Pentobarbital


w223



General information:


Withdrawn ID: w223
Canonical SMILES:
Standard InChI:
Standard InChIKey:
ATC class(es): N05CA01
Molecular Formula: C11H18N2O3
Molweight: 226.272



Withdrawal information:


Withdrawn due to drug safety reasons:Yes
First approved: 1930
First death: 1929
First withdrawn: 1985
Last withdrawn: 1985
Reference: https://www.ncbi.nlm.nih.gov/pubmed/26174446



Side-effects:

Total reported cases (submitted by medical professionals) with Pentobarbital as primary suspect: 94


Reported final outcomes:
Intervention required to prevent permanent impairment/damage: 51
Hospitalization (initial or prolonged): 9
Death: 8
Life-Threatening condition: 3


Reported side-effects:

Side-effect Case number
OXYGEN SATURATION DECREASED46
PROCEDURAL COMPLICATION15
ASPIRATION13
CARDIAC ARREST12
HAEMODYNAMIC INSTABILITY10
Lactic acidosis9
Neuropathy peripheral7
HYPOXIA6
Urinary tract infection4
Pneumonia4
Fungal infection4
COMPLETED SUICIDE4
APNOEA4
HYPOTENSION4
HYPOVENTILATION3
Cerebral atrophy3
DEEP VEIN THROMBOSIS3
BRADYCARDIA3
AGITATION3
Toxicity to various agents3
METABOLIC ACIDOSIS3
IRRITABILITY2
RESPIRATORY DISTRESS2
CARDIO-RESPIRATORY ARREST2
SEDATION2
Acute kidney injury2
DRUG TOXICITY1
FACE OEDEMA1
DRUG LEVEL DECREASED1
DYSPNOEA1
Abdominal compartment syndrome1
DRUG INEFFECTIVE1
DRUG ERUPTION1
DRUG EFFECT PROLONGED1
DELIRIUM1
DEATH1
CRYING1
COORDINATION ABNORMAL1
CONDITION AGGRAVATED1
CHOREOATHETOSIS1
CEREBRAL SALT-WASTING SYNDROME1
BRAIN OEDEMA1
BLOOD TEST ABNORMAL1
ACCIDENTAL OVERDOSE1
VOMITING1
RESPIRATORY ARREST1
TREATMENT FAILURE1
TRANSFERRIN SATURATION DECREASED1
THROMBOCYTOPENIA1
TACHYCARDIA1
SWOLLEN TONGUE1
SUBARACHNOID HAEMORRHAGE1
STRIDOR1
SNORING1
Sepsis1
SCREAMING1
RESUSCITATION1
RESTLESSNESS1
RESPIRATORY DEPRESSION1
FALL1
Renal failure1
PHARMACEUTICAL PRODUCT COMPLAINT1
PAIN1
OBSTRUCTIVE AIRWAYS DISORDER1
MUSCLE TWITCHING1
MOANING1
METASTATIC NEOPLASM1
MEDICATION ERROR1
LOSS OF CONSCIOUSNESS1
LARYNGOSPASM1
INJURY1
Hypokalaemia1
HEPATIC ENZYME INCREASED1





Toxicity information:

Toxicity class: 3
Toxicity type: multiple
LD50: 145 mg/kg



External links:

ChEBML: CHEMBL448
DrugBank: DB00312