Bupropion

General information:

Withdrawn ID:	w236
Canonical SMILES:
Standard InChI:
Standard InChIKey:
ATC class(es):	N06AX12
Molecular Formula:	C13H18ClNO
Molweight:	239.741

Withdrawal information:

Withdrawn due to drug safety reasons:	Yes
First approved:	1985
First withdrawn:	1986
Last withdrawn:	1986
Reference:	https://www.ncbi.nlm.nih.gov/pubmed/25502485

Side-effects:

Total reported cases (submitted by medical professionals) with Bupropion as primary suspect:	10057

Reported final outcomes:

Hospitalization (initial or prolonged):	3057
Death:	2925
Life-Threatening condition:	520
Disability:	158
Intervention required to prevent permanent impairment/damage:	123
Congenital anomaly:	101

Reported side-effects:

Side-effect	Case number
COMPLETED SUICIDE	2328
TOXICITY TO VARIOUS AGENTS	1130
OVERDOSE	838
INTENTIONAL OVERDOSE	809
Seizure	684
DRUG INEFFECTIVE	627
NAUSEA	602
DEPRESSION	530
ANXIETY	473
CARDIO-RESPIRATORY ARREST	436
HEADACHE	434
CONVULSION	431
DRUG ABUSE	417
PRODUCT SUBSTITUTION ISSUE	410
DIZZINESS	409
SUICIDE ATTEMPT	388
CARDIAC ARREST	371
DEATH	365
VOMITING	355
HYPOTENSION	348
AGITATION	345
TREMOR	342
INSOMNIA	341
ELECTROCARDIOGRAM QT PROLONGED	332
POISONING	330
SUICIDAL IDEATION	325
DRUG INTERACTION	316
FEELING ABNORMAL	305
SEROTONIN SYNDROME	297
TACHYCARDIA	284
ELECTROCARDIOGRAM QRS COMPLEX PROLONGED	253
FATIGUE	252
STATUS EPILEPTICUS	250
Generalised tonic-clonic seizure	247
CONDITION AGGRAVATED	233
CONFUSIONAL STATE	227
URTICARIA	218
SOMNOLENCE	203
RASH	200
GRAND MAL CONVULSION	189
IRRITABILITY	175
PHARMACEUTICAL PRODUCT COMPLAINT	172
RESPIRATORY ARREST	171
MALAISE	170
DYSPNOEA	168
LOSS OF CONSCIOUSNESS	164
PRURITUS	149
HALLUCINATION	144
HYPERHIDROSIS	143
THERAPEUTIC RESPONSE UNEXPECTED WITH DRUG SUBSTITUTION	139
DIARRHOEA	138
CONSTIPATION	134
PALPITATIONS	133
ASTHENIA	131
AGGRESSION	130
SINUS TACHYCARDIA	128
FALL	128
MENTAL STATUS CHANGES	127
COMA	126
DRUG EXPOSURE DURING PREGNANCY	122
DISTURBANCE IN ATTENTION	120
OFF LABEL USE	119
HYPERTENSION	112
DRUG HYPERSENSITIVITY	112
MYOCLONUS	111
CARDIOGENIC SHOCK	111
PYREXIA	110
MYDRIASIS	107
TINNITUS	106
PRODUCT QUALITY ISSUE	106
PRODUCT ODOUR ABNORMAL	104
UNRESPONSIVE TO STIMULI	103
HYPERSENSITIVITY	103
DEPRESSED LEVEL OF CONSCIOUSNESS	102
MEMORY IMPAIRMENT	99
DRY MOUTH	99
WEIGHT INCREASED	97
CHEST PAIN	97
PSYCHOTIC DISORDER	93
FOETAL EXPOSURE DURING PREGNANCY	93
ABDOMINAL PAIN UPPER	93
PAIN	92
CRYING	91
HEART RATE INCREASED	90
DISORIENTATION	90
DELIRIUM	88
VISION BLURRED	86
SLEEP DISORDER	86
LETHARGY	86
Intentional product misuse	86
DEPRESSED MOOD	85
METABOLIC ACIDOSIS	84
ARTHRALGIA	84
RESTLESSNESS	83
PANIC ATTACK	83
AMNESIA	82
HALLUCINATION, VISUAL	80
DRUG EFFECT DECREASED	80
BRADYCARDIA	80
ANGER	80
PARAESTHESIA	79
BLOOD PRESSURE INCREASED	79
ABDOMINAL PAIN	78
WEIGHT DECREASED	77
GAIT DISTURBANCE	77
DECREASED APPETITE	76
ABNORMAL BEHAVIOUR	73
MYALGIA	72
ACCIDENTAL OVERDOSE	71
NERVOUSNESS	69
ABDOMINAL DISCOMFORT	69
VENTRICULAR TACHYCARDIA	67
INCORRECT ROUTE OF DRUG ADMINISTRATION	67
HYPOAESTHESIA	67
ABORTION SPONTANEOUS	67
Hyperreflexia	65
FEELING JITTERY	65
MEDICATION ERROR	63
DRUG WITHDRAWAL SYNDROME	62
MIGRAINE	61
EPILEPSY	61
ALOPECIA	61
PNEUMONIA ASPIRATION	60
MOOD SWINGS	60
MATERNAL DRUGS AFFECTING FOETUS	59
EUPHORIC MOOD	58
ENCEPHALOPATHY	58
ARRHYTHMIA	58
VERTIGO	57
DYSKINESIA	57
THINKING ABNORMAL	56
HYPONATRAEMIA	55
DYSARTHRIA	55
RHABDOMYOLYSIS	54
MOOD ALTERED	54
INCORRECT DOSE ADMINISTERED	54
Exposure via ingestion	54
CARDIOTOXICITY	53
Postmortem blood drug level increased	52
DRUG INTOLERANCE	52
SYNCOPE	51
INTENTIONAL SELF-INJURY	51
INAPPROPRIATE SCHEDULE OF DRUG ADMINISTRATION	50
Acute kidney injury	50
SPEECH DISORDER	49
MENTAL DISORDER	49
PULSELESS ELECTRICAL ACTIVITY	48
MUSCLE SPASMS	48
MANIA	48
CHEST DISCOMFORT	48
BALANCE DISORDER	48
DEHYDRATION	47
VISUAL IMPAIRMENT	46
RESPIRATORY FAILURE	46
PULMONARY OEDEMA	46
PSYCHOMOTOR HYPERACTIVITY	46
ERYTHEMA	46
WITHDRAWAL SYNDROME	45
URINARY INCONTINENCE	45
PARANOIA	45
HYPOXIA	45
DRUG DEPENDENCE	45
BLOOD CREATINE PHOSPHOKINASE INCREASED	45
DYSGEUSIA	44
PNEUMONIA	43
LEUKOCYTOSIS	43
DYSPHAGIA	43
ADVERSE EVENT	43
RASH PRURITIC	42
HALLUCINATION, AUDITORY	42
FLUSHING	42
ANGIOEDEMA	42
PAIN IN EXTREMITY	41
ELECTROENCEPHALOGRAM ABNORMAL	41
CIRCULATORY COLLAPSE	41
SEDATION	40
RENAL FAILURE	40
OEDEMA PERIPHERAL	40
APHASIA	40
SWELLING FACE	39
MUSCULAR WEAKNESS	39
HOT FLUSH	39
DELUSION	39
AREFLEXIA	39
ACUTE RESPIRATORY DISTRESS SYNDROME	39
ABDOMINAL DISTENSION	39
UNEVALUABLE EVENT	37
POISONING DELIBERATE	37
NIGHTMARE	37
MUSCLE RIGIDITY	37
Contraindicated product administered	37
APATHY	37
ALANINE AMINOTRANSFERASE INCREASED	37
TREATMENT NONCOMPLIANCE	36
Product use in unapproved indication	36
FEAR	36
DISEASE RECURRENCE	36
CLONUS	36
ADVERSE DRUG REACTION	36
TRANSAMINASES INCREASED	35
PSORIASIS	35
LIP SWELLING	35
INTENTIONAL DRUG MISUSE	35
IMPAIRED WORK ABILITY	35
CHILLS	35
SUPRAVENTRICULAR TACHYCARDIA	34
ROAD TRAFFIC ACCIDENT	34
MUSCULOSKELETAL STIFFNESS	34
MUSCLE TWITCHING	34
BRAIN OEDEMA	34
BACK PAIN	34
ANAPHYLACTIC REACTION	34
PUPIL FIXED	33
Product residue present	33
POSTICTAL STATE	33
NO THERAPEUTIC RESPONSE	33
HEPATIC ENZYME INCREASED	33
COUGH	33
COGNITIVE DISORDER	33
PARKINSONISM	32
JOINT SWELLING	32
HEART DISEASE CONGENITAL	32
BRAIN INJURY	32
ATRIAL FIBRILLATION	32
ASTHMA	32
Wrong technique in product usage process	31
Torsade de pointes	31
TONGUE BITING	31
LYMPHADENOPATHY	31
Exposure during pregnancy	31
DYSTONIA	31
DYSPEPSIA	31
DRUG TOXICITY	31
ATRIAL SEPTAL DEFECT	31
VISUAL ACUITY REDUCED	30
Product use issue	30
PARTIAL SEIZURES	30
MEDICATION RESIDUE	30
GASTROOESOPHAGEAL REFLUX DISEASE	30
FEELING HOT	30
DRUG LEVEL INCREASED	30
ASPARTATE AMINOTRANSFERASE INCREASED	30
WRONG TECHNIQUE IN DRUG USAGE PROCESS	29
TACHYPNOEA	29
RASH ERYTHEMATOUS	29
MENTAL IMPAIRMENT	29
MAJOR DEPRESSION	29
Lupus-like syndrome	29
BLOOD PRESSURE DECREASED	29
AKATHISIA	29
VENTRICULAR EXTRASYSTOLES	28
THERAPEUTIC RESPONSE UNEXPECTED	28
GENERAL PHYSICAL HEALTH DETERIORATION	28
STEVENS-JOHNSON SYNDROME	27
NO ADVERSE EVENT	27
ENERGY INCREASED	27
Drug titration error	27
URINARY RETENTION	26
THROMBOCYTOPENIA	26
THERAPY NON-RESPONDER	26
SWELLING	26
STRESS	26
MYOCARDIAL INFARCTION	26
Intentional product use issue	26
DRUG SCREEN POSITIVE	26
DRUG DISPENSING ERROR	26
ALTERED STATE OF CONSCIOUSNESS	26
VENTRICULAR FIBRILLATION	25
SHOCK	25
RESPIRATORY DEPRESSION	25
MULTIPLE DRUG OVERDOSE	25
Medication residue present	25
ILL-DEFINED DISORDER	25
GASTROINTESTINAL DISORDER	25
Drug prescribing error	25
DRUG ADMINISTRATION ERROR	25
BRAIN DEATH	25
ANOREXIA	25
URINARY TRACT INFECTION	24
THERAPEUTIC RESPONSE DECREASED	24
Therapeutic product effect incomplete	24
SKIN LESION	24
RASH GENERALISED	24
PREGNANCY	24
PANCREATITIS	24
NYSTAGMUS	24
HEAD INJURY	24
BODY TEMPERATURE INCREASED	24
BLOOD GLUCOSE INCREASED	24
AUTONOMIC NERVOUS SYSTEM IMBALANCE	24
ACIDOSIS	24
RETCHING	23
PERSECUTORY DELUSION	23
NECROSIS	23
LACTIC ACIDOSIS	23
IMPAIRED DRIVING ABILITY	23
HYPOMANIA	23
EMOTIONAL DISORDER	23
DECREASED INTEREST	23
CEREBROVASCULAR ACCIDENT	23
ATAXIA	23
ASPIRATION	23
AFFECTIVE DISORDER	23
AFFECT LABILITY	23
ABNORMAL DREAMS	23
Ventricular septal defect	22
RENAL FAILURE ACUTE	22
OEDEMA	22
HYPERTHERMIA	22
DERMATITIS ALLERGIC	22
CONTUSION	22
BRUXISM	22
APNOEA	22
TREATMENT FAILURE	21
RESPIRATORY DISTRESS	21
PERSONALITY CHANGE	21
PARKINSON'S DISEASE	21
NIGHT SWEATS	21
NERVOUS SYSTEM DISORDER	21
HYPOTHERMIA	21
HYPOGLYCAEMIA	21
HUNGER	21
Drug-induced liver injury	21
COORDINATION ABNORMAL	21
Blood lactic acid increased	21
BLOOD CREATININE INCREASED	21
