Cisapride


w28



General information:


Withdrawn ID: w28
Canonical SMILES:
Standard InChI:
Standard InChIKey:
ATC class(es): A03FA02
Molecular Formula: C23H29ClFN3O4
Molweight: 465.945



Withdrawal information:


Withdrawn due to drug safety reasons:Yes
First approved: 1993
First death: 1993
First withdrawn: 1999
Last withdrawn: 2002
Reference: https://www.ncbi.nlm.nih.gov/pubmed/21574210



Side-effects:

Total reported cases (submitted by medical professionals) with Cisapride as primary suspect: 483


Reported final outcomes:
Hospitalization (initial or prolonged): 232
Death: 147
Life-Threatening condition: 106
Disability: 7
Intervention required to prevent permanent impairment/damage: 7
Congenital anomaly: 1


Reported side-effects:

Side-effect Case number
ELECTROCARDIOGRAM QT PROLONGED332
CARDIAC DISORDER88
VENTRICULAR TACHYCARDIA79
VENTRICULAR FIBRILLATION72
TORSADE DE POINTES72
PALPITATIONS53
CHEST PAIN45
INJURY32
DISABILITY31
ELECTROCARDIOGRAM QT CORRECTED INTERVAL PROLONGED26
Death24
ARRHYTHMIA24
PNEUMONIA23
DYSPNOEA21
CONDITION AGGRAVATED18
ATRIAL FIBRILLATION16
ABDOMINAL PAIN16
RESPIRATORY FAILURE15
MEDICATION ERROR15
TACHYCARDIA14
Drug ineffective14
DEPRESSION14
DEHYDRATION14
VOMITING13
Sepsis12
DIARRHOEA12
VENTRICULAR EXTRASYSTOLES11
CARDIAC ARREST11
RENAL FAILURE10
Nausea10
MYOCARDIAL INFARCTION10
URINARY TRACT INFECTION9
IMPAIRED GASTRIC EMPTYING9
GASTROOESOPHAGEAL REFLUX DISEASE9
FUNDOPLICATION9
CHEST DISCOMFORT9
ANXIETY9
SUPRAVENTRICULAR TACHYCARDIA8
SMALL INTESTINAL OBSTRUCTION8
PAIN8
DRUG INTERACTION8
SUICIDE ATTEMPT7
PLEURAL EFFUSION7
HYPERTENSION7
HEART RATE IRREGULAR7
HEART RATE INCREASED7
DIZZINESS7
CORONARY ARTERY DISEASE7
CARDIAC FAILURE7
BRONCHITIS7
SYNCOPE6
Sinus tachycardia6
SINUS BRADYCARDIA6
ELECTROCARDIOGRAM ABNORMAL6
CEREBROVASCULAR ACCIDENT6
CARDIAC FAILURE CONGESTIVE6
ASTHENIA6
ANAEMIA6
RESPIRATORY DISTRESS5
Pneumonia aspiration5
OESOPHAGITIS5
MALIGNANT NEOPLASM PROGRESSION5
LOSS OF CONSCIOUSNESS5
HYPOKALAEMIA5
HEADACHE5
HAEMOGLOBIN DECREASED5
DECREASED APPETITE5
COMPLETED SUICIDE5
ABDOMINAL DISTENSION5
VIRAL INFECTION4
VAGUS NERVE DISORDER4
SUDDEN DEATH4
SEPTIC SHOCK4
Road traffic accident4
RESPIRATORY ARREST4
RECTAL HAEMORRHAGE4
PYREXIA4
PULMONARY OEDEMA4
NO ADVERSE DRUG EFFECT4
MEMORY IMPAIRMENT4
MALAISE4
Lung neoplasm malignant4
