Orciprenaline
General information:
| Withdrawn ID: | w242 |
|---|---|
| Canonical SMILES: | |
| Standard InChI: | |
| Standard InChIKey: | |
| ATC class(es): | R03AB03 |
| R03CB03 | |
| R03CB53 | |
| Molecular Formula: | C11H17NO3 |
| Molweight: | 211.258 |
Withdrawal information:
| Withdrawn due to drug safety reasons: | Yes |
|---|---|
| First approved: | 2003 |
| First withdrawn: | 2009 |
| Last withdrawn: | 2009 |
| Reference: | https://www.ncbi.nlm.nih.gov/pubmed/23920058 |
Side-effects:
| Total reported cases (submitted by medical professionals) with Orciprenaline as primary suspect: | 10 |
|---|
Reported final outcomes:
| Hospitalization (initial or prolonged): | 5 |
|---|---|
| Life-Threatening condition: | 3 |
| Disability: | 1 |
| Intervention required to prevent permanent impairment/damage: | 1 |
Reported side-effects:
| Side-effect | Case number |
|---|---|
| ATRIAL FIBRILLATION | 1 |
| HYPERHIDROSIS | 1 |
| FEBRILE NEUTROPENIA | 1 |
| DYSPNOEA | 1 |
| DRUG INTERACTION | 1 |
| DIARRHOEA | 1 |
| DEPRESSION | 1 |
| CIRCULATORY COLLAPSE | 1 |
| CHEST PAIN | 1 |
| BONE PAIN | 1 |
| HYPOKINESIA | 1 |
| ASTHENIA | 1 |
| ARRHYTHMIA SUPRAVENTRICULAR | 1 |
| ANTICONVULSANT DRUG LEVEL INCREASED | 1 |
| ALCOHOL ABUSE | 1 |
| Adverse drug reaction | 1 |
| ACUTE MYOCARDIAL INFARCTION | 1 |
| ABORTION INDUCED | 1 |
| ABDOMINAL PAIN | 1 |
| PALPITATIONS | 1 |
| UTERINE CONTRACTIONS DURING PREGNANCY | 1 |
| TREMOR | 1 |
| SUICIDAL IDEATION | 1 |
| STRESS CARDIOMYOPATHY | 1 |
| RASH MACULO-PAPULAR | 1 |
| PULMONARY OEDEMA | 1 |
| Product name confusion | 1 |
| PNEUMONIA | 1 |
| PARAESTHESIA | 1 |
| Wrong drug | 1 |
| OVERDOSE | 1 |
| NEUTROPENIC SEPSIS | 1 |
| MUCOSAL INFLAMMATION | 1 |
| LUNG CONSOLIDATION | 1 |
| LIP SWELLING | 1 |
| Intercepted product prescribing error | 1 |
| INFECTION | 1 |
| HYPOTENSION | 1 |
Filtered ChEMBL targets:
| Target UniProtKB ID | Activity in nm | Target Name | Target gene |
|---|---|---|---|
| P07550 | 501.19 | Beta-2 adrenergic receptor | ADRB2_HUMAN |
Toxicity information:
| Toxicity class: | 5 |
|---|---|
| Toxicity type: | cardiovascular |
| LD50: | 3370 mg/kg |
External links:
| ChEBML: | CHEMBL776 |
|---|---|
| DrugBank: | DB00816 |