NEUROTOXICITY	20
MULTIPLE DRUG OVERDOSE INTENTIONAL	20
MOTOR DYSFUNCTION	20
INFLUENZA LIKE ILLNESS	20
HYPOXIC-ISCHAEMIC ENCEPHALOPATHY	20
HYPOKALAEMIA	20
Extra dose administered	20
DYSPHEMIA	20
DEPRESSIVE SYMPTOM	20
SWOLLEN TONGUE	19
PRURITUS GENERALISED	19
Peripheral swelling	19
PATENT DUCTUS ARTERIOSUS	19
OROPHARYNGEAL PAIN	19
INAPPROPRIATE ANTIDIURETIC HORMONE SECRETION	19
EMOTIONAL DISTRESS	19
DRUG DOSE OMISSION	19
DISCOMFORT	19
Cardiomyopathy	19
BLISTER	19
ANAEMIA	19
TRANSIENT ISCHAEMIC ATTACK	18
TEARFULNESS	18
SOCIAL AVOIDANT BEHAVIOUR	18
Product prescribing error	18
POOR QUALITY SLEEP	18
GASTROINTESTINAL HAEMORRHAGE	18
FLATULENCE	18
EXTRAPYRAMIDAL DISORDER	18
CYANOSIS	18
BURNING SENSATION	18
ANGINA PECTORIS	18
ACUTE GENERALISED EXANTHEMATOUS PUSTULOSIS	18
ABORTION INDUCED	18
Subacute cutaneous lupus erythematosus	17
SKIN EXFOLIATION	17
SINUS BRADYCARDIA	17
SEXUAL DYSFUNCTION	17
Rheumatoid arthritis	17
Reversible cerebral vasoconstriction syndrome	17
RESTLESS LEGS SYNDROME	17
PUPILLARY REFLEX IMPAIRED	17
Product dispensing error	17
INTESTINAL ISCHAEMIA	17
ERYTHEMA MULTIFORME	17
DIPLOPIA	17
COMPARTMENT SYNDROME	17
COLD SWEAT	17
ANHEDONIA	17
ACUTE LUNG INJURY	17
WHITE BLOOD CELL COUNT INCREASED	16
TIC	16
SMALL FOR DATES BABY	16
SLEEP APNOEA SYNDROME	16
MATERNAL EXPOSURE DURING PREGNANCY	16
LIBIDO INCREASED	16
HYPOAESTHESIA ORAL	16
HYPERTONIA	16
HYPERTENSIVE CRISIS	16
HEPATITIS	16
HEPATIC STEATOSIS	16
HEPATIC FAILURE	16
HALLUCINATIONS, MIXED	16
HAEMODYNAMIC INSTABILITY	16
Gaze palsy	16
DYSPHONIA	16
CAESAREAN SECTION	16
ANGIONEUROTIC OEDEMA	16
Ventricular arrhythmia	15
TRANSPOSITION OF THE GREAT VESSELS	15
Therapy change	15
Therapy cessation	15
SEPSIS	15
RHINORRHOEA	15
PULMONARY CONGESTION	15
PREMATURE BABY	15
POLLAKIURIA	15
PANIC REACTION	15
NEUROLEPTIC MALIGNANT SYNDROME	15
Methaemoglobinaemia	15
Loss of personal independence in daily activities	15
Head discomfort	15
DYSSTASIA	15
ANGLE CLOSURE GLAUCOMA	15
ALCOHOL USE	15
TONIC CONVULSION	14
LACERATION	14
INCREASED APPETITE	14
INCOHERENT	14
HAEMATOCHEZIA	14
ERECTILE DYSFUNCTION	14
DRUG ABUSER	14
DISSOCIATION	14
DEPENDENCE	14
DEAFNESS	14
CEREBRAL INFARCTION	14
CELLULITIS	14
CARDIAC DISORDER	14
WHEEZING	13
VISUAL DISTURBANCE	13
VASCULITIS	13
THROMBOSIS	13
THROAT TIGHTNESS	13
SOPOR	13
PULMONARY HAEMORRHAGE	13
Product solubility abnormal	13
Presyncope	13
Prescription drug used without a prescription	13
PARALYSIS	13
NECK PAIN	13
JOINT DISLOCATION	13
HYPOTHYROIDISM	13
HYPERACUSIS	13
HEMIPARESIS	13
GAMMA-GLUTAMYLTRANSFERASE INCREASED	13
FORMICATION	13
FEELING COLD	13
EJECTION FRACTION DECREASED	13
DEMENTIA	13
Contraindicated drug administered	13
CONGENITAL ANOMALY	13
CLONIC CONVULSION	13
CATATONIA	13
BRADYPHRENIA	13
BLOOD PRESSURE SYSTOLIC INCREASED	13
BLOOD POTASSIUM DECREASED	13
Accidental exposure to product by child	13
VAGINAL HAEMORRHAGE	12
TOXIC EPIDERMAL NECROLYSIS	12
Tachyarrhythmia	12
SERUM SICKNESS	12
PSYCHIATRIC DECOMPENSATION	12
PAROSMIA	12
PARAESTHESIA ORAL	12
OXYGEN SATURATION DECREASED	12
OBSESSIVE-COMPULSIVE DISORDER	12
MYOCARDIAL ISCHAEMIA	12
MOVEMENT DISORDER	12
MIDDLE INSOMNIA	12
LOCAL SWELLING	12
LEUKOPENIA	12
Labelled drug-drug interaction medication error	12
Ileus paralytic	12
HYPERVENTILATION	12
HYPERSOMNIA	12
GASTROINTESTINAL SOUNDS ABNORMAL	12
FEELING OF DESPAIR	12
EYELID OEDEMA	12
EYE SWELLING	12
EATING DISORDER	12
DYSURIA	12
Cardiovascular insufficiency	12
C-REACTIVE PROTEIN INCREASED	12
BUNDLE BRANCH BLOCK LEFT	12
BIPOLAR I DISORDER	12
ACTIVITIES OF DAILY LIVING IMPAIRED	12
ACCIDENTAL POISONING	12
WHITE BLOOD CELL COUNT ABNORMAL	11
TENSION	11
TARDIVE DYSKINESIA	11
Tachyphrenia	11
STARING	11
SKIN REACTION	11
Seizure like phenomena	11
RESPIRATORY RATE INCREASED	11
RASH PAPULAR	11
PSYCHIATRIC SYMPTOM	11
POTENTIATING DRUG INTERACTION	11
PLEURAL EFFUSION	11
PHARYNGOLARYNGEAL PAIN	11
PERIPHERAL COLDNESS	11
NICOTINE DEPENDENCE	11
NASOPHARYNGITIS	11
MULTI-ORGAN FAILURE	11
INFLUENZA	11
Inappropriate schedule of product administration	11
Illness	11
HYPOKINESIA	11
HOSTILITY	11
FACE OEDEMA	11
DIABETES MELLITUS INADEQUATE CONTROL	11
DIABETES MELLITUS	11
CHOROIDAL EFFUSION	11
CHOKING	11
BLOOD GLUCOSE DECREASED	11
BLOOD CHOLESTEROL INCREASED	11
BLOOD ALKALINE PHOSPHATASE INCREASED	11
BLINDNESS	11
BIPOLAR DISORDER	11
APPETITE DISORDER	11
Accidental exposure to product	11
Substance use disorder	10
Substance abuse	10
RESPIRATORY DISORDER	10
RESPIRATORY ACIDOSIS	10
RASH MACULO-PAPULAR	10
PRIAPISM	10
PHOTOPHOBIA	10
Patient dissatisfaction with treatment	10
NEPHROLITHIASIS	10
LOGORRHOEA	10
LIVER INJURY	10
LIVER FUNCTION TEST ABNORMAL	10
LIBIDO DECREASED	10
INTERNATIONAL NORMALISED RATIO INCREASED	10
INCONTINENCE	10
ILLUSION	10
HYPOTONIA	10
HYPERGLYCAEMIA	10
HAEMATOMA	10
GUN SHOT WOUND	10
FLUID RETENTION	10
FAILURE TO THRIVE	10
Exposure via breast milk	10
EPISTAXIS	10
ECCHYMOSIS	10
DRY SKIN	10
DRY EYE	10
DRUG ERUPTION	10
DISTRACTIBILITY	10
DISABILITY	10
DEREALISATION	10
COLITIS	10
BLOOD BILIRUBIN INCREASED	10
ASPHYXIA	10
ACCIDENTAL EXPOSURE	10
ABASIA	10
Weight fluctuation	9
THROAT IRRITATION	9
Therapeutic product effect decreased	9
STOMACH DISCOMFORT	9
SKIN DISCOLOURATION	9
SINUSITIS	9
SALIVARY HYPERSECRETION	9
REFUSAL OF TREATMENT BY PATIENT	9
RASH MACULAR	9
Product label confusion	9
Premature delivery	9
POST-TRAUMATIC STRESS DISORDER	9
PHARYNGEAL OEDEMA	9
Peripheral venous disease	9
Papilloedema	9
PALLOR	9
OBSESSIVE THOUGHTS	9
MIOSIS	9
INJURY	9
Inability to afford medication	9
IMPULSIVE BEHAVIOUR	9
ILEUS	9
HEPATIC FUNCTION ABNORMAL	9
HALLUCINATION, TACTILE	9
HAEMORRHAGE	9
Feeling drunk	9
EYE PAIN	9
EYE MOVEMENT DISORDER	9
Erythrodermic psoriasis	9
DRUG WITHDRAWAL SYNDROME NEONATAL	9
Depersonalisation/derealisation disorder	9
CUTANEOUS LUPUS ERYTHEMATOSUS	9
CHOREOATHETOSIS	9
CEREBRAL DISORDER	9
Cardiomyopathy acute	9
BRONCHOSPASM	9
BLOOD UREA INCREASED	9
BEZOAR	9
Automatism	9
ARTHRITIS	9
ALCOHOL POISONING	9
ACNE	9
URTICARIA GENERALISED	8
TOOTH FRACTURE	8
TONIC CLONIC MOVEMENTS	8
Taste disorder	8
Sudden cardiac death	8
SELF-INJURIOUS IDEATION	8
RECTAL HAEMORRHAGE	8
PULSE ABSENT	8
PULMONARY EMBOLISM	8
PRODUCTIVE COUGH	8
Product physical issue	8
Pneumatosis intestinalis	8
PLATELET COUNT DECREASED	8
PETIT MAL EPILEPSY	8
ORAL PAIN	8
ORAL DISCOMFORT	8
MYOCLONIC EPILEPSY	8
LIVE BIRTH	8
LIMB DISCOMFORT	8
INFECTION	8
Hypoplastic left heart syndrome	8
HYPOPHAGIA	8
HYPOACUSIS	8
HYPERAESTHESIA	8
HEPATOTOXICITY	8
HEPATIC NECROSIS	8
HAEMORRHAGE INTRACRANIAL	8
GESTATIONAL DIABETES	8
GASTROINTESTINAL PAIN	8
FOOD CRAVING	8
Food allergy	8
FIBROMYALGIA	8
FAECES DISCOLOURED	8
Exposure during breast feeding	8
ECZEMA	8
DYSPHORIA	8
DYSGRAPHIA	8
Drug ineffective for unapproved indication	8
DERMATITIS	8
DEAFNESS UNILATERAL	8
Deafness neurosensory	8
CONGESTIVE CARDIOMYOPATHY	8
CHRONIC OBSTRUCTIVE PULMONARY DISEASE	8
CARDIAC FAILURE CONGESTIVE	8
CARDIAC FAILURE	8
BICUSPID AORTIC VALVE	8
ASCITES	8
WRONG DRUG ADMINISTERED	7
VENTRICULAR HYPOKINESIA	7
Upper respiratory tract infection	7
Therapeutic response changed	7
SYSTEMIC LUPUS ERYTHEMATOSUS	7
Sympathomimetic effect	7
SUICIDAL BEHAVIOUR	7
SUDDEN DEATH	7
SOMNAMBULISM	7
SCAR	7
RASH PUSTULAR	7
PRODUCT FORMULATION ISSUE	7
PERICARDIAL EFFUSION	7
PERFORMANCE STATUS DECREASED	7
PAIN IN JAW	7
NASAL CONGESTION	7
Myocarditis	7
MUSCLE CONTRACTIONS INVOLUNTARY	7
MULTIPLE SCLEROSIS	7
MOBILITY DECREASED	7
IRRITABLE BOWEL SYNDROME	7
INTRA-UTERINE DEATH	7
INFLAMMATION	7
HYPOTONIA NEONATAL	7
HYPERKALAEMIA	7
HOSPITALISATION	7
HEART RATE DECREASED	7
GLOSSODYNIA	7
GASTRIC DISORDER	7
Fracture	7
FOAMING AT MOUTH	7
FEELINGS OF WORTHLESSNESS	7