GASTROINTESTINAL HAEMORRHAGE4
GASTRITIS4
FATIGUE4
Electrocardiogram T wave abnormal4
DYSPHAGIA4
DIABETES MELLITUS4
CARDIO-RESPIRATORY ARREST4
CACHEXIA4
BUNDLE BRANCH BLOCK RIGHT4
BRADYCARDIA4
AUTONOMIC NEUROPATHY4
ATRIOVENTRICULAR BLOCK FIRST DEGREE4
ASTHMA4
ABDOMINAL HERNIA4
VERTIGO3
Urosepsis3
UPPER RESPIRATORY TRACT INFECTION3
SUPRAVENTRICULAR EXTRASYSTOLES3
SUICIDAL IDEATION3
SOMNOLENCE3
RENAL FAILURE ACUTE3
REFLUX OESOPHAGITIS3
POLLAKIURIA3
PERITONITIS3
PERITONEAL CARCINOMA3
PALLOR3
OVERDOSE3
OESOPHAGOGASTRIC FUNDOPLASTY3
OEDEMA3
Myocardial ischaemia3
MITRAL VALVE PROLAPSE3
MENTAL DISORDER3
INTESTINAL PERFORATION3
ILEUS3
HYPOTENSION3
Hyperkalaemia3
Hospitalisation3
HIATUS HERNIA3
HEART INJURY3
HAEMATOCHEZIA3
FALL3
EXTRASYSTOLES3
DUODENITIS3
DRUG EFFECT DECREASED3
Diabetic ketoacidosis3
CARDIOMYOPATHY3
CARDIOMEGALY3
CARDIAC VALVE DISEASE3
BUNDLE BRANCH BLOCK LEFT3
BLOOD POTASSIUM INCREASED3
BACK PAIN3
ANOREXIA3
ANGINA PECTORIS3
ABDOMINAL PAIN UPPER3
WOUND INFECTION2
WHITE BLOOD CELL COUNT INCREASED2
WEIGHT INCREASED2
VENTRICULAR HYPERTROPHY2
VENTRICULAR ARRHYTHMIA2
URTICARIA2
TRICUSPID VALVE INCOMPETENCE2
TRANSIENT ISCHAEMIC ATTACK2
Thrombosis2
THROMBOCYTOPENIA2
THERAPEUTIC AGENT TOXICITY2
SUDDEN INFANT DEATH SYNDROME2
SPINAL FRACTURE2
SLEEP APNOEA SYNDROME2
SINUSITIS2
SHOCK2
Scleroderma2
RESPIRATORY TRACT INFECTION2
RESPIRATORY DISORDER2
QRS axis abnormal2
PULSE ABNORMAL2
Pulmonary hypertension2
PULMONARY EMBOLISM2
POSTOPERATIVE INFECTION2
Post procedural complication2
Parkinson's disease2
PAIN IN EXTREMITY2
OVARIAN CANCER2
OESOPHAGEAL OBSTRUCTION2
MUSCULOSKELETAL CHEST PAIN2
MUSCLE SPASMS2
MULTI-ORGAN FAILURE2
MITRAL VALVE CALCIFICATION2
LUNG NEOPLASM2
Lethargy2
Jaundice cholestatic2
Intestinal pseudo-obstruction2
INTESTINAL OBSTRUCTION2
INTERVERTEBRAL DISC PROTRUSION2
INSOMNIA2
INFLUENZA2
Incorrect dose administered2
HYPOGLYCAEMIA2
HAEMOPTYSIS2
GENERAL PHYSICAL HEALTH DETERIORATION2
GASTROSTOMY2
GASTRIC PERFORATION2
GASTRIC OUTLET OBSTRUCTION2
GASTRIC CANCER2
FOOD INTOLERANCE2
FEELING ABNORMAL2
Feeding intolerance2
ESCHERICHIA INFECTION2
EPIGASTRIC DISCOMFORT2
EMPHYSEMA2
Electrolyte imbalance2
Dilatation atrial2
DIAPHRAGMATIC HERNIA2
Diabetic gastropathy2
Device related infection2
DEPRESSED LEVEL OF CONSCIOUSNESS2
DECUBITUS ULCER2
CYSTIC FIBROSIS PANCREATIC2
