Vitamin E

General information:

Withdrawn ID:	w189
Canonical SMILES:
Standard InChI:
Standard InChIKey:
ATC class(es):	A11HA03
Molecular Formula:	C29H50O2
Molweight:	430.706

Withdrawal information:

Withdrawn due to drug safety reasons:	Yes
First approved:	1983
First death:	1984
First withdrawn:	1984
Last withdrawn:	1984
Reference:	https://www.ncbi.nlm.nih.gov/pubmed/25739461

Side-effects:

Total reported cases (submitted by medical professionals) with Vitamin E as primary suspect:	5

Reported final outcomes:

Hospitalization (initial or prolonged):	1
Life-Threatening condition:	1
Intervention required to prevent permanent impairment/damage:	1

Reported side-effects:

Side-effect	Case number
Drug dispensing error	2
Product substitution issue	2
PRODUCT ODOUR ABNORMAL	2
MEDICATION ERROR	1
AUTOIMMUNE HEPATITIS	1
BILIARY DILATATION	1
CARDIAC ARREST	1
Cerebral haemorrhage	1
Erythema	1
HEPATIC NECROSIS	1
Hydrocephalus	1
Hyperthyroidism	1
INTERNATIONAL NORMALISED RATIO INCREASED	1
LIVER INJURY	1
Wrong drug administered	1
OXYGEN SATURATION DECREASED	1
Product quality issue	1
PRODUCT TASTE ABNORMAL	1
PULSE ABSENT	1
RESPIRATORY RATE DECREASED	1
RESPIRATORY RATE INCREASED	1
RETCHING	1
SINUS BRADYCARDIA	1
TUBERCULIN TEST POSITIVE	1

Filtered ChEMBL targets:

Target UniProtKB ID	Activity in nm	Target Name	Target gene
P02545	112.2	Prelamin-A/C	LMNA_HUMAN
P09211	500	Glutathione S-transferase P	GSTP1_HUMAN
P10636	3548.1	Microtubule-associated protein tau	TAU_HUMAN
P49638	2420	Alpha-tocopherol transfer protein	TTPA_HUMAN

Toxicity information:

Toxicity class:	5
Toxicity type:	hepatic
LD50:	5000 mg/kg

External links:

ChEBML:	CHEMBL47
DrugBank:	DB00163