EYE DISORDER	7
ENURESIS	7
EAR DISCOMFORT	7
DYSPNOEA EXERTIONAL	7
DRY THROAT	7
DRUG SCREEN FALSE POSITIVE	7
DRUG LEVEL ABOVE THERAPEUTIC	7
Diverticulitis	7
DEPRESSION SUICIDAL	7
DEPERSONALISATION	7
CORNEAL REFLEX DECREASED	7
CORNEAL OEDEMA	7
COMPLEX PARTIAL SEIZURES	7
CEREBRAL HAEMORRHAGE	7
CEREBRAL ATROPHY	7
CEREBELLAR SYNDROME	7
CARBON MONOXIDE POISONING	7
BUNDLE BRANCH BLOCK RIGHT	7
Brugada syndrome	7
BREAST PAIN	7
BLOOD LACTATE DEHYDROGENASE INCREASED	7
BLOOD ALCOHOL INCREASED	7
Anticholinergic syndrome	7
AMENORRHOEA	7
ABDOMINAL PAIN LOWER	7
VISUAL FIELD DEFECT	6
TRISMUS	6
Toxic encephalopathy	6
TOOTHACHE	6
THROMBOTIC THROMBOCYTOPENIC PURPURA	6
TENDERNESS	6
Surgery	6
STOMATITIS	6
SKIN LACERATION	6
Serum sickness-like reaction	6
SEPTIC SHOCK	6
SCREAMING	6
SCHIZOAFFECTIVE DISORDER	6
Respiratory alkalosis	6
RENAL TUBULAR NECROSIS	6
RENAL DISORDER	6
REACTION TO DRUG EXCIPIENTS	6
PSYCHOMOTOR RETARDATION	6
Product dose omission issue	6
PRESSURE OF SPEECH	6
POSTURING	6
POOR PERSONAL HYGIENE	6
PARADOXICAL DRUG REACTION	6
PANIC DISORDER	6
PAIN OF SKIN	6
Osteomyelitis	6
NODAL RHYTHM	6
NEUTROPENIA	6
MUSCLE TIGHTNESS	6
Multiple organ dysfunction syndrome	6
Mucosal dryness	6
MENORRHAGIA	6
Long QT syndrome	6
JAUNDICE	6
INTRACRANIAL PRESSURE INCREASED	6
INTENTIONAL MISUSE	6
Insurance issue	6
INITIAL INSOMNIA	6
HOMICIDAL IDEATION	6
HEPATOCELLULAR INJURY	6
Hepatitis toxic	6
HEMIPLEGIA	6
HALLUCINATION, OLFACTORY	6
HAEMATEMESIS	6
GASTROENTERITIS	6
GASTRIC ULCER	6
Gait inability	6
Full blood count abnormal	6
FEEDING DISORDER	6
FAECALOMA	6
Exposure to toxic agent	6
Eructation	6
EOSINOPHILIA	6
Endotracheal intubation	6
ELECTROCARDIOGRAM ST SEGMENT ELEVATION	6
Electrocardiogram QRS complex abnormal	6
ECONOMIC PROBLEM	6
DRUG EXPOSURE VIA BREAST MILK	6
Drug effect incomplete	6
DENTAL CARIES	6
COVID-19	6
Congenital tricuspid valve atresia	6
COAGULOPATHY	6
CHROMATURIA	6
CHOLELITHIASIS	6
CARDIOMEGALY	6
CARDIAC MURMUR	6
BURSITIS	6
Brain stem syndrome	6
Bradypnoea	6
BONE PAIN	6
BLOOD SODIUM DECREASED	6
BLOOD CREATINE INCREASED	6
BLINDNESS CORTICAL	6
Anomalous pulmonary venous connection	6
ANAPHYLACTIC SHOCK	6
ALCOHOLISM	6
ALCOHOL ABUSE	6
ACUTE PSYCHOSIS	6
Acute hepatic failure	6
ACUTE CORONARY SYNDROME	6
Univentricular heart	5
TUNNEL VISION	5
Transcription medication error	5
Tongue pruritus	5
TONGUE DISORDER	5
THROMBOPHLEBITIS	5
THIRST	5
Therapy partial responder	5
SUSPICIOUSNESS	5
SUBDURAL HAEMATOMA	5
STUPOR	5
Sputum discoloured	5
SNEEZING	5
Sleep disorder due to a general medical condition	5
SKIN PLAQUE	5
SKIN ODOUR ABNORMAL	5
SKIN DISORDER	5
SKIN BURNING SENSATION	5
SINUS ARRHYTHMIA	5
Sexually inappropriate behaviour	5
SELF INJURIOUS BEHAVIOUR	5
PURPURA	5
PUPILS UNEQUAL	5
Product label issue	5
Product coating issue	5
PRE-ECLAMPSIA	5
POSTURE ABNORMAL	5
POST PROCEDURAL COMPLICATION	5
Poor quality product administered	5
POLYURIA	5
POLYDIPSIA	5
PHYSICAL ASSAULT	5
PHOTOSENSITIVITY REACTION	5
PANCYTOPENIA	5
OSTEOARTHRITIS	5
ORTHOSTATIC HYPOTENSION	5
Opisthotonus	5
OBSTRUCTIVE AIRWAYS DISORDER	5
OBESITY	5
NEGATIVE THOUGHTS	5
MYOPATHY	5
MUSCULOSKELETAL PAIN	5
MUSCLE DISORDER	5
MOUTH ULCERATION	5
Mouth swelling	5
MOTION SICKNESS	5
Microcytic anaemia	5
Meningioma	5
LUNG DISORDER	5
JOINT STIFFNESS	5
Injection site pain	5
Injection site abscess	5
INHIBITORY DRUG INTERACTION	5
Infarction	5
Incorrect route of product administration	5
IMMOBILE	5
Hypopnoea	5
HYPERTRIGLYCERIDAEMIA	5
HYPERLIPIDAEMIA	5
HYPERBILIRUBINAEMIA	5
HEPATOMEGALY	5
HALLUCINATION, GUSTATORY	5
HAEMOGLOBIN DECREASED	5
HAEMODIALYSIS	5
Foetal death	5
FACIAL BONES FRACTURE	5
EYE PRURITUS	5
EXCORIATION	5
ELEVATED MOOD	5
EDUCATIONAL PROBLEM	5
DROWNING	5
Dissociative disorder	5
Disorganised speech	5
DEVELOPMENTAL DELAY	5
CYTOLYTIC HEPATITIS	5
Craniocerebral injury	5
CORONARY ARTERY OCCLUSION	5
CONVULSIVE THRESHOLD LOWERED	5
CONJUNCTIVITIS	5
Coma scale abnormal	5
Coeliac disease	5
Coarctation of the aorta	5
CLUMSINESS	5
Chorea	5
Central nervous system lesion	5
CARDIOVASCULAR DISORDER	5
BREECH PRESENTATION	5
BRAIN HERNIATION	5
Blood test abnormal	5
BLEPHAROSPASM	5
AUTOIMMUNE DISORDER	5
ATRIAL FLUTTER	5
Aortic valve incompetence	5
ANTIDEPRESSANT DRUG LEVEL INCREASED	5
ACCIDENTAL DRUG INTAKE BY CHILD	5
ACCIDENTAL DEATH	5
Abscess sterile	5
YAWNING	4
WHITE BLOOD CELL COUNT DECREASED	4
VIRAL INFECTION	4
VERBAL ABUSE	4
Ventricular tachyarrhythmia	4
Vasoplegia syndrome	4
Underdose	4
ULCER	4
TOXICOLOGIC TEST ABNORMAL	4
TOXIC SKIN ERUPTION	4
TORTICOLLIS	4
THOUGHT BLOCKING	4
TERMINAL INSOMNIA	4
SUBARACHNOID HAEMORRHAGE	4
STRIDOR	4
STRESS CARDIOMYOPATHY	4
STILLBIRTH	4
SPINAL FRACTURE	4
SPINAL COMPRESSION FRACTURE	4
SLUGGISHNESS	4
Sleep-related eating disorder	4
Sleep paralysis	4
SENSORY DISTURBANCE	4
Sensitisation	4
SENSE OF OPPRESSION	4
SENSATION OF FOREIGN BODY	4
SELF-MEDICATION	4
SELF ESTEEM DECREASED	4
Secondary adrenocortical insufficiency	4
SCHIZOPHRENIA	4
Rhinitis allergic	4
RHINALGIA	4
Renal impairment	4
RED BLOOD CELL SEDIMENTATION RATE INCREASED	4
RASH MORBILLIFORM	4
PUSTULAR PSORIASIS	4
Pulmonary artery stenosis congenital	4
Product use complaint	4
PREMATURE RUPTURE OF MEMBRANES	4
Portal venous gas	4
Polycystic ovaries	4
PO2 DECREASED	4
Pharyngeal swelling	4
PAST-POINTING	4
PARESIS	4
Paralysis flaccid	4
PAINFUL RESPIRATION	4
OLIGURIA	4
OESOPHAGEAL SPASM	4
ODYNOPHAGIA	4
OCULAR HYPERAEMIA	4
NEUTROPHIL COUNT INCREASED	4
Neurological decompensation	4
Neuralgia	4
NEGATIVISM	4
MYOSITIS	4
MYOGLOBINURIA	4
MUTISM	4
MUSCULOSKELETAL DISCOMFORT	4
MUSCLE SPASTICITY	4
MUSCLE FATIGUE	4
MUSCLE CRAMP	4
Multiple fractures	4
MUCOUS MEMBRANE DISORDER	4
MORBID THOUGHTS	4
MICTURITION DISORDER	4
METRORRHAGIA	4
MALABSORPTION	4
LYMPHOPENIA	4
Loss of libido	4
Lip pruritus	4
LIP OEDEMA	4
LIP DISORDER	4
LIMB INJURY	4
LEGAL PROBLEM	4
Language disorder	4
LACRIMATION INCREASED	4
JUDGEMENT IMPAIRED	4
JOINT EFFUSION	4
Job dissatisfaction	4
Intervertebral disc protrusion	4
Intervertebral disc disorder	4
INTENTION TREMOR	4
IMPAIRED SELF-CARE	4
IMPAIRED HEALING	4
Ideas of reference	4
Hyporeflexia	4
HYPOPERFUSION	4
Hypocalcaemia	4
Hypertonia neonatal	4
HYPERPHAGIA	4
Hydrocephalus	4
HOMICIDE	4
HERNIA	4
HEPATIC ENZYME ABNORMAL	4
HEARING IMPAIRED	4
HAEMANGIOMA CONGENITAL	4
HAEMANGIOMA	4
GYNAECOMASTIA	4
GRANDIOSITY	4
GOUT	4
GLAUCOMA	4
GINGIVAL BLEEDING	4
GENERALISED OEDEMA	4
GASTROINTESTINAL INFECTION	4
FRUSTRATION	4
Fluid overload	4
Feeling of body temperature change	4
FEELING GUILTY	4
FEEDING DISORDER NEONATAL	4
False positive investigation result	4
FALLOT'S TETRALOGY	4
FAECAL INCONTINENCE	4
Facial paralysis	4
FACE INJURY	4
Eye irritation	4
Extrasystoles	4
Encephalopathy neonatal	4
EMOTIONAL POVERTY	4
ELECTROCARDIOGRAM ST SEGMENT DEPRESSION	4
ELECTROCARDIOGRAM ABNORMAL	4
EAR PAIN	4
DRUG WITHDRAWAL CONVULSIONS	4
Drug use disorder	4
Drug resistance	4
Drug reaction with eosinophilia and systemic symptoms	4
Drug effective for unapproved indication	4
Dizziness postural	4
DISSEMINATED INTRAVASCULAR COAGULATION	4
DERMATITIS BULLOUS	4
Decorticate posture	4
Cyanosis central	4
CRYPTORCHISM	4
CONVERSION DISORDER	4
Contraindicated product prescribed	4
Congenital pulmonary valve atresia	4
CONDUCTION DISORDER	4
COMPLICATIONS OF MATERNAL EXPOSURE TO THERAPEUTIC DRUGS	4
COLOSTOMY	4
CIRCUMSTANCE OR INFORMATION CAPABLE OF LEADING TO MEDICATION ERROR	4
Carpal tunnel syndrome	4
CARDIOPULMONARY FAILURE	4
CARDIAC FLUTTER	4
Carcinoembryonic antigen increased	4
BULIMIA NERVOSA	4
Bronchitis	4
Breast engorgement	4
BREAST CANCER	4
BRAIN NEOPLASM	4
BLOOD URINE PRESENT	4
BLOOD PRESSURE FLUCTUATION	4
BLOOD ETHANOL INCREASED	4