COUGH2
CORONARY ARTERY ATHEROSCLEROSIS2
CONTRAINDICATION TO MEDICAL TREATMENT2
CONSTIPATION2
CONGESTIVE CARDIOMYOPATHY2
CONFUSIONAL STATE2
CHRONIC RESPIRATORY FAILURE2
Chronic obstructive pulmonary disease2
CHOLESTASIS2
CHOKING2
CEREBRAL INFARCTION2
Cellulitis2
CARDIAC FLUTTER2
C-REACTIVE PROTEIN INCREASED2
BRONCHOPNEUMONIA2
BRONCHIOLITIS2
BLOOD PRESSURE SYSTOLIC INCREASED2
BLOOD POTASSIUM DECREASED2
BLOOD CREATININE INCREASED2
Bacterial sepsis2
AORTIC VALVE CALCIFICATION2
ADVERSE EVENT2
ADHESION2
ACUTE RESPIRATORY FAILURE2
ACUTE MYOCARDIAL INFARCTION2
ACIDOSIS2
WHITE BLOOD CELL DISORDER1
WHEEZING1
WEIGHT GAIN POOR1
WEIGHT DECREASED1
VOMITING PSYCHOGENIC1
Volvulus of small bowel1
Volvulus1
VIRUS SEROLOGY TEST POSITIVE1
VIRAL UPPER RESPIRATORY TRACT INFECTION1
VICTIM OF CRIME1
Vascular device infection1
VARICOSE ULCERATION1
URINARY INCONTINENCE1
Urethral obstruction1
Ureteral stent insertion1
Unevaluable event1
TUMOUR HAEMORRHAGE1
TREATMENT NONCOMPLIANCE1
TRAUMATIC INTRACRANIAL HAEMORRHAGE1
Transaminases increased1
Toxic epidermal necrolysis1
TOURETTE'S DISORDER1
TONIC CONVULSION1
TONGUE NEOPLASM MALIGNANT STAGE UNSPECIFIED1
THERAPY NON-RESPONDER1
Therapeutic response decreased1
TESTICULAR RETRACTION1
TENDON RUPTURE1
SUPERINFECTION1
STRESS SYMPTOMS1
Stoma complication1
Staphylococcal sepsis1
SPONDYLOSIS1
Spinal fusion surgery1
SMALL INTESTINE CARCINOMA RECURRENT1
SMALL INTESTINE CARCINOMA1
SLEEP DISORDER1
SKIN GRAFT1
Sjogren's syndrome1
SEPSIS SYNDROME1
Sensory loss1
Seizure1
SCREAMING1
RUPTURED CEREBRAL ANEURYSM1
Right ventricular failure1
RHYTHM IDIOVENTRICULAR1
RHINITIS1
Rhabdomyolysis1
RESPIRATORY MONILIASIS1
RESPIRATORY DEPRESSION1
REFUSAL OF TREATMENT BY PATIENT1
RED BLOOD CELL COUNT DECREASED1
RADIUS FRACTURE1
PURULENT PERICARDITIS1
Pulmonary fibrosis1
Pulmonary artery stenosis congenital1
PSORIASIS1
Pseudomembranous colitis1
Pruritus1
PROSTATITIS1
Product label confusion1
Product availability issue1
Procedural pain1
Postoperative respiratory failure1
POSTOPERATIVE ADHESION1
Post procedural haemorrhage1
PORPHYRIA1
POLYMYOSITIS1
POLYMYALGIA1
PO2 INCREASED1
PNEUMOTHORAX1
Pneumonia legionella1
PLATELET COUNT INCREASED1
PHOTOPHOBIA1
PHARYNGOLARYNGEAL PAIN1
PHARYNGITIS1
PERICARDITIS1
PERICARDIAL EFFUSION1
PCO2 DECREASED1
PARKINSONIAN REST TREMOR1
