Flunitrazepam

General information:

Withdrawn ID:	w230
Canonical SMILES:
Standard InChI:
Standard InChIKey:
ATC class(es):	N05CD03
Molecular Formula:	C16H12FN3O3
Molweight:	313.283

Withdrawal information:

Withdrawn due to drug safety reasons:	Yes
First approved:	1975
First withdrawn:	1996
Last withdrawn:	1996
Reference:	https://dij.sagepub.com/content/35/1/293.full.pdf

Side-effects:

Total reported cases (submitted by medical professionals) with Flunitrazepam as primary suspect:	9

Reported final outcomes:

Hospitalization (initial or prolonged):	5
Life-Threatening condition:	1

Reported side-effects:

Side-effect	Case number
Overdose	4
Altered state of consciousness	2
Drug withdrawal syndrome	2
Toxicity to various agents	2
Hallucination, visual	2
Delirium	2
Coma	2
Dehydration	1
COORDINATION ABNORMAL	1
Delusion	1
Disorientation	1
DIZZINESS	1
DRUG ABUSER	1
Drug dependence	1
Drug eruption	1
DRUG INTERACTION	1
DRUG LEVEL INCREASED	1
ASTHENIA	1
Hallucination, auditory	1
GENERAL PHYSICAL HEALTH DETERIORATION	1
Generalised tonic-clonic seizure	1
Heart rate abnormal	1
Hepatic function abnormal	1
Hyporeflexia	1
Hypotension	1
Inflammation	1
Intentional overdose	1
LOSS OF CONSCIOUSNESS	1
Neuroleptic malignant syndrome	1
NYSTAGMUS	1
Oxygen saturation decreased	1
Pneumonia aspiration	1
Respiratory disorder	1
Rhabdomyolysis	1
Suicide attempt	1

Filtered ChEMBL targets:

Target UniProtKB ID	Activity in nm	Target Name	Target gene
P18507	1.4	Gamma-aminobutyric acid receptor subunit gamma-2	GBRG2_HUMAN

Toxicity information:

Toxicity class:	6
Toxicity type:	multiple
LD50:	8687 mg/kg

External links:

ChEBML:	CHEMBL13280
DrugBank:	DB01544