BLOOD CHLORIDE DECREASED	4
BEDRIDDEN	4
Autoscopy	4
AUTOIMMUNE HEPATITIS	4
AURA	4
ATELECTASIS	4
Arterial occlusive disease	4
APPARENT DEATH	4
Antidepressant discontinuation syndrome	4
ANOSMIA	4
Ankle fracture	4
ANION GAP INCREASED	4
ANAPHYLACTOID REACTION	4
Alcohol withdrawal syndrome	4
Airway peak pressure increased	4
AGRAPHIA	4
Acute myocardial infarction	4
ACNE CYSTIC	4
ABULIA	4
WOUND HAEMORRHAGE	3
WOUND	3
VITAMIN D DEFICIENCY	3
VAGINAL DISCHARGE	3
Urine output decreased	3
UPPER LIMB FRACTURE	3
ULCERATIVE KERATITIS	3
TYPE IV HYPERSENSITIVITY REACTION	3
TYPE 2 DIABETES MELLITUS	3
TUBULOINTERSTITIAL NEPHRITIS	3
Troponin increased	3
TRISOMY 21	3
Tricuspid valve incompetence	3
TONGUE OEDEMA	3
Tongue coated	3
TOBACCO USER	3
Thyroiditis	3
THYROID DISORDER	3
Therapy interrupted	3
TESTICULAR PAIN	3
Temporomandibular joint syndrome	3
TEMPORAL LOBE EPILEPSY	3
TEMPERATURE INTOLERANCE	3
TALIPES	3
SUPRAVENTRICULAR EXTRASYSTOLES	3
SUDDEN HEARING LOSS	3
SUBCUTANEOUS EMPHYSEMA	3
STRESS SYMPTOMS	3
Sputum purulent	3
SNORING	3
SLOW RESPONSE TO STIMULI	3
Sleep disorder due to general medical condition, insomnia type	3
SKIN ULCER	3
SINUS HEADACHE	3
SENSATION OF PRESSURE	3
Sedative therapy	3
Secondary immunodeficiency	3
SCIATICA	3
Right ventricular failure	3
RHINITIS	3
RETROGRADE AMNESIA	3
RETINAL TEAR	3
Reduced facial expression	3
Rebound effect	3
QUALITY OF LIFE DECREASED	3
PUPILLARY DISORDER	3
PULMONARY VALVE STENOSIS CONGENITAL	3
PULMONARY HYPERTENSION	3
PSYCHOMOTOR SKILLS IMPAIRED	3
Psoriatic arthropathy	3
PRURIGO	3
Product dose omission	3
PRODUCT COUNTERFEIT	3
Product complaint	3
Product availability issue	3
Procedural pain	3
Prescribed overdose	3
PREMATURE EJACULATION	3
PREGNANCY ON ORAL CONTRACEPTIVE	3
PREGNANCY INDUCED HYPERTENSION	3
Pre-existing condition improved	3
Poor feeding infant	3
Pneumothorax	3
PLATELET COUNT INCREASED	3
PHARYNGITIS	3
PETECHIAE	3
PERSONALITY DISORDER	3
Parasomnia	3
OVARIAN CYST	3
ORAL HERPES	3
Oral disorder	3
Oral candidiasis	3
OLIGOMENORRHOEA	3
OEDEMA MUCOSAL	3
Ocular icterus	3
OCULAR HYPERTENSION	3
OCULAR DISCOMFORT	3
NORMAL NEWBORN	3
Neuropathy peripheral	3
Neuromyopathy	3
NEUROLOGICAL SYMPTOM	3
NEPHROPATHY	3
Neonatal toxicity	3
Neonatal respiratory distress syndrome	3
NASAL DISCOMFORT	3
MYOPIA	3
MUSCLE CONTRACTURE	3
Mouth haemorrhage	3
MONARTHRITIS	3
Mixed liver injury	3
Metabolic surgery	3
METABOLIC DISORDER	3
MENSTRUATION IRREGULAR	3
Marital problem	3
Manic symptom	3
MALNUTRITION	3
MACULE	3
MACROGLOSSIA	3
LOBAR PNEUMONIA	3
Liver function test increased	3
Lipoedema	3
LIPASE INCREASED	3
LIP BLISTER	3
Ligament sprain	3
LARYNGEAL OEDEMA	3
Laboratory test interference	3
Ischaemic stroke	3
IRON DEFICIENCY ANAEMIA	3
Intrusive thoughts	3
INTRAOCULAR PRESSURE INCREASED	3
Intestinal dilatation	3
Intercepted product dispensing error	3
Intentional underdose	3
INCREASED TENDENCY TO BRUISE	3
Incorrect product storage	3
IMPULSE-CONTROL DISORDER	3
IMPRISONMENT	3
IMPATIENCE	3
Immunodeficiency	3
Immune thrombocytopenic purpura	3
IDIOPATHIC THROMBOCYTOPENIC PURPURA	3
HYPOVENTILATION	3
HYPOSPADIAS	3
HYPERVIGILANCE	3
HYPERTHYROIDISM	3
Hypertensive emergency	3
HYPERNATRAEMIA	3
HYPERINSULINISM	3
HYPERCHOLESTEROLAEMIA	3
Hydrocele	3
HIP FRACTURE	3
HIATUS HERNIA	3
Herbal interaction	3
HEPATITIS CHOLESTATIC	3
Helplessness	3
HEART RATE IRREGULAR	3
Hangover	3
Haemoptysis	3
Haemolytic anaemia	3
HAEMATURIA	3
GROWTH RETARDATION	3
GRIMACING	3
GLOSSITIS	3
Gingival discolouration	3
Genital pain	3
GASTRITIS	3
Galactorrhoea	3
Frustration tolerance decreased	3
Foot fracture	3
Food poisoning	3
FOETAL GROWTH RETARDATION	3
FOETAL DISORDER	3
FLIGHT OF IDEAS	3
Femur fracture	3
FACIAL PALSY	3
FACIAL PAIN	3
Extensor plantar response	3
Exposure via inhalation	3
Exposure via body fluid	3
Exercise tolerance decreased	3
Executive dysfunction	3
EPILEPTIC AURA	3
ELECTROCARDIOGRAM T WAVE ABNORMAL	3
Ejection fraction abnormal	3
DRUG CLEARANCE DECREASED	3
Drooling	3
Double inlet left ventricle	3
Disease progression	3
DIARRHOEA HAEMORRHAGIC	3
DIALYSIS	3
DIABETES INSIPIDUS	3
DERMATITIS EXFOLIATIVE	3
Dermatitis atopic	3
Delusion of grandeur	3
DECREASED ACTIVITY	3
DECEREBRATION	3
Deafness bilateral	3
CYSTITIS	3
Coronary artery disease	3
CONSCIOUSNESS FLUCTUATING	3
CONGENITAL HAND MALFORMATION	3
Congenital aortic stenosis	3
CONCUSSION	3
COMPULSIONS	3
Complex regional pain syndrome	3
COMMUNICATION DISORDER	3
Colitis ulcerative	3
COGWHEEL RIGIDITY	3
CLEFT PALATE	3
Claustrophobia	3
CHORIOAMNIONITIS	3
CHOLESTASIS	3
CHOKING SENSATION	3
Central nervous system necrosis	3
BUNDLE BRANCH BLOCK	3
BRONCHOPNEUMONIA	3
BREAST TENDERNESS	3
BRADYKINESIA	3
BLOOD TRIGLYCERIDES INCREASED	3
BLOOD BICARBONATE DECREASED	3
BLINDNESS TRANSIENT	3
Binge eating	3
Binge drinking	3
Back disorder	3
AUTISM	3
Asthenopia	3
ARTHROPATHY	3
APHTHOUS STOMATITIS	3
AORTIC VALVE STENOSIS	3
Anorgasmia	3
ANGIOPATHY	3
Agranulocytosis	3
AGEUSIA	3
Adrenergic syndrome	3
Wrong product stored	2
Wrong dose	2
Withdrawal hypertension	2
Vulvovaginal swelling	2
VIIth nerve paralysis	2
Ventricular hypoplasia	2
VASOSPASM	2
UTERINE HAEMORRHAGE	2
URINE ODOUR ABNORMAL	2
Urine amphetamine positive	2
UPPER-AIRWAY COUGH SYNDROME	2
UNINTENDED PREGNANCY	2
UNEXPECTED THERAPEUTIC DRUG EFFECT	2
UMBILICAL CORD ABNORMALITY	2
ULCER HAEMORRHAGE	2
TYPE 1 DIABETES MELLITUS	2
TROPONIN I INCREASED	2
TREMOR NEONATAL	2
Transaminases abnormal	2
Tooth infection	2
TOOTH DISORDER	2
Tongue paralysis	2
Tongue dry	2
TONGUE BLISTERING	2
Thunderclap headache	2
THERAPY REGIMEN CHANGED	2
Therapeutic product cross-reactivity	2
TESTICULAR SWELLING	2
TENDONITIS	2
TENDON RUPTURE	2
TENDON PAIN	2
Tendon injury	2
Temperature regulation disorder	2
SYSTOLIC DYSFUNCTION	2
Systemic inflammatory response syndrome	2
Symptom recurrence	2
Symptom masked	2
Sunburn	2
SUFFOCATION FEELING	2
Substance-induced psychotic disorder	2
Stress at work	2
STOOL ANALYSIS ABNORMAL	2
Spinal pain	2
Spinal cord infarction	2
Spinal column stenosis	2
Soft tissue injury	2
SOCIAL PROBLEM	2
SOCIAL PHOBIA	2
SMOKER	2
Small intestinal resection	2
Slow speech	2
SLEEP TERROR	2
Sleep deficit	2
SKULL FRACTURE	2
SKIN SWELLING	2
SKIN IRRITATION	2
SKIN HYPERPIGMENTATION	2
Skin abrasion	2
Sjogren's syndrome	2
SINUS DISORDER	2
Sexual activity increased	2
SERUM FERRITIN INCREASED	2
SENSATION OF HEAVINESS	2
SELECTIVE MUTISM	2
Secretion discharge	2
SCRATCH	2
SCHIZOPHRENIA, PARANOID TYPE	2
Scab	2
Saccadic eye movement	2
ROTATOR CUFF SYNDROME	2
Rosacea	2
Right ventricular hypertrophy	2
Retinal vascular thrombosis	2
Retinal detachment	2
RESUSCITATION	2
Resting tremor	2
Renal failure chronic	2
Quadriparesis	2
QRS AXIS ABNORMAL	2
Pupillary light reflex tests abnormal	2
Pulmonary valve stenosis	2
Pulmonary artery stenosis	2
Pulmonary artery dilatation	2
Product taste abnormal	2
Product selection error	2
Product packaging confusion	2
Product difficult to swallow	2
Product colour issue	2
PROCTALGIA	2
Procedural nausea	2
Procedural hypertension	2
Procedural complication	2
Prescribed underdose	2
Premature separation of placenta	2
PREMATURE MENOPAUSE	2
Postmortem blood drug level abnormal	2
POSTMENOPAUSAL HAEMORRHAGE	2
Postictal paralysis	2
POSTICTAL HEADACHE	2
POOR WEIGHT GAIN NEONATAL	2
Poor venous access	2
POLYNEUROPATHY	2
Polydipsia psychogenic	2
POLYARTHRITIS	2
PNEUMONITIS	2
PNEUMONIA PRIMARY ATYPICAL	2
Plagiocephaly	2
PIGMENTATION DISORDER	2
PHONOPHOBIA	2
PHARYNGITIS STREPTOCOCCAL	2
Pharyngeal paraesthesia	2
Pharyngeal exudate	2
PERITONITIS	2
PERITONEAL ADHESIONS	2
PERIPHERAL ISCHAEMIA	2
PERIORBITAL OEDEMA	2
PERICARDITIS	2
Pemphigus	2
PELVIC PAIN	2
PCO2 INCREASED	2