PANIC REACTION1
Pancreatic carcinoma metastatic1
PAIN EXACERBATED1
OVARIAN CYST1
OTITIS MEDIA1
Oral candidiasis1
Off label use1
OESOPHAGEAL SPASM1
Oesophageal carcinoma stage 01
OESOPHAGEAL CARCINOMA1
Obstruction1
NOSOCOMIAL INFECTION1
Non-small cell lung cancer stage IV1
Non-small cell lung cancer1
NICOTINE DEPENDENCE1
NEUTROPHIL PERCENTAGE DECREASED1
NEUTROPENIA1
Neuroendocrine carcinoma1
NERVOUSNESS1
NERVOUS SYSTEM DISORDER1
NEPHROPATHY TOXIC1
Nephrolithiasis1
NEPHRITIS INTERSTITIAL1
NEONATAL DISORDER1
Necrotising colitis1
NASOPHARYNGITIS1
MYOCARDITIS1
MYALGIA1
MUSCULAR WEAKNESS1
MUSCULAR DYSTROPHY1
MUSCLE STRAIN1
MUSCLE HYPERTROPHY1
MUSCLE FATIGUE1
MUSCLE DISORDER1
MUSCLE CONTRACTIONS INVOLUNTARY1
Multiple organ dysfunction syndrome1
Multiple allergies1
MITRAL VALVE INCOMPETENCE1
MITRAL VALVE DISEASE1
Migraine1
METASTATIC CARCINOMA OF THE BLADDER1
Metastases to bone1
METABOLIC ACIDOSIS1
MENTAL IMPAIRMENT1
MARKEDLY REDUCED DIETARY INTAKE1
MALNUTRITION1
MAJOR DEPRESSION1
LYMPHOCYTE PERCENTAGE INCREASED1
LYMPHADENITIS1
LUNG TRANSPLANT REJECTION1
LUNG TRANSPLANT1
LUNG INFILTRATION1
LUNG ABSCESS1
LOCALISED INFECTION1
LIVER FUNCTION TEST ABNORMAL1
LIVER DISORDER1
LIMB INJURY1
LEUKOCYTOSIS1
LEG AMPUTATION1
LACERATION1
KNEE ARTHROPLASTY1
JUGULAR VEIN THROMBOSIS1
JOINT INJURY1
Jaundice1
IRRITABILITY1
IRON DEFICIENCY ANAEMIA1
INTRADUCTAL PAPILLOMA OF BREAST1
INTESTINAL HYPOMOTILITY1
Intentional overdose1
INFECTION IN AN IMMUNOCOMPROMISED HOST1
INFECTION1
INFARCTION1
INCONTINENCE1
Immobile1
Ileostomy closure1
ILEOCOLOSTOMY1
Hysterectomy1
HYPOTHYROIDISM1
Hyponatraemia1
HYPOGAMMAGLOBULINAEMIA1
Hypoalbuminaemia1
HYPERVENTILATION1
HYPERTRIGLYCERIDAEMIA1
HYPERTHYROIDISM1
HYPERSOMNIA1
Hypersensitivity1
HYPERHIDROSIS1
Hyperglycaemia1
Hypercapnia1
Hip fracture1
HERNIA1
HEPATOSPLENOMEGALY1
HEPATITIS TOXIC1
HEPATITIS ACUTE1
HEPATITIS1
HEPATIC STEATOSIS1
HEPATIC HAEMATOMA1
Hepatic function abnormal1
HEPATIC CIRRHOSIS1
Hemiparesis1
HEART VALVE INSUFFICIENCY1
HEART VALVE INCOMPETENCE1
HEART RATE ABNORMAL1
HEAD INJURY1
HAIR GROWTH ABNORMAL1
HAEMORRHOIDS1
HAEMORRHOID OPERATION1
Haemorrhagic anaemia1
HAEMORRHAGE1
HAEMATURIA1
HAEMATOCRIT DECREASED1
HAEMATEMESIS1
Growth retardation1
GROIN PAIN1
GLYCOSYLATED HAEMOGLOBIN INCREASED1
Generalised oedema1
Gastrointestinal stoma complication1
