED1
Cardiac enzymes increased1
Cardiac assistance device user1
Cardiac amyloidosis1
CARCINOID SYNDROME1
CANDIDIASIS1
Calcinosis1
Bursitis1
BUNDLE BRANCH BLOCK RIGHT1
BUNDLE BRANCH BLOCK LEFT1
Bulbar palsy1
BREATHING-RELATED SLEEP DISORDER1
Breath sounds abnormal1
BREAST DISORDER1
BREAST CYST1
Breast cancer recurrent1
Brain neoplasm1
Brain natriuretic peptide increased1
Brain death1
Brain contusion1
Bradyphrenia1
Bone swelling1
BONE NEOPLASM MALIGNANT1
Bone neoplasm1
BONE MARROW DISORDER1
BONE INFECTION1
Bone cancer1
Body temperature increased1
Blood urine present1
BLOOD TESTOSTERONE DECREASED1
Blood testosterone abnormal1
BLOOD PRESSURE SYSTOLIC INCREASED1
BLOOD PRESSURE SYSTOLIC DECREASED1
BLOOD PRESSURE DIASTOLIC DECREASED1
Blood pressure ambulatory increased1
Blood phosphorus decreased1
Blood magnesium abnormal1
Blood loss anaemia1
BLOOD IMMUNOGLOBULIN M INCREASED1
BLOOD GASES ABNORMAL1
BLOOD ELECTROLYTES ABNORMAL1
BLOOD CREATINE PHOSPHOKINASE INCREASED1
Blood creatine abnormal1
Blood cholesterol decreased1
BLOOD CALCIUM INCREASED1
Blood calcium abnormal1
Blood blister1
Blood bilirubin increased1
Blood alcohol abnormal1
BLOOD ALBUMIN DECREASED1
BLINDNESS TRANSIENT1
Blepharitis1
Bleeding time prolonged1
BLADDER STENOSIS1
Bile duct cancer1
BENIGN PROSTATIC HYPERPLASIA1
BENIGN BREAST NEOPLASM1
BARRETT'S OESOPHAGUS1
BACTERIURIA1
BACTERIAL TEST POSITIVE1
BACTERIA URINE IDENTIFIED1
AUTONOMIC NERVOUS SYSTEM IMBALANCE1
Auditory disorder1
ATRIAL SEPTAL DEFECT1
ATRIAL NATRIURETIC PEPTIDE INCREASED1
Aspiration1
Asphyxia1
Aspergilloma1
ASCITES1
Arthropod bite1
Arthritis bacterial1
Arteriosclerosis1
ARTERIAL STENOSIS1
Arrhythmic storm1
Appetite disorder1
Appendicitis1
APNOEA1
APHTHOUS STOMATITIS1
APHAGIA1
APATHY1
Aortic valve stenosis1
Aortic valve sclerosis1
Aortic valve replacement1
ANTICOAGULATION DRUG LEVEL ABOVE THERAPEUTIC1
ANHIDROSIS1
ANGIOPATHY1
ANGIONEUROTIC OEDEMA1
ANGIOGRAM1
ANGER1
ALTERED STATE OF CONSCIOUSNESS1
Allergy to animal1
ALLERGIC SINUSITIS1
Alcohol use1
ALANINE AMINOTRANSFERASE1
AGITATION POSTOPERATIVE1
ADENOCARCINOMA1
Acute respiratory failure1
ACUTE LEFT VENTRICULAR FAILURE1
ACUTE HEPATIC FAILURE1
ACUTE CORONARY SYNDROME1
ACTIVATED PARTIAL THROMBOPLASTIN TIME SHORTENED1
ACTIVATED PARTIAL THROMBOPLASTIN TIME PROLONGED1
ACCIDENTAL EXPOSURE1
ACCELERATED IDIOVENTRICULAR RHYTHM1
Abscess oral1
Abscess1
Abnormal faeces1
ABDOMINAL SYMPTOM1
Abdominal neoplasm1





Filtered ChEMBL targets:

Target UniProtKB ID Activity in nm Target Name Target gene
Q12809 4.1 Potassium voltage-gated channel subfamily H member 2 KCNH2_HUMAN



Toxicity information:

Toxicity class: 5
Toxicity type: cardiovascular
LD50: 2600 mg/kg



External links:

ChEBML: CHEMBL473
DrugBank: DB00204