PARTNER STRESS	2
PARAKERATOSIS	2
PAPULE	2
Oxygen saturation abnormal	2
OTITIS MEDIA	2
Ostomy bag placement	2
Osteoporosis	2
Oscillopsia	2
OROPHARYNGEAL SWELLING	2
OROPHARYNGEAL DISCOMFORT	2
ORGANISING PNEUMONIA	2
Organ failure	2
ORBITAL OEDEMA	2
Oral pruritus	2
ORAL MUCOSAL ERUPTION	2
Oral mucosal blistering	2
Onychoclasis	2
OESOPHAGITIS	2
OESOPHAGEAL RUPTURE	2
OESOPHAGEAL PAIN	2
Oesophageal hypomotility	2
OEDEMA MOUTH	2
Obstructive sleep apnoea syndrome	2
Nodule	2
Nodal arrhythmia	2
NO ADVERSE EFFECT	2
Neutrophil count decreased	2
Neuromuscular blockade	2
Neurogenic bladder	2
Neurodegenerative disorder	2
NERVE INJURY	2
Neoplasm recurrence	2
Neonatal behavioural syndrome	2
NASAL SEPTAL OPERATION	2
Nasal oedema	2
MYOGLOBIN BLOOD INCREASED	2
Myocardial stunning	2
Myocardial fibrosis	2
MUSCULOSKELETAL CHEST PAIN	2
MUCOUS STOOLS	2
MUCOSAL INFLAMMATION	2
Mineral metabolism disorder	2
MIGRAINE WITH AURA	2
Middle ear effusion	2
MICTURITION URGENCY	2
MERYCISM	2
MENTAL RETARDATION	2
Mental fatigue	2
MENINGITIS	2
MASKED FACIES	2
MACULAR DEGENERATION	2
Lymph node pain	2
LUNG INFILTRATION	2
LOWER RESPIRATORY TRACT INFECTION	2
Loss of employment	2
LOSS OF CONTROL OF LEGS	2
LIVER DISORDER	2
LISTLESS	2
Lipoma	2
LIP INJURY	2
Ligament injury	2
LICHENOID KERATOSIS	2
LEUKOCYTOCLASTIC VASCULITIS	2
Left ventricular hypertrophy	2
Laryngospasm	2
LARYNGOMALACIA	2
LARGE INTESTINE PERFORATION	2
Laparotomy	2
Labelled drug-drug interaction issue	2
KYPHOSIS	2
Knee arthroplasty	2
JAW DISORDER	2
Ischaemia	2
Intestinal pseudo-obstruction	2
INTESTINAL OBSTRUCTION	2
Interstitial lung disease	2
Intercepted product selection error	2
Inner ear disorder	2
Injection site necrosis	2
Injection site induration	2
Injection site erythema	2
Injection site discharge	2
Infusion related reaction	2
Infantile apnoea	2
INDURATION	2
INDIFFERENCE	2
Incorrect drug dosage form administered	2
Incorrect drug administration duration	2
INAPPROPRIATE AFFECT	2
Inadequate analgesia	2
IMPAIRED GASTRIC EMPTYING	2
Ileal atresia	2
IIIRD NERVE PARALYSIS	2
Iatrogenic injury	2
Hypovolaemic shock	2
Hypoplastic right heart syndrome	2
HYPOCHONDRIASIS	2
HYPOAESTHESIA FACIAL	2
Hyperuricaemia	2
HYPERTHERMIA MALIGNANT	2
Hypertensive urgency	2
Hyperlactacidaemia	2
HYPERAEMIA	2
Humerus fracture	2
Housebound	2
Hospice care	2
HIGH DENSITY LIPOPROTEIN DECREASED	2
HICCUPS	2
HEPATOCELLULAR DAMAGE	2
HEPATIC PAIN	2
Hepatic cirrhosis	2
Heart sounds abnormal	2
HEART RATE ABNORMAL	2
Heart injury	2
HAIR DISORDER	2
HAEMORRHOIDS	2
GINGIVITIS	2
GENERALISED ERYTHEMA	2
GENERALISED ANXIETY DISORDER	2
General symptom	2
Gastrointestinal necrosis	2
Gastrointestinal hypomotility	2
GASTROENTERITIS VIRAL	2
GASTRIC VOLVULUS	2
Gastric hypomotility	2
GASTRIC HAEMORRHAGE	2
GASTRIC BYPASS	2
Frequent bowel movements	2
Foreign body	2
FOOD AVERSION	2
FOETAL MALFORMATION	2
Foetal growth restriction	2
Focal segmental glomerulosclerosis	2
FLAT ANTERIOR CHAMBER OF EYE	2
FLAT AFFECT	2
FEBRILE NEUTROPENIA	2
FAT INTOLERANCE	2
FAMILY STRESS	2
Eyelid function disorder	2
EYELID DISORDER	2
EYELID BLEEDING	2
Eye operation	2
EYE HAEMORRHAGE	2
EXCITABILITY	2
EXCESSIVE EYE BLINKING	2
ESSENTIAL TREMOR	2
ESSENTIAL HYPERTENSION	2
Erection increased	2
Embolic stroke	2
Electronic cigarette user	2
ELECTROLYTE IMBALANCE	2
Electrocardiogram ST-T segment abnormal	2
ELECTROCARDIOGRAM REPOLARISATION ABNORMALITY	2
Electrocardiogram QT interval abnormal	2
Electrocardiogram QRS complex shortened	2
Ejection fraction	2
ECTOPIC KIDNEY	2
EAR MALFORMATION	2
DYSMENORRHOEA	2
DYSLEXIA	2
DRUG TOLERANCE INCREASED	2
DRUG TOLERANCE DECREASED	2
DRUG TOLERANCE	2
DRUG DIVERSION	2
DROP ATTACKS	2
DIFFICULTY IN WALKING	2
Diastolic hypertension	2
DIABETES MELLITUS INSULIN-DEPENDENT	2
Device related sepsis	2
DERMATOSIS	2
DEEP VEIN THROMBOSIS	2
Cystic lymphangioma	2
COSTOCHONDRITIS	2
CORONARY ARTERY STENOSIS	2
Corneal light reflex test abnormal	2
CONVULSION NEONATAL	2
Conjunctivitis viral	2
Congenital musculoskeletal anomaly	2
Congenital hydrocephalus	2
Congenital central nervous system anomaly	2
Congenital cardiovascular anomaly	2
CONGENITAL ATRIAL SEPTAL DEFECT	2
COLOBOMA	2
COLITIS ISCHAEMIC	2
Chronic kidney disease	2
Chronic fatigue syndrome	2
CHEST INJURY	2
CHEILITIS	2
CERVICAL VERTEBRAL FRACTURE	2
CERVICAL INCOMPETENCE	2
CEREBRAL HAEMATOMA	2
CATARACT	2
Carnitine deficiency	2
Cardiac septal hypertrophy	2
Cardiac output decreased	2
CARDIAC ENZYMES INCREASED	2
CARBON DIOXIDE DECREASED	2
Capsular contracture associated with breast implant	2
Burns second degree	2
Breath odour	2
BREAST SWELLING	2
BREAST DISORDER	2
BREAST DISCHARGE	2
BREAST CYST	2
Bowel movement irregularity	2
BODY TEMPERATURE FLUCTUATION	2
BODY MASS INDEX INCREASED	2
BODY DYSMORPHIC DISORDER	2
BLOOD THYROID STIMULATING HORMONE INCREASED	2
BLOOD THYROID STIMULATING HORMONE DECREASED	2
Blood testosterone decreased	2
BLOOD SODIUM INCREASED	2
Blood prolactin increased	2
Blood pressure diastolic decreased	2
BLOOD PH INCREASED	2
BLOOD PH DECREASED	2
BLOOD OSMOLARITY DECREASED	2
Blood iron increased	2
BLOOD IMMUNOGLOBULIN E INCREASED	2
BLOOD GLUCOSE FLUCTUATION	2
Blood gases abnormal	2
Blood count abnormal	2
BLOOD CORTISOL INCREASED	2
Bladder prolapse	2
BLADDER DISORDER	2
BILIRUBIN CONJUGATED INCREASED	2
BILE DUCT STONE	2
Benign intracranial hypertension	2
BELLIGERENCE	2
Basilar artery occlusion	2
Basedow's disease	2
BANDAEMIA	2
Autonomic dysreflexia	2
AURICULAR SWELLING	2
ATTENTION-SEEKING BEHAVIOUR	2
ATTENTION DEFICIT/HYPERACTIVITY DISORDER	2
ATRIOVENTRICULAR DISSOCIATION	2
ATRIOVENTRICULAR BLOCK	2
ARTERIOSCLEROSIS	2
Apraxia	2
Appendicectomy	2
APNOEIC ATTACK	2
APHAGIA	2
APGAR SCORE LOW	2
Aortic valve disease	2
AORTA HYPOPLASIA	2
Anuria	2
ANTINUCLEAR ANTIBODY POSITIVE	2
ANTEPARTUM HAEMORRHAGE	2
ANOXIC ENCEPHALOPATHY	2
ANISOMETROPIA	2
Anion gap abnormal	2
Anion gap	2
ANGINA UNSTABLE	2
ANENCEPHALY	2
Anal incontinence	2
Anal fissure	2
Amyotrophic lateral sclerosis	2
AMNIOTIC FLUID VOLUME DECREASED	2
ALPHA 1 FOETOPROTEIN ABNORMAL	2
Alcohol detoxification	2
Agitation neonatal	2
ADVERSE REACTION	2
Administration site reaction	2
Administration site abscess sterile	2
Acute respiratory failure	2
ACUTE PULMONARY OEDEMA	2
ACCOMMODATION DISORDER	2
Accident at work	2
ACANTHOSIS	2
Abstains from recreational drugs	2
ABORTION MISSED	2
ABNORMAL SENSATION IN EYE	2
Abnormal loss of weight	2
ABDOMINAL TENDERNESS	2
Wrong product administered	1
Wrong patient received medication	1
WOUND SECRETION	1
WOLFF-PARKINSON-WHITE SYNDROME	1
White matter lesion	1
WEIGHT DECREASE NEONATAL	1
WEIGHT ABNORMAL	1
Walking disability	1
Vulvovaginal pruritus	1
Vulvovaginal erythema	1
Vulvovaginal candidiasis	1
Vulval disorder	1
Vomiting in pregnancy	1
VOCAL CORD PARALYSIS	1
Vitreous floaters	1
Vitreous detachment	1
Vitamin D decreased	1
Vitamin B12 decreased	1
VISUAL EVOKED POTENTIALS ABNORMAL	1
VIRAL UPPER RESPIRATORY TRACT INFECTION	1
VIRAL SKIN INFECTION	1
Viral rash	1
VIRAL PERICARDITIS	1
VIRAL OESOPHAGITIS	1
Violence-related symptom	1
Victim of homicide	1
Vestibular neuronitis	1
VESTIBULAR DISORDER	1
VESICOURETERIC REFLUX	1
Vertebral wedging	1
VENTRICULAR HYPERTROPHY	1
VENTRICULAR FLUTTER	1
VENTRICULAR DYSFUNCTION	1
Ventricular drainage	1
Venous thrombosis limb	1
Venous insufficiency	1
Vena cava thrombosis	1
Vein rupture	1
Vein of Galen aneurysmal malformation	1
Vasogenic cerebral oedema	1
Vascular wall hypertrophy	1
VASCULAR RUPTURE	1
Vascular injury	1
Vascular dementia	1
Vaginal odour	1
Vaginal disorder	1
Uterine leiomyoma	1
UTERINE CONTRACTIONS DURING PREGNANCY	1
Uterine cancer	1
UROSEPSIS	1
URINE OSMOLARITY INCREASED	1