GASTROINTESTINAL OBSTRUCTION1
Gastrointestinal motility disorder1
GASTROINTESTINAL INJURY1
Gastrointestinal hypomotility1
Gastrointestinal disorder1
Gastroenteritis sapovirus1
GASTROENTERITIS EOSINOPHILIC1
Gastroenteritis1
GASTRIC ULCER HAEMORRHAGE1
GASTRIC STENOSIS1
Gastric fistula1
GASTRIC DILATATION1
Gastric cancer stage IV1
GANGRENE1
GALLBLADDER ABSCESS1
Fungal sepsis1
Functional gastrointestinal disorder1
Frequent bowel movements1
FOAMING AT MOUTH1
FLUID RETENTION1
FIBROMYALGIA1
Femur fracture1
FEEDING DISORDER1
FAECALOMA1
Facial paralysis1
Expired product administered1
ESCHERICHIA URINARY TRACT INFECTION1
ESCHERICHIA SEPSIS1
EOSINOPHIL PERCENTAGE INCREASED1
ENURESIS1
Enterovirus infection1
Enterocolitis1
Enterococcal infection1
Enteritis1
ENDOSCOPY UPPER GASTROINTESTINAL TRACT ABNORMAL1
Endocarditis1
ENCEPHALOPATHY1
EMPYEMA1
ELECTROMECHANICAL DISSOCIATION1
Electrocardiogram T wave inversion1
ELECTROCARDIOGRAM ST SEGMENT ELEVATION1
Electrocardiogram ST segment abnormal1
Electrocardiogram QRS complex prolonged1
Electrocardiogram QRS complex abnormal1
ELECTROCARDIOGRAM P WAVE ABNORMAL1
ELBOW DEFORMITY1
EJECTION FRACTION DECREASED1
EFFUSION1
ECTOPIC PREGNANCY1
Dystonia1
DYSPNOEA EXERTIONAL1
Dyspepsia1
DRY MOUTH1
DRUG TOXICITY1
Drug prescribing error1
Drug hypersensitivity1
Drug dose omission1
Drug administration error1
DOLICHOCOLON ACQUIRED1
DIVERTICULUM INTESTINAL1
DIVERTICULUM1
Diverticular perforation1
DISEASE PROGRESSION1
DILATATION VENTRICULAR1
DIASTOLIC DYSFUNCTION1
DIALYSIS1
DIABETIC NEUROPATHY1
Diabetic gastroparesis1
DIABETIC COMPLICATION1
Diabetic coma1
DIABETES MELLITUS NON-INSULIN-DEPENDENT1
Diabetes mellitus inadequate control1
Diabetes insipidus1
DENTAL CARIES1
DEMENTIA1
CYTOLYTIC HEPATITIS1
CYANOSIS1
CORONARY ANGIOPLASTY1
CONVULSION1
Contusion1
Congenital megacolon1
CONGENITAL ATRIAL SEPTAL DEFECT1
Congenital anomaly1
CONDUCTION DISORDER1
COMPUTERISED TOMOGRAM ABDOMEN ABNORMAL1
COMMUNICATION DISORDER1
COLONIC POLYP1
COLON CANCER1
COLLAGEN DISORDER1
Colitis1
Coagulopathy1
CLOSTRIDIUM TEST POSITIVE1
CLOSTRIDIUM DIFFICILE COLITIS1
Chronic hepatic failure1
CHOLELITHIASIS1
Cholecystitis infective1
CHOLECYSTITIS ACUTE1
CHOLECYSTITIS1
Chills1
CHEST X-RAY ABNORMAL1
CHEST WALL PAIN1
CEREBRAL ISCHAEMIA1
Catheter site infection1
CATHETER RELATED COMPLICATION1
