Astemizole

General information:

Withdrawn ID:	w46
Canonical SMILES:
Standard InChI:
Standard InChIKey:
ATC class(es):	R06AX11
Molecular Formula:	C28H31FN4O
Molweight:	458.57

Withdrawal information:

Withdrawn due to drug safety reasons:	Yes
First approved:	1988
First withdrawn:	1989
Last withdrawn:	2003

Filtered ChEMBL targets:

Target UniProtKB ID	Activity in nm	Target Name	Target gene
O75604	5011.9	Ubiquitin carboxyl-terminal hydrolase 2	UBP2_HUMAN
P02545	7943.3	Prelamin-A/C	LMNA_HUMAN
P04439	2500	HLA class I histocompatibility antigen, A alpha chain	HLAA_HUMAN
P10636	1584.9	Microtubule-associated protein tau	TAU_HUMAN
P23415	4200	Glycine receptor subunit alpha-1	GLRA1_HUMAN
P35346	4070	Somatostatin receptor type 5	SSR5_HUMAN
P35367	2.089	Histamine H1 receptor	HRH1_HUMAN
Q12809	0.9	Potassium voltage-gated channel subfamily H member 2	KCNH2_HUMAN
Q16637	1995.3	Survival motor neuron protein	SMN_HUMAN
Q5BJF2	95	Sigma intracellular receptor 2	SGMR2_HUMAN
Q99720	1258.93	Sigma non-opioid intracellular receptor 1	SGMR1_HUMAN
Q9H3N8	7943.28	Histamine H4 receptor	HRH4_HUMAN

Toxicity information:

Toxicity class:	5
Toxicity type:	cardiovascular
LD50:	2560 mg/kg

External links:

ChEBML:	CHEMBL296419
DrugBank:	DB00637