Urine flow decreased	1
Urine abnormality	1
Urinary tract infection bacterial	1
Urinary tract disorder	1
Urinary hesitation	1
Urge incontinence	1
Upper gastrointestinal haemorrhage	1
Upper airway obstruction	1
UMBILICAL CORD VASCULAR DISORDER	1
ULTRASOUND ANTENATAL SCREEN ABNORMAL	1
TYPE I HYPERSENSITIVITY	1
TRISOMY 18	1
TRISOMY 15	1
TRIPLE VESSEL BYPASS GRAFT	1
Trichiasis	1
TRAUMATIC LUNG INJURY	1
Traumatic intracranial haemorrhage	1
TRAUMATIC DELIVERY	1
TRANSIENT PSYCHOSIS	1
Transfusion	1
Tracheal inflammation	1
TOXOPLASMOSIS	1
TOXIC SHOCK SYNDROME	1
Tooth resorption	1
Tooth extraction	1
Tonsillitis streptococcal	1
TONGUE ULCERATION	1
Tongue spasm	1
Tongue movement disturbance	1
Tongue eruption	1
Tongue discomfort	1
TONGUE DISCOLOURATION	1
Tidal volume increased	1
Tick-borne viral encephalitis	1
Tick paralysis	1
Thyroidectomy	1
Thyroid gland injury	1
THROMBOPHLEBITIS SUPERFICIAL	1
THROMBOCYTOPENIA NEONATAL	1
THREAT OF REDUNDANCY	1
Thoracic vertebral fracture	1
Thirst decreased	1
Thermal burn	1
THERAPEUTIC PRODUCT INEFFECTIVE	1
Therapeutic agent-diagnostic test interaction	1
Therapeutic agent urine positive	1
Theft	1
TENSION HEADACHE	1
SYSTEMIC LUPUS ERYTHEMATOSUS RASH	1
Synovitis	1
Synostosis	1
SYNCOPE VASOVAGAL	1
Symblepharon	1
Suspected suicide	1
Suspected product quality issue	1
Suspected counterfeit product	1
SUDDEN INFANT DEATH SYNDROME	1
Substance-induced mood disorder	1
SUBILEUS	1
SUBDURAL HAEMORRHAGE	1
SUBCLAVIAN ARTERY OCCLUSION	1
SUBACUTE HEPATIC FAILURE	1
STUBBORNNESS	1
Streptococcal infection	1
STRABISMUS	1
Sticky skin	1
Sternal fracture	1
Stereotypy	1
Stenosis	1
STATUS ASTHMATICUS	1
STAPHYLOCOCCAL SCALDED SKIN SYNDROME	1
STAB WOUND	1
SPOUSAL ABUSE	1
SPLENOMEGALY	1
SPLEEN MALFORMATION	1
Spinal nerve stimulator implantation	1
SPINAL DISORDER	1
Spinal cord injury	1
SPEECH DISORDER DEVELOPMENTAL	1
Spasmodic dysphonia	1
SOMATOFORM DISORDER	1
Somatisation disorder	1
Somatic symptom disorder	1
Somatic delusion	1
Soft tissue necrosis	1
Smooth muscle antibody positive	1
Small intestinal obstruction	1
SLEEP PHASE RHYTHM DISTURBANCE	1
SLEEP ATTACKS	1
Skin warm	1
Skin tightness	1
SKIN TEST POSITIVE	1
Skin sensitisation	1
SKIN OEDEMA	1
SKIN NODULE	1
SKIN INJURY	1
Skin fissures	1
Skin erosion	1
SKIN DEGENERATIVE DISORDER	1
Skin atrophy	1
SINUS RHYTHM	1
Single photon emission computerised tomogram abnormal	1
SIMILAR REACTION ON PREVIOUS EXPOSURE TO DRUG	1
Shoplifting	1
SHARED PSYCHOTIC DISORDER	1
Sexual relationship change	1
SERUM SEROTONIN INCREASED	1
Sensory processing disorder	1
Sensory loss	1
SENSORY INTEGRATIVE DYSFUNCTION	1
Semen volume decreased	1
Self-consciousness	1
SELF ESTEEM INFLATED	1
Sedation complication	1
SECONDARY HYPOGONADISM	1
Seborrhoeic keratosis	1
Sebaceous gland disorder	1
Seasonal allergy	1
SEASONAL AFFECTIVE DISORDER	1
SCROTAL DISORDER	1
Scoliosis	1
SCHIZOPHRENIFORM DISORDER	1
SCHIZOPHRENIA SIMPLE	1
Scaphocephaly	1
Sarcoma excision	1
Rotator cuff repair	1
Risus sardonicus	1
Right ventricular dysfunction	1
Rib fracture	1
RHONCHI	1
Rhinitis perennial	1
RETINOPATHY HYPERTENSIVE	1
RETINOPATHY	1
RETINITIS PIGMENTOSA	1
Retinal vein occlusion	1
RETINAL PIGMENT EPITHELIOPATHY	1
Retinal depigmentation	1
RESPIRATORY TRACT IRRITATION	1
Respiratory symptom	1
RESPIRATORY SIGHS	1
RESPIRATORY RATE DECREASED	1
RESPIRATORY RATE	1
RESPIRATORY FATIGUE	1
Respiration abnormal	1
Repetitive speech	1
RENAL PAIN	1
RENAL INJURY	1
Renal hypoplasia	1
Renal cancer	1
RENAL AMYLOIDOSIS	1
RED BLOOD CELL COUNT DECREASED	1
RECTAL POLYP	1
RECTAL FISSURE	1
Reading disorder	1
REACTION TO COLOURING	1
RAYNAUD'S PHENOMENON	1
RASH VESICULAR	1
RASH SCARLATINIFORM	1
Rapid eye movements sleep abnormal	1
RADIUS FRACTURE	1
Quadrantanopia	1
PYURIA	1
PYROMANIA	1
Pyramidal tract syndrome	1
PYELONEPHRITIS	1
Pustule	1
PURULENT DISCHARGE	1
Pulmonary valve disease	1
PULMONARY MASS	1
Pulmonary fibrosis	1
Pulmonary arterial hypertension	1
Psychotic symptom	1
PSYCHOSOMATIC DISEASE	1
PSYCHOMOTOR AGITATION	1
Pseudostroke	1
PSEUDOMEMBRANOUS COLITIS	1
Pseudolymphoma	1
PSEUDO LYMPHOMA	1
Pruritus genital	1
PROTEINURIA	1
PROTEIN URINE PRESENT	1
PROSTATIC SPECIFIC ANTIGEN INCREASED	1
PROSTATIC PAIN	1
Prostatic calcification	1
Prostate cancer	1
Prolactin-producing pituitary tumour	1
Product used for unknown indication	1
Product substitution error	1
PRODUCT SIZE ISSUE	1
Product shape issue	1
PRODUCT PACKAGING ISSUE	1
Product name confusion	1
Product dosage form confusion	1
Product contamination physical	1
Product communication issue	1
Product commingling	1
Product appearance confusion	1
Prinzmetal angina	1
PREMATURE LABOUR	1
Precancerous cells present	1
PRE-EXISTING DISEASE	1
POVERTY OF THOUGHT CONTENT	1
Poverty of speech	1
Postural orthostatic tachycardia syndrome	1
Postpartum depression	1
POSTNASAL DRIP	1
Post-traumatic neck syndrome	1
POST PROCEDURAL BILE LEAK	1
Post concussion syndrome	1
PORPHYRINURIA	1
PORPHYRIA NON-ACUTE	1
POOR QUALITY DRUG ADMINISTERED	1
POOR PERIPHERAL CIRCULATION	1
Polyp	1
Polymorphic light eruption	1
POLYMENORRHOEA	1
POLYHYDRAMNIOS	1
PODAGRA	1
PO2 INCREASED	1
Pneumonia necrotising	1
Pneumonia bacterial	1
PLEURITIC PAIN	1
Pleurisy	1
PLACENTAL DISORDER	1
Pityriasis rosea	1
Pituitary tumour	1
PITTING OEDEMA	1
PINEAL GLAND CYST	1
PILONIDAL CYST CONGENITAL	1
Physical product label issue	1
PHRENIC NERVE PARALYSIS	1
PHOTOPSIA	1
PHOSPHENES	1
Phimosis	1
Philadelphia chromosome positive	1
PHARYNX DISCOMFORT	1
Pharyngeal erythema	1
PHARMACEUTICAL PRODUCT COUNTERFEIT	1
Peyronie's disease	1
Persistent left superior vena cava	1
Persistent genital arousal disorder	1
Persistent foetal circulation	1
PERONEAL NERVE PALSY	1
Peripheral vascular disorder	1
PERIPHERAL ARTERIAL OCCLUSIVE DISEASE	1
Pericardial haemorrhage	1
PERIARTHRITIS	1
PENIS DISORDER	1
Penile pain	1
Penile cancer	1
Pelvic fracture	1
Pelvic floor dysfunction	1
PECTUS EXCAVATUM	1
PATIENT RESTRAINT	1
Patellofemoral pain syndrome	1
Patella fracture	1
Partial seizures with secondary generalisation	1
PAROTITIS	1
Parkinsonian gait	1
Parathyroidectomy	1
PARAPLEGIA	1
Paranasal sinus hypersecretion	1
Pancreatitis acute	1
Pancreatic mass	1
Pancreatic enzymes decreased	1
PANCREATIC ABSCESS	1
PALATAL OEDEMA	1
Oxygen therapy	1
Ovarian enlargement	1
OVARIAN DISORDER	1
Ototoxicity	1
Osteosclerosis	1
OSTEONECROSIS	1
Orthostatic tremor	1
Oropharyngeal plaque	1
Orgasm abnormal	1
ORAL SOFT TISSUE DISORDER	1
ORAL INTAKE REDUCED	1
OPTIC NEURITIS	1
OPTIC ISCHAEMIC NEUROPATHY	1
Oppositional defiant disorder	1
OPIATES POSITIVE	1
OPHTHALMOLOGICAL EXAMINATION	1
OPEN WOUND	1
ONYCHOPHAGIA	1
Onychomycosis	1
Onychomadesis	1
Onycholysis	1
Oligospermia	1
OLIGODIPSIA	1
OILY SKIN	1
OESTRADIOL DECREASED	1
Oesophageal obstruction	1
Oesophageal dysplasia	1
Oedema genital	1
Oculocephalogyric reflex absent	1
OBSTRUCTION	1
OBSESSIVE-COMPULSIVE PERSONALITY DISORDER	1
NUCLEAR MAGNETIC RESONANCE IMAGING BRAIN ABNORMAL	1
NOSOCOMIAL INFECTION	1
NOSE DEFORMITY	1
NORMOCHROMIC NORMOCYTIC ANAEMIA	1
Nonspecific reaction	1
Noninfective encephalitis	1
NON-CARDIAC CHEST PAIN	1
Nocturnal dyspnoea	1
Nocturia	1
NO REACTION ON PREVIOUS EXPOSURE TO DRUG	1
NO ADVERSE REACTION	1
NO ADVERSE DRUG EFFECT	1
Night blindness	1
NEUTROPHILIA	1
NEUTROPHIL PERCENTAGE INCREASED	1
Neutrophil count	1
NEUROSENSORY HYPOACUSIS	1
Neuropsychiatric syndrome	1
NEURONE-SPECIFIC ENOLASE INCREASED	1
NEUROLOGICAL EXAMINATION ABNORMAL	1
Neurogenic shock	1
NEURODERMATITIS	1
Neuritis	1
Nerve compression	1
NEPHROTIC SYNDROME	1
NEPHROSCLEROSIS	1
Nephrogenic diabetes insipidus	1
NEPHRITIS INTERSTITIAL	1
NEPHRITIS	1
Neoplasm malignant	1
NEOPLASM	1