CAROTID BRUIT1
Cardiogenic shock1
CARDIOACTIVE DRUG LEVEL INCREASED1
CARDIAC MURMUR1
CANDIDIASIS1
CALCINOSIS1
BRONCHOPULMONARY DYSPLASIA1
BRONCHOPNEUMOPATHY1
BRONCHITIS ACUTE1
BRONCHIAL INFECTION1
BRONCHIAL HYPERACTIVITY1
BREAST NEOPLASM MALE1
BRAIN TUMOUR OPERATION1
Brain injury1
BRAIN DAMAGE1
BRADYPNOEA1
BLOOD UREA INCREASED1
BLOOD UREA DECREASED1
BLOOD SODIUM DECREASED1
BLOOD PROLACTIN INCREASED1
BLOOD PRESSURE INCREASED1
BLOOD PRESSURE DECREASED1
BLOOD MAGNESIUM DECREASED1
Blood loss anaemia1
BLOOD GLUCOSE INCREASED1
BLOOD GLUCOSE FLUCTUATION1
Blood glucose decreased1
BLOOD FOLLICLE STIMULATING HORMONE INCREASED1
BLOOD CREATININE DECREASED1
BLOOD BILIRUBIN INCREASED1
BLOOD BICARBONATE DECREASED1
Biloma infected1
BILIRUBIN CONJUGATED INCREASED1
BILE DUCT CANCER1
Benign bone neoplasm1
BASE EXCESS NEGATIVE1
BALANITIS1
ATRIOVENTRICULAR CANAL1
ATRIOVENTRICULAR BLOCK1
ATRIAL THROMBOSIS1
Atrial septal defect1
ATRIAL HYPERTROPHY1
ATRIAL FLUTTER1
ATHEROSCLEROSIS1
ATELECTASIS1
ATAXIA1
Aspiration1
Asphyxia1
ASPERGILLOSIS1
ASCITES1
ARTHRITIS1
Arteriosclerosis coronary artery1
ARTERIOSCLEROSIS1
APPENDICITIS PERFORATED1
APHAGIA1
AORTIC VALVE SCLEROSIS1
AORTIC VALVE INCOMPETENCE1
ANOXIC ENCEPHALOPATHY1
Ankle fracture1
ANGIOGRAM ABNORMAL1
ANDROGENS ABNORMAL1
AMYLOIDOSIS1
ALOPECIA1
AGGRESSION1
ADENOVIRUS INFECTION1
ADENOIDECTOMY1
Adenocarcinoma pancreas1
ACUTE RESPIRATORY DISTRESS SYNDROME1
Acute kidney injury1
ACUTE CORONARY SYNDROME1
ACQUIRED PYLORIC STENOSIS1
ACCOMMODATION DISORDER1
Accidental overdose1
ABSCESS1
ABDOMINAL ADHESIONS1





Filtered ChEMBL targets:

Target UniProtKB ID Activity in nm Target Name Target gene
P08908 794.33 5-hydroxytryptamine receptor 1A 5HT1A_HUMAN
P14416 227 D(2) dopamine receptor DRD2_HUMAN
P21728 1700 D(1A) dopamine receptor DRD1_HUMAN
P28223 6.31 5-hydroxytryptamine receptor 2A 5HT2A_HUMAN
P34969 1000 5-hydroxytryptamine receptor 7 5HT7R_HUMAN
P41595 39.81 5-hydroxytryptamine receptor 2B 5HT2B_HUMAN
P46098 1995.26 5-hydroxytryptamine receptor 3A 5HT3A_HUMAN
Q12809 6.457 Potassium voltage-gated channel subfamily H member 2 KCNH2_HUMAN
Q13639 79.43 5-hydroxytryptamine receptor 4 5HT4R_HUMAN



Toxicity information:

Toxicity class: 5
Toxicity type: cardiovascular
LD50: 3000 mg/kg



External links:

ChEBML: CHEMBL1729
DrugBank: DB00604