Neonatal tachypnoea	1
Neonatal hypoxia	1
NEONATAL DISORDER	1
NEONATAL ASPIRATION	1
NEONATAL ASPHYXIA	1
NECROTISING COLITIS	1
Neck mass	1
Neck injury	1
NASOPHARYNGEAL DISORDER	1
NASAL SEPTUM PERFORATION	1
NASAL SEPTUM DISORDER	1
Nasal inflammation	1
Nasal flaring	1
Nasal dryness	1
NARCOLEPSY	1
Nail disorder	1
Naevus flammeus	1
Myocardial strain	1
Myocardial necrosis marker increased	1
MYASTHENIA GRAVIS	1
MUSCULOSKELETAL DISORDER	1
Muscle injury	1
MUSCLE ATROPHY	1
MURDER	1
Multiple sclerosis relapse	1
Multiple injuries	1
MULTIPLE EPIPHYSEAL DYSPLASIA	1
MULTIPLE CONGENITAL ABNORMALITIES	1
MUCOSAL HAEMORRHAGE	1
MOTOR DEVELOPMENTAL DELAY	1
Monoplegia	1
MIXED CONNECTIVE TISSUE DISEASE	1
MITRAL VALVE STENOSIS	1
MILK ALLERGY	1
MIDDLE EAR DISORDER	1
MICROTIA	1
MICROPHTHALMOS	1
MICROPENIS	1
MICROGNATHIA	1
Metastases to liver	1
METASTASES TO CENTRAL NERVOUS SYSTEM	1
Metamorphopsia	1
METABOLIC ENCEPHALOPATHY	1
MERALGIA PARAESTHETICA	1
MENTAL DISORDER DUE TO A GENERAL MEDICAL CONDITION	1
MENTAL DISABILITY	1
Menstruation delayed	1
Menstrual disorder	1
Menopausal symptoms	1
MENOMETRORRHAGIA	1
Meniscus injury	1
Meningioma benign	1
MENIERE'S DISEASE	1
MENARCHE	1
Melanocytic naevus	1
Mediastinal disorder	1
Mechanical ventilation	1
Mechanical urticaria	1
Measles	1
Mean arterial pressure decreased	1
Mastitis	1
Mastication disorder	1
Male orgasmic disorder	1
Madarosis	1
MACROGNATHIA	1
LYMPHOMA	1
Lymphoid tissue hyperplasia	1
LYMPHANGIECTASIA	1
Lymphadenitis	1
Lung opacity	1
LUNG CONSOLIDATION	1
Lung assist device therapy	1
LOW DENSITY LIPOPROTEIN INCREASED	1
LOW CARDIAC OUTPUT SYNDROME	1
Low birth weight baby	1
Loss of visual contrast sensitivity	1
LOOSE TOOTH	1
LOCALISED OSTEOARTHRITIS	1
LOCALISED OEDEMA	1
Liver iron concentration increased	1
Liposarcoma	1
Lipoma excision	1
LIP PAIN	1
Lip dry	1
LIMB MALFORMATION	1
LIMB DEFORMITY	1
LIFE SUPPORT	1
LEUKOENCEPHALOPATHY	1
LEUKOENCEPHALOMYELITIS	1
LEUKAEMIA	1
Lentigo	1
Left ventricular dysfunction	1
Left ventricle outflow tract obstruction	1
Large for dates baby	1
Lactose intolerance	1
Lack of spontaneous speech	1
Laboratory test abnormal	1
Knee operation	1
KLEBSIELLA INFECTION	1
Kidney infection	1
Ketosis	1
KERATOCONJUNCTIVITIS SICCA	1
Keratitis	1
KAWASAKI'S DISEASE	1
JUVENILE ARTHRITIS	1
Jugular vein thrombosis	1
JOINT WARMTH	1
JOINT RANGE OF MOTION DECREASED	1
Joint injury	1
JEALOUS DELUSION	1
Jaw operation	1
JAW FRACTURE	1
JAUNDICE NEONATAL	1
JAUNDICE CHOLESTATIC	1
ISOIMMUNISATION	1
ISCHAEMIC HEPATITIS	1
Irregular breathing	1
Investigation	1
Intraventricular haemorrhage	1
INTRAOCULAR PRESSURE TEST	1
INTRACRANIAL ANEURYSM	1
INTRACARDIAC THROMBUS	1
Intestinal transit time decreased	1
Intestinal perforation	1
INTESTINAL FUNCTIONAL DISORDER	1
INTERVERTEBRAL DISC INJURY	1
Intervertebral disc compression	1
Interruption of aortic arch	1
Intercepted product storage error	1
Intercepted medication error	1
INTERCEPTED DRUG DISPENSING ERROR	1
Intentional dose omission	1
Intensive care	1
Injury corneal	1
Injection site bruising	1
Injection related reaction	1
Inguinal hernia	1
Infertility	1
INFANTILE APNOEIC ATTACK	1
INDUCED LABOUR	1
INCREASED UPPER AIRWAY SECRETION	1
Incorrect product dosage form administered	1
Incorrect dosage administered	1
INABILITY TO CRAWL	1
Impaired quality of life	1
Immune thrombocytopenia	1
Immune system disorder	1
Illness anxiety disorder	1
ILEAL PERFORATION	1
IDIOSYNCRATIC DRUG REACTION	1
Hypovolaemia	1
HYPORESPONSIVE TO STIMULI	1
Hypophosphataemia	1
Hypoosmolar state	1
Hypoglycaemia neonatal	1
HYPOGEUSIA	1
Hypoalbuminaemia	1
Hypertransaminasaemia	1
HYPERTENSIVE NEPHROPATHY	1
Hypertensive heart disease	1
HYPERTELORISM OF ORBIT	1
Hypersexuality	1
Hyperintensity in brain deep nuclei	1
Hyperdynamic left ventricle	1
Hyperchloraemia	1
Hypercapnia	1
Hypercalcaemia	1
HYPERADRENALISM	1
Hydronephrosis	1
Hydrometra	1
HORMONE LEVEL ABNORMAL	1
HIV INFECTION	1
Histrionic personality disorder	1
HIGH ARCHED PALATE	1
HERPES ZOSTER	1
HERPES VIRUS INFECTION	1
HERNIA CONGENITAL	1
HEPATOSPLENOMEGALY	1
HEPATITIS B	1
HEPATIC FIBROSIS	1
Hepatic enzyme	1
Hepatic cancer	1
Henoch-Schonlein purpura	1
HEAT EXHAUSTION	1
Heart transplant	1
Head banging	1
Hand fracture	1
HAIR TEXTURE ABNORMAL	1
Hair growth abnormal	1
HAIR COLOUR CHANGES	1
Haemorrhoids thrombosed	1
Haemorrhagic stroke	1
HAEMORRHAGE URINARY TRACT	1
HAEMORRHAGE SUBCUTANEOUS	1
Haemophagocytic lymphohistiocytosis	1
HAEMOGLOBIN S DECREASED	1
Haemoglobin increased	1
Haemoglobin	1
HAEMOCONCENTRATION	1
HAEMATOLOGY TEST ABNORMAL	1
HAEMATOCRIT DECREASED	1
Haemangioma of skin	1
Guillain-Barre syndrome	1
Grunting	1
Groin pain	1
GRANULOMA	1
GRANULOCYTOPENIA	1
GOITRE	1
Glycosylated haemoglobin increased	1
Glucose tolerance impaired	1
GLOMERULONEPHRITIS	1
GLOMERULAR FILTRATION RATE DECREASED	1
Glioma	1
Gingival abscess	1
Genital swelling	1
Genital rash	1
GENITAL HERPES	1
Genetic polymorphism	1
Gender dysphoria	1
GASTROSTOMY TUBE INSERTION	1
GASTROINTESTINAL MALFORMATION	1
Gastrointestinal inflammation	1
Gastrointestinal complication associated with device	1
Gastroduodenitis	1
Gastritis viral	1
GASTRIC ULCER HAEMORRHAGE	1
Gastric operation	1
Gastric mucosa erythema	1
Gastric fistula	1
Gambling disorder	1
GAMBLING	1
Gallbladder pain	1
Gallbladder disorder	1
Fungal skin infection	1
FUNGAL OESOPHAGITIS	1
Fungaemia	1
Frontal lobe epilepsy	1
Freezing phenomenon	1
FREE FATTY ACIDS DECREASED	1
Foreign body in throat	1
Foreign body in respiratory tract	1
Foreign body in gastrointestinal tract	1
FOREIGN BODY ASPIRATION	1
Forceps delivery	1
Foot deformity	1
Food refusal	1
Food intolerance	1
FOOD INTERACTION	1
FOETAL HEART RATE ABNORMAL	1
Foetal distress syndrome	1
FOETAL ARRHYTHMIA	1
Focal dyscognitive seizures	1
FLOUR SENSITIVITY	1
FLASHBACK	1
FLANK PAIN	1
FISTULA	1
FINGER DEFORMITY	1
FIBROSIS	1
Female orgasmic disorder	1
FEELING HOT AND COLD	1
FEEDING DISORDER OF INFANCY OR EARLY CHILDHOOD	1
Fear of death	1
Factor V Leiden mutation	1
Facial paresis	1
Eyelid ptosis congenital	1
EYELID PTOSIS	1
EYELID PAIN	1
EYE ROLLING	1
EYE DISCHARGE	1
Eye burns	1
EXTREMITY CONTRACTURE	1
EXTRAOCULAR MUSCLE DISORDER	1
Expressive language disorder	1
Exophthalmos	1
Exomphalos	1
Exfoliative rash	1
ESCHERICHIA URINARY TRACT INFECTION	1
ERYTHEMA NODOSUM	1
Erysipelas	1
Erosive oesophagitis	1
Epiglottic erythema	1
EPIGASTRIC DISCOMFORT	1
Epidermal necrosis	1
EOSINOPHIL COUNT ABNORMAL	1
Environmental exposure	1
Entropion	1
Enterocolitis viral	1
ENTEROCOLITIS HAEMORRHAGIC	1
ENTERITIS	1
Endotracheal intubation complication	1
Endometriosis	1
Encephalomalacia	1
Encephalitis	1
Enanthema	1
Empty sella syndrome	1
EMPHYSEMA	1
EMBOLISM ARTERIAL	1
ELECTROMECHANICAL DISSOCIATION	1
ELECTROENCEPHALOGRAM	1
Electrocardiogram T wave inversion	1
Electrocardiogram QT interval	1
ELECTRIC SHOCK	1
Ejaculation disorder	1
Ejaculation delayed	1
ECZEMA ASTEATOTIC	1
ECTOPIC PREGNANCY	1
Ear tube insertion	1
Ear pruritus	1
Ear infection staphylococcal	1
Ear infection	1
Ear haemorrhage	1
EAR DISORDER	1
EAR CONGESTION	1
DYSPHASIA	1
DYSMORPHISM	1
DYSLIPIDAEMIA	1
DYSAESTHESIA	1
Dysacusis	1
DUODENAL ULCER HAEMORRHAGE	1
Drug-genetic interaction	1
DRUG RASH WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS	1
DRUG NAME CONFUSION	1
Drug level decreased	1
Drug level changed	1
DRUG LEVEL BELOW THERAPEUTIC	1
DRUG LABEL CONFUSION	1
DRUG INTERACTION INHIBITION	1
DRUG HALF-LIFE INCREASED	1
Drug effect less than expected	1
Drug effect faster than expected	1
DRUG EFFECT DELAYED	1
Drug dose titration not performed	1
Drug dispensed to wrong patient	1
Drug administered to patient of inappropriate age	1
DOUBLE URETER	1
Diverticulum	1
DISTURBANCE IN SOCIAL BEHAVIOUR	1
Distributive shock	1
DISINHIBITION	1
Disease complication	1
DILATATION VENTRICULAR	1
DILATATION ATRIAL	1
DIASTOLIC HYPOTENSION	1
DIASTOLIC DYSFUNCTION	1
Diaphragmatic paralysis	1
DIAPHRAGMATIC HERNIA	1
DIABETES MELLITUS NON-INSULIN-DEPENDENT	1
DEXTROCARDIA	1
DEVICE OCCLUSION	1
Device expulsion	1
Dermatitis contact	1
Dermatitis acneiform	1
Dermal cyst	1
Dependence on respirator	1
Dengue fever	1
DEMYELINATION	1
DELUSIONAL DISORDER, PERSECUTORY TYPE	1
Delusion of parasitosis	1
DELIVERY	1
DELIRIUM TREMENS	1
DELAYED FONTANELLE CLOSURE	1
DEFORMITY	1
DEFICIENCY ANAEMIA	1
Debridement	1
DEAFNESS TRANSITORY	1
Dacryostenosis acquired	1
Cytogenetic analysis abnormal	1
CYSTOCELE	1
Cystitis interstitial	1
CYP2C19 polymorphism	1
CUTANEOUS VASCULITIS	1
Cushingoid	1
CSF PROTEIN INCREASED	1
CSF LACTATE INCREASED	1
CRYPTOPHTHALMOS	1
Crohn's disease	1
Critical illness	1
CREATINE PHOSPHOKINASE DECREASED	1
Craniosynostosis	1
Cortisol increased	1
CORONARY ARTERY SURGERY	1
CORONARY ARTERY BYPASS	1
Coronary arterial stent insertion	1
Cor pulmonale	1
COPROLALIA	1
CONSTRICTED AFFECT	1
Conjunctivitis bacterial	1
CONJUNCTIVITIS ALLERGIC	1
Conjunctival hyperaemia	1
Conjunctival disorder	1
Congenital tricuspid valve incompetence	1
Congenital pulmonary artery anomaly	1
Congenital mitral valve stenosis	1
Congenital hydronephrosis	1
Congenital heart valve disorder	1
CONGENITAL EYE DISORDER	1
Congenital cystic kidney disease	1
Congenital coronary artery malformation	1
Congenital brain damage	1
CONCOMITANT DISEASE AGGRAVATED	1
Colonoscopy	1
Colon cancer	1
Colitis microscopic	1
Cold-stimulus headache	1
Coating in mouth	1
Cluster headache	1
Clubbing	1
Clostridium difficile infection	1
CLITORAL ENGORGEMENT	1
CLAVICLE FRACTURE	1
Clang associations	1
Chronic myeloid leukaemia	1
CHRONIC LYMPHOCYTIC LEUKAEMIA	1
CHROMOSOME ABNORMALITY	1
CHROMOSOMAL MUTATION	1
Chromatopsia	1
Chorioretinopathy	1
CHOLECYSTITIS INFECTIVE	1
CHOLECYSTITIS CHRONIC	1
CHOLECYSTITIS ACUTE	1
CHOLECYSTITIS	1
CHEYNE-STOKES RESPIRATION	1
CHEST X-RAY ABNORMAL	1
CHEST WALL PAIN	1
Chest wall mass	1
CHANGE OF BOWEL HABIT	1
Change in sustained attention	1
CERVIX CERCLAGE PROCEDURE	1
CERUMEN IMPACTION	1
Cerebrovascular disorder	1
Cerebral small vessel ischaemic disease	1
Cerebral hypoperfusion	1
CEREBRAL CYST	1
CEREBRAL ATAXIA	1
CEREBRAL ARTERY EMBOLISM	1
Cerebellar stroke	1
CEPHALHAEMATOMA	1
Central obesity	1
CENTRAL NERVOUS SYSTEM LYMPHOMA	1
Central nervous system infection	1
CELL DEATH	1
Carotid artery disease	1
Carotid arteriosclerosis	1
Cardiovascular symptom	1
CARDIOSPASM	1
Cardiac malposition	1
Cardiac fibrillation	1
Cardiac dysfunction	1
Cardiac death	1
Carcinoid syndrome	1
Capillary nail refill test abnormal	1
CAPILLARY DISORDER	1
Candida infection	1
CAMPBELL DE MORGAN SPOTS	1
Burning mouth syndrome	1
BRONCHOPULMONARY ASPERGILLOSIS	1
Bronchiectasis	1
BRONCHIAL HYPERREACTIVITY	1
Brief resolved unexplained event	1
Breath sounds abnormal	1
Breath holding	1
BREATH ALCOHOL TEST POSITIVE	1
BREAST MASS	1
BREAST ENLARGEMENT	1
BREAST DISORDER MALE	1
Breast disorder female	1
Breast cancer stage II	1
Breast cancer metastatic	1
BREAKTHROUGH PAIN	1
BRAIN STEM HAEMORRHAGE	1
Brain operation	1
Brain malformation	1
BRAIN DAMAGE	1
BRAIN CONTUSION	1
Bradycardia neonatal	1
BRACHIAL PLEXUS INJURY	1
Borderline personality disorder	1
BONE MARROW FAILURE	1
Bone lesion	1
BONE DISORDER	1
Body temperature decreased	1
BODY HEIGHT BELOW NORMAL	1
Blunted affect	1
Blood pressure systolic decreased	1
Blood pressure orthostatic	1
Blood pressure normal	1
Blood pressure diastolic increased	1
Blood pressure abnormal	1
BLOOD POTASSIUM INCREASED	1
BLOOD POTASSIUM ABNORMAL	1
BLOOD PHOSPHORUS DECREASED	1
Blood phosphorus abnormal	1
Blood magnesium decreased	1
BLOOD LUTEINISING HORMONE INCREASED	1
Blood loss anaemia	1
BLOOD LACTATE DEHYDROGENASE ABNORMAL	1
BLOOD KETONE BODY DECREASED	1
BLOOD IRON DECREASED	1
Blood immunoglobulin G increased	1
BLOOD GLUCOSE ABNORMAL	1
BLOOD FOLLICLE STIMULATING HORMONE INCREASED	1
BLOOD ELECTROLYTES ABNORMAL	1
BLOOD DISORDER	1
Blood creatinine abnormal	1
Blood creatine phosphokinase MB increased	1
BLOOD CREATINE PHOSPHOKINASE ABNORMAL	1
BLOOD CORTISOL DECREASED	1
Blood cholesterol abnormal	1
BLOOD CATECHOLAMINES INCREASED	1
BLOOD CALCIUM DECREASED	1
BLOOD CAFFEINE INCREASED	1
BLOOD BLISTER	1
BLOOD BILIRUBIN UNCONJUGATED INCREASED	1
BLOOD BICARBONATE INCREASED	1
BLOOD AMYLASE INCREASED	1
Blood alkaline phosphatase abnormal	1
Blood aldosterone increased	1
BLINDNESS UNILATERAL	1
BLEEDING TIME PROLONGED	1
BLEEDING PERIPARTUM	1
Bladder spasm	1
Bladder outlet obstruction	1
Bladder operation	1
Bladder discomfort	1
BITE	1
Bipolar II disorder	1
BILIRUBIN URINE	1
Biliary colic	1
Bile duct obstruction	1
BIFASCICULAR BLOCK	1
Bicytopenia	1
BENIGN PROSTATIC HYPERPLASIA	1
Benign breast neoplasm	1
Behcet's syndrome	1
Behaviour disorder	1
Basilar artery stenosis	1
Basal ganglia haemorrhage	1
Basal cell carcinoma	1
BARRETT'S OESOPHAGUS	1
BACK INJURY	1
Bacillus infection	1
AZOOSPERMIA	1
AUTOSOMAL CHROMOSOME ANOMALY	1
Auditory disorder	1
Atypical pneumonia	1
ATROPHY OF TONGUE PAPILLAE	1
ATRIOVENTRICULAR SEPTAL DEFECT	1
ATRIOVENTRICULAR BLOCK FIRST DEGREE	1
Atrial tachycardia	1
ATRIAL SEPTAL DEFECT ACQUIRED	1
Atopy	1
ATONIC SEIZURES	1
ASTROCYTOMA	1
Asthma exercise induced	1
Asterixis	1
Aspiration bronchial	1
Aspiration bone marrow abnormal	1
ASPHYXIATING THORACIC DYSTROPHY	1
ARTHRITIS REACTIVE	1
ARTERITIS	1
ARTERIOPATHIC DISEASE	1
Arnold-Chiari malformation	1
APTYALISM	1
Appendicitis	1
APPARENT LIFE THREATENING EVENT	1
Apnoea neonatal	1
Aphthous ulcer	1
APHONIA	1
Aortic disorder	1
Aortic dilatation	1
Aortic arteriosclerosis	1
ANXIETY DISORDER	1
ANTITHROMBIN III INCREASED	1
ANTISOCIAL PERSONALITY DISORDER	1
ANTIPSYCHOTIC DRUG LEVEL ABOVE THERAPEUTIC	1
Antiphospholipid syndrome	1
ANTIDEPRESSANT DRUG LEVEL DECREASED	1
ANTIDEPRESSANT DRUG LEVEL BELOW THERAPEUTIC	1
ANTIDEPRESSANT DRUG LEVEL ABOVE THERAPEUTIC	1
ANTICONVULSANT DRUG LEVEL BELOW THERAPEUTIC	1
ANTI-THYROID ANTIBODY POSITIVE	1
Anterograde amnesia	1
Anoxia	1
Anosognosia	1
Ankle operation	1
Anisocoria	1
ANGIOMYOLIPOMA	1
Anastomotic leak	1
ANALGESIC EFFECT	1
Anal pruritus	1
Anal fistula	1
Anal abscess	1
Anaemia megaloblastic	1
Anaemia macrocytic	1
Amylase increased	1
AMPHETAMINES POSITIVE	1
Amniocentesis abnormal	1
Ammonia increased	1
AMBLYOPIA	1
ALOPECIA EFFLUVIUM	1
ALLERGIC RESPIRATORY SYMPTOM	1
Allergic reaction to excipient	1
Allergic oedema	1
ALCOHOLIC	1
Alcohol use disorder	1
Alanine aminotransferase abnormal	1
AKINESIA	1
AGORAPHOBIA	1
ADRENAL INSUFFICIENCY	1
Adjustment disorder	1
Acute stress disorder	1
ACUTE FEBRILE NEUTROPHILIC DERMATOSIS	1
ACQUIRED DIAPHRAGMATIC EVENTRATION	1
ACOUSTIC NEUROMA	1
Acidosis hyperchloraemic	1
Accident	1
ACALCULIA	1
ABORTION OF ECTOPIC PREGNANCY	1
Abdominal wall disorder	1
ABDOMINAL WALL ANOMALY	1
ABDOMINAL TRANSPOSITION	1
Abdominal symptom	1

Filtered ChEMBL targets:

Target UniProtKB ID	Activity in nm	Target Name	Target gene
P07510	7.9	Acetylcholine receptor subunit gamma	ACHG_HUMAN
P11230	7.9	Acetylcholine receptor subunit beta	ACHB_HUMAN
P23975	443	Sodium-dependent noradrenaline transporter	SC6A2_HUMAN
P30926	1.8	Neuronal acetylcholine receptor subunit beta-4	ACHB4_HUMAN
P36544	7900	Neuronal acetylcholine receptor subunit alpha-7	ACHA7_HUMAN
Q01959	441	Sodium-dependent dopamine transporter	SC6A3_HUMAN

Toxicity information:

Toxicity class:	3
Toxicity type:	neurological
LD50:	250 mg/kg

External links:

ChEBML:	CHEMBL894
DrugBank